This document describes the development and evaluation of liquisolid compacts of curcumin, an antioxidant with poor solubility. Various liquisolid formulations of curcumin were prepared using different liquid vehicle to drug ratios, carrier materials, coating materials, and amounts. The formulations were evaluated for pre-compression properties, tablet properties like hardness and friability, drug content, and in-vitro dissolution. The liquisolid technique enhanced the solubility and dissolution rate of curcumin compared to its pure form. The results showed that liquisolid systems could be considered as an effective technique to improve the solubility and dissolution of curcumin.

1. INTRODUCTION
Curcuma longa
MATERIALS AND METHODS
Application of Mathematical Model for Designing the
Liquisolid Systems
Preparation of Curcumin Liquisolid Compacts
Enhancement of Curcumin Solubility by Liquisolid Technique
Mamatha G T1, Vinay A P1*, Parthiban S1, Senthilkumar G P1
Abstract:
in-vitro
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2. Preformulation Studies of Liquisolid Powder System
1. Bulk Density
2. Tapped Density
3. Angle of Repose
4. Carr’s Index
5. Hausner’s Ratio
6. FTIR Study
7. DSC Study
Post Compression Studies of Liquisolid Tablets
1. Weight Variation
2. Hardness
3. Friability Test
Table 1: Formulation of Curcumin Liquisolid Tablets
Formulation
Code
Liquid
Vehicle
Drug : Liquid
Vehicle Ratio
R Value Lf
Carrier
Material
Q=W/Lf
Coating
Material
q=Q/R
SSG ~5% Talc ~1%
Unit Dose
(in Mg)
2

3. 4. Drug Content
5. In-Vitro Dissolution Studies
RESULTS AND DISCUSSION
Determination of λ-max by UV Spectroscopy
Standard Calibration Curve of Curcumin
Solubility Studies
Fourier Transforms Infrared (FTIR) Spectroscopy
DSC Study
Preformulation Studies of Liquisolid Powder System
Figure 1:
Figure 2:
Absorbance(nm)
Concentration (μg/ml)
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4. Figure 3:
Figure 4:
Figure 5:
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5. Evaluation of Liquisolid Tablets
1. Hardness
2. Weight Variation Test
3. Disintegration Time
4. Drug Content
Figure 6:
Table 2: Results of Preformulation Study
Formulation
Code
Bulk Density
(gm/ml)
Tapped Density
(gm/ml)
Angle of Repose
(Ɵ) ± SD
Carr's
Index %
Hausner's
Ratio
Table 3: Evaluation of Liquisolid Tablets
Formulation
Code
Weight
Variation
Hardness
(kg/cm)
Disintegration Time
(min)
Drug Content
% w/w
Friability
%
Table 4: Cumulative Percent Drug Release of Curcumin Liquisolid Formulation
Time LSF 1 LSF 2 LSF 3 DCT
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6. 5. Friability
In-vitro Dissolution Study of Curcumin Liquisolid
Tablet
in-vitro
In-vitro
CONCLUSION
in-vitro
REFERENCES
Figure 7:
%CumulativeDrugRelease
Time (Min)
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7. Cite this article as:
et al
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