This document describes the development and evaluation of sustained release matrix tablets of paliperidone using natural polymers. Tablets were prepared using different polymers like xanthan gum, guar gum, and locust bean gum. The tablets were evaluated for precompression parameters like angle of repose, bulk density, tapped density, Carr's index, and Hausner's ratio. Post compression evaluation included hardness, thickness, friability, and drug content. In vitro drug release studies were performed and the release kinetics was found to follow Korsemeyer-Peppas model, indicating drug release by non-Fickian diffusion. The formulation with locust bean gum showed sustained release over 12 hours and is a promising candidate for once-daily dos

1. INTRODUCTION
in-vitro
Xanthomonas Compestris
MATERIALS AND METHODS
Precompression Characterization
1. Angle of Repose
Preparation and Evaluation of Sustained Release Matrix
Tablets of Paliperidone Using Natural Polymers
Shrishail M Ghurghure1, Deepak S Bhosale1, Mahewash Sana A Pathan1*
Abstract:
in-vitro in-vitro
1

2. 2. Bulk and Tapped Densities
3. Determination of Carr’s Index
4. Determination of Hausner’s Ratio
Evaluation of the Compressed Tablets
1. Weight Variation Test
2. Hardness
3. Friability
Table 1: Formulation of Matrix Tablet of Paliperidone
S. No. Ingredients F1 F2 F3
Table 2: Precompression Parameters of Paliperidone Formulations
Formulation code
Angle of
Repose(θ)
Bulk Density
(g/cc)
Tapped
Density(g/cc)
Hausner’s
Ratio
Carr’s Index
(%)
Table 3: Post Compression Evaluation of Paliperidone Tablets
Formulation Code Hardness (kg/cm)
(n=3)
Thickness (mm)
(n=3)
Friability
(n=10)
Drug Content
(%)
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3. 4. Determination of Drug Content
5. In-Vitro Dissolution Study
Table 4: Absorbance of Paliperidone at Different Concentration
S. No. Conc. (μg/ml) Abs (nm)
Table 5: Cumulative % Drug Release of Paliperidone Tablet
Time (hr) F1 F2 F3
Table 6: Release Kinetics of F3 Batch of Tablets
Time
(Hr)
%
Cumulative
Drug Release
% Drug
Remaining
Log %
Cumulative Drug
Remaining
Square Root
of Time
Log
Time
Cube root of %
Drug
Remaining
Log %
Cumulative
Drug Release
Table 7: Release Kinetics Data of F3 Batch
S. No. Release Kinetics X-axis Y-axis Slope (n) Intercept R2 Linear Equation
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4. RESULTS AND DISCUSSION
in-
vitro
Figure 1:
Figure 2:
Figure 3:
Abs(nm)
Conc. (μg/ml)
Calibration curve
%Release
Time (hr)
%cumulativedrugrelease
Time (hr)
Zero order release kinetics
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5. Figure 4:
Figure 5:
Figure 6:
Figure 7:
Log%cumulativedrug
release
Time (hr)
First order release kinetics
%cumulativedrugrelease
Time (hr)
Higuchi release kinetics
Cuberootof%drugrelease
Time (hr)
Hixon Crowell release kinetics
Log%cumulativedrugrelease
Log Time
Korsemeyer Peppas release kinetics
5

6. CONCLUSION
in-vitro
REFERENCES
in-vitro
in-vitro
in-vitro
in-vitro
Cite this article as:
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