This document discusses influenza (flu), including its causes, symptoms, high-risk groups, diagnosis, treatment and prevention. Some key points:
- Influenza is caused by influenza viruses that infect the respiratory tract and can cause illness from mild to severe. Outbreaks occur yearly.
- High-risk groups include young children, elderly adults, pregnant women and those with underlying health conditions.
- Symptoms include fever, cough, sore throat and body aches. Severe cases can lead to pneumonia or respiratory failure.
- Diagnosis involves virus detection tests on respiratory samples. Treatment focuses on antiviral drugs, rest and fever control. Prevention includes annual flu vaccines and good hygiene practices.
What is influenza ,ethology ,types ,presentations signs and symptoms ,epidemic influenza ,laboratory investigations , management , the WHO guidelines in dealing with cases and contact
Influenza is a respiratory infection caused by a virus (germ). Influenza occurs most often during the winter and easily spreads from person to person. Most people who get influenza feel sick for a week or two and recover. In some people, influenza leads to more serious lung infections.
What is influenza ,ethology ,types ,presentations signs and symptoms ,epidemic influenza ,laboratory investigations , management , the WHO guidelines in dealing with cases and contact
Influenza is a respiratory infection caused by a virus (germ). Influenza occurs most often during the winter and easily spreads from person to person. Most people who get influenza feel sick for a week or two and recover. In some people, influenza leads to more serious lung infections.
The new virus has made the jump from pigs to humans and has demonstrated it can also pass from human to human. This is why it is demanding so much attention from health authorities. The virus passes from human to human like other types of flu, either through coughing, sneezing, or by touching infected surfaces, although little is known about how the virus acts on humans.
Measles is a highly contagious viral infection.
It is exanthematous disease with fewer, cough, coryza (rhinitis) and conjunctivitis.
Before the widespread use of measles vaccines, it was estimated that measles caused between 5 million and 8 million deaths worldwide each year.
all about rabies
epidemiology of rabies,
pathogenesis of rabies,
clinical features of rabies,
treatment of rabies,
prevention of rabies,
rabies virus,
post exposure prophylaxis,
rabies in dogs
The new virus has made the jump from pigs to humans and has demonstrated it can also pass from human to human. This is why it is demanding so much attention from health authorities. The virus passes from human to human like other types of flu, either through coughing, sneezing, or by touching infected surfaces, although little is known about how the virus acts on humans.
Measles is a highly contagious viral infection.
It is exanthematous disease with fewer, cough, coryza (rhinitis) and conjunctivitis.
Before the widespread use of measles vaccines, it was estimated that measles caused between 5 million and 8 million deaths worldwide each year.
all about rabies
epidemiology of rabies,
pathogenesis of rabies,
clinical features of rabies,
treatment of rabies,
prevention of rabies,
rabies virus,
post exposure prophylaxis,
rabies in dogs
Epidemiology & Control Measures of Measles.pptxAB Rajar
It is an acute highly infectious disease of childhood caused by a specific virus of the group myxovirus.
One of the top five causes of vaccine-preventable deaths in the world
Easy to prevent – the vaccine costs less than US$1 and gives life-long immunity
Found in every part of the world – measles outbreaks have taken place on every continent and in all climates
One of the most contagious diseases – 90% of those exposed to the measles virus will catch it if they do not have immunity
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
2. An acute respiratory illness caused by influenza viruses.
Affects the upper and/or lower respiratory tract.
Nearly every year outbreaks of illness occurs of variable
extent and disease severity.
Result in significant morbidity in general population and
increased in mortality rates among high-risk patients.
3. Shortness of breath
Pain or pressure in the
chest or abdomen
Dizziness
Confusion
Severe or persistent
vomiting
Flu-like symptoms
improve but then return
with fever and worse
cough
4. Dyspnoea
Bluish discoloration of skin
Not drinking enough fluids
Severe or persistent vomiting
Not waking up or not interacting
Irritable
Flu-like symptoms
5. Birth to 4 years old
Pregnant women
>65 years old
Long-term aspirin therapy
Disorders of the pulmonary or cardiovascular system.
