The document outlines a patient safety campaign at Tufts Medical Center aimed at improving hand hygiene to reduce hospital-acquired infections, which claim 90,000 lives annually in the U.S. The campaign, featuring the slogan 'speak up. wash up.', was developed through extensive research and targeted communication strategies to engage both staff and patients, achieving significant increases in hand hygiene compliance. Key components included localized messaging, visible leadership involvement, and a variety of educational materials to foster a culture of accountability among healthcare providers.