This document discusses how regions can transform their workforce to succeed in the emerging "grandchildren's economy." It argues that the approaches used in the past, such as vertical business models, will not work and that new strategies are needed. One such strategy presented is "Strategic Doing," which provides discipline to transform regions by focusing efforts, requiring collaboration, and taking flexible, opportunistic approaches. The document also outlines the funding program of the North Central Indiana Opportunity Fund, which provides exploratory, demonstration, and implementation grants to innovative, regional ideas that leverage assets and are sustainable.