The document describes the histological features of various oral lesions seen on hematoxylin and eosin staining of biopsy specimens. These include premalignant lesions like mild and moderate epithelial dysplasia and carcinoma in situ. Other conditions described are lichen planus, oral submucous fibrosis, salivary gland diseases like necrotizing sialometaplasia and chronic sialadenitis, benign salivary gland tumors like pleomorphic adenoma, Warthin's tumor and oncocytoma. Malignant salivary gland tumors discussed include mucoepidermoid carcinoma and adenoid cystic carcinoma. Features of perineural invasion are also highlighted. Finally benign and malignant oral neoplasms like

1. Pathology Practical

2. Premalignant lesions and
conditions CPC

3. Mild Epithelial
Dysplasia
H&E showing :
1. Stratified squamous
epithelium .
2. Hyper chromatism.
3. Cellular polymorphism.
4. Loss of polority .
5. Basal hyperplasia .
6. Some cell in mitosis.
7. Some chronic
inflammatory cells

4. Moderate Epithelial
Dysplasia
H&E showing :
1. Hyperplatic Stratified
squamous epithelium .
2. Hyper chromatism.
3. Loss of polority
Basal cell .
4. Loss of adhesion.
5. Increase mitotic cell
6. Presence of abnormal
mitotic cell
7. Infiltration of chronic
inflammatory cells

5. Carcinoma in situ
H&E showing :
1. Stratified squamous
epithelium .
2. Bulbus retroprocess
3. Dysplastic change from
top to bottom.
4. Loss of adhesion.
5. Increase mitotic cell
6. Presence of abnormal
mitotic cell.
7. Cellular polymorphism.
8. Nuclear polymorphism.
9. Infiltration of chronic
inflammatory cells

6. Lichen planus
H&E showing :
1. Atrophy of Stratified
squamous epithelium .
2. Hyper chratosis .
3. Diffuse of chronic
inflammatory cells.
4. Basal cell degeneration.
5. Leuko faction.
6. Sirett`s body & breakle
cell in basal layer.

7. Oral Submucous
Fibrosis
H&E showing :
1. Atrophy of Stratified
squamous epithelium .
2. Hyper chratosis .
3. Hyper paarachratosis.
4. Absence of retroprocess.
5. Fibrosis of sup epith. &
underling CT

8. Salivary Gland Disease & Benign
Tumors

9. Necrotizing silometaplasia
• H&E section showing degenerated acini of minor salivary glands .
• Metaplasia of ductal epithelium forming nest-like structures .
• Infiltration of chronic inflammatory cells .

10. Cont….
• H&E section showing degenerated acini of minor salivary glands .
• Metaplasia of ductal epithelium forming nest-like structures .
• Infiltration of chronic inflammatory cells .

11. Cont….
• H&E section showing degenerated acini of minor salivary glands .
• Metaplasia of ductal epithelium forming nest-like structures .
• Infiltration of chronic inflammatory cells .

12. Chronic sialadenitis
• H&E section showing atrophy of acini and dilatation of the duct .
• Infiltration of chronic inflammatory cells .

13. Cont….
• H&E section showing atrophy of acini and dilatation of the duct .
• Infiltration of chronic inflammatory cells .

14. Pleomorphic adenoma
• H&E Proliferation of ductal epithelial and myoepithelial cells in the
form of sheet-like structures .
• Many ductal-like structures and myxoid-like structures .

15. Cont….
• Proliferation of ductal epithelial and myoepithelial cells in the form of
sheet-like structures .
• Many ductal-like structures and myxoid-like structures .

16. Cont….
• H&E Proliferation of ductal epithelial and myoepithelial cells in the
form of sheet-like structures .
• Many ductal-like structures and myxoid-like structures .

17. Warthin’s tumor
• H&E section showing composed of papillary projections and cystic
spaces . Forms of two types of oncocytic eosinophilic cells : basal cells (
cuboidal ) and columnar cells . Between these projections, there is
proliferation of diffuse chronic inflammatory cells and germinal cells

18. Oncocytoma
H&E section showing polyhedral cells with granular eosinophilic
cytoplasm arranged in sheets or duct-like structures .

19. MucoepidermoidCarcinoma
• H&E Many cystic spaces and two types of cells : Mucous cells
surrounding cystic space , Dark-stained epidermoid cells in fibrous C.T.
stroma .

20. Cont….
• H&E Many cystic spaces and two types of cells : Mucous cells
surrounding cystic space , Dark-stained epidermoid cells in fibrous C.T.
stroma .

21. Cribriform Pattern of Adenoid Cystic Carcinoma
H&E section showing proliferation of isomorphic basophilic basalloid
( basal-like ) cells surrounding many cystic spaces in C.T. stroma taking
Swiss-cheese pattern ( cribri-form pattern ) .

22. Solid pattern of Adenoid Cystic Carcinoma
H&E section showing proliferation of isomorphic basophilic basalloid (
basal-like ) cells surrounding many cystic spaces in C.T.

23. Perineural Invasion
H&E section showing proliferation of isomorphic basophilic basalloid
( basal-like ) cells surrounding many cystic spaces in C.T. and there is
perineural invasion

24. Benign & malignant neoplasma

25. Squamouscell Papilloma
• H&E section showing finger like projection of hyperplastic Stratified
keratinized squamous epithelium supported by vascular CT. core .
• Superficial epithelial cell showing pernuclear vaculization

26. Keratoacanthoma
H&E section showing exophytic growth of hyperplastic Stratified squamous
epithelium with central crater containing keratin plug & CT. showing Infiltration
of chronic inflammatory cells .

27. Fibroma
H&E section showing proliferated of collagen in form of bundles and
fibroblast surrounded by fibers CT. capsule and covered by stretched
Stratified squamous epithelium.

28. Squamouscell Carcinoma
• Tuomur showing malignant epithelial cell forming nests invading CT
stroma. The Malignant cell is hyperchromatic and mitosis can be seen.
• keratin pearl & indivdul cell keratinization also present . Infiltration of
chronic inflammatory cells in CT stroma. and degenrated muscle also seen

29. Fibrosarcoma
• Malignant fibroblast arranged in vascicels & delicate CT. fibers
• The fibroblast are hyperchromatic polymorphic and some mitosis.

30. Thank you …….