Global warming indicates the danger of increasing temperature of earth and its environment. This ppt also tell us about the harm of early future. Melting Icelands or glaciers & increasing sea water level
Global warming indicates the danger of increasing temperature of earth and its environment. This ppt also tell us about the harm of early future. Melting Icelands or glaciers & increasing sea water level
Professor Sir David King at the Bristol Festival Of IdeasJames Barlow
A talk given by Professor Sir David King - former Chief Scientific Adviser to the UK Government - at the Bristol Festival of Ideas, relating to his book "The Hot Topic"
Professor Sir David King at the Bristol Festival Of IdeasJames Barlow
A talk given by Professor Sir David King - former Chief Scientific Adviser to the UK Government - at the Bristol Festival of Ideas, relating to his book "The Hot Topic"
global warming needs to be lessen in order for us to live longer. we must educate people about this so that they will become knowledgeable on its effects and harm to people living on earth.
Syftet med lagstiftningsreformen är framför allt att förbättra service som tillhandahålls hemma och boendeservice enligt socialvårdslagen. För socialvårdslagens del gäller reformen utöver äldre personer även andra klienter inom socialvården. Reformen träder i huvudsak i kraft samtidigt som strukturreformen av ordnandet av social- och hälsovårdstjänster, det vill säga den 1 januari 2023.
Genom reformen ändras socialvårdslagen och äldreomsorgslagen. Till följd av dessa ändringar medför reformen även tekniska ändringar i klientavgiftslagen och i lagen om privat socialservice.
Lainsäädäntöuudistuksessa parannetaan erityisesti sosiaalihuoltolain kotiin annettavia palveluja ja asumispalveluja. Sosiaalihuoltolain osalta uudistus koskee iäkkäiden lisäksi myös muita sosiaalihuollon asiakkaita. Uudistus tulee pääsääntöisesti voimaan 1.1.2023 yhtä aikaa sosiaali- ja terveyspalveluiden järjestämisen rakenneuudistuksen kanssa.
Uudistuksella muutetaan sosiaalihuoltolakia ja vanhuspalvelulakia. Muutosten johdosta uudistuksessa tehdään myös teknisiä muutoksia asiakasmaksulakiin ja yksityisistä sosiaalipalveluista annettuun lakiin.
Diaesitykseen on päivitetty 16.12.22 ohjeistus yhteisöllisen asumisen ja ympärivuorokautisen palveluasumisen toteuttamisesta samassa rakennuskokonaisuudessa.
More from Sosiaali- ja terveysministeriö / yleiset (20)
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. Lessons from reducing air
pollution, it can be done and it
works!
Prof.Pat Goodman
Europe day 13th
June 2013
Helsinki
pat.goodman@dit.ie
3. Talk structure
Sources of air pollution
Air pollution and health
Examples of reducing air pollution and
health benefits
WHO work
Conclusions
4. Where does air pollution come
from?
Most of the harmful pollution, the very
fine particles come from combustion
process;
Namely burning such as coal, oil wood
And engine emissions, especially diesel
Can also have industrial sources
8. Dublin SMOG 1982
Dublin 1982 Case Fatality Rates
Kelly and Clancy, Irish Medical Journal; 77:10: 322-324. 1984CFR
2
3
4
5
6
7
8
9
10
Jan '80 Jan '81 Jan '82 Jan '83
Date
10. Dublin space heating 1980s
The main source of particulate pollution
was the burning of coal in open grates
Space heating for homes was
100% solid fuel for social housing
80% for private housing
(partially supported by Government grants
to reduce the dependence on imported oil)
11.
12. Dublin Coal ban
30th
Sept 1990
Banned the marketing, sale and
distribution of smoky coal in greater
Dublin
14. Effect of Air Pollution Control on
Mortality in Dublin
Clancy et al, Lancet
• Effect of ban on sale of
coal on air pollution in
Dublin
– 36 µg/m3 BS (-71%)
– 11 µg/m3 SO2 (-34%)
• Effect on mortality
– 7% Total Mortality
– 13% Cardiovascular
– 16% Respiratory
– 3% Other
15. JAWMA 2009 extensions of
the Irish coal ban1998 Ban Cities
0
10
20
30
40
50
60
70
80
90
100
w
w
w
w
w
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w
v
s
a
w
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1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006
BlackSmoke(µg/m
3
)
Arklow Drogheda Dundalk Limerick Wexford
1998 Ban
16. Utah Valley, 1980s
• Winter inversions trap local pollution
• Natural test chamber
• Local Steel mill contributed ~50% PM2.5
• Shut down July 1986-August 1987
• Natural Experiment
17. Large difference in air quality
when inversions trap air pollution in valley
Utah Valley: Clean day
Utah Valley: Dirty day
(PM10 = 220 µg/m3
)
18. When the steel mill was open, total children’s hospital
admissions for respiratory conditions approx.
doubled.
Mill
Open
Mill
Closed
19. Event Authors Outcomes
German
Reunification
Peters et al 2009
Suguri et al 2006
Frye et al 2003
Improved air quality and
health benefits
Improved Lung function in
Children
Improved FVC, drop in
bronchitis etc
Bejing Olympic
Games Summer
2008
Li et al 2010
Huang et al 2009
Drop in Asthma admissions
Improved heart rate criteria
Residential Wood
Burning SJ Valley
CA.
Lightall et al 2009 Improved air quality.
Mortality and morbidity cost
savings
Stockholm
Congestion Charging
Zone
Johanson et al 2009 Improved life expectancy
Workplace Smoking Goodman et al 2009 Reduced MI, improved
23. Other evidence
APHEA in Europe
NMMAPS in the US
Air pollution harmful even at low levels
24. The challenges!
Cooking on open fires indoors (very
high exposures in developing countries)
Industrial development in developing
countries
Developed countries, nee dto reduce
fuel consumption, and thus emissions!
For example, in the 1980s I moved to the Provo/Orem area of Utah. This metro area is situated in a mountain valley. Temperature inversions often trap air pollution near the valley floor which serves as a natural test chamber for pollution exposure. Furthermore, in the 1980s the largest local source of air pollution, the Geneva Steel Mill, shut down for 13-months and then reopened, providing a novel natural experiment.
On days without an inversion, like the one in this photo, the air in Utah Valley is very clean. However, as illustrated in this photo on the right, when inversions trap local air pollution, air quality can get very bad—but not as bad as the killer smog episodes of Meuse Valley, Donora, or London. If you look closely, you can see “thermal bubbles” on the top of the inversion layer above smoke stacks of the steel mill.
The intermittent operation of the steel mill provided a natural experiment, where the primary source of pollution in our natural exposure chamber was shut off for 13 months and then turned back on. We used this opportunity to study pollution effects on children’s respiratory hospitalizations. The operation of the mill clearly contributed to elevated levels of air pollution and pediatric hospital admissions for bronchitis, asthma, and total respiratory conditions were approximately doubled.