SlideShare a Scribd company logo
MOOD STABLIZER
OR
ANTI MANIC DRUGS
MS.POOJA SEN
NURSING LECTURER
INTRODUCTION
• It is also know as a mood stablizer,this drug used to
treat mood disorder. This is diverse group of drug used
primarily of bipolar disorder and other condition related
to thematically through the presence of mood
abnormality .
HISTORY
• 1817- Lithium was discovered as a chemical element.
• 1871- First recorded use as a treatment of mania.
• By the beginning of 20th use of lithium was abandoned due to its
toxicity.
• 1949- use of lithium for mania rediscovered by JOHN CADE.
• 1970 – FDA approved use of lithium for mania.
• 1995- sodium valproate approved for acute type of mania.
DEFINITION
Any medication that is able to decrease vulnerability to
subsequent episodes of mania or depression and not
exacerbate the current episode od maintains phase of
treatment.
Mood stabilizer is a drugs which is used for treatment of
bipolar affective disorders.
CLASSIFICATION
There is no any specific classification of mood stabilizer
but we can classify the mood stabilizers in 3 categories.
1. Lithium
2. Anti Convulsant Drugs
3. Anti psychotic Drugs
1. LITHIUM
Lithium is a element with the atomic number 3 and atomic
weight 7. It was discovered by FJ CADE in 1949 and is a
most effective and commonly used drug in the treatment of
mania.
Lithium has been used for over years.
1. LITHIUM
Lithium Classification- Lithium carbonate, Lithium chloride
DOSE -
Adult – 900-1800 mg/day
Children 15-20 mg/day
Starting from 300 mg/day
LITHIUM
MECHANISM OF ACTION
• Accelerate presynaptic re-uptake & destructions of
catecholamine like norepinephrine
• Inhibit the release of catecholamines at the synapses.
• Decreases the post synaptic serotonin receptors.
INDICATION
• Acute mania
• Schizoaffective Disorder
• Cyclothymia
• Impulsivity or aggression
• Bulimia Nervosa
• Bipolar Disorder
• Borderline personality disorder
• Trichotillomania
• Cluster headaches
• Pre menstrual dysphoric
disorder
• Severe alcoholism
CONTRA INDICATION
• Cardiac, renal, thyroid or neurological dysfunction
• During first trimester of pregnancy & lactation
• Severe dehydration (because it inhibit the reabsorption
of water leading excessive urination & thirst )
PHARMACOKINETICS
Lithium is readily absorbed with peak plasma level occurring 2-4
hours after a single oral dose of lithium carbonate, lithium is
distributed rapidly in liver & kidney and more slowly in muscles,
brain and bone. Elimination occur through kidney. Lithium is
reabsorbed in the proximal tubules and its influenced by sodium
balance. Depletion of sodium can cause lithium toxicity.
SIDE EFFECT
• Neurological – Tremors, Motor hyper activity , muscles weakness ,
seizure
• Renal(due to blocking od ADH) – Polydipsia (the condition
abnormal thirst) Polyuria ( an abnormal large output of urine,
Nephrotic syndrome
• G I – Nausea, Vomiting , Diarrhea, Abdominal pain, Metallic taste
SIDE EFFECT
• Endocrine – Abnormal thyroid function, Goiter ,wight gain
• During Pregnancy & Lactation – Teratogenic Possibility,
incidence of Ebstein's Anomaly ( distortion and downward
displacement of tricuspid valve in right ventricles)
• Secreted through milk and can cause toxicity in child.
LITHIUM TOXICITY
• First lithium toxicity was discover by 1898.
• Name originated from LITHOS means stone.
• It discover through minerals.
• Use of lithium firstly used in 1949 by Australian doctor for
the treatment of mania.
Blood lithium level
• Therapeutic level – 0.8 – 1.2 meq/L
• Prophylactic level – 0.6 – 1.2 meq/L
• Toxic level - 2 meq/L
Toxicity occurs when the serum lithium level is -
More than 2 meq/L
STAGES –
 Acute Toxicity – acute toxicity occurs when you swallow too much of lithium
prescription at one time.
Symptoms- diarrhea, dizziness, nausea, weakness, pain ,vomiting ,
 Chronic Toxicity – chronic toxicity occur when you take a little too much
lithium prescription every day for while, this usually actually quite easy to do ,
because dehydration , other condition or how your body handles the lithium.
Symptoms- tremor, kidney failure, memory problems, movement problems.
Sign & symptoms of
lithium toxicity
• Nephrotoxicity
• Muscles weakness
• Convulsion
• Dysarthria (difficulty in speaking)
• Lethargy
• Confusion
• Coma
• Nystagmus (involuntary eye movement)
• Ataxia ( loss of control of
body movement)
• Coarse tremor(hand) an
involuntary trembling of the
body or limbs.
• Nausea & Vomiting
• Impaired memory
• Impaired concentration
Management of Lithium Toxicity
• Discontinue the drug immediately.
• For significant short term ingestions residual gastric content
should be removed by induction of emesis, gastric lavage.
• Assess serum lithium level and ECG as soon as possible.
• Maintain fluid and electrolyte balance.
• Thyroid function and kidney function test also be done.
Management of Lithium Toxicity
• Lithium must be taken on a regular basis preferably at the
same time daily.
• Frequent serum lithium level evaluation is important. Blood
for determination of lithium levels should be drawn in the
morning approximately 12-14 hours after the last dose was
taken.
2. CARBAMAZEPINE
• It is available in market under different trade names like Tegretol, Mazetol,
Zeptol and Retard.
DOSE- 600-1800 Mg Orally, in divided doses ,the therapeutic blood levels are
612 ug/ml. Toxic blood levels are attained at more then 15ug/ml.
Its mood stabilizing mechanism is not clearly established its anti convulsant
action my however by decreasing synaptic transmission in the CNS.
MECHANISM OF ACTION
• Carbamazepine is a medication used to treat various conditions, including
epilepsy, trigeminal neuralgia, and bipolar disorder.
• Epilepsy: Carbamazepine is effective in controlling focal seizures and
generalized tonic-clonic seizures.
• Trigeminal Neuralgia: It is used to alleviate the intense facial pain associated
with trigeminal neuralgia, a chronic pain condition affecting the trigeminal
nerve.
• Bipolar Disorder: Carbamazepine is prescribed for mood stabilization in
bipolar disorder, helping to prevent manic and depressive episodes.
INDICATION
• Rapid cycling bipolar disorder
• Acute depression
• Impulse control
• Aggression
• Psychosis with epilepsy
• Borderline personality disorder
• Cocaine withdrawal syndrome
INDICATION
CONTRAINDICATION
• Hypersensitivity to carbamazepine
• History of bone marrow depression
• Pregnancy and lactation
• Glaucoma
• History of cardiac ,renal damage
SIDE EFFECT
• Confusion
• Drowsiness
• Headache
• Hypertension
• Jaundice
• Hepatitis
• Dry mouth
• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Ataxia
• Oliguria
• Bone marrow depression
NURSES RESPONCIBILITY
• Since the drug may cause dizziness and drowsiness advice him to avoid
driving and other activities requiring alertness.
• Advice patient not to consume alcohol when he is on the drug therapy.
• Emphasize the importance of regular follow up visits and periodic
examination of blood count and monitoring of cardiac, renal, hepatic
and bone marrow functions.
3.SODIUM VALPROATE
• Sodium valproate is an anticonvulsant drug used as a mood
stabilizer.it is also known by the trade names Encorate chrono ,
valparin , exilex , epival , epilim and Depakote.
• DOSE- The usual dose is 15 mg/kg/day with a maximum of 60
mg/kg/day orally.
The drug acts on gamma aminobutyric acid GABA an inhibitory amino acid
neurotransmitter. GABA receptors activation servers to reduce neuronal
excitability.
MECHANISM OF ACTION
• Acute mania, prophylactic treatment of bipolar
• Schizoaffective disorder
• Seizure
• Other disorder like bulimia nervosa, OCD, PTSD
INDICATION
CONTRAINDICATION
Hypersensitivity to valproic acid , hepatic disease
(condition that damages the liver and prevents it from
functioning well.)
use cautiously with children below 2 years , pregnancy
lactation.
SIDE EFFECT
• Confusion
• Drowsiness
• Headache
• Wight gain
• Dry mouth
• Tremor
• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Dysarthria
NURSES RESPONCIBILITY
• Since the drug may cause dizziness and drowsiness advice him to
avoid driving and other activities requiring alertness.
• Advice patient not to consume alcohol when he is on the drug
therapy.
• Explain the patient to take the drug immediately after food to
reduce GI irritation.
• Advice to come for regular follow up and periodic examination of
blood count ,hepatic function and thyroid function. therapeutic
serum level of valproic acid is 50-100 micrograms /ml.
THANK YOU

