This document discusses the properties and uses of vinca alkaloids, a class of anti-mitotic and anti-microtubule agents that includes vincristine, vinblastine, vinorelbine, and vindesine. They are cell-cycle specific cytotoxic agents used in combination chemotherapy to treat lymphomas, breast cancer, and testicular carcinoma. They work by binding to mitotic spindle proteins and causing metaphase arrest. Side effects include neurotoxicity, nausea, vomiting, alopecia, and myelosuppression.

2.  Anti-mitotic and anti-microtubule alkaloid
agent.
 Cell- cycle specific cytotoxic agents
 Produced synthetically.

7.  Vincristine
 Vinblastine
 Vinorelbine
 Vindesine

8.  INDICATIONS - Combination chemotherapy of
1. Lymphomas ( HL , NHL)
2. Advanced breast cancer
3. Non- seminomatous testicular carcinoma

9.  Cell cycle specific M phase action, binds to
proteins of mitotic spindle causing
metaphase arrest.
 Specific action- Inhibits angiogenesis

10. 1. Death of rapidly replicating malignant cells.
2. Has immunosuppressive properties.

11.  CNS- Seizures, neurotoxicity, depression
 RESP- Bronchospasm
 GI- Nausea, Vomiting, Anorexia, Constipation
 DERM- Alopecia
 ENDO- SIADH
 HEMAT- Anemia, Leukopenia,Thrombocyopenia
 LOCAL- Phlebitis at IV site
 METAB- Hyperuricemia
 NEURO- Neuritis, peripheral neuropathy

12.  1mg/ml in 10 ml
vial

13.  Onset- 5-7 Days
 Peak- 10 days
 Duration- 7-14 Day

14. NURSING IMPLICATIONS

15.  Indications- used alone or in combination
with
1. HL
2. Leukemias
3. Neuroblastoma
4. Malignant melanoma
5. Rhabdomyosarcoma
6. Wilm’s tumour

16. 1. CNS- Insomnia, Depression
2. EENT- Diplopia, Cortical blindness
3. RESP- Bronchospasm
4. GI- Nausea, Vomiting, Abdominal cramps,
Anorexia, Constipation, Stomatitis
5. GU-Gonadal suppression, Nocturia, Oliguria,
Urinary retention
6. Derm- Alopecia
7. Endo- SIADH
8. Hemat- Anemia, Leukopenia, Thrombocytopenia
9. Local- Phlebitis at IV site
10. Neuro- Ascending peripheral neurapathy

17.  1mg/ml in 1-25 ml
vials

18.  ONSET- unknown
 PEAK- 4 days
 DURATION- 7 days

19. NURSING IMPLICATIONS