The orbital cavity contains the eyeball, muscles, nerves, vessels and fat. It is pear-shaped and surrounded by seven bones. The roof is formed by the frontal bone and sphenoid, the floor by the maxilla and zygomatic, and the lateral wall by the zygomatic and sphenoid. The thin medial wall contains the ethmoid bone. Openings include the superior and inferior orbital fissures for nerves and vessels, and the optic canal. The orbital cavity is lined with periosteum and contains the eyeball suspensory muscles. With age, the bones thin and absorb, creating openings.
The ciliary ganglion is one of four parasympathetic ganglia of the head and neck. It receives preganglionic parasympathetic fibers from the EWN via the CN III.
It supplies the eye via short ciliary nerves not only with parasympathetic fibers, but also with sensory and sympathetic fibers that pass through the ganglion.
Gross anatomy
Shape: Flat/lenticular
Size: 2 mm*1mm (smallest)
Location: posterolaterally in the intra-conal space of the orbit between the optic nerve and the LR muscle. 10 mm from Zinn, 15-20 mm from posterior pole
It is just lateral to the ophthalmic artery as it crosses the optic nerve from lateral to medial
Sympathetic root
from the ICA (from the superior cervical ganglion) via the nasociliary nerve, a branch of the trigeminal nerve
fibers pass through the ganglion without synapsing.
Roots
Parasympathetic root (motor)
from the Edinger-Westphal nucleus of the CN III via the inferior division; nerve to the IO muscle.
fibers synapse in the ganglion
Roots
Parasympathetic root (motor)
from the Edinger-Westphal nucleus of the CN III via the inferior division; nerve to the IO muscle.
fibers synapse in the ganglion
Sensory root
via the small communicating branch of the ciliary ganglion (from CN V1)
fibers pass through the ganglion without synapsing
The ciliary ganglion is one of four parasympathetic ganglia of the head and neck. It receives preganglionic parasympathetic fibers from the EWN via the CN III.
It supplies the eye via short ciliary nerves not only with parasympathetic fibers, but also with sensory and sympathetic fibers that pass through the ganglion.
Gross anatomy
Shape: Flat/lenticular
Size: 2 mm*1mm (smallest)
Location: posterolaterally in the intra-conal space of the orbit between the optic nerve and the LR muscle. 10 mm from Zinn, 15-20 mm from posterior pole
It is just lateral to the ophthalmic artery as it crosses the optic nerve from lateral to medial
Sympathetic root
from the ICA (from the superior cervical ganglion) via the nasociliary nerve, a branch of the trigeminal nerve
fibers pass through the ganglion without synapsing.
Roots
Parasympathetic root (motor)
from the Edinger-Westphal nucleus of the CN III via the inferior division; nerve to the IO muscle.
fibers synapse in the ganglion
Roots
Parasympathetic root (motor)
from the Edinger-Westphal nucleus of the CN III via the inferior division; nerve to the IO muscle.
fibers synapse in the ganglion
Sensory root
via the small communicating branch of the ciliary ganglion (from CN V1)
fibers pass through the ganglion without synapsing
The orbits are conical or four-sided pyramidal cavities, which open into the midline of the face and point back into the head. Each consists of a base, an apex and four walls.[4]
Each orbit is formed by seven bones –
Frontal bone
Ethmoidal bone
Lacrimal bone
Palatine bone
Maxilla bone
Zygomatic bone
Sphenoid bone
It contains following subheadings:
-maxilla and mandible anatomy
-TMJ(Temporo mandibular joint)
-Muscles of mastication
By:
Dr. Syed Irfan Qadeer
Prof. and HOD Department of Anatomy
SPIDMS,Lucknow
Dr, Kathirvel Gopalakrishnan
M.D.S (OMFS)
Presentation on Anatomy of orbit which helps for a quick refresh.
Applied aspects described well and slides contains images for easy understanding of the subject.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
2. Function
What is the function of the Orbit ?
The orbit holds the eye in the correct
position.
The orbit also protects the eye because
the bones surrounding the eye “stick
out” further than the eye, objects tend
to hit the orbit and not the eye.
3. Introduction
• The orbital cavities :
a pair of large bony sockets that contain:
the eyeballs, their associated muscles, nerves,
vessels, and fat, and most of the lacrimal apparatus.
• Each one is pear shaped ,and its apex is directed
posteriorly ,medially ,and slightly upward.
• The medial wall runs antero-posteriorly parallel to
sagittal plane ,the lateral wall diverges at angle of about
45degrees
• The orbit forms from seven bones :
(maxilla ,palatine ,zygomatic , sphenoid ,frontal ,
ethmoid ,and lacrimal ).
4.
5.
6. Walls of cavity Lined with periosteum , apex at the medial end of
superior orbital fissure
7. Walls of the orbital cavity
• Roof :
• Formed by the orbital plate of frontal bone and to a small
extent of lesser wing of sphenoid posteriorly.concave
• Anterolaterally there is slight depression ( lacrimal fosse) for
orbital part of lacrimal gland .
• Anteriomedially the roof is invaded by fronat air sinuses
• The Roof is thin and fragile and in old age portions of roof
may be absorbed so it may be Easily fx
• The Roof separates orbital cavity from anterior crainal fossa
and frontal lobe.