More Related Content

What's hot

Tranquilizers
TranquilizersTranquilizers
Tranquilizers
Hasanul Karim
 
Lithium
LithiumLithium
Lithium
Basil Wilson
 
Psychopharmacology
PsychopharmacologyPsychopharmacology
Psychopharmacology
divya2709
 
Mood stabilizing agents
Mood stabilizing agentsMood stabilizing agents
Mood stabilizing agents
Sharika Ratish
 
Antimanic drugs and mood stabilizing agents
Antimanic drugs and mood stabilizing agentsAntimanic drugs and mood stabilizing agents
Antimanic drugs and mood stabilizing agents
http://neigrihms.gov.in/
 
Psychotropic drugs
Psychotropic drugsPsychotropic drugs
Psychotropic drugs
Edgar Manood
 
Anti-anxiety.pptx
Anti-anxiety.pptxAnti-anxiety.pptx
Haldol education 2014
Haldol education 2014Haldol education 2014
Haldol education 2014
dhexel
 
lithium toxicity
lithium toxicitylithium toxicity
lithium toxicity
Reejan Paudel
 
Lithium
LithiumLithium
Lithium
Shah Parind
 
Unit 1 role of psychiatric nurse
Unit 1 role of psychiatric nurseUnit 1 role of psychiatric nurse
Unit 1 role of psychiatric nurse
Princy Abraham
 
Antidepressant.pptx
Antidepressant.pptxAntidepressant.pptx
Antidepressant.pptx
Cherraan's college of Nursing
 
PSYCHOPHARMCOLOGY- INTRODUCTION.pdf
PSYCHOPHARMCOLOGY- INTRODUCTION.pdfPSYCHOPHARMCOLOGY- INTRODUCTION.pdf
PSYCHOPHARMCOLOGY- INTRODUCTION.pdf
Tejal Virola
 
Psychotropic medications
Psychotropic medications Psychotropic medications
Psychotropic medications
HI HI
 
Mood stabilizer
Mood stabilizerMood stabilizer
Mood stabilizer
KshirabdhiTanaya4
 
Neuroleptics (antipsychotics)
Neuroleptics (antipsychotics)Neuroleptics (antipsychotics)
Neuroleptics (antipsychotics)
Mohsin Aziz
 
Anticonvulsive medication
Anticonvulsive medicationAnticonvulsive medication
Anticonvulsive medication
Johny Wilbert
 
Mood Stabilizers | Psychotropic Drugs | Mental Health | Juhin J
Mood Stabilizers | Psychotropic Drugs | Mental Health | Juhin JMood Stabilizers | Psychotropic Drugs | Mental Health | Juhin J
Mood Stabilizers | Psychotropic Drugs | Mental Health | Juhin J
Juhin J
 
psychotropic drugs.pptx
psychotropic drugs.pptxpsychotropic drugs.pptx
psychotropic drugs.pptx
Cherraan's college of Nursing
 
Antiparkinsonian Drugs (Full Lecture)
Antiparkinsonian Drugs (Full Lecture) Antiparkinsonian Drugs (Full Lecture)
Antiparkinsonian Drugs (Full Lecture)
Sawsan Aboul-Fotouh
 

What's hot (20)

Tranquilizers
TranquilizersTranquilizers
Tranquilizers
 
Lithium
LithiumLithium
Lithium
 
Psychopharmacology
PsychopharmacologyPsychopharmacology
Psychopharmacology
 
Mood stabilizing agents
Mood stabilizing agentsMood stabilizing agents
Mood stabilizing agents
 
Antimanic drugs and mood stabilizing agents
Antimanic drugs and mood stabilizing agentsAntimanic drugs and mood stabilizing agents
Antimanic drugs and mood stabilizing agents
 
Psychotropic drugs
Psychotropic drugsPsychotropic drugs
Psychotropic drugs
 
Anti-anxiety.pptx
Anti-anxiety.pptxAnti-anxiety.pptx
Anti-anxiety.pptx
 
Haldol education 2014
Haldol education 2014Haldol education 2014
Haldol education 2014
 
lithium toxicity
lithium toxicitylithium toxicity
lithium toxicity
 
Lithium
LithiumLithium
Lithium
 
Unit 1 role of psychiatric nurse
Unit 1 role of psychiatric nurseUnit 1 role of psychiatric nurse
Unit 1 role of psychiatric nurse
 
