6. Most of them were convicted in
court on account of using or
possessing cocaine and other
banned drugs.
Few famous/celebrated drugs
obtained from plants are:
20. In general alkaloidal salts are
soluble in water and their free
forms are soluble in organic
solvents (mainly ether and
chloroform).
Some of the pseudo and proto
alkaloids show higher solubility in
water e. g. colchicine and caffeine.
21. They are basic in nature due
to the lone pair of electrons on
nitrogen.
Their salt formation with an
inorganic acid prevents many
a time their decomposition.
22. Extraction
One has to consider following
steps in sequential manner for
the extraction of alkaloids:
23. Separation of the alkaloid from
unwanted material(Hardly any
plant which contains only one
alkaloid exclusively.)
Separation of each individual
alkaloid from the mixture using
chromatographic techniques.
27. Functions in plants
Waste metabolites
Waste products or secretary
products
They play defensive roles in
plants.
But their exact role in plants is a
debatable issue.
28. Nomenclature
From the generic name
Atropine from Atropa belladona
From the specific name
Belladonine from A. belladona
From common name
Ergotamine from ergot
29. From their specific pharmacological
actions
Narcotine from Papaver somniferum
Morphine from p somniferum.
From the name of discoverer
Pelletierine from the bark of Puniea granatum.
Generally with all the alkaloids
suffix ine is added.
30. Classification
They can be classified based on
their:
pharmacological actions
biosynthetic precursors and mostly
used
chemical structure which we will
see in detail:
37. No manipulation in opium alkaloids can
be done without the permission of Govt.
of India.
Neemuch and Ghazipur: Govt. opium
factories.
Alkaloid colony in Neemuch.
Alkaloids pvt. ltd. (Secunderabad, AP)