Lipoproteins are complexes of lipids and proteins that transport lipids in blood plasma. There are five major classes of lipoproteins - chylomicrons, very low density lipoproteins (VLDL), low density lipoproteins (LDL), high density lipoproteins (HDL), and free fatty acid-albumin. They differ in their lipid and protein composition and function to transport lipids between tissues and the liver. Genetic defects in lipoprotein metabolism can result in various hyperlipoproteinemias or hypolipoproteinemias.
This PPT contains content of Gluconeogenesis, Steps involved in Gluconeogenesis, (Gluconeogenesis from Pyruvate, Gluconeogenesis from lactate, Gluconeogenesis from amino acids, Gluconeogenesis from glycerol, Gluconeogenesis from Propionate), Regulation and significance of Gluconeogenesis
Plasma Proteins For Therapeutic Use; An Introduction to Blood PLASMA & its Se...Maryam Pazireh
An INTRODUCTION TO PLASMA & its Separation Methods;
what is Plasma & its composition, What does it do in the body, and Plasma Proteins as pharmaceutical crops
Introduction to calcium
Sources of calcium
Dietary requirement of calcium
Calcium absorption
Biochemical function of calcium
Calcium in blood
Calcium estimation
Factors regulating calcium level in blood
Disease states of calcium
This PPT contains content of Gluconeogenesis, Steps involved in Gluconeogenesis, (Gluconeogenesis from Pyruvate, Gluconeogenesis from lactate, Gluconeogenesis from amino acids, Gluconeogenesis from glycerol, Gluconeogenesis from Propionate), Regulation and significance of Gluconeogenesis
Plasma Proteins For Therapeutic Use; An Introduction to Blood PLASMA & its Se...Maryam Pazireh
An INTRODUCTION TO PLASMA & its Separation Methods;
what is Plasma & its composition, What does it do in the body, and Plasma Proteins as pharmaceutical crops
Introduction to calcium
Sources of calcium
Dietary requirement of calcium
Calcium absorption
Biochemical function of calcium
Calcium in blood
Calcium estimation
Factors regulating calcium level in blood
Disease states of calcium
Lipids are insoluble in water, the problem of transportation in the aqueous plasma is solved by associating nonpolar lipids (triacylglycerols and cholesteryl esters) with amphipathic lipids (phospholipids and cholesterol) and proteins to make water-miscible lipoproteins.
lipoproteins transfer lipids such as triacylglycerol, cholestryl ester, fat soluble vitamins in the body. there are 5 categories of lipoproteins which includes chylomicrone, VLDL, IDL, LDL and HDL. LDL-cholesterol is called bad cholestrol while HDL-cholesterol is called good cholesterol.
Coronary heart disease due to atherosclerotic process is the major cause of death.Lipids have been implicated for enhanced atherosclerosis. The major lipids involved are triacy glycerol and cholesterol which are transported in the plasma by lipoproteins. So a better understanding of lipid transport and its abnormalities is essential for medical and health professional students.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
2. Lipoproteins are molecular complexes that
consist of lipids and proteins (conjugated
proteins).
They function as transport vehicles for lipids
in blood plasma.
Lipoproteins deliver the lipid components
(cholesterol, triacylglycerol etc.) to various
tissues for utilization.
3. A lipoprotein basically consist of a neutral
lipid core (with triacylglycerol and/or
cholesteryl ester) surrounded by a coat shell
of phospho- lipids, apoproteins and
cholesterol.
The polar portions (amphiphilic) of phospho-
lipids and cholesterol are exposed on the
surface of lipoproteins so that lipoprotein is
soluble in aqueous solution.
4.
5. Five major classes of lipoproteins are
identified in human plasma, based on their
separation by electrophoresis
6.
7. 1) Chylomicrons :
They are synthesized in the intestine and
transport exogenous(dietary) triacylglycerol
to various tissues.
They consists of highest (99%) quantity of
lipid and lower (1%) concentration of
protein.
The chylomicrons are the least in density and
the largest in size, among the lipoproteins.
