THE PRESENTATION INCLUDES INTRODUCTION, CLASSIFICATION( PRIMARY AND SECONDARY POLYCYTHEMIA), ETIOLOGY & PATHOPHYSIOLOGY, CLINICAL MENIFESTATIONS AND MANAGEMENT(MEDICAL AND NURSING) OF POLYCYTHEMIA.
THE PRESENTATION INCLUDES INTRODUCTION, CLASSIFICATION( PRIMARY AND SECONDARY POLYCYTHEMIA), ETIOLOGY & PATHOPHYSIOLOGY, CLINICAL MENIFESTATIONS AND MANAGEMENT(MEDICAL AND NURSING) OF POLYCYTHEMIA.
This PPT covers pathophysiology of thrombocytopenia which includes causes of thrombocytopenia, symptoms of thrombocytopenia and diagnosis of thrombocytopenia
When your blood has too few platelets, mild
to serious bleeding can occur. Bleeding can occur inside your body (internal
bleeding) or underneath your skin or from the surface of your skin (external
bleeding).
A normal platelet count in adults ranges
from 150,000 to 450,000 platelets per microliter of blood. A platelet count of
less than 150,000 platelets per microliter is lower than normal. If your blood
platelet count falls below normal, you have thrombocytopenia.
However, the risk for serious bleeding
doesn't occur until the count becomes very low—less than 10,000 or 20,000
platelets per microliter. Mild bleeding sometimes occurs when the count is less
than 50,000 platelets per microliter.
Many factors can cause a low platelet
count, such as:
-- The body's bone marrow doesn't make enough
platelets.
-- The bone marrow makes enough platelets, but
the body destroys them or uses them up.
-- The spleen holds on to too many platelets.
The spleen is an organ that normally stores about one-third of the body's
platelets. It also helps your body fight infection and remove unwanted cell
material.
-- A combination of the above factors.
-- How long thrombocytopenia lasts depends on
its cause. It can last from days to years.
The treatment for this condition also
depends on its cause and severity. Mild thrombocytopenia often doesn't require
treatment. If the condition causes or puts you at risk for serious bleeding,
you may need medicines or blood or
platelet transfusions. Rarely, the spleen may need to be removed.
Polycythaemia (erythrocytosis) is defined as an increase in the haemoglobin concentration above the upper limit of normal for the patient's age and sex.
This PPT covers pathophysiology of thrombocytopenia which includes causes of thrombocytopenia, symptoms of thrombocytopenia and diagnosis of thrombocytopenia
When your blood has too few platelets, mild
to serious bleeding can occur. Bleeding can occur inside your body (internal
bleeding) or underneath your skin or from the surface of your skin (external
bleeding).
A normal platelet count in adults ranges
from 150,000 to 450,000 platelets per microliter of blood. A platelet count of
less than 150,000 platelets per microliter is lower than normal. If your blood
platelet count falls below normal, you have thrombocytopenia.
However, the risk for serious bleeding
doesn't occur until the count becomes very low—less than 10,000 or 20,000
platelets per microliter. Mild bleeding sometimes occurs when the count is less
than 50,000 platelets per microliter.
Many factors can cause a low platelet
count, such as:
-- The body's bone marrow doesn't make enough
platelets.
-- The bone marrow makes enough platelets, but
the body destroys them or uses them up.
-- The spleen holds on to too many platelets.
The spleen is an organ that normally stores about one-third of the body's
platelets. It also helps your body fight infection and remove unwanted cell
material.
-- A combination of the above factors.
-- How long thrombocytopenia lasts depends on
its cause. It can last from days to years.
The treatment for this condition also
depends on its cause and severity. Mild thrombocytopenia often doesn't require
treatment. If the condition causes or puts you at risk for serious bleeding,
you may need medicines or blood or
platelet transfusions. Rarely, the spleen may need to be removed.
Polycythaemia (erythrocytosis) is defined as an increase in the haemoglobin concentration above the upper limit of normal for the patient's age and sex.
