The results of my research work.Got four new alkaloids from my research project and presented before the authorized committee of the institute of chemical sciences,Gomal university.
This presentation is all about Alkaloids which are organic compounds. Their occurence, where they found in nature. Various physical and chemical properties of alkaloids. Why they are basic in nature, How they are classified and several tests for alkaloids. The extraction process used for alkaloids extraction. Finally few alkaloids with their medicinal uses,structures and few hetreocyclic compounds present in alkaloids.
Alkaloids are a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms.
The term alkaloid was coined by Meissner, a German pharmacist, in 1819.
Alkaloids are cyclic organic compounds containing nitrogen in a negative state of oxidation with limited distribution among living organisms.
Most alkaloids contain oxygen in their molecular structure; those compounds are usually colorless crystals at ambient conditions.
Some alkaloids are colored, like berberine (yellow) and sanguinarine (orange).
Most alkaloids are weak bases, but some, such as theobromine and theophylline, are amphoteric.
Many alkaloids dissolve poorly in water but readily dissolve in organic solvents.
Most alkaloids have a bitter taste or are poisonous when ingested.
this ppt is about alkaloids. it talks first introduction then classifications then we talk about the properties , applications ,then lastly we talked about the extraction. alkaloids are very important our daily life. alkaloid is simply means water soluble base.is detected by either by preciptants or colour reagent ,Alkaloids are often divided into the following major groups:
True alkaloids
pseudo alkaloids
Proto alkaloids
False alkaloids.
This presentation is about alkaloids in plants ...it includes introduction about alkaloids ,types of alkaloids,structure ,classification and therapeutic uses of alkaloids
This presentation is all about Alkaloids which are organic compounds. Their occurence, where they found in nature. Various physical and chemical properties of alkaloids. Why they are basic in nature, How they are classified and several tests for alkaloids. The extraction process used for alkaloids extraction. Finally few alkaloids with their medicinal uses,structures and few hetreocyclic compounds present in alkaloids.
Alkaloids are a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms.
The term alkaloid was coined by Meissner, a German pharmacist, in 1819.
Alkaloids are cyclic organic compounds containing nitrogen in a negative state of oxidation with limited distribution among living organisms.
Most alkaloids contain oxygen in their molecular structure; those compounds are usually colorless crystals at ambient conditions.
Some alkaloids are colored, like berberine (yellow) and sanguinarine (orange).
Most alkaloids are weak bases, but some, such as theobromine and theophylline, are amphoteric.
Many alkaloids dissolve poorly in water but readily dissolve in organic solvents.
Most alkaloids have a bitter taste or are poisonous when ingested.
this ppt is about alkaloids. it talks first introduction then classifications then we talk about the properties , applications ,then lastly we talked about the extraction. alkaloids are very important our daily life. alkaloid is simply means water soluble base.is detected by either by preciptants or colour reagent ,Alkaloids are often divided into the following major groups:
True alkaloids
pseudo alkaloids
Proto alkaloids
False alkaloids.
This presentation is about alkaloids in plants ...it includes introduction about alkaloids ,types of alkaloids,structure ,classification and therapeutic uses of alkaloids
Introduction, classification, isolation, purification, biological activity of alkaloids, general methods of structural determination of alkaloids, structural elucidation of Morphine, Reserpine and Emetine
Occurrence and classification of alkaloidsJasmineJuliet
Alkaloid definition, Alkaloid history, Occurrence of Alkaloids, Distribution of Alkaloids in nature, Classification of Alkaloids in Different categories, Pharmacological actions of Alkaloids. Alkaloids classification based on chemical structure, belongs to plant family, Based on Biochemical precursor, Based on Biological activity.
Alkaloids: Introduction, Property and classification OP VERMA
Alkaloids are major secondary metabolites reported in higher plants. In this PPT I have covered Introduction, Property, Clarification and identification tests.
Isolation of Alkaloid from a Medical Plant (A Case Study of Morinda Lucida)iosrjce
The isolation and detection of alkaloids content of Morinda lucida (Ezeogwu) from Rubiceace family,
a medicinal plant was carried out using solvent extraction process. The dried powdered leaves of the plant were
divided into batches. Different solvents were used on them. After 6 days of occasional shaking, it was filtered.
The filtrates were used for testing the presence of alkaloids in Morida Lucida. Mayer’s reagents Wagner and
Lugol’s reagents and 5m sodium hydroxide were used as detecting reagents. Mayer’s reagent yields cream
precipitate in both acidic and alkaline extracts. Wagner and Lugol’s reagents yield reddish brown precipitate in
both acidic and alkaline extracts. 5ml sodium hydroxide gave white swirling precipitate. Other coloured
precipitate like orange and pale orange was gotten as a result of difference in solvents used for isolation. The
presence of the above precipitate indicates the presence of alkaloids in Morinda Lucida.