8. 2) Very low density lipoproteins:
They are produced in liver and intestine and
are responsible for the transport of
endogenously synthesized triacylglycerols.
9. 3) Low density lipoproteins(LDL):
They are formed from VLDL in the blood
circulation.
They transport cholesterol from liver to
other tissues.
10. 4) High density lipoproteins(HDL):
They are mostly synthesized in liver.
Three different fractions of HDL (1, 2 and 3)
can be identified by ultracentrifugation.
HDL particles transport cholesterol from
peripheral tissues to liver (reverse
cholesterol transport).
11. 5) Free fatty acids-albumin:
Free fatty acids in the circulation are in a
bound form to albumin.
Each molecule of albumin can hold about 20-
30 molecules of free fatty acids
This lipoprotein can not be separated by
electrophoresis.
12. The protein component of lipoproteins are
called apolipoproteins or, simply apoproteins.
They perform the following functions-
---Act as structural components of
lipoproteins.
---Recognize the cell membrane surface
receptors.
---Activate enzymes involved in lipoprotein
metabolism
13.
14. Chylomicrons (nascent) are synthesized in
the small intestine during the course of fat
absorption.
They contain apoprotein B48 and mostly
triacylglycerols.
Apo B48 name is given since this apoprotein
contains 48% of protein coded by apo B gene
(apo B100 is found in LDL and VLDL).
.
15. Chylomicrons are produced when nascent
particles combine with apo C II and apo E,
derived from HDL .
The liver synthesizes nascent VLDL containing
apo B100 which are rich in triacylglycerols
and cholesterol.
Circulating HDL donates apo C II and apo E to
convert nascent VLDL to VLDL.
16. Role of lipoprotein lipase:
The enzyme lipoprotein lipase is present in
the capillary walls of adipose tissue, cardiac
and skeletal muscle besides other tissues.
It hydrolyses a portion of triacylglycerols
present in chylomicrons and to VLDL
liberate free fatty acids and glycerol.
Lipoprotein lipase is activated by apo C II.
17. Uptake of chylomicron remnants by liver:
As the triacylglycerols of chylomicrons and
VLDL are degraded, they lose the apo C II
which is returned to HDL.
The chylomicron remnants are taken up by
receptors present on the hepatocytes of
liver.
18.
19. During the course of VLDL metabolism,
intermediate density lipoprotein (IDL) is
formed which lose apo-E and get converted
to LDL.
The apo E is returned to HDL.
LDL contains high cholesterol (free and
esterified) and less triacylglycerol.
20. Cholesterol ester transfer protein (CETP):
CETP is synthesized in the liver, and it
facilitates the exchange of components
between different lipoproteins.
CETP can transfer cholestreol esters from
HDL to VLDL or LDL, in exchange for TG
21. The most important function of LDL is to
supply cholesterol to the extrahepatic
tissues.
The LDL particles bind to the specific
receptor pits (identified as glycoprotein) on
the cell membrane.
The shape of the pit is stabilized by a protein
called clathrin.
Apo B100 is responsible for the recognition of
LDL receptor sites.
22. Deficiency of LDL receptors:
A defect in LDL receptors results in the elevation
of plasma LDL, hence plasma cholesterol.
However, plasma triacylglycerol concentration
remains normal.
Deficiency of LDL receptors is observed in type
IIa hyperbetalipoproteinemia.
This disorder is associated with a very high risk
of atherosclerosis (particularly of coronary
artery)
23. High density lipoproteins are synthesized in
the liver as discoidal particles- nascent HDL.
They contain free cholesterol and phospho-
lipids (mostly lecithin) and apoproteins (A,
CII, E etc.).
24. Role of LCAT in HDL metabolism :
The plasma enzyme lecithin-cholesterol acyl-
transferase (LCAT) catalyses the esterification of
free cholesterol (by fatty acid of lecithin)
present in the extrahepatic tissues and transfers
to the HDL.
Apoprotein a promotes the activity of LCAT.
HDL also accepts free cholesterol from other
lipoproteins in circulation and cell membrane of
peripheral tissues.
25.