Hematemesis- vomiting of blood , a brief studymartinshaji
There can be many causes of hematemesis, such as: bleeding ulcers. prolonged and vigorous retching that causes tears in the esophageal mucosa (known as Mallory-Weiss Syndrome) gastric or intestinal varices.Haematemesis is simply defined as “vomiting blood”. It is caused by bleeding from part of the upper portion of the gastrointestinal tract. It has a wide range of possible causes, depending on the site of blood loss and the tissue that is actively bleeding. Hence it is necessary to analyse and treat the condition perfectly , this is brief study about all the aspects hematemesis ,vomiting of blood including etiology, definition,management ,treatment by drugs etc
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Nursing Care of Clients with Peripheral Vascular Disorders Part 2 of 3 Carmela Domocmat
Nursing Care of Clients with Peripheral Vascular Disorders Part 2 of 3: Arterial disorders such as Arterial occlusive disease, Arterial embolism, Arterial thrombosis, Thromboangiitis obliterans (Buerger’s disease), Aortitis, Aortoiliac disease, Aneurysms, Raynaud’s disease, and Thoracic outlet syndrome
A blood clot in a deep vein, usually in the legs.
This condition is serious because blood clots can loosen and lodge in the lungs.
Leg pain or swelling may occur, but there may be no symptoms.
Treatments include medication and use of compression stockings.
Anatomy of pituitary glands,its secretions and disorders due to its imbalance.
Adrenal gland anatomy,its secretions and tumors of adrenal gland and disorders associated with it.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
3. DEFINITION
It is an abnormally increased concentration
of haemoglobin in the blood, either through
reduction of plasma volume or increase in
red cell numbers.
4.
5. People with polycythemia have an increase
in hematocrit, hemoglobin or red blood cell
count above the normal limits.
6.
7.
8.
9. RISK FACTORS
chronic hypoxia
long-term cigarette smoking
familial and genetic predisposition
living in high altitudes
long-term exposure to carbon monoxide (tunnel
workers, car garage attendants, residents ofhighly
polluted cities)
11. PRIMARY POLYCYTHEMIA
Primary Polycythemia occurs when excess
red blood cells are produced as a result of an
abnormality of the bone marrow.
Often, excess white blood cells and platelets
are also produced.
12.
13. SECONDARY POLYCYTHEMIA
Secondary polycythemia is usually due to
increased erythropoietin (EPO) production
either in response to chronic hypoxia (low
blood oxygen level) or from an erythropoietin
secreting tumor.
14.
15.
16. RELATIVE POLYCYTHEMIA
Relative erythrocytosis is an increase in RBC
numbers without an increase in total RBC mass.
Usually, this is caused by loss of plasma volume
with resultant hemo-concentration, as seen in
severe dehydration related to vomiting and
diarrhea.
17.
18. STRESS POLYCYTHEMIA
Stress polycythemia is a term applied to a
chronic (long standing) state of low plasma
volume which is seen commonly in active,
hard working, anxious, middle-aged men. In
these people, the red blood cell volume is
normal, but the plasma volume is low.
19.
20.
21.
22.
23.
24.
25.
26. CLINICAL MANIFESTATIONS
SYMPTOMS RESULTS FROM INCREASED
BLOOD VOLUME:
Cyanosis
Reddened face with engorged retinalveins
Itching after bath
Feeling of fullness in head withheadache
Weakness, fatigue and dizziness
27. Tinnitus (ringing or buzzing in the ears.)
Parasthesia, numbness, burning or weakness in
hands and legs.
Visual disturbances
Nose bleeding
Abdominal bloating
28. SYMPTOMS FROM INCREASED VISCOSITY:
Angina
Dyspnea
Hypoxia
Bone and joint pain
thrombophlebitis
29. OTHER SYMPTOMSARE
Weight loss
Breathing difficulty when lying down
Chronic cough
Night sweats and sleep disturbances
Burning sensation over fingers or toes
Splenomegaly and hepatomegaly
Formation of blood clots in the bloodvessels
30.
