This document provides an overview of anesthesia considerations for laparoscopic surgeries. It discusses the history of laparoscopy, physiological effects of pneumoperitoneum including on the cardiovascular, respiratory, central nervous and renal systems. It also outlines respiratory complications like subcutaneous emphysema, pneumothorax, gas embolism and their treatment. The effects of patient positioning and conduct of anesthesia are summarized.
A basic overview on the management of intra-operative bronchospasm: the risk factors, triggers, diagnosis, prevention and management. Includes a case scenario – discussion.
A basic overview on the management of intra-operative bronchospasm: the risk factors, triggers, diagnosis, prevention and management. Includes a case scenario – discussion.
Neuromuscular monitoring, also known as train of four monitoring, is a technique used during recovery from the application of general anesthesia to objectively determine how well a patient's muscles are able to function. It involves the application of electrical stimulation to nerves and recording of muscle response using, for example, an acceleromyograph. Neuromuscular monitoring is typically used when neuromuscular-blocking drugs have been part of the general anesthesia and the doctor wishes to avoid postoperative residual curarization (PORC) in the patient, that is, the residual paralysis of muscles stemming from these drugs.
Neuromuscular monitoring, also known as train of four monitoring, is a technique used during recovery from the application of general anesthesia to objectively determine how well a patient's muscles are able to function. It involves the application of electrical stimulation to nerves and recording of muscle response using, for example, an acceleromyograph. Neuromuscular monitoring is typically used when neuromuscular-blocking drugs have been part of the general anesthesia and the doctor wishes to avoid postoperative residual curarization (PORC) in the patient, that is, the residual paralysis of muscles stemming from these drugs.
This presentation of introduction of laparoscopic surgery made by Dr. R.K. Mishra Director and chief surgeon World Laparoscopy Hospital. Dr. Mishra in this presentation has explained present pas and future of laparoscopic surgery. Laparoscopy is a surgical procedure which uses a special surgical instrument called a laparoscope to look inside the body, or to perform certain operations. World Laparoscopy Hospital is the center of excellence for laparoscopic and da vinci robotic surgery training and considered as one of the best institute in the world. For more detail about laparoscopic surgery please visit: http://www.laparoscopyhospital.com
World Laparoscopy Hospital provides learning by doing. It provides real-world laparoscopic surgery experience by allowing the trainee to get hands-on directly with whatever surgeons are learning and developing a sense of empowerment. After taking this laparoscopic training course, surgeons and gynecologists can perform laparoscopic surgery them self on their patients with confidence.
The anesthetic problems during minimal access surgery
are related to the cardiopulmonary effects of pneumoperitoneum, carbon dioxide (CO2) absorption, extraperitoneal
gas insufflation, venous embolism, and inadvertent injuries
to intraabdominal organs. Optimal anesthetic care of
patients undergoing laparoscopic surgery is very much
important. Good anesthetic techniques facilitate riskfree surgery and allow early detection and reduction of
complications.
In young patients, fit for diagnostic laparoscopy, general
anesthesia is the preferred method and does not impose
any increased risk. Adequate anesthesia and analgesia
are essential and endotracheal intubation and controlled
ventilation should be considered. The pneumoperitoneum
can be created safely under local anesthesia provided that
the patient is adequately sedated throughout the procedure.
For successful laparoscopy under local anesthesia, intravenous (IV) medication for sedation should be given
The anesthetic problems during minimal access surgery are related to the cardiopulmonary effects of pneumoperitoneum, carbon dioxide (CO2) absorption, extraperitoneal
gas insufflation, venous embolism, and inadvertent injuries to intraabdominal organs.
World Laparoscopy Hospital provides learning by doing. It provides real-world laparoscopic surgery experience by allowing the trainee to get hands-on directly with whatever surgeons are learning and developing a sense of empowerment. After taking this laparoscopic training course, surgeons and gynecologists can perform laparoscopic surgery on their patients with confidence.
Initial development of “minimal access surgery” began
in the animal laboratory and was later studied in selected
academic centers. It was imported to the community
hospitals only when its benefits and safety were established.
The development of laparoscopic cholecystectomy was not
designed to enhance the safety of the procedure, but rather to
reduce the discomfort associated with the surgical incision.