Antidepressant.pptx
Antidepressant.pptxAntidepressant.pptx
Antidepressant.pptx
 
PSYCHOPHARMCOLOGY- INTRODUCTION.pdf
PSYCHOPHARMCOLOGY- INTRODUCTION.pdfPSYCHOPHARMCOLOGY- INTRODUCTION.pdf
PSYCHOPHARMCOLOGY- INTRODUCTION.pdf
 
Psychotropic medications
Psychotropic medications Psychotropic medications
Psychotropic medications
 
Mood stabilizer
Mood stabilizerMood stabilizer
Mood stabilizer
 
Neuroleptics (antipsychotics)
Neuroleptics (antipsychotics)Neuroleptics (antipsychotics)
Neuroleptics (antipsychotics)
 
Anticonvulsive medication
Anticonvulsive medicationAnticonvulsive medication
Anticonvulsive medication
 
Mood Stabilizers | Psychotropic Drugs | Mental Health | Juhin J
Mood Stabilizers | Psychotropic Drugs | Mental Health | Juhin JMood Stabilizers | Psychotropic Drugs | Mental Health | Juhin J
Mood Stabilizers | Psychotropic Drugs | Mental Health | Juhin J
 
psychotropic drugs.pptx
psychotropic drugs.pptxpsychotropic drugs.pptx
psychotropic drugs.pptx
 
Antiparkinsonian Drugs (Full Lecture)
Antiparkinsonian Drugs (Full Lecture) Antiparkinsonian Drugs (Full Lecture)
Antiparkinsonian Drugs (Full Lecture)
 

Similar to MOOD STABLIZERS DRUGS.pptx

Antimaniacs- drugs , bipolar disorder, etc
Antimaniacs- drugs , bipolar disorder, etcAntimaniacs- drugs , bipolar disorder, etc
Antimaniacs- drugs , bipolar disorder, etc
vijiarumugamvsvs
 
Antimanic drugs and its pharmacology
Antimanic drugs and its pharmacologyAntimanic drugs and its pharmacology
Antimanic drugs and its pharmacology
Koppala RVS Chaitanya
 
Drugs for Affective Disorders
Drugs for Affective DisordersDrugs for Affective Disorders
Drugs for Affective Disorders
RAJESHWAR CHAVAN
 
Pharmacotherapy
PharmacotherapyPharmacotherapy
Pharmacotherapy
Hala Sayyah
 
presentation on mood stablizers focusing on side effects.
presentation on mood stablizers focusing on side effects.presentation on mood stablizers focusing on side effects.
presentation on mood stablizers focusing on side effects.
ShafaqShafiq
 
Anticholinergic drugs
Anticholinergic drugsAnticholinergic drugs
Anticholinergic drugs
DrVishal Kandhway
 
Anticholinergic drugs
Anticholinergic drugsAnticholinergic drugs
Anticholinergic drugs
DrVishal Kandhway
 
Anti manic drug lithium
Anti manic drug  lithiumAnti manic drug  lithium
Anti manic drug lithium
Rifat Zakir
 
Pharmacology of Drugs used in bipolar disorder & mania
Pharmacology of Drugs used in bipolar disorder & maniaPharmacology of Drugs used in bipolar disorder & mania
Pharmacology of Drugs used in bipolar disorder & mania
shikha dwivedi
 
ANTIDEPRESSANTS.pptx
ANTIDEPRESSANTS.pptxANTIDEPRESSANTS.pptx
ANTIDEPRESSANTS.pptx
KisukeUrahara28
 
therapies in psychiatry 1111111111111111
therapies in psychiatry 1111111111111111therapies in psychiatry 1111111111111111
therapies in psychiatry 1111111111111111
MaryemSafdar2
 
Therapeutic modalities in psychiatry
Therapeutic modalities in psychiatryTherapeutic modalities in psychiatry
Therapeutic modalities in psychiatry
Enoch R G
 
Pharmacology of anti epileptic drugs
Pharmacology of anti epileptic drugsPharmacology of anti epileptic drugs
Pharmacology of anti epileptic drugs
Arfi12
 
Mania!!!
Mania!!!Mania!!!
Parasympatholytics/ Anticholinergic/ Muscarinic blockers/ Atropine
Parasympatholytics/ Anticholinergic/ Muscarinic blockers/ AtropineParasympatholytics/ Anticholinergic/ Muscarinic blockers/ Atropine
Parasympatholytics/ Anticholinergic/ Muscarinic blockers/ Atropine
mayur kale
 
antimania-210724111151.pptx
antimania-210724111151.pptxantimania-210724111151.pptx
antimania-210724111151.pptx
Imtiyaz60
 
mood stabilizers.pptx
mood stabilizers.pptxmood stabilizers.pptx
mood stabilizers.pptx
ManmeetKaur216
 
Antipsychotics, Antidepressants (dopamine)
Antipsychotics, Antidepressants (dopamine)Antipsychotics, Antidepressants (dopamine)
Antipsychotics, Antidepressants (dopamine)
BikashAdhikari26
 
AYESHA TABASSUM - LITHIUM SALT._ SEDATIVES.pptx
AYESHA TABASSUM - LITHIUM SALT._  SEDATIVES.pptxAYESHA TABASSUM - LITHIUM SALT._  SEDATIVES.pptx
AYESHA TABASSUM - LITHIUM SALT._ SEDATIVES.pptx
Nawabsahab14
 
Antimanic drugs
Antimanic drugsAntimanic drugs
Antimanic drugs
MangeshBansod2
 

Similar to MOOD STABLIZERS DRUGS.pptx (20)

Antimaniacs- drugs , bipolar disorder, etc
Antimaniacs- drugs , bipolar disorder, etcAntimaniacs- drugs , bipolar disorder, etc
Antimaniacs- drugs , bipolar disorder, etc
 
Antimanic drugs and its pharmacology
Antimanic drugs and its pharmacologyAntimanic drugs and its pharmacology
Antimanic drugs and its pharmacology
 
Drugs for Affective Disorders
Drugs for Affective DisordersDrugs for Affective Disorders
Drugs for Affective Disorders
 
Pharmacotherapy
PharmacotherapyPharmacotherapy
Pharmacotherapy
 
presentation on mood stablizers focusing on side effects.
presentation on mood stablizers focusing on side effects.presentation on mood stablizers focusing on side effects.
presentation on mood stablizers focusing on side effects.
 
