This document discusses patient safety and monitoring in anesthesia. It covers key topics like ensuring patient safety in anesthesia, important parameters to monitor such as ECG, SpO2, blood pressure, end tidal CO2 and temperature. It discusses the importance of continuous monitoring and vigilance to prevent adverse events. It also covers hypothermia and hyperthermia, noting complications of each, and how to prevent and treat hypothermia with warming measures. Malignant hyperthermia, a rare inherited disorder triggered by certain anesthetics, is also summarized.
This is presentation of basic for anaesthesia technician, about how to check anaesthesia machine before start the procedure. What is the mandatory steps to perform.
This is presentation of basic for anaesthesia technician, about how to check anaesthesia machine before start the procedure. What is the mandatory steps to perform.
Dr rowan molnar anaesthetics study guide part iiDr. Rowan Molnar
Dr rowan molnar anaesthetics study guide part ii
Identification of patient requiring procedure
Referral to perioperative service
Screening for level of workup required
Pre-anaesthetic assessment/plan
Referral & investigations as required.
Admission at appropriate pre-op interval
Post-operative drug/fluid/other therapy
Appropriate post op level of care & stay
Discharge at earliest appropriate point
Dr Rowan Molnar,
Dr Rowan Molnar Anaesthetics,
Dr Rowan
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...
Patient Safety & Monitoring during Anesthesia
1. PATIENT SAFTEY AND MONITORING
Gradian Health Systems
Simulation-Based Product Training
2. Agenda
2
I. Patient Safety in Anesthesia
II. Patient Monitoring
III. Hypothermia vs Hyperthermia
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
3. I. Patient Safety in Anesthesia
3
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
4. Safety in Anesthesia
4
• Safety in anesthesia is the highest priority
• Anesthesia is considered a high risk specialty compared to
other branches of medicine
• Theoretical high risk of morbidity and mortality and
considerable risk of adverse events
• Anesthesia is likened to aviation industry: no room for error
OVERVIEW
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
5. Safety in Anesthesia
5
DOCUMENTED ADVERSE EVENTS IN ANESTHESIA
▪ Cardiac arrest
▪ Perioperative MI
▪ Pulmonary aspiration
▪ Drug overdose/toxicity
▪ Anaphylaxis
▪ Convulsions
▪ Nerve palsies
▪ Organ injury: kidney, liver
▪ Failed airway/airway
obstruction
▪ Post-op nausea / vomiting, sore
throat
▪ Persistent sedation
▪ Hemodynamic instability
▪ Delirium
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
6. Safety in Anesthesia
6
TOP CAUSES OF CARDIAC ARREST UNDER ANETHESIA
• Drug overdose / adverse reaction
• Rhythm disturbances
• Perioperative MI
• Airway obstruction
• High/total spinal
• Lack of vigilance
• Bleeding
• Over-dosage of inhalation agent
• Aspiration
• Technical problem in anesthesia system
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
7. Safety in Anesthesia
7
ANETHESIA MORTALITY
• Anesthesia-related deaths have been drastically reduced over the years
• 1970’s: 1 death per 5,000 anesthetics administered
• 1999: 1 death per 200,000-300,000 anesthetics administered
• Modern day surgical patients are sicker, aged; high surgical burden
• Modern anesthesia is safer due to:
▪ Advanced monitoring equipment
▪ Safer drugs
▪ Advanced anesthetic machines
▪ Advanced airway management
▪ Improved anesthetic/surgical skills and knowledge
▪ Better guidelines and protocols
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
8. Safety in Anesthesia
8
POTENTIAL CAUSES OF ADVERSE EVENTS IN ANETHESIA
• Lack of equipment or
essential supplies
• Poor supervision of
junior staff
• Organizational factors
HUMAN FACTORS PATIENT FACTORS SYSTEMS FACTORS
• Lack of vigilance
• Poor teamwork or
communication
• Lack of clinical
knowledge
• Poor technical
skills
• Co-morbidities (e.g.
severe illness)
• Emergency conditions
• Difficult airway
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
9. Safety in Anesthesia
9
A SAFE SYSTEM
• Preoperative Considerations
• Intraoperative Considerations
• Postoperative Considerations
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
Safe
Surgery
Patient
Facilities,
Equipment,
Drugs
Anesthetist's
Skills
Surgeon's
Skills
10. Safety in Anesthesia
10
ROUTINE PREOPERATIVE ASSESSMENT
Emergency or Elective:
• Patient risk factors
• Make an anesthetic plan
• Discuss/address any concerns
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
11. Safety in Anesthesia
11
INTRAOPERATIVE CONSIDERATIONS
• Prepare/check all equipment
• Prepare and label all required drugs
• Assistance
• Avoid cluttered workspaces
• WHO surgical checklist
• Intraoperative monitoring
• Ongoing vigilance and communication
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
13. Safety in Anesthesia
13
POSTOPERATIVE CONSIDERATIONS
• Awake + alert
• Airway clear
• Breathing well
• Circulation stable
• Temperature stable
• Pain controlled
• Wound not bleeding
• All lines flushed
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
14. Safety in Anesthesia
14
• Be well-prepared
• Always do safety checks in theater
• Beware of similar-looking drugs, cluttered workspace
and distractions
• Always prioritize safety
• Be sure to do a thorough handover
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
SUMMARY OF RECOMMENDATIONS
16. Patient Monitoring
16
• Continuous palpation of the radial pulsations
• Respiration depth and frequency
• Muscle movements
• Skin color
• Stages of excitation or sedation
HISTORY OF CLINICAL ASSESSMENT
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
17. Patient Monitoring
17
• Essential for ensuring patient safety
• Modern monitors have made anesthesia practice significantly
easier than before
• Both digital and clinical monitoring should be used for clinical
judgement
• Digital monitors should not replace provider’s clinical
assessment clinical judgement is superior to monitor
output
GENERAL INFORMATION
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
18. Patient Monitoring
18
• To maintain the patient’s normal physiology and hemostasis
• To reduce and treat response to anesthesia and surgical stress
• To prevent and treat complications due to anesthetic drugs
• To prevent and treat intraoperative complications (hypothermia,
bleeding etc.)