Metabolic diseases
6. Outbreaks recorded virtually every year, their extent
and severity varies.
Localized outbreaks take place at variable intervals,
usually every 1–3 years.
The most recent pandemic emerged in March of 2009.
Caused by an influenza A/H1N1 virus that rapidly
spread worldwide over several months.
7. RNA viruses of orthomyxoviridae family ,influenza A, B, and
C viruses are clinically important.
A, B, or C is based on antigenic characteristics of the
nucleoprotein (NP) and matrix (M) protein antigens.
Influenza A viruses are further subdivided on the basis of
the surface hemagglutinin (H) and neuraminidase (N)
antigens .
individual strains are designated according to the site of
origin, isolate number, year of isolation, and subtype—for
example, influenza A/California/07/2009 (H1N1).
8. Influenza A has 16 distinct H subtypes and 9 distinct N
subtypes.
H1, H2, H3, N1, and N2 have been associated with
epidemics of disease in humans.
Influenza B and C viruses are similarly designated, H
and N antigens from these viruses do not receive
subtype designations.
Intratypic variations in influenza B :less extensive ,
In Influenza C virus: Absent
9. The hemagglutinin is the site by which the virus binds
to sialic acid cell receptors, whereas the neuraminidase
degrades the receptor and plays a role in the release of
the virus from infected cells after replication has taken
place.
14. Benefits of antiviral therapy
Shortening the duration of symptoms
Decreases the risk of complicated disease
Decreases viral shedding
Timing
Best if initiated with in <48 hrs of initiation
May still help after 48 hr if the symptoms are severe or
pregnant patient
15. Secondary bacterial infection
Retrospective pathological review suggested secondary
bacterial infection as the major cause of death in
pandemic H1N1 in 1918
Occurs several days after onset
Staphylocoocci aureus including MRSA
Nacrotizing pneumonia
Pneumatocele
Gram negative bacteria
16. Inhibitors of viral penetration and
uncoating
Amantadine
Rimantadine
Neuraminidase inhibitors
Oseltamavir
Zanamavir
Peramivir
17. Amantadine and its -methyl derivative rimantadine are
uniquely configured tricyclic amines.
18. They inhibit an early step in viral replication, viral
uncoating.
Have an effect on a late step in viral assembly.
Site of action :M2 protein, an integral membrane
protein that functions as an ion channel.
Drug inhibit the acid-mediated dissociation of the
ribonucleoprotein complex in replication.
19. Side effects include :
nervousness,
light-headedness,
difficulty concentrating,
insomnia, and
loss of appetite
Nausea & vominting
Ankle edema
20. Seasonal prophylaxis: amantadine or rimantadine (200
mg/day) is ~70-90% protective against influenza A illness.
Pandemic influenza, in preventing nosocomial influenza
and outbreaks.
Treatment : Influenza A , modest effect
(100mg bd x 5 days)
21. First orally active neuraminidase inhibitor
Mechanism of action
Oseltamivir is a prodrug
Competitive inhibitor of
sialic acid, found on the surface proteins of normal host
cells
Blocking the activity of the viral neuraminidase enzyme,
oseltamivir prevents new viral particles from being
released by infected cells
22.
23. Dosing
Given to >1 yr of age
TREATMENT :75 mg twice daily for 5 days
PROPHYLACTIC : 75 mg once daily for 14 days shown to
be safe and effective for up to six weeks
24. Side effects
Common ADRs:-Nausea, vomiting, diarrhea,
abdominal pain, and headache.
Rare ADRs include: hepatitis and elevated liver
enzymes, rash, allergic reactions including
anaphylaxis, and Stevens-Johnson syndrome
Postmarketing surveillance: toxic epidermal
necrolysis, cardiac arrhythmia, seizure, confusion,
aggravation of diabetes
25. Zanamivir is a sialic acid analog tha inhibits the
neuraminidases of influenza A and B viruses.