Anticholinergic drugs
Anticholinergic drugsAnticholinergic drugs
Anticholinergic drugs
 
Anticholinergic drugs
Anticholinergic drugsAnticholinergic drugs
Anticholinergic drugs
 
Anti manic drug lithium
Anti manic drug  lithiumAnti manic drug  lithium
Anti manic drug lithium
 
Pharmacology of Drugs used in bipolar disorder & mania
Pharmacology of Drugs used in bipolar disorder & maniaPharmacology of Drugs used in bipolar disorder & mania
Pharmacology of Drugs used in bipolar disorder & mania
 
ANTIDEPRESSANTS.pptx
ANTIDEPRESSANTS.pptxANTIDEPRESSANTS.pptx
ANTIDEPRESSANTS.pptx
 
therapies in psychiatry 1111111111111111
therapies in psychiatry 1111111111111111therapies in psychiatry 1111111111111111
therapies in psychiatry 1111111111111111
 
Therapeutic modalities in psychiatry
Therapeutic modalities in psychiatryTherapeutic modalities in psychiatry
Therapeutic modalities in psychiatry
 
Pharmacology of anti epileptic drugs
Pharmacology of anti epileptic drugsPharmacology of anti epileptic drugs
Pharmacology of anti epileptic drugs
 
Mania!!!
Mania!!!Mania!!!
Mania!!!
 
Parasympatholytics/ Anticholinergic/ Muscarinic blockers/ Atropine
Parasympatholytics/ Anticholinergic/ Muscarinic blockers/ AtropineParasympatholytics/ Anticholinergic/ Muscarinic blockers/ Atropine
Parasympatholytics/ Anticholinergic/ Muscarinic blockers/ Atropine
 
antimania-210724111151.pptx
antimania-210724111151.pptxantimania-210724111151.pptx
antimania-210724111151.pptx
 
mood stabilizers.pptx
mood stabilizers.pptxmood stabilizers.pptx
mood stabilizers.pptx
 
Antipsychotics, Antidepressants (dopamine)
Antipsychotics, Antidepressants (dopamine)Antipsychotics, Antidepressants (dopamine)
Antipsychotics, Antidepressants (dopamine)
 
AYESHA TABASSUM - LITHIUM SALT._ SEDATIVES.pptx
AYESHA TABASSUM - LITHIUM SALT._  SEDATIVES.pptxAYESHA TABASSUM - LITHIUM SALT._  SEDATIVES.pptx
AYESHA TABASSUM - LITHIUM SALT._ SEDATIVES.pptx
 
Antimanic drugs
Antimanic drugsAntimanic drugs
Antimanic drugs
 

More from PoojaSen20

PSYCHIATRIC DRUGS USED IN CHILD PSYCHITRIC DISORDERS.pptx
PSYCHIATRIC DRUGS USED IN CHILD PSYCHITRIC DISORDERS.pptxPSYCHIATRIC DRUGS USED IN CHILD PSYCHITRIC DISORDERS.pptx
PSYCHIATRIC DRUGS USED IN CHILD PSYCHITRIC DISORDERS.pptx
PoojaSen20
 
ANTA ABUSE DRUGS OR ANTI CRAVING DRUGS .pptx
ANTA ABUSE DRUGS OR ANTI CRAVING DRUGS .pptxANTA ABUSE DRUGS OR ANTI CRAVING DRUGS .pptx
ANTA ABUSE DRUGS OR ANTI CRAVING DRUGS .pptx
PoojaSen20
 
ANTI ANXIETY DRUGS OR HYPNO SEDATIVE DRUGS .pptx
ANTI ANXIETY  DRUGS OR HYPNO SEDATIVE DRUGS .pptxANTI ANXIETY  DRUGS OR HYPNO SEDATIVE DRUGS .pptx
ANTI ANXIETY DRUGS OR HYPNO SEDATIVE DRUGS .pptx
PoojaSen20
 
Psycho Pharmacology v INTRODUCTION.pptx
Psycho Pharmacology    v INTRODUCTION.pptxPsycho Pharmacology    v INTRODUCTION.pptx
Psycho Pharmacology v INTRODUCTION.pptx
PoojaSen20
 
ANTI DEPRRESANT DRUGS.pptx
ANTI          DEPRRESANT      DRUGS.pptxANTI          DEPRRESANT      DRUGS.pptx
ANTI DEPRRESANT DRUGS.pptx
PoojaSen20
 
ANTIPSYCHOTIC DRUGS or major tranquilizer .pptx
ANTIPSYCHOTIC  DRUGS or major tranquilizer .pptxANTIPSYCHOTIC  DRUGS or major tranquilizer .pptx
ANTIPSYCHOTIC DRUGS or major tranquilizer .pptx
PoojaSen20
 
CARE OF DEATH PATIENT .pptx
CARE OF DEATH PATIENT              .pptxCARE OF DEATH PATIENT              .pptx
CARE OF DEATH PATIENT .pptx
PoojaSen20
 
psychiatric nursing HISTORY COLLECTION .docx
psychiatric  nursing HISTORY  COLLECTION  .docxpsychiatric  nursing HISTORY  COLLECTION  .docx
psychiatric nursing HISTORY COLLECTION .docx
PoojaSen20
 
PROCESS RECORDING FORMAT.docx
PROCESS      RECORDING        FORMAT.docxPROCESS      RECORDING        FORMAT.docx
PROCESS RECORDING FORMAT.docx
PoojaSen20
 
mini mental status format.docx
mini    mental       status     format.docxmini    mental       status     format.docx
mini mental status format.docx
PoojaSen20
 
MENTAL STATUS EXAMINATION format.docx
MENTAL     STATUS EXAMINATION format.docxMENTAL     STATUS EXAMINATION format.docx
MENTAL STATUS EXAMINATION format.docx
PoojaSen20
 
PRINICIPAL OF PSYCHIATRIC NURSING.ppt
PRINICIPAL OF    PSYCHIATRIC NURSING.pptPRINICIPAL OF    PSYCHIATRIC NURSING.ppt
PRINICIPAL OF PSYCHIATRIC NURSING.ppt
PoojaSen20
 
