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![• Polymer of deoxyribonucleotides
• Double stranded right handed
helix
• 2nm , 34 nm, 10
• A=T , C≡G
• Antiparallel
• Complementry
• Chargaff’s rule
• Sense strand [coding strand],
Template strand(Anti sense
strand)](https://image.slidesharecdn.com/nucleicacidchemistry-190224072911/85/Nucleic-acid-chemistry-34-320.jpg)
Uploaded bySohil Takodara
Nucleic acid chemistry
Nucleotides are the basic building blocks of nucleic acids like DNA and RNA. They consist of three components: a nitrogenous base (either a purine or pyrimidine), a pentose sugar (ribose in RNA and deoxyribose in DNA), and a phosphate group. There are two types of purine bases - adenine and guanine, and three types of pyrimidine bases - cytosine, thymine, and uracil. Nucleotides bond together to form polynucleotides like DNA and RNA, which carry the genetic code of living organisms. DNA is double-stranded and found in the nucleus, while RNA is single-stranded and can be found both inside
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Nucleic acid chemistry
- 6.
- 7. Purines • Adenine(A) • Guanine(G) •Hypoxanthine • Xanthine Pyrimidines • Cytosine(C) • Uracil(U) • Thymine(T) Sugar • Ribose • Deoxyribose THIAMINE..??
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- 16.
- 18.
- 19. O || HO — O— OH | OH Phosphoric acid
- 20.
- 21. N N N NH2 | N H CH —O — P — OH2 | OH OH H OH HH Adenosine -5’-monophosphate O || O N N NH2 | Adenosine Adenine (Base) Phosphoric acid Ribose(Sugar)
- 23. Nucleotide Abbreviation Adenosine monophosphate Guanosinemonophosphate Cytidine monophosphate Uridine monophosphate AMP GMP CMP UMP
- 24. Nucleotide Abbreviation Deoxyadenosine monophosphate Deoxyguanosinemonophosphate Deoxycytidine monophosphate Deoxythymidine monophosphate dAMP dGMP dCMP dTMP
- 25.
- 26. Nucleotide Function Adenoside triphosphate(ATP)Chemical energy of Cell Adenosine diphosphate(ADP) Oxidative Phosphorylation Cyclic AMP(c-AMP) Secondary messenger S-Adenosyl Methionine Methyl donor
- 27. Nucleotide Function Guanosine diphosphate(GDP)Substrate level phosphorylation(SLP) Guanosine triphosphate(GTP) SLP and energy source Cyclic GMP Secondary messenger(NO,NG)
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- 33. DNA • Deoxyribose • Doublestranded • A,T,G,C • Nuclear • Follows Chargaff’s rule RNA • Ribose • Single stranded • A,U,G,C • Extranuclear • Doesn’t follow
- 34. • Polymer ofdeoxyribonucleotides • Double stranded right handed helix • 2nm , 34 nm, 10 • A=T , C≡G • Antiparallel • Complementry • Chargaff’s rule • Sense strand [coding strand], Template strand(Anti sense strand)
- 39. DNA • Deoxyribose • Doublestranded • A,T,G,C • Nuclear • Follows Chargaff’s rule RNA • Ribose • Single stranded • A,U,G,C • Extranuclear • Doesn’t follow
- 41. 5’ A TG C A T G 3’ Coding Strand (DNA) 3’ T A C G T A C 5’ Template strand (DNA) 5’ AU G C A U G 3’ mRNA
- 48.
- 53.
- 54. -C-G- -G -C-G--G- -G-C- -C -G-C- -C- -C-G- -G -C-G- -G- -G-C- -C -G-C- -C- Transition Transversion
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- 57. -C-G- -G -C-G-A--G- -G-C- -C -G-C-T- -C- -C-G- -G -C-G-G- -G-C- -C -G-C-C- Insertion Deletion