The fierce economical competition in medicine fueled by
the managed care movement led to the rapid adoption of
laparoscopic surgery among surgeons and gynecologist in
community hospitals who were not formally trained in this
technique and acquired their knowledge by subscribing to
short courses.
Low complication rates were reported by centers
specializing in laparoscopic surgery, mostly in academic
centers. These centers were able to reduce the complication
rate to minimum by developing proficiency in this surgery.
Regrettably, many inexperienced surgeons perform this
technique within sufficient training and are responsible for
the majority of complications seen during the performance
of laparoscopic surgery
Initial development of “minimal access surgery” began in the animal laboratory and was later studied in selected academic centers. It was imported to the community hospitals only when its benefits and safety were established.
Acid base balance & ABG interpretation,Dept of anesthesiology,JJMMC,DavangereGopan Gopalakrisna Pillai
Acid base balance and ABG interpretation presented by Dr.Gopan.G,Post-Graduate student. Chairperson : Dr.Ravi.R,Professor, Department of Anaesthesiology & Critical care,JJMMC,Davangere.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
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2 Case Reports of Gastric Ultrasound
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
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Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
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Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Anaesthesia for laparoscopic surgeries
1.
2. DEPARTMENT OF ANESTHESIOLOGY
JJMMC, DAVANGERE
Anesthesia for laproscopic surgeries
Chairperson : Dr. Ravikumar, Professor.
Presented by : Dr. Gopan.G.
Date : 16/07/2013
3. Overview
• Introduction & History.
• Definition, IAP.
• Risks & Benefits.
• Alteration in physiology (System wise).
• Associated complications & treatment.
• Effect of position.
• Conduct of anaesthesia.
• Conclusion.
4. Introduction
• Laparoscopic techniques offer shorter in-
patient stay and reduced perioperative
morbidity.
• risks associated with individual laparoscopic
techniques or due to the physiological changes
associated with the creation of a
pneumoperitoneum.
• anesthetic techniques for laparoscopic surgery
must be refined to anticipate these differences
from open surgery.
5. History
• traced back to the tenth century A.D
• Arabian physician Abulkasim(936 – 1013) used
reflected light to inspect cervix.
• The term “laparoscopy” was coined by a
Swedish physician Hans Christian Jacobaeus
• Richard Zollikofer of Switzerland promoted the
use of Carbon dioxide for insufflating
peritoneum.
6. DEFINITION
• Laparoscopy is a “minimally invasive”
procedure allowing endoscopic access to the
peritoneal cavity after insufflation of a gas to
create space between the anterior abdominal
wall and the viscera.
• The space is necessary for safe manipulation of
instruments and organs.
7. What all gases can be used?
• Air, oxygen, carbon dioxide, argon and helium
• ideal gas for insufflation should be nontoxic,
colourless, readily soluble in blood, easily
ventilated through lungs, nonflammable and
inexpensive
• most widely used gas for insufflation-CO2
8. Gasless laparoscopy….?
• Peritoneal cavity is expanded using abdominal
wall lift obtained with a fan retractor.
• Gasless laparoscopy compromises surgical
exposure and increases technical difficulty.
• Appealing for patients with severe cardiac or
pulmonary disease.
9. • IAP is the steady pressure within the closed
abdominal cavity.
• normal values of IAP are 0-5 mmHg.
• values more than 12-14 mmHg compromises
venous return.
• Initial flow : 4-6 L/min.
• Maintenance : 200-400 ml/min.
Intra-abdominal pressure(IAP)
10. What are the benefits of laparoscopy?
• shortened recovery time and reduced morbidity.
• reduced manipulation of the bowel and
peritoneum, decreased incidence of
postoperative ileus, early enteral intake and
decreased requirements for iv fluids.
11. Benefits cont‟d….
• laparoscopic wounds are smaller when
compared to open techniques.
• complications associated with postoperative
pain and wound healing will be minimal.
• Particularly useful in obese patients in whom
open procedures would be technically
challenging.
12. Are there any risks?
• Damage to solid viscera, bowel, bladder or
blood vessels due to surgical instuments.
• Vascular injuries of large vessels.
• Venous gas embolism can result in catastrophic
circulatory collapse.