PSYCHIATRIC History collection FORMAT.pptx
PSYCHIATRIC   History collection FORMAT.pptxPSYCHIATRIC   History collection FORMAT.pptx
PSYCHIATRIC History collection FORMAT.pptx
PoojaSen20
 
SAMPLING METHODS ( PROBABILITY SAMPLING).pptx
SAMPLING METHODS ( PROBABILITY SAMPLING).pptxSAMPLING METHODS ( PROBABILITY SAMPLING).pptx
SAMPLING METHODS ( PROBABILITY SAMPLING).pptx
PoojaSen20
 
sampling and its process. pptx
sampling and its process.           pptxsampling and its process.           pptx
sampling and its process. pptx
PoojaSen20
 
CARE OF TERMINALLY ILL PATIENT .pptx
CARE OF TERMINALLY ILL PATIENT              .pptxCARE OF TERMINALLY ILL PATIENT              .pptx
CARE OF TERMINALLY ILL PATIENT .pptx
PoojaSen20
 
DIFFRENCES BETWEEN CULTURE & CIVILIZATION.pptx
DIFFRENCES BETWEEN CULTURE & CIVILIZATION.pptxDIFFRENCES BETWEEN CULTURE & CIVILIZATION.pptx
DIFFRENCES BETWEEN CULTURE & CIVILIZATION.pptx
PoojaSen20
 
TRANSCULTURAL SOCIETY .pptx
TRANSCULTURAL SOCIETY                              .pptxTRANSCULTURAL SOCIETY                              .pptx
TRANSCULTURAL SOCIETY .pptx
PoojaSen20
 
society and its types nd chracterstics.pptx
society and its types nd chracterstics.pptxsociety and its types nd chracterstics.pptx
society and its types nd chracterstics.pptx
PoojaSen20
 
DIFFRENCE BETWEEN COMMUNITY & SOCIETY.pptx
DIFFRENCE BETWEEN COMMUNITY & SOCIETY.pptxDIFFRENCE BETWEEN COMMUNITY & SOCIETY.pptx
DIFFRENCE BETWEEN COMMUNITY & SOCIETY.pptx
PoojaSen20
 

More from PoojaSen20 (20)

PSYCHIATRIC DRUGS USED IN CHILD PSYCHITRIC DISORDERS.pptx
PSYCHIATRIC DRUGS USED IN CHILD PSYCHITRIC DISORDERS.pptxPSYCHIATRIC DRUGS USED IN CHILD PSYCHITRIC DISORDERS.pptx
PSYCHIATRIC DRUGS USED IN CHILD PSYCHITRIC DISORDERS.pptx
 
ANTA ABUSE DRUGS OR ANTI CRAVING DRUGS .pptx
ANTA ABUSE DRUGS OR ANTI CRAVING DRUGS .pptxANTA ABUSE DRUGS OR ANTI CRAVING DRUGS .pptx
ANTA ABUSE DRUGS OR ANTI CRAVING DRUGS .pptx
 
ANTI ANXIETY DRUGS OR HYPNO SEDATIVE DRUGS .pptx
ANTI ANXIETY  DRUGS OR HYPNO SEDATIVE DRUGS .pptxANTI ANXIETY  DRUGS OR HYPNO SEDATIVE DRUGS .pptx
ANTI ANXIETY DRUGS OR HYPNO SEDATIVE DRUGS .pptx
 
Psycho Pharmacology v INTRODUCTION.pptx
Psycho Pharmacology    v INTRODUCTION.pptxPsycho Pharmacology    v INTRODUCTION.pptx
Psycho Pharmacology v INTRODUCTION.pptx
 
ANTI DEPRRESANT DRUGS.pptx
ANTI          DEPRRESANT      DRUGS.pptxANTI          DEPRRESANT      DRUGS.pptx
ANTI DEPRRESANT DRUGS.pptx
 
ANTIPSYCHOTIC DRUGS or major tranquilizer .pptx
ANTIPSYCHOTIC  DRUGS or major tranquilizer .pptxANTIPSYCHOTIC  DRUGS or major tranquilizer .pptx
ANTIPSYCHOTIC DRUGS or major tranquilizer .pptx
 
CARE OF DEATH PATIENT .pptx
CARE OF DEATH PATIENT              .pptxCARE OF DEATH PATIENT              .pptx
CARE OF DEATH PATIENT .pptx
 
psychiatric nursing HISTORY COLLECTION .docx
psychiatric  nursing HISTORY  COLLECTION  .docxpsychiatric  nursing HISTORY  COLLECTION  .docx
psychiatric nursing HISTORY COLLECTION .docx
 
PROCESS RECORDING FORMAT.docx
PROCESS      RECORDING        FORMAT.docxPROCESS      RECORDING        FORMAT.docx
PROCESS RECORDING FORMAT.docx
 
mini mental status format.docx
mini    mental       status     format.docxmini    mental       status     format.docx
mini mental status format.docx
 
MENTAL STATUS EXAMINATION format.docx
MENTAL     STATUS EXAMINATION format.docxMENTAL     STATUS EXAMINATION format.docx
MENTAL STATUS EXAMINATION format.docx
 
PRINICIPAL OF PSYCHIATRIC NURSING.ppt
PRINICIPAL OF    PSYCHIATRIC NURSING.pptPRINICIPAL OF    PSYCHIATRIC NURSING.ppt
PRINICIPAL OF PSYCHIATRIC NURSING.ppt
 
PSYCHIATRIC History collection FORMAT.pptx
PSYCHIATRIC   History collection FORMAT.pptxPSYCHIATRIC   History collection FORMAT.pptx
PSYCHIATRIC History collection FORMAT.pptx
 
SAMPLING METHODS ( PROBABILITY SAMPLING).pptx
SAMPLING METHODS ( PROBABILITY SAMPLING).pptxSAMPLING METHODS ( PROBABILITY SAMPLING).pptx
SAMPLING METHODS ( PROBABILITY SAMPLING).pptx
 
sampling and its process. pptx
sampling and its process.           pptxsampling and its process.           pptx
sampling and its process. pptx
 
CARE OF TERMINALLY ILL PATIENT .pptx
CARE OF TERMINALLY ILL PATIENT              .pptxCARE OF TERMINALLY ILL PATIENT              .pptx
CARE OF TERMINALLY ILL PATIENT .pptx
 
DIFFRENCES BETWEEN CULTURE & CIVILIZATION.pptx
DIFFRENCES BETWEEN CULTURE & CIVILIZATION.pptxDIFFRENCES BETWEEN CULTURE & CIVILIZATION.pptx
DIFFRENCES BETWEEN CULTURE & CIVILIZATION.pptx
 
