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Effect of friction, distribution of force, compaction and solubility suraj seminar

This document discusses the effects of friction, force distribution, compaction, and solubility in pharmaceutical manufacturing. It describes how interparticulate and die wall friction affect tablet production, and how lubricants can reduce friction. It also explains that compaction involves compressing and consolidating powders through applied force, and describes the different phases of elastic and plastic deformation that occur during compaction. Finally, it defines solubility and discusses its importance for drug bioavailability and therapeutic effectiveness since drugs must be soluble to be absorbed.

Education◦
EFFECT OF FRICTION , DISTRIBUTION OF FORCE, COMPACTION AND SOLUBILITY RAJGAD DNYANPEETH COLLEGE OF PHARMACY, BHOR, PUNE (412206) Presented by : Pund Suraj Babanrao M. Pharm 1st Year (Pharmaceutics) R.D’s College of Pharmacy Bhor, Pune
Contents  Effect of Friction  Distribution of Force  Compaction Profile  Solubility
Effect of Friction Two major Component to the Frictional force: 1. Interparticulate Friction:  this arises at particle/ particle contacts and can be expressed in term of a coefficient of interparticulate friction m1. it is more significant at low applied loads.  Material that reduced this effect are reffered to as Glidants.  Eg. Colloidal silica, talc, corn starch
2. Die-wall Friction:  This result from material being pressed against the die wall and moved down it; it is expressed as mw, the coefficient of die wall friction.  Most tablets contain a small amount of an additive design to reduced die wall friction; such additives are called lubricants. Ex. Mg. stearate, talc, PEG, Waxes, stearic acid
Distribution Of Force Fm= Fa+Fb 2 Fa = FI + Fd Fa= Force applied to upper punch. FI= force transmitted to lower punch Fd= is the reaction at the die wall due to friction at the surface. Fm= mean force
Compaction Compaction is defined as ‘Compression & Consolidation’ of a two phase system (particulate solid-gas) due to applied force.
Compaction Profile  Radial pressures due to the attempt of material to expand horizontally.  Axial pressure is due to attempt of material to constrict vertically. QA= shows early repacking AB= elastic deformation BC= plastic deformation CD= Elastic recovery DE= plastic recovery
Energy involved in Compaction  Tablet machines, roller compactors, and similar types of equipment required a high input of mechanical work.  The work involve in various phase of tablets operation includes.  That necessary to overcome friction between particles.  That necessary to overcome friction betweent the particles and machine parts.  That required to induce elastic and / plastic deformation of the materials,  That required to cause brittle fracture within the materials,  That associated with the mechanical operation of various machine parts.
Solubility  Solubility is defined as Quantitative terms as concentration of solute in concentration of solute in concentrated solution at a certain temprature , and in qualitative way it can be defined as a spontaneous interaction of two or more substance to form a homogenious molecular dispersion.
Importance of Solubility  Therapeutics effectiveness of a drug depends upon the bioavailability and ultimately upon the solubility of drug molecule.  It is important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown.  Any drug to be absorbed must be soluble or present in the form of an aqueous solution at the site of absorption.
Reference  The theory & practice of industrial pharmacy- Lachman  Text book of biopharmaceutics and pharmacokinetics by brahmankar, page no. 349-366  Internet
Effect of friction, distribution of force, compaction and solubility suraj seminar