Opioid Pharmacology
•Download as PPT, PDF•
28 likes•20,103 views
This document summarizes the pharmacology of various opioid analgesics. It discusses classical opioid effects like analgesia, sedation, respiratory depression. It then profiles specific opioids like fentanyl, sufentanil, morphine, hydromorphone, remifentanil and others. It also discusses evidence for different mu opioid receptor subtypes and the potential for mu-1 selective agonists.
![Disclosure ,[object Object],[object Object]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
Recommended
More Related Content
What's hot
What's hot (20)
Similar to Opioid Pharmacology
Similar to Opioid Pharmacology (20)
More from shabeel pn
More from shabeel pn (20)
Recently uploaded
Recently uploaded (20)
Opioid Pharmacology
- 1. Comparative Opioid Pharmacology
- 7. Morphine The prototypical opioid
- 9. Simulation of Morphine Time Course Dahan et al. Anesthesiology. 2004 Nov;101(5):1201-9.
- 10. Fentanyl The ever morphing molecule
- 12. How we think of fentanyl: (small part of the market)
- 13. Fentanyl morph 1: Duragesic
- 14. Fentanyl morph 2: Actiq
- 15. Fentanyl morph 3: E-trans fentanyl Viscusi et al, JAMA 2004 291:1333
- 16. Fentanyl morph 4: Inhaled liposomal fentanyl Hung et al, Anesthesiology 1995 83:277-84
- 17. Fentanyl morph 5: Inhaled fentanyl aerosol Mather et al, Br J Clin Pharmacol 1998 46:37
- 18. Fentanyl morph 6: Effervescent Fentanyl (OraVescent) Pather et al, http://www.drugdeliverytech.com/cgi-bin/articles.cgi?idArticle=5
- 19. Sufentanil Newly morphing molecule
- 21. Sufentanil morph 1: Implantable sufentanil delivery http://www.drugdeliverytech.com/cgi-bin/articles.cgi?idArticle=115
- 23. Hydromorphone A better morphine
- 27. Methadone The Under-Utilized Opioid
- 32. Comparative Onset of Opioid Drug Effect
- 33. Context Sensitive Half Time
- 34. 50% Effect Site Decrement Time
- 35. 20% Effect Site Decrement Time
- 36. Rise to Steady State
- 37. Relative Potency
- 38. 50 g fentanyl at 10 minutes
- 39. 50 g/hour fentanyl at 2 hours
- 40. Opioid Receptor
- 44. MOR-1 gene splice variants (gene=OPRM) Gavril Pasternak, http://www.mskcc.org/mskcc/html/11384.cfm
- 45. Antisense lowers morphine analgesia (no effect on m6g) Gavril Pasternak, Life Sciences 2001:68, 2213
- 46. Antisense lowers m6g analgesia (no effect on morphine) Gavril Pasternak, Life Sciences 2001:68, 2213
- 49. “ Power corrupts, PowerPoint corrupts absolutely” dr shabeel pn