TRANSCULTURAL SOCIETY .pptx
TRANSCULTURAL SOCIETY                              .pptxTRANSCULTURAL SOCIETY                              .pptx
TRANSCULTURAL SOCIETY .pptx
 
society and its types nd chracterstics.pptx
society and its types nd chracterstics.pptxsociety and its types nd chracterstics.pptx
society and its types nd chracterstics.pptx
 
DIFFRENCE BETWEEN COMMUNITY & SOCIETY.pptx
DIFFRENCE BETWEEN COMMUNITY & SOCIETY.pptxDIFFRENCE BETWEEN COMMUNITY & SOCIETY.pptx
DIFFRENCE BETWEEN COMMUNITY & SOCIETY.pptx
 

Recently uploaded

A Independência da América Espanhola LAPBOOK.pdf
A Independência da América Espanhola LAPBOOK.pdfA Independência da América Espanhola LAPBOOK.pdf
A Independência da América Espanhola LAPBOOK.pdf
Jean Carlos Nunes Paixão
 
MARY JANE WILSON, A “BOA MÃE” .
MARY JANE WILSON, A “BOA MÃE”           .MARY JANE WILSON, A “BOA MÃE”           .
MARY JANE WILSON, A “BOA MÃE” .
Colégio Santa Teresinha
 
Wound healing PPT
Wound healing PPTWound healing PPT
Wound healing PPT
Jyoti Chand
 
Chapter 4 - Islamic Financial Institutions in Malaysia.pptx
Chapter 4 - Islamic Financial Institutions in Malaysia.pptxChapter 4 - Islamic Financial Institutions in Malaysia.pptx
Chapter 4 - Islamic Financial Institutions in Malaysia.pptx
Mohd Adib Abd Muin, Senior Lecturer at Universiti Utara Malaysia
 
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
Nguyen Thanh Tu Collection
 
คำศัพท์ คำพื้นฐานการอ่าน ภาษาอังกฤษ ระดับชั้น ม.1
คำศัพท์ คำพื้นฐานการอ่าน ภาษาอังกฤษ ระดับชั้น ม.1คำศัพท์ คำพื้นฐานการอ่าน ภาษาอังกฤษ ระดับชั้น ม.1
คำศัพท์ คำพื้นฐานการอ่าน ภาษาอังกฤษ ระดับชั้น ม.1
สมใจ จันสุกสี
 
Leveraging Generative AI to Drive Nonprofit Innovation
Leveraging Generative AI to Drive Nonprofit InnovationLeveraging Generative AI to Drive Nonprofit Innovation
Leveraging Generative AI to Drive Nonprofit Innovation
TechSoup
 
How to Add Chatter in the odoo 17 ERP Module
How to Add Chatter in the odoo 17 ERP ModuleHow to Add Chatter in the odoo 17 ERP Module
How to Add Chatter in the odoo 17 ERP Module
Celine George
 
How to Manage Your Lost Opportunities in Odoo 17 CRM
How to Manage Your Lost Opportunities in Odoo 17 CRMHow to Manage Your Lost Opportunities in Odoo 17 CRM
How to Manage Your Lost Opportunities in Odoo 17 CRM
Celine George
 
How to Setup Warehouse & Location in Odoo 17 Inventory
How to Setup Warehouse & Location in Odoo 17 InventoryHow to Setup Warehouse & Location in Odoo 17 Inventory
How to Setup Warehouse & Location in Odoo 17 Inventory
Celine George
 
Liberal Approach to the Study of Indian Politics.pdf
Liberal Approach to the Study of Indian Politics.pdfLiberal Approach to the Study of Indian Politics.pdf
Liberal Approach to the Study of Indian Politics.pdf
WaniBasim
 
South African Journal of Science: Writing with integrity workshop (2024)
South African Journal of Science: Writing with integrity workshop (2024)South African Journal of Science: Writing with integrity workshop (2024)
South African Journal of Science: Writing with integrity workshop (2024)
Academy of Science of South Africa
 
The Diamonds of 2023-2024 in the IGRA collection
The Diamonds of 2023-2024 in the IGRA collectionThe Diamonds of 2023-2024 in the IGRA collection
The Diamonds of 2023-2024 in the IGRA collection
Israel Genealogy Research Association
 
বাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
বাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdfবাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
বাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
eBook.com.bd (প্রয়োজনীয় বাংলা বই)
 
How to Build a Module in Odoo 17 Using the Scaffold Method
How to Build a Module in Odoo 17 Using the Scaffold MethodHow to Build a Module in Odoo 17 Using the Scaffold Method
How to Build a Module in Odoo 17 Using the Scaffold Method
Celine George
 
Pengantar Penggunaan Flutter - Dart programming language1.pptx
Pengantar Penggunaan Flutter - Dart programming language1.pptxPengantar Penggunaan Flutter - Dart programming language1.pptx
Pengantar Penggunaan Flutter - Dart programming language1.pptx
Fajar Baskoro
 
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Dr. Vinod Kumar Kanvaria
 
NEWSPAPERS - QUESTION 1 - REVISION POWERPOINT.pptx
NEWSPAPERS - QUESTION 1 - REVISION POWERPOINT.pptxNEWSPAPERS - QUESTION 1 - REVISION POWERPOINT.pptx
NEWSPAPERS - QUESTION 1 - REVISION POWERPOINT.pptx
iammrhaywood
 
Cognitive Development Adolescence Psychology
Cognitive Development Adolescence PsychologyCognitive Development Adolescence Psychology
Cognitive Development Adolescence Psychology
paigestewart1632
 
How to Create a More Engaging and Human Online Learning Experience
How to Create a More Engaging and Human Online Learning Experience How to Create a More Engaging and Human Online Learning Experience
How to Create a More Engaging and Human Online Learning Experience
Wahiba Chair Training & Consulting
 

Recently uploaded (20)

A Independência da América Espanhola LAPBOOK.pdf
A Independência da América Espanhola LAPBOOK.pdfA Independência da América Espanhola LAPBOOK.pdf
A Independência da América Espanhola LAPBOOK.pdf
 
MARY JANE WILSON, A “BOA MÃE” .
MARY JANE WILSON, A “BOA MÃE”           .MARY JANE WILSON, A “BOA MÃE”           .
MARY JANE WILSON, A “BOA MÃE” .
 