31. Due to etiological factors such as tissue
hypoxia .smoking ,genetics
Polycythemia is an increased number of
red blood cells in the blood.
the levels of hemoglobin (Hgb),
hematocrit (Hct), or the red blood cell
(RBC) count may be elevated
Then lead to polycythemia.
32.
33. DIAGNOSIS
HISTORY COLLECTION AND PHYSICAL
EXAMINATION:
History usually includes questions
about smoking, living at high altitudes, breathing
difficulty, sleep disturbances and chronic cough.
34.
35. Blood tests
The blood studies will show
An increase in the number of red blood cells
Elevated hematocrit measurement
Elevated levels of hemoglobin
Very low levels of erythropoietin
36. Bone marrow aspiration or biopsy
If an examination of the bone
marrow shows that it's producing higher than
normal numbers of blood cells, it may be a sign
of polycythemia.
39. MANAGEMENT
PHLEBOTOMY:
Drawing a certain amount of blood
out of the veins in a procedure called
phlebotomy is usually the first treatment option
for people with polycythemia.
This reduces the number of blood
cells and decreases your blood volume, making
it easier for your blood to function properly.
40. Low-dose aspirin
The doctor may recommend that to takea
low dose of aspirin to reduce your risk of bloodclots.
Low-dose aspirin may also helpreduce
burning pain in your feet or hands.
41. Medication to decrease blood cells.
For people with polycythemia, who
aren't helped by phlebotomy alone,
medications, such as hydroxyurea (Droxia,
Hydrea), to suppress the bone marrow's ability
to produce blood cells may be used.
Interferon alpha may be used to
stimulate the immune system to fight the
overproduction of red blood cells.
42. Therapy to reduce itching.
If you have bother some itching,
the doctor may prescribe medication, such
as antihistamines, or recommend ultraviolet
light treatment to relieve your discomfort.
43. LIFESTYLE AND HOME REMEDIES
Exercise.
Moderate exercise, such as walking,
can improve the blood flow, which decreases
your risk of blood clots.
Leg and ankle stretches and
exercises also can improve the blood
circulation.
44. Avoid tobacco.
Using tobacco can cause the
blood vessels to narrow, increasing the risk
of heart attack or stroke due to blood clots.
Watch for sores.
Poor circulation can make it
difficult for sores to heal, particularly on the
hands and feet. Inspect the feet regularly
and tell the doctor about any sores.
45. Be good to your skin.
Toreduce itching, bath in cool water
and pat your skin dry. Avoid hot tubs, heated
whirlpools, and hot showers or baths.
Try not to scratch, as it can damage
your skin and increase the risk of infection. Use
lotion to keep your skin moist.
46. Avoid extreme temperatures.
Poor blood flow increases the risk of
injury from hot and cold temperatures. In cold
weather, always wear warm clothing, particularly
on your hands and feet. In hot weather, protect
yourself from the sun and drink plenty of liquids.
47. NURSING MANAGEMENT
Monitor for peripheral and cerebral thrombosis.
Assist the patient for ambulation
Perform phlebotomy as per doctors order
Administer iv fluids and encourage to take oral fluids
Administer pain management measures
Advice to do regular exercise
48. Instruct to avoid tobacco
Advise to maintain skin hygiene
Avoid extreme temperatures
Provide psychological support to the patient.
49. NURSING DIAGNOSIS
Impaired tissue perfusion related to phlebotomy
as evidenced by cyanosis.
Acute pain related to surgical interventionas
evidenced by verbalization
Impaired breath pattern related to decreased
level of RBC in blood as evidenced by dyspnea.
50. Imbalanced nutrition less than body
requirement related to less oral intake of food
as evidenced by weight loss.
Fear and anxiety related to outcome of
disease condition as evidenced by frequent
doubts.
Knowledge deficit regarding home care
management as evidenced by frequent
doubts.