Health benefits of plant alkaloids A Lecture By Mr Allah Dad Khan Former DG ...Mr.Allah Dad Khan
Health benefits of plant alkaloids A Lecture By Mr Allah Dad Khan Former DG Agriculture Extension Khyber Pakhtun Khwa Province & Visiting Professor Agriculture University Peshawar Pakistan
Alkaloids are basic - they form water soluble salts. Most alkaloids are well-defined crystalline substances which unite with acids to form salts. In plants, they may exist
in the free state,
as salts or
as N-oxides.
Introduction, classification, isolation, purification, biological activity of alkaloids, general methods of structural determination of alkaloids, structural elucidation of Morphine, Reserpine and Emetine
Occurrence and classification of alkaloidsJasmineJuliet
Alkaloid definition, Alkaloid history, Occurrence of Alkaloids, Distribution of Alkaloids in nature, Classification of Alkaloids in Different categories, Pharmacological actions of Alkaloids. Alkaloids classification based on chemical structure, belongs to plant family, Based on Biochemical precursor, Based on Biological activity.
Alkaloids: Introduction, Property and classification OP VERMA
Alkaloids are major secondary metabolites reported in higher plants. In this PPT I have covered Introduction, Property, Clarification and identification tests.
Isolation of Alkaloid from a Medical Plant (A Case Study of Morinda Lucida)iosrjce
The isolation and detection of alkaloids content of Morinda lucida (Ezeogwu) from Rubiceace family,
a medicinal plant was carried out using solvent extraction process. The dried powdered leaves of the plant were
divided into batches. Different solvents were used on them. After 6 days of occasional shaking, it was filtered.
The filtrates were used for testing the presence of alkaloids in Morida Lucida. Mayer’s reagents Wagner and
Lugol’s reagents and 5m sodium hydroxide were used as detecting reagents. Mayer’s reagent yields cream
precipitate in both acidic and alkaline extracts. Wagner and Lugol’s reagents yield reddish brown precipitate in
both acidic and alkaline extracts. 5ml sodium hydroxide gave white swirling precipitate. Other coloured
precipitate like orange and pale orange was gotten as a result of difference in solvents used for isolation. The
presence of the above precipitate indicates the presence of alkaloids in Morinda Lucida.
Health benefits of plant alkaloids A Lecture By Mr Allah Dad Khan Former DG ...Mr.Allah Dad Khan
Health benefits of plant alkaloids A Lecture By Mr Allah Dad Khan Former DG Agriculture Extension Khyber Pakhtun Khwa Province & Visiting Professor Agriculture University Peshawar Pakistan
Alkaloids are basic - they form water soluble salts. Most alkaloids are well-defined crystalline substances which unite with acids to form salts. In plants, they may exist
in the free state,
as salts or
as N-oxides.
Alkaloids are a group of naturally occurring chemical compounds that contain mostly basic nitrogen atoms. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure are also termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.
Alkaloids are produced by a large variety of organisms including bacteria, fungi, plants, and animals. They can be purified from crude extracts of these organisms by acid-base extraction. Alkaloids have a wide range of pharmacological activities including antimalarial (e.g. quinine), antiasthma (e.g. ephedrine), anticancer (e.g. homoharringtonine),cholinomimetic (e.g. galantamine), vasodilatory (e.g. vincamine), antiarrhythmic (e.g. quinidine), analgesic (e.g. morphine),antibacterial (e.g. chelerythrine), and antihyperglycemic activities (e.g. piperine). Many have found use in traditional or modern medicine, or as starting points for drug discovery. Other alkaloids possess psychotropic (e.g. psilocin) and stimulant activities (e.g. cocaine, caffeine, nicotine, theobromine), and have been used in entheogenic rituals or as recreational drugs. Alkaloids can be toxic too (e.g. atropine, tubocurarine). Although alkaloids act on a diversity of metabolic systems in humans and other animals, they almost uniformly evoke a bitter taste
Alkaloids are basic (alkali-like), nitrogen-containing organic constituents found in some plants.Alkaloids are normally classified according to the heterocyclic ring system they possess, but some authors prefer a classification based on their biosynthetic origins from amino acids, e.g. phenylalanine, tyrosine or tryptophan. (Justin et al.) Many individual names are formed by adding the suffix "-ine" to the species or generic alkaloids. For example, atropine is isolated from the plant Atropa belladonna, strychnine is obtained from the seed of Strychnine tree. Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation and antimetastasis effects on various types of cancers both in vitro and in vivo. Alkaloids, such as camptothecin and vinblastine, have already been successfully developed into anticancer drugs.
Alkaloids A Lecture By Mr Allah Dad Khan Former DG Agriculture Extension Khyb...Mr.Allah Dad Khan
Alkaloids A Lecture By Mr Allah Dad Khan Former DG Agriculture Extension Khyber Pakhtun Khwa Province & Visiting Professor Agriculture University Peshawar Pakistan
ALKALOIDS AND GLUCOSINOLATES ROLE IN PLANT’S RESISTANCE AGAINST INSECTSMuhammad Kamran (Sial)
BICHEMICAL BASES OF RESISTANCE IN PLANTS TO INSECTS
ALKALOIDS AND GLUCOSINOLATES ROLE IN PLANT’S RESISTANCE AGAINST INSECTS
Numerous alkaloids are toxic and deterrent to insects
alkaloids are feeding deterrent to many insects
DMDP
crucifer-feeding insects
Pharmacognocy is the study of plant chemistry. In this presentation, Ellen Kamhi PhD RN, The Natural Nurse , reviews the class of plant chemical called ALKALOIDS. These include plant chemicals that can be healing, and others that are toxic. Pain relievers, such as morphine, are included in this class, as well as stimulants such as caffeine.