• severity depends on the volume of CO2
injected, rate of injection, patient position, and
type of laparoscopic procedure.
13. Risks cont‟d…..
• Pnuemoperitoneum can cause ventilation-
perfusion mismatch.
• „well leg compartment syndrome‟.
• lower limb pain, rhabdomyolysis, and
potentially myoglobin-associated acute renal
failure.
14. What happens on creating a
pneumoperitoneum?
• As the volume of the abdomen increases,
abdominal wall compliance decreases and intra-
abdominal pressure (IAP) climbs.
• When the IAP exceeds physiological thresholds,
blood flow in individual organ systems become
compromised, potentially increasing patient‟s
morbidity and mortality.
15. What are the hemodynamic effects of
pnuemoperitoneum in CVS?
16. So what can be done?....
• Reduction in venous return and cardiac output
can be attenuated by increasing circulating
volume before the pneumoperitoneum is
produced.
• Increased filling pressures can be achieved by
fluid loading or tilting the patient to a slight
head-down position before peritoneal
insufflation.
• Pneumatic compression device & elastic
bandages prevents pooling.
17. What are the hemodynamic
repercussions in cardiac patients?
• Patients (ASA class III or IV) who are volume
depleted experience the most severe
hemodynamic changes.
• Preoperative preload augmentation offsets the
hemodynamic effect of pneumoperitoneum.
• Intravenous nitroglycerin, nicardipine, or
dobutamine has been used to manage the
hemodynamic changes induced by increased
IAP.
18. Reasons for arrythmias during
laparoscopy….
1. Reflex increases of vagal tone may result from
sudden stretching of the peritoneum.
2. Hypercarbia & hypoxia.
3. Gas embolism.
4. Lighter planes of anaesthesia.
5. Volatile anaesthetics
• Treatment consists of interruption of insufflation,
atropine administration, inj. Lignocaine, Amiodarone
and deepening of anesthesia after recovery of the
heart rate.
19. What are the effects of
pneumoperitoneum on respiratory
system?
• Limitation of diaphragmatic and anterior
abdominal wall movement causes decreased
lung volumes, atelectasis and dead space
ventilation.
• Functional residual capacity (FRC), already
reduced by induction of general anesthesia,
decreases even further, by 20 to 25 per cent, 5
min after abdominal insufflation.
20. Cont‟d
• Respiratory compliance decreases by 30 to 50%
in healthy individuals.
• The respiratory resistance increases due to an
increase in lung and chest wall resistance.
• Approximately 15 min after abdominal deflation,
respiratory compliance and resistance return to
pre-insufflation level.
21. Cont‟d
• Healthy patients tolerate pneumoperitoneum
well, despite the respiratory changes.
• In obese, ASA III to IV patients and patients with
pulmonary disease, superimposed
pnuemoperitoneum could produce deleterious
effects in pulmonary mechanics.
22. Effect of pnuemoperitoneum on
PaCO2?
• CO2 is absorbed from the peritoneal cavity and
carried by blood through the systemic and
portal veins and excreted via the lungs.
• Pneumoperitoneum increases pulmonary
excretion of CO2 (VCO2) and PaCO2.
• High increase in VCO2 and PaCO2 does not
happen because of impaired peritoneal
perfusion due to haemodynamic changes and
enormous buffering capacity of the blood.
23. PaCO2…………. Cont‟d
• under general anesthesia, PaCO2 progressively
increases and reaches a plateau 15 to 30 min
after beginning of CO2 insufflation.
• the main mechanism of the increased PaCO2
during CO2 pneumoperitoneum is absorption of
CO2 rather than the mechanical ventilatory
repercussions of increased IAP.
• Correction of increased PaCO2 can be achieved
by a 10% to 25% increase in alveolar ventilation.
24. What is the role of Capnography
during laparoscopy
• It serves as a non-invasive monitor of
PaCO2 during CO2 insufflation.
• helps in detection of accidental intravascular
insufflation of CO2.
• EtCO2 increases in Endo-Bron.Intubation, Sub.
Cut.emphysema & capnothorax and decreases
in Pneumothorax & CO2 embolism.
25. Capnography during laparoscopy…
• Mean gradients (Δa-EtCO2) do not change
significantly during peritoneal insufflation of
CO2.
