Non Infectious Granulomatous Disorders

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Ibrahim Farag

When histiocytes form granulomas within the skin, the cutaneous disorders are referred to as GRANULOMATOUS.

Health & Medicine

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Dermatology Illustrated
Study Guide &
Comprehensive Board
Review 2012
Bolognia Dermatology
Essentials
Weedon Skin Pathology
Essentials

Actinic keratoses: Erythematous scaly lesions on sun-damaged skin & considered “precancerous” lesions that have the potential to progress into invasive SCC. Bowen’s disease: SCC in situ It has the potential to progress to invasive SCC. Leukoplakia: Leukoplakia refers to a white patch or plaque on the oral mucosa that cannot be wiped off and cannot be characterized clinically or pathologically as any other disease.

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Urticaria is characterized by WEALS (hives) or ANGIOEDEMA (swellings, in 10%) or both (in 40%). There are several types of urticaria Spontaneous urticaria Acute spontaneous urticaria Spontaneous wheals and/or angioedema <6 />6 wk Urticarias induced by physical agents dermographic urticaria Eliciting factor: mechanical shearing forces (wheals arising after 1–5 min) Cold contact urticaria Eliciting factor: cold objects/air/fluids/wind Solar urticaria Eliciting factor: UV and/or visible light Delayed pressure urticaria Eliciting factor: vertical pressure (wheals arising with a 3–12 h latency) Heat contact urticaria Eliciting factor: localized heat Hot water bottle Hot drink Vibratory urticaria/angioedema Eliciting factor: vibratory forces, e.g. pneumatic hammer/Jack hammer Other inducible urticarias Contact urticaria Elicitation by contact with urticariogenic substance Aquagenic urticaria Eliciting factor: water Cholinergic urticaria Elicitation by increase of body core temperature due to physical exercises, spicy food, stress Exercise-induced anaphylaxis/urticaria Eliciting factor: physical exercise

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There are several dermatoses that occur during pregnancy or immediately postpartum, in particular polymorphic eruption of pregnancy, pemphigoid gestationis, and atopic eruption of pregnancy. Pruritus due to intrahepatic cholestasis of pregnancy leads to nonspecific skin lesions, including excoriations due to scratching. Impetigo herpetiformis simply represents pustular psoriasis occurring during pregnancy, and this may be related to the relative hypocalcemia of pregnancy. Lastly, there are physiologic changes that occur during pregnancy.

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Insects Bites & Stings: can be divided into 2 groups venomous insect such as a bee or wasp, which uses this as a defense mechanism by injecting toxic and painful venom through its stinger. Non-venomous insect bites pierce the skin to feed on blood. This usually results in intense itching. Papular Urticaria: common disorder manifested by chronic or recurrent papules caused by a HYPERSENSITIVITY REACTION to the bites of mosquitoes, fleas, bedbugs, and other insects

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