ALKALOIDS
Alkaloids are a class of naturally occurring organic compounds that mostly contain basic nitrogen atoms.
This group also includes some related compounds with neutral and even weakly acidic properties.
Alkaloids are derived from plant sources they are basic they contain one or more nitrogen atoms (usually in a heterocyclic ring) and they usually have a marked physiological action.
Function of alkaloids
they may function as stimulants or regulators in activities like growth, metabolism and reproduction.
They may act as reservoirs for protein synthesis
Properties of alkaloids
Alkaloids are colourless, crystalline, non-volatile, solids, a few such as coniine and nicotine are liquids and a few even coloured, viz. berberine is yellow.
the alkaloids are bitter in taste and have pronounced physiological activity
Classification of alkaloids
a. Taxonomic classification- On the basis of taxonomic profile of the drug. For ex. Solanaceous alkaloids.
b. Biogenetic classification- On the basis of amino acid precursor. For ex. Phenylalanine, Tyrosine alkaloids
c. Pharmacological classification- On the basis therapeutic activity of the alkaloid For ex. Morphine as analgesic, Quinine as antimalarial.
d. Chemical classification- On the basis of basic chemical structure of alkaloid. It is of further three types-
1. True alkaloid- The alkaloids which have all basic properties of alkaloids, derived from amino acid and contain Nitrogen in heterocyclic ring. Ex. Atropine, Morphine.
2. Proto alkaloid- The alkaloid in which nitrogen atom is not present in the ring, but it is present outside the ring I form of amino group, so also called amino alkaloids or biological amines. Ex. Ephedrine.
3. Pseudo alkaloids- Actually these are not alkaloids. These are not derived from amino acid and not give basic identification tests of alkaloids. These are Steroidal (Solanine), Terpenoidal (Diterpene alkaloid) and Purine alkaloid (Caffeine).
chemical classification of alkaloids
Alkaloid is one of the secondary metabolites produced by the plants which helps indirectly in their normal growth, development and reproduction.
Alkaloid is defined as naturally occurring organic compounds which is basic in nature and contains one or more Nitrogen atom in their heterocyclic ring. E.g Atropine, Morphine, Quinine etc.
Alkaloids are classified into different categories as mentioned below:
1. Based on amino acid precursor used for synthesis:
a. True alkaloid: It is synthesized from amino acid precursor and have nitrogen atom in its heterocyclic ring
b. Proto alkaloid: It is derived from amino acid precursor but do not contain nitrogen atom in their basic heterocyclic ring.
c. Pseudo alkaloid: It is not derived from amino acid precursor but contains heterocyclic nitrogen atom in their ring.
2. Based on chemical nature:
a. Indole alkaloid
b. Quinoline alkaloid
c. Pyridine alkaloid etc...
Occurrence and classification of alkaloidsJasmineJuliet
Alkaloids definition, Alkaloids history, Occurrence of alkaloids, Alkaloids distribution in nature, Classification of Alkaloids in different categories, Functions of alkaloids.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
3. A class of naturally occurring organic nitrogen-containing
bases.
Some synthetic compounds of similar structure are also
termed alkaloids.
In addition to carbon, hydrogen and nitrogen, alkaloids
may also contain oxygen, sulfur and more rarely other
elements such as chlorine, bromine, and phosphorus.
Natural compounds containing nitrogen in the exocyclic
position (mescaline, serotonin, dopamine, etc.) are usually
attributed to amines rather than alkaloids.
ALKALOIDS
3
4. The name "alkaloids" (German: Alkaloid) was
introduced in 1819 by the German chemist Carl
Friedrich , and is derived from Latin root Latin: alkali
(which, in turn, comes from the Arabic al- qalwī –
"ashes of plants").
Biological precursors of most alkaloids are amino acids.
There are a few typical reactions involved in the
biosynthesis of various classes of alkaloids, including
synthesis of Schiff bases and Mannich reaction.
4
5. CARBAZOLE, an aromatic heterocyclic organic compound.
Tricyclic structure, consisting of two six-membered benzene rings
fused on either side of a five-membered nitrogen-containing ring.
5
8. Powdered plant material
Defatted with non-polar solvent
Defatted plant material
Moist with water and treated with NH3, Dil. Lime solution (Free Alkaloid)
Extracted with organic solvent like chloroform, ether
Extract, Concentrate it
Dissolved in Dil. Acid (Alkaloidal salt)
Aqueous phase Organic phase impurities
Basified with ammonia or sodium
Bi-carbonate or Dil. KOH
Aqueous phase Organic phase(Free Alkaloid)
Evaporate to dryness
Crude Alkaloids
Extraction of Alkaloids
8