This document summarizes information on 10 different protein synthesis inhibitor antibiotics: fidaxomicin, chloramphenicol, clindamycin, quinupristin/dalfopristin, and linezolid. It describes the mechanism of action, spectrum of activity, resistance, pharmacokinetics, and adverse effects of each drug. The primary uses are for treating infections caused by gram-positive bacteria like Staphylococcus aureus and antibiotic-resistant strains. Side effects vary between the drugs but include gastrointestinal issues, hematological toxicities, and neurological adverse events with prolonged use.