Wound healing PPT
Wound healing PPTWound healing PPT
Wound healing PPT
 
Chapter 4 - Islamic Financial Institutions in Malaysia.pptx
Chapter 4 - Islamic Financial Institutions in Malaysia.pptxChapter 4 - Islamic Financial Institutions in Malaysia.pptx
Chapter 4 - Islamic Financial Institutions in Malaysia.pptx
 
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
 
คำศัพท์ คำพื้นฐานการอ่าน ภาษาอังกฤษ ระดับชั้น ม.1
คำศัพท์ คำพื้นฐานการอ่าน ภาษาอังกฤษ ระดับชั้น ม.1คำศัพท์ คำพื้นฐานการอ่าน ภาษาอังกฤษ ระดับชั้น ม.1
คำศัพท์ คำพื้นฐานการอ่าน ภาษาอังกฤษ ระดับชั้น ม.1
 
Leveraging Generative AI to Drive Nonprofit Innovation
Leveraging Generative AI to Drive Nonprofit InnovationLeveraging Generative AI to Drive Nonprofit Innovation
Leveraging Generative AI to Drive Nonprofit Innovation
 
How to Add Chatter in the odoo 17 ERP Module
How to Add Chatter in the odoo 17 ERP ModuleHow to Add Chatter in the odoo 17 ERP Module
How to Add Chatter in the odoo 17 ERP Module
 
How to Manage Your Lost Opportunities in Odoo 17 CRM
How to Manage Your Lost Opportunities in Odoo 17 CRMHow to Manage Your Lost Opportunities in Odoo 17 CRM
How to Manage Your Lost Opportunities in Odoo 17 CRM
 
How to Setup Warehouse & Location in Odoo 17 Inventory
How to Setup Warehouse & Location in Odoo 17 InventoryHow to Setup Warehouse & Location in Odoo 17 Inventory
How to Setup Warehouse & Location in Odoo 17 Inventory
 
Liberal Approach to the Study of Indian Politics.pdf
Liberal Approach to the Study of Indian Politics.pdfLiberal Approach to the Study of Indian Politics.pdf
Liberal Approach to the Study of Indian Politics.pdf
 
South African Journal of Science: Writing with integrity workshop (2024)
South African Journal of Science: Writing with integrity workshop (2024)South African Journal of Science: Writing with integrity workshop (2024)
South African Journal of Science: Writing with integrity workshop (2024)
 
The Diamonds of 2023-2024 in the IGRA collection
The Diamonds of 2023-2024 in the IGRA collectionThe Diamonds of 2023-2024 in the IGRA collection
The Diamonds of 2023-2024 in the IGRA collection
 
বাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
বাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdfবাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
বাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
 
How to Build a Module in Odoo 17 Using the Scaffold Method
How to Build a Module in Odoo 17 Using the Scaffold MethodHow to Build a Module in Odoo 17 Using the Scaffold Method
How to Build a Module in Odoo 17 Using the Scaffold Method
 
Pengantar Penggunaan Flutter - Dart programming language1.pptx
Pengantar Penggunaan Flutter - Dart programming language1.pptxPengantar Penggunaan Flutter - Dart programming language1.pptx
Pengantar Penggunaan Flutter - Dart programming language1.pptx
 
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
 
NEWSPAPERS - QUESTION 1 - REVISION POWERPOINT.pptx
NEWSPAPERS - QUESTION 1 - REVISION POWERPOINT.pptxNEWSPAPERS - QUESTION 1 - REVISION POWERPOINT.pptx
NEWSPAPERS - QUESTION 1 - REVISION POWERPOINT.pptx
 
Cognitive Development Adolescence Psychology
Cognitive Development Adolescence PsychologyCognitive Development Adolescence Psychology
Cognitive Development Adolescence Psychology
 
How to Create a More Engaging and Human Online Learning Experience
How to Create a More Engaging and Human Online Learning Experience How to Create a More Engaging and Human Online Learning Experience
How to Create a More Engaging and Human Online Learning Experience
 

