Osteomyelitis is an inflammation of the bone marrow that typically begins in the cancellous bone and spreads to cortical bone and periosteum. It is caused by a failure of microcirculation in cancellous bone and establishment of infection. While it can affect the maxilla, osteomyelitis more commonly impacts the mandible due to its blood supply originating from the inferior alveolar artery. Osteomyelitis of the mandible is usually preceded by odontogenic infections or mandible fractures and is more likely to occur in immunocompromised individuals. It is treated through surgical debridement, antibiotic administration, and stabilization of mandible fractures.