This document discusses local anesthetic systemic toxicity (LAST). It begins by describing how local anesthetics work by interrupting nerve conduction. It then classifies local anesthetics based on their structure and duration of action. Key points include the toxic doses of various local anesthetics, factors that influence rate of absorption and duration of action, and clinical presentation of LAST including CNS and CVS toxicity. The document concludes with recommendations for prevention, diagnosis and treatment of LAST, including the use of Intralipid therapy.