26. Any free cholesterol taken up by HDL undergoes
LCAT-catalysed esterification.
Due to the addition of cholesterol, HDL particles
become spherical.
The HDL particles, with cholesteryl ester trapped
inside, enter the hepatocytes by a receptor-mediated
endocytosis.
In the liver, the cholesteryl esters are degraded to
cholesterol.
The latter is utilized for the synthesis of bile acids
and lipoproteins or excreted into bile (as cholesterol)
27. Functions of HDL:
1)Transport of cholesterol (as ester) from
peripheral tissue to liver for its degradation and
excretion (scavenger action).
2)HDL serves as a reservoir of apoproteins. They
accept apoproteins (CII and E) and donate the
same to other lipoproteins-chylomicrons and
VLDL.
3)The apoprotein CII of HDL serves as an activator
of lipoprotein lipase.
28. Inherited disorders of lipoproteins in some
individuals resulting in primary hyper-or
hypolipoproteinemias.
These are due to genetic defects in lipoprotein
metabolism and transport.
The secondary acquired lipoprotein disorders are
due to some other diseases(e.g. Diabetes
mellitus, nephrotic syndrome, atherosclerosis,
hypothyroidism etc.), resulting in abnormal
lipoprotein pattern which often resembles the
primary inherited condition.
29. Hyperlipoproteinemias:
Elevation in one or more of the lipoprotein
fractions constitutes hyperlipoproteinemias.
These disorders may be either primary or
secondary.
1) Type I:
This is due to familial lipoprotein lipase
deficiency. The enzyme defect causes increase in
plasma chylomicron and triacylglycerol levels.
30. 2) Type IIa:
This is also known as hyperbetalipoprotein-emia
and is caused by a defect in LDL receptors.
Secondary type IIa hyperlipo-proteinemia is
observed in association with diabetes mellitus,
hypothyroidism, nephrotic syndrome etc.
This disorder is characterized by hyper-
cholesterolemia.
31. 3) Type IIb:
Both LDL and VLDL increase along with elevation
in plasma cholesterol and triacylglycerol.
This is believed to be due to overproduction of
apo B.
4) Type III:
This is commonly known as broad beta disease
and characterized by the appearance of a broad
β-band corresponding to intermediate density
lipoprotein (IDL) on electrophoresis.
32. 5) Type IV:
This is due to the overproduction of endogenous
triacyl glycerols with a concomitant rise in VLDL.
Type IV disorder is usually associated with
obesity, alcoholism, diabetes mellitus etc.
6) Type V:
Both chylomicrons and VLDL are elevated.
This is mostly a secondary condition, due to
disorders such as obesity, diabetes and excessive
alcohol consumption etc.
33.
34. Hypolipoproteinemias:
Although low levels of plasma lipids (not
HDL!) within the normal range may be
beneficial to the body, very low lipid levels
are undesirable.
These are commonly associated with certain
abnormalities.
35. 1) Familial hypobetalipoproteinemia:
It is an inherited disorder probably due to an
impairment in the synthesis of apoprotein B.
The plasma LDL concentration in the
affected individuals is between 10 to 50% of
normal values.
This disorder is harmless, and the individuals
have healthy and long life.
36. 2) Abetalipoproteinemia:
This is a rare disorder due to a defect in the synthesis of
apoprotein B.
It is characterized by a total absence of β-lipoprotein
(LDL) in plasma.
Triacylglycerols are not found in plasma, but they
accumulate in liver and intestine.
Serum cholesterol level is low.
Abetalipoproteinemia is associated with decreased
absorption of fat and fat soluble vitamins.
Impairment in physical growth and mental retardation are
commonly observed.
37. Familial alpha-lipoprotein deficiency(Tangier
disease):
The plasma HDL particles are almost absent.
Due to this, the reverse transport of cholesterol is
severely affected leading to the accumulation of
cholesteryl esters in tissues.
An absence of apoprotein C II-which activates
lipoprotein lipase –is also found.
The plasma triacylglycerol level are elevated.
The affected individuals are at an increased risk of
atherosclerosis.