Liquid chromatography-mass spectrometry (LC-MS) is an analytical technique that combines liquid chromatography with mass spectrometry. It has high sensitivity and selectivity. LC-MS is commonly used in pharmacokinetics studies to analyze drugs in biological samples. It is also used in proteomics to identify over 1000 proteins in complex samples like human serum. Additionally, LC-MS has various applications in drug development such as metabolite identification, quantitative bioanalysis, and quality control.