• lack of correlation between PaCO2 and EtCO2 is
seen particularly in those with impaired CO2
excretion capacity, and cardiopulmonary
disturbances.
26. Cont‟d
• Hypercapnia can develop, even in the absence
of abnormal EtCO2.
• Postoperative intra-abdominal CO2 retention
can result in increased respiratory rate and
EtCO2 of patients breathing spontaneously.
27. What are the physiological
effects of carbon- dioxide?
• In awake, healthy individuals, breathing a gas
mixture containing CO2 produces a feeling of
discomfort, acute distress with disorientation,
dyspnea and anxiety.
• Narcosis occurs with a PaCO2 greater than 90
mmHg.
28. Physiological effects of carbon-
dioxide cont‟d…..
• 10-15 minutes after CO2 insufflation due to
reflex vasodilatation, an increase in ICP is
seen.
• For each 1mmHg increase in PaCO2, CBF
increases 1.8ml/100g/min and cerebral
volume increases 0.04ml/100gm.
29. Physiological effects of carbon-
dioxide cont‟d…..
• PaCO2 level has the regulatory effect on
ventilation via central & peripheral
chemoreceptors.
• The activation of receptors in the
chemosensitive area results in stimulation of
the inspiratory center.
• The chemosensitive area, located in the ventral
surface of medulla, is extremely sensitive to
hydrogen ions.
30. Physiological effects of carbon-
dioxide cont‟d…..
• CO2, which easily crosses the blood-brain
barrier, indirectly controls inspiratory centre by
formation of carbonic acid, which dissociates to
produce HCO3
- and H+ & increase in the rate of
respiration.
• The maximal stimulation is attained at a PaCO2
level of about 100 mmHg. Any further increase
results in respiratory depression.
31. Physiological effects of carbon-
dioxide cont‟d…..
• CO2 produces excitation of the sympathetic
nervous system
• High levels of CO2 influence the release of
catecholamines from the adrenal medulla.
32. Physiological effects of carbon-
dioxide cont‟d…..
• The cardiovascular effects of hypercarbia are
the result of a balance between the direct
cardiodepressant effect of CO2 and increased
activity of the sympathetic nervous system.
• Activation of the sympathetic nervous system
by CO2 in healthy individuals overcompensates
for direct cardiodepression.
33. Respiratory Complications:
1)CO2 Subcutaneous Emphysema
• Accidental extraperitoneal insufflation.
• Any increase in ETCO2 occurring after ETCO2 has
plateaued should suggest this complication.
34. CO2 Subcutaneous Emphysema
cont’d….
• Temporarily STOP….!
• subcutaneous emphysema readily resolves
once insufflation has ceased.
• resumed after correction of hypercapnia using a
lower insufflation pressure.
35. Respiratory Complications:
2) Pneumothorax, Pneumomediastinum,
Pneumopericardium
• peritoneal cavity ---potential channels--- pleural
and pericardial sacs.
• Defects in the diaphragm or weak points in the
aortic and esophageal hiatus allow gas passage
into the thorax.
• pleural tears occurs during laparoscopic
surgical procedures at the level of the
gastroesophageal junction.
36. Pneumothorax, Pneumomediastinum,
Pneumopericardium cont’d……
• For diffusible gas such as CO2 without
associated pulmonary trauma, spontaneous
resolution of the pneumothorax occurs within
30 to 60 minutes.
• For capnothorax, treatment with positive end-
expiratory pressure (PEEP) is an alternative to
chest tube placement.
• If pneumothorax is secondary to rupture of
preexisting bullae, thoracocentesis is
mandatory.
37. Respiratory Complications:
3)Endobronchial Intubation
• cephalad movement of the carina & diaphragm
during pneumoperitoneum, leads to
endobronchial intubation.
• Oxygen saturation decreases as measured by
pulse oximetry (SpO2) associated with an
increase in plateau airway pressure & increase
in EtCO2 .
38. Respiratory Complications:
4) Gas Embolism
• most feared and dangerous complication of
laparoscopy.
• Early events, occurring with 0.5 mL/kg of air or
less, include changes in Doppler sounds and
increased mean pulmonary artery pressure.
• lethal dose of embolized CO2 is approximately
five times greater than that of air.