MOOD STABLIZERS DRUGS.pptx

  • 1. MOOD STABLIZER OR ANTI MANIC DRUGS MS.POOJA SEN NURSING LECTURER
  • 2. INTRODUCTION • It is also know as a mood stablizer,this drug used to treat mood disorder. This is diverse group of drug used primarily of bipolar disorder and other condition related to thematically through the presence of mood abnormality .
  • 3. HISTORY • 1817- Lithium was discovered as a chemical element. • 1871- First recorded use as a treatment of mania. • By the beginning of 20th use of lithium was abandoned due to its toxicity. • 1949- use of lithium for mania rediscovered by JOHN CADE. • 1970 – FDA approved use of lithium for mania. • 1995- sodium valproate approved for acute type of mania.
  • 4. DEFINITION Any medication that is able to decrease vulnerability to subsequent episodes of mania or depression and not exacerbate the current episode od maintains phase of treatment. Mood stabilizer is a drugs which is used for treatment of bipolar affective disorders.
  • 5. CLASSIFICATION There is no any specific classification of mood stabilizer but we can classify the mood stabilizers in 3 categories. 1. Lithium 2. Anti Convulsant Drugs 3. Anti psychotic Drugs
  • 6. 1. LITHIUM Lithium is a element with the atomic number 3 and atomic weight 7. It was discovered by FJ CADE in 1949 and is a most effective and commonly used drug in the treatment of mania. Lithium has been used for over years.
  • 7. 1. LITHIUM Lithium Classification- Lithium carbonate, Lithium chloride DOSE - Adult – 900-1800 mg/day Children 15-20 mg/day Starting from 300 mg/day
  • 8. LITHIUM MECHANISM OF ACTION • Accelerate presynaptic re-uptake & destructions of catecholamine like norepinephrine • Inhibit the release of catecholamines at the synapses. • Decreases the post synaptic serotonin receptors.
  • 9. INDICATION • Acute mania • Schizoaffective Disorder • Cyclothymia • Impulsivity or aggression • Bulimia Nervosa • Bipolar Disorder • Borderline personality disorder • Trichotillomania • Cluster headaches • Pre menstrual dysphoric disorder • Severe alcoholism
  • 10. CONTRA INDICATION • Cardiac, renal, thyroid or neurological dysfunction • During first trimester of pregnancy & lactation • Severe dehydration (because it inhibit the reabsorption of water leading excessive urination & thirst )
  • 11. PHARMACOKINETICS Lithium is readily absorbed with peak plasma level occurring 2-4 hours after a single oral dose of lithium carbonate, lithium is distributed rapidly in liver & kidney and more slowly in muscles, brain and bone. Elimination occur through kidney. Lithium is reabsorbed in the proximal tubules and its influenced by sodium balance. Depletion of sodium can cause lithium toxicity.
  • 12. SIDE EFFECT • Neurological – Tremors, Motor hyper activity , muscles weakness , seizure • Renal(due to blocking od ADH) – Polydipsia (the condition abnormal thirst) Polyuria ( an abnormal large output of urine, Nephrotic syndrome • G I – Nausea, Vomiting , Diarrhea, Abdominal pain, Metallic taste
  • 13. SIDE EFFECT • Endocrine – Abnormal thyroid function, Goiter ,wight gain • During Pregnancy & Lactation – Teratogenic Possibility, incidence of Ebstein's Anomaly ( distortion and downward displacement of tricuspid valve in right ventricles) • Secreted through milk and can cause toxicity in child.
  • 14. LITHIUM TOXICITY • First lithium toxicity was discover by 1898. • Name originated from LITHOS means stone. • It discover through minerals. • Use of lithium firstly used in 1949 by Australian doctor for the treatment of mania.
  • 15. Blood lithium level • Therapeutic level – 0.8 – 1.2 meq/L • Prophylactic level – 0.6 – 1.2 meq/L • Toxic level - 2 meq/L
  • 16. Toxicity occurs when the serum lithium level is - More than 2 meq/L STAGES –  Acute Toxicity – acute toxicity occurs when you swallow too much of lithium prescription at one time. Symptoms- diarrhea, dizziness, nausea, weakness, pain ,vomiting ,  Chronic Toxicity – chronic toxicity occur when you take a little too much lithium prescription every day for while, this usually actually quite easy to do , because dehydration , other condition or how your body handles the lithium. Symptoms- tremor, kidney failure, memory problems, movement problems.
  • 17. Sign & symptoms of lithium toxicity • Nephrotoxicity • Muscles weakness • Convulsion • Dysarthria (difficulty in speaking) • Lethargy • Confusion • Coma • Nystagmus (involuntary eye movement) • Ataxia ( loss of control of body movement) • Coarse tremor(hand) an involuntary trembling of the body or limbs. • Nausea & Vomiting • Impaired memory • Impaired concentration
  • 18. Management of Lithium Toxicity • Discontinue the drug immediately. • For significant short term ingestions residual gastric content should be removed by induction of emesis, gastric lavage. • Assess serum lithium level and ECG as soon as possible. • Maintain fluid and electrolyte balance. • Thyroid function and kidney function test also be done.
  • 19. Management of Lithium Toxicity • Lithium must be taken on a regular basis preferably at the same time daily. • Frequent serum lithium level evaluation is important. Blood for determination of lithium levels should be drawn in the morning approximately 12-14 hours after the last dose was taken.
  • 20. 2. CARBAMAZEPINE • It is available in market under different trade names like Tegretol, Mazetol, Zeptol and Retard. DOSE- 600-1800 Mg Orally, in divided doses ,the therapeutic blood levels are 612 ug/ml. Toxic blood levels are attained at more then 15ug/ml.
  • 21. Its mood stabilizing mechanism is not clearly established its anti convulsant action my however by decreasing synaptic transmission in the CNS. MECHANISM OF ACTION
  • 22. • Carbamazepine is a medication used to treat various conditions, including epilepsy, trigeminal neuralgia, and bipolar disorder. • Epilepsy: Carbamazepine is effective in controlling focal seizures and generalized tonic-clonic seizures. • Trigeminal Neuralgia: It is used to alleviate the intense facial pain associated with trigeminal neuralgia, a chronic pain condition affecting the trigeminal nerve. • Bipolar Disorder: Carbamazepine is prescribed for mood stabilization in bipolar disorder, helping to prevent manic and depressive episodes. INDICATION
  • 23. • Rapid cycling bipolar disorder • Acute depression • Impulse control • Aggression • Psychosis with epilepsy • Borderline personality disorder • Cocaine withdrawal syndrome INDICATION
  • 24. CONTRAINDICATION • Hypersensitivity to carbamazepine • History of bone marrow depression • Pregnancy and lactation • Glaucoma • History of cardiac ,renal damage
  • 25. SIDE EFFECT • Confusion • Drowsiness • Headache • Hypertension • Jaundice • Hepatitis • Dry mouth • Nausea • Vomiting • Diarrhea • Abdominal pain • Ataxia • Oliguria • Bone marrow depression
  • 26. NURSES RESPONCIBILITY • Since the drug may cause dizziness and drowsiness advice him to avoid driving and other activities requiring alertness. • Advice patient not to consume alcohol when he is on the drug therapy. • Emphasize the importance of regular follow up visits and periodic examination of blood count and monitoring of cardiac, renal, hepatic and bone marrow functions.
  • 27. 3.SODIUM VALPROATE • Sodium valproate is an anticonvulsant drug used as a mood stabilizer.it is also known by the trade names Encorate chrono , valparin , exilex , epival , epilim and Depakote. • DOSE- The usual dose is 15 mg/kg/day with a maximum of 60 mg/kg/day orally.
  • 28. The drug acts on gamma aminobutyric acid GABA an inhibitory amino acid neurotransmitter. GABA receptors activation servers to reduce neuronal excitability. MECHANISM OF ACTION
  • 29. • Acute mania, prophylactic treatment of bipolar • Schizoaffective disorder • Seizure • Other disorder like bulimia nervosa, OCD, PTSD INDICATION
  • 30. CONTRAINDICATION Hypersensitivity to valproic acid , hepatic disease (condition that damages the liver and prevents it from functioning well.) use cautiously with children below 2 years , pregnancy lactation.
  • 31. SIDE EFFECT • Confusion • Drowsiness • Headache • Wight gain • Dry mouth • Tremor • Nausea • Vomiting • Diarrhea • Abdominal pain • Dysarthria
  • 32. NURSES RESPONCIBILITY • Since the drug may cause dizziness and drowsiness advice him to avoid driving and other activities requiring alertness. • Advice patient not to consume alcohol when he is on the drug therapy. • Explain the patient to take the drug immediately after food to reduce GI irritation. • Advice to come for regular follow up and periodic examination of blood count ,hepatic function and thyroid function. therapeutic serum level of valproic acid is 50-100 micrograms /ml.