Pharmacokinetic data
Bioavailability- 2% (oral)
Protein binding- <10%
Metabolism- Negligible
Half life- 2.5–5.1 hours
Excretion- Renal
Routes- Inhalation
26. Mechanism of action
Zanamivir works by binding to the active site of the
neuraminidase protein, rendering the influenza virus
unable to escape its host cell and infect others.
It is also an inhibitor of influenza virus replication in
vitro and in vivo
27. Dosing
Two inhalation (10 mg per puff) twice a day for 5 days
After inhalation, zanamivir is concentrated in the lungs
and oropharynx,
15% of the dose is absorbed and excreted in urine
28.
29. Side effects
Headache
Bronchospasm and cough (contraindicated in asmatics)
Zanamivir has not been known to cause toxic effects,
does not spread around through the body's systemic
circulation and
No signs of viral resistance from any flu
30. Age group (in years)
Antiviral drug Children≤ 12 13-64 ≥65
Oseltamivir
Treatment (A&B) <15 kg: 30 mg bd; >15–23 kg: 45
mg bd; >23–40 kg: 60 mg bd
75mg po bd 75mg po bd
Prophylaxis(A&B) <15 kg: 30 mg od; >15–23 kg: 45
mg od; >23–40 kg: 60 mg od
75mg od 75mg od
Zanamivir
Treatment (A&B) 10mg bd inhalation 10mg bd 10mg bd
Prophylaxis(A&B) 10mg od 10mg od 10mg od
Amantadine
Treatment (A) Age 1–9, 5 mg/kg in 2 divided
doses, up to 150 mg/d
Age 10, 100 mg
PO bd
≤ 100 mg/d
Prophylaxis, (A) Age 1–9, 5 mg/kg in 2 divided
doses, up to 150 mg/d
Age 10, 100 mg
PO bd
≤ 100 mg/d
Rimantadine
Treatment, (A) Not approved 100 mg PO bd 100–200 mg/d
Prophylaxis, (A) Age 1–9, 5 mg/kg in 2 divided
doses, up to 150 mg/d
Age 10, 100 mg
PO bd
100–200 mg/d
31.
32. Avoid close contact
With sick people. Keep safe distance
Stay home when you are sick
If possible, stay home from work, school and office
Cover your mouth and nose
Cover mouth and nose with tissue when coughing or
sneezing
Clean your hands
Frequent hand washing will protect you from germs
Avoid touching your eyes, nose or mouth
33. Drink plenty of fluids and eat nutritious food
Get plenty of sleep to be physically active.
Manage your stress.
Get treatment and/or prevention of the infection with
antiviral drugs.
35. Facemasks (disposable, single use masks) for
persons who enter crowded settings
Respirators (N95 or higher filtering facepiece
respirator) for persons who have unavoidable close
contact with infectious person
No clear scientific evidence regarding the effectiveness of facemasks
and respirators in protecting against influenza
When contact is unavoidable
36. Medical institutions
To maintain good infection control
Schools
To perform preventive measures such as morning
inspection, temperature measurement, school
suspension for the sick, outbreak notification
37. The influenza vaccine, also known as flu shot, is an
annual vaccination using a vaccine specific for a given
year to protect against the highly variable influenza virus
Two types of influenza vaccines are available:
TIV :of trivalent (three strains; usually A/H1N1, A/H3N2,
and B) inactivated (killed) vaccine)
LAIV: (nasal spray )of live attenuated influenza vaccine
38. Mechanism of action
TIV works by putting into the bloodstream those parts
of three strains of flu virus that the body uses to create
antibodies
LAIV works by inoculating the body with those same
three strains, but in a modified form that cannot cause
illness.
Prepration
Pandemrix by GlaxoSmithKline (GSK)
Focetria by Novartis