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ANTI
PARKINSONIAN
DRUGS
MS.POOJA SEN
NURSING LECTURER
In clinical practice anti cholinergic drugs, amantadine and
the dopaminergic have their primary use of drugs induced
Parkinson, acute dystonia and medication induced tremor.
Anticholinergics
Dopaminergic
Monoamine
Anticholinergics – Trihexyphenidyl,
Benztropine, Biperiden
Dopaminergic - Bromocriptine,
carbidopa, levodopa
Monoamine oxidase type B inhibitor-
Selegiline
INDICATION
 Drug induced parkinsonism
Acute dystonia
Medication induced tremor
DOSE
1-2 Mg per day orally initially.
Maximum dose up to 15 mg/day in
divided dose.
MECHANISM OF ACTION
It acts by increasing the release of dopamine from
presynaptic vesicles, blocking the reuptake of dopamine into
presynaptic nerve terminal or by exerting an agonist effect
on postsynaptic dopamine receptors.
SIDE EFFECT
 Tachycardia
 Orthostatic hypotension
 Dry mouth
 Nausea
 Constipation
 Vomiting
 Urinary retention and decreased sweating
 Dizziness
 Nervousness
 Drowsiness
 Weakness
 Headache
 Confusion
 Blurred Vision
 Mydriasis
NURSES RESPONCIBILITY
 Assess parkinsonian and extrapyramidal symptoms, medication should
be tapered gradually.
 Caution patient to make position changes slowly to minimize orthostatic
hypotension.
 Instruct the patient about frequent rinsing of mouth and good oral
hygiene.
 Caution patient that this medication decreases perspiration and over
heating may occur during hot weather.

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ANTI PARKISON DRUGS.pptx

  • 2. In clinical practice anti cholinergic drugs, amantadine and the dopaminergic have their primary use of drugs induced Parkinson, acute dystonia and medication induced tremor. Anticholinergics Dopaminergic Monoamine
  • 3. Anticholinergics – Trihexyphenidyl, Benztropine, Biperiden Dopaminergic - Bromocriptine, carbidopa, levodopa Monoamine oxidase type B inhibitor- Selegiline
  • 4. INDICATION  Drug induced parkinsonism Acute dystonia Medication induced tremor
  • 5. DOSE 1-2 Mg per day orally initially. Maximum dose up to 15 mg/day in divided dose.
  • 6. MECHANISM OF ACTION It acts by increasing the release of dopamine from presynaptic vesicles, blocking the reuptake of dopamine into presynaptic nerve terminal or by exerting an agonist effect on postsynaptic dopamine receptors.
  • 7. SIDE EFFECT  Tachycardia  Orthostatic hypotension  Dry mouth  Nausea  Constipation  Vomiting  Urinary retention and decreased sweating  Dizziness  Nervousness  Drowsiness  Weakness  Headache  Confusion  Blurred Vision  Mydriasis
  • 8. NURSES RESPONCIBILITY  Assess parkinsonian and extrapyramidal symptoms, medication should be tapered gradually.  Caution patient to make position changes slowly to minimize orthostatic hypotension.  Instruct the patient about frequent rinsing of mouth and good oral hygiene.  Caution patient that this medication decreases perspiration and over heating may occur during hot weather.