8. •Floor :
• Formed largely by orbital plate of maxilla , orbital
surface of zygomatic ,small orbital process of
palatine.
• Separate the orbital cavity from maxillary sinus.
• Floor is continuous with lateral wall anteriorly, but
seperated posteriorly by inferior orbital fissure .
• Ifr orb fiss__forward infraorb groove –canal --
foramen at face
• Commonly involved in BLOW OUT FRACTURES
• Easily invaded by tumors of the maxillary antrum
9.
10. • Lateral wall :
• Is the thickest wall.
• anterior 1/3 is formed by zygomatic bone.
• posterior 2/3 is formed by greater wing of sphenoid.
• it is continuous with roof anteriorly but seperated
posteriorly by superior orbital fissure which communicate
with middle cranial fossa .
• On the anterior part of the wall,there is a prominence
the marginal tubercle of whitnall.It give attachment to
the check ligament of the lateral rectus muscle and to the
suspensory ligament of the eyeball and lateral palpepral
ligament
11.
12. Medial wall
•Thinnest orbital wall:0.2-0.4mm thick
•Majority of it is formed by Lamina papyracea
Formed by four bone from anterior to posterior :
1. frontal process of maxilla,
2. lacrimal bone,
3.Orbital plate of ethmoid ,largest part
4.body of sphenoid.
Lacrimal groove: on anterior part of medial wall ,for lacrimal
sac , formed by lacrimal bone posterior ,frontal process of maxilla
anterior,bounded by lacrimal crests, continuous below with
nasolacrimal canal.
16. 1. Since it is the thinnest,ethmoiditis is the commonest cause o
f orbital cellulitis, especially in children.
2. Frequently eroded by chronic inflammatory lesions, neoplas
ms,cysts.
3. It is easily fractured during trauma.
4. Hemorrhage can occur due to trauma to the ethmoidal
vessels.
17. Relations of the bony orbit :
• Superior
anteromedially : frontal air sinus.
anterior cranial fossa .
• inferior
maxillary air sinus
• Lateral
anteriorly : temperal fossa.
posteriorly :middle cranial fossa.
• Medially
nasal cavity ,ethmoidal sinus , sphenoid sinus.
21. Superior orbital fissure
Between lesser and greater wings of sphenoid
,roof & lateral wall
Connect middle cranial fossa with cavity
Widest part at medial end
Midway on lower edge – small,sharp spine for
lateral rectus
Content pass : occulomotor, trochlear abducent
,opthalmic n and vein ,sympathtic nerve plexus
,recurrent branch of lacrimal art, Orbital branch of
middle meningeal art
22. Inferior orbital fissure
Between greater wing of sphenoid and maxilla
Connect pterygopalatine & infratemporal fossae
with the cavity
Closed by periorbita and m of muller
Content :maxillary n ( infraorbital) ,zygomatic n ,
branch of pterygopalatine ganglion,,inf opthamic
vein
23.
24. • Optic canal:
1.lies in the lesser wing of sphenoid.
2.is situated close to the apex of the orbit.
3.Measuring 4 to 10 mm long.
4.It connects the orbit to the middle cranial fossa .
5.related medially to body of sphenoid.
6. transmit optic nerve, ophthalmic artery with its
surrounding sympathetic plexus .
25.
26. • Ethmoidal foramina:
1. lies in frontoethmoidal suture or in frontal bone.
2. anterior foramen open in anterior cranial fossa at lateral edge ocribriform
plate transmit anterior ethmoidal artery and nerve
3. posterior foramen traverse ethmoidal bone , transmit posterior
ethmoidal artery and nerve.
.
27. • Zygomaticofacial and zygomaticotemperal foramen:
1. lies on the lateral wall of orbit.
2. Zygomaticofacial foramen transmit Zygomaticofacial nerve.
3. zygomaticotemperal foramen transmit zygomaticotemperal nerve.
28. Orbital periosteum
( orbital fascia)
• Is the periosteum of the bone that form the wall of orbit,
loosely attached to bone .
• At orbital margin, the periorbita is continuous with
periosteum on external surface of skull, give attachment to
the orbital septum.
• At lacrimal groove it splits to enclose lacrimal sac and
continue inferior to form periosteum of nasolacrimal canal.
29.
30. • Posteriorly, around optic canal and medial end of superior
orbital fissure, it thickens to form a fibrous ring (common tendinous ring).
• Periorbita receive its sensory innervations from branch of
trigeminal nerve.
32. • Is a thin layer of smooth muscle that bridge
the inferior orbital fissure .
• Its embedded in the fascia of periorbita
• Nerve supply : sympathetic nerves
• Apart from its possible effect on the position of the
eyeball in the orbit, the muscle seems to be mainly concerned
with directing facial venous blood to or away from the
cavernous sinus which acts as a heat exchanger for internal
carotid blood.
33. Effect of age on orbital
cavity
At birth : Relatively large and ossified margins .
- Protect the eye during parturition
Young children :
1. Look more laterally than adult
2. Superior & inferior orbital fissure are wider, become
narrowed by growth of greater wing of sphenoid.
3. Distance between the orbit are small and increases
by growth of frontal& ethmoidal sinuses
Old age :
Bony absorption >>> holes in roof , med & lat walls.