WHY MONITOR DURING SURGERY?
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
19. Patient Monitoring
19
SMOOTH INDUCTION ADEQUATE MATINENCE
EMERENCY AND
RECOVERY
WHAT ARE WE AIMING FOR?
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
20. Patient Monitoring
20
WHAT SHOULD YOU MONITOR IN A NORMAL CASE?
• Electrocardiogram (ECG)
• Saturation (SPO2)
• Blood Pressure (BP)
• End tidal carbon dioxide
(ETCO2)
• Temperature (T)
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
22. Patient Monitoring
22
WHAT DOES THE ECG TELL YOU?
Heart Rate
Normal Rhythm
Abnormal Rhythm
Ischemic Changes
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
23. Patient Monitoring
23
DANGER SIGNALS ON ECG
• Increase in T wave amplitude of more than 25%, suggesting
intravascular injection of local anesthetic drug with epinephrine
• Prominent T waves seen in hyperkaliemia, succinylcholine
injection, use of halothane in patients with muscular dystrophy
and after massive blood transfusion
• Prolonged QT interval in hypocalcaemia during rapid
transfusion of citrated blood and blood products
• Prolonged QT with T wave flattening in hypokalemia
• ST segment changes in cardiac ischemia
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
24. Patient Monitoring
24
ECG CONNECTION
3-Electrode System
Red right
Yellow left
Black apex
*Able to read leads I, II, III
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
25. Patient Monitoring
25
ECG CONNECTION
5-Electrode System
Red right
Yellow left
Black under red
Green under yellow
White central
*Able to read any of the 12 leads: I, II, III,
avR, avL, avF, V1-V6
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
26. Patient Monitoring
26
HOW TO ATTACH ECG ELECTRODES
• Choose a bony prominence
• Avoid fatty regions
• Avoid hairy areas (use jelly)
• Position them far away from eachother
• Ensure good contact with the skin
• If the electrodes will not be accessible during the surgery,
cover them after ensuring good ECG trace
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
27. Patient Monitoring
27
IF NO TRACE (NOISE)
• Follow ECG cable (patient to monitor)
• Ensure good contact with the patient
• Ensure proper fitting of cable connections
• Ensure proper fitting of the cable to the monitor
• Change monitor settings
• Ensure ’earthing’ of the monitor (earth cable from behind)
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
28. Patient Monitoring
28
SPO2
SPO2 is the oxygen
content expressed as a
percentage of the oxygen
capacity
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
29. Patient Monitoring
29
SPO2
• One of the most important indicators to monitor
• Should be continued through perioperative period
• Waveform of pulse oximeter = plethysmography
(arterial waveform)
• Indicates pulse oximeter is reading the arterial O2
saturation
• Without waveform pulse oximeter, readings are
unreliable and incorrect
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
30. Patient Monitoring
30
WHAT DOES THE PULSE OXIMETER TELL YOU?
• SPO2
• Pulse rate vs heart rate
• Peripheral perfusion status (loss of waveform in hypotension
and in cold extremities)
• Irregularity of rhythm
• Cardiac arrest
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
31. Patient Monitoring
31
ATTACHING THE PROBE
• Attached to finger, toe, or
ear lobe
• Red light is applied to nail
• Typically attached to the
limb with the IV line
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
32. Patient Monitoring
32
SPO2 READINGS
• Normal person on room air (O2 = 21%) ˃ 96%
• Patient under GA (100% O2) = 98-100%
• It is not acceptable for O2 saturation to decrease below 96%
with 100% O2 under GA.
Search and treat for possible causes of hypoxia
if SPO2 < 96%
This suggests hypoxemia
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
33. Patient Monitoring
33
POSSIBLE CAUSES OF ERRORS
• Slipped or misplaced on the patient’s finger
• Patient movement and shivering
• Poor tissue perfusion (vasoconstriction, cold extremities
etc.)
• Poor tissue perfusion (hypotension and shock)
• Cardiac arrest
• Electrical interference from cautery in some monitors
• Nail polish and stains (should be removed in advance)
• Bright ambient light
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
34. Patient Monitoring
34
• Keep the sound on at all times
• Pay attention to the sound of the pulse oximeter
• Hypoxia should be treated immediately
• Do clinical examination
• Clinical judgement is more important
• Call for help
DO NOT SILENCE MONITORS
OR
USE HEADPHONES
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
36. Patient Monitoring
36
COMMON CAUSES OF ERRORS
• Disconnection of pressure line
• Leakage from damaged cuff
• Compressed line (under
someone’s foot or under a
weal)
• Incorrect cuff size: cuff cannot
inflate due to infant or neonate
limits
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
37. Patient Monitoring
37
CAPNOGRAPHY (End Tidal CO2)
Continuous CO2 measurement displayed as a waveform sampled
from the patient’s airway during ventilation
What is ETCO2?
A point on the capnograph. It is the final measurement at the
endpoint of the patient’s expiration before inspiration begins again.
It is usually the highest CO2 measurement during ventilation.
UAM Simulation-based Training I Lecture Content | Patient Safety & Monitoring
NORMAL VALUES
• 30 – 43 mmHg
• 4.0 – 5.7 kPa
• 4.0 – 5.6%