Measures of mortality provide important information for epidemiological studies. They include crude death rate, specific death rates, case fatality rate, proportional mortality rate, and survival rate. Standardized rates allow for comparisons between populations with different age compositions. Some challenges include incomplete reporting, inaccurate information, and non-uniformity across locations. However, mortality measures are useful for explaining trends, prioritizing health issues, designing interventions, and assessing public health programs.
Measurements of morbidity and mortality
At the end of the session, the students shall be able to
List the basic measurements in epidemiology
Select an appropriate tools of measurement
Measure morbidity & mortality
Perform standardization of rates
Standardization of rates by Dr. Basil TumainiBasil Tumaini
Standardization of rates by Dr. Basil Tumaini, presented during the residency at Muhimbili University of Health and Allied Sciences, Epidemiology class
Measurements of morbidity and mortality
At the end of the session, the students shall be able to
List the basic measurements in epidemiology
Select an appropriate tools of measurement
Measure morbidity & mortality
Perform standardization of rates
Standardization of rates by Dr. Basil TumainiBasil Tumaini
Standardization of rates by Dr. Basil Tumaini, presented during the residency at Muhimbili University of Health and Allied Sciences, Epidemiology class
Unit: 6 Demographic Rates and Ratios vital statistics SMVDCoN ,J&K
Rate measures the occurrence of some particular event in a population during a given period of time. It indicates the change in some event that take place in a population over a period of time like death rate or birth rate.A ratio is a relationship between two numbers indicating how many times the first number contains the second.
As per John M. Last (1988) Epidemiology is the study of the distribution and determinants of health related states or events in specified populations, and the application of this study to the control of health problems.
The Presentation explains basic models of disease causation, to understand the etiology or causes of disease & altered production and helps to understand the applicability of causal criteria applied to epidemiological studies.
Although there is very less material in web ,I try to make the topic lucid . I also stuck in sampling part but i feel it helpful for readers .
Commends are welcome
Unit: 6 Demographic Rates and Ratios vital statistics SMVDCoN ,J&K
Rate measures the occurrence of some particular event in a population during a given period of time. It indicates the change in some event that take place in a population over a period of time like death rate or birth rate.A ratio is a relationship between two numbers indicating how many times the first number contains the second.
As per John M. Last (1988) Epidemiology is the study of the distribution and determinants of health related states or events in specified populations, and the application of this study to the control of health problems.
The Presentation explains basic models of disease causation, to understand the etiology or causes of disease & altered production and helps to understand the applicability of causal criteria applied to epidemiological studies.
Although there is very less material in web ,I try to make the topic lucid . I also stuck in sampling part but i feel it helpful for readers .
Commends are welcome
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
2. Easy to obtain.
Obtained information is accurate
Provides
starting point for many
epidemiological studies-major resource for
epidemiologist.
3. 2 parts
Part
1-immediate cause, underlying
cause which started the whole trend of
events leading to death.
Part2-any significant associated
disease that contributed to the death
but did not directly lead to it.
4. Defined as
Disease or injury that initiated the train of
morbid events leading directly to death.
Circumstancesof the accident or violence
which produced the fatal injury.
5. CAUSE OF DEATH Approximate
interval
between
onset &
death
1.Immediate A
cause
Underlying B
cause C
2.Comorbid
conditions
6. Setof questions are added to the basic
structure
In
order to improve the quality of maternal
mortality and infant mortality data.
To
provide method of collecting data on
deaths during pregnancy and infancy.
7. Incomplete reporting of deaths
Lack of accuracy-age , cause of death-lack
of diagnostic evidence , inexperience of
the certifying doctor , absence of
postmortem.
Lack of uniformity-hampers national and
international comparability
8. Choosing a single cause of death-only
underlying cause of death is recorded in
some countries. Certain risk factors and
diseases that contribute to death are not
recorded.
Changing coding systems and diagnostic
methods affect the validity.
Diseases with low fatality
9. Explaining trends in overall mortality.
Indicating priorities for health action and
resource allocation.
Designing intervention programs.
Assessment of public health problems and
programs.
Give important clues for epidemiological
research.
10. MEASURES OF
MORTALITY
Crude death rate
Specific death rate
Case fatality rate
Proportional mortality rate
Survival rate
Adjusted or standardised rate
11. The no. of deaths (from all causes) per
1000 estimated mid-year population ,in
a given place.
No. of deaths during the year
*1000
Mid year population
16. Specific death rate in age group 15-20yrs =
No. of deaths in age group 15-
20yrs the during the year
*1000
Mid year population
17. Specific death rate due to tuberculosis =
No. of deaths due to tuberculosis
the during the year
*1000
Mid year population
18. Indicate killing power if a disease
Eg:-a/c infection like cholera
Variable with diff epidemics of same
disease-related to virulence
No. of deaths due to the
particular disease
*100
Total no. of cases of the
same disease
19. Number of deaths due to a particular
cause or in a specific age group per
100(or1000) deaths...
Used for broad d/s groups or major
public health problems
Does not indicate risk of dying from
the disease
20. Proportional mortality rate due to TB =
No. of deaths due to tuberculosis
the during the year
*100
Total no. of deaths
during the year
21. Proportion of survivers in a group
studied and followed over a period of
time
Usually 5year survival taken
Prognosis of disease indicated eg:-
cancer
Efficiency of treatment modality
22. Total no. of patients alive after 5
years
*100
Total no. of patients diagnosed
or treated
24. Standard population-no in each age &
sex known
Find ASDR of the population to be
evaluated
Apply to standard population
Calculate total expected deaths
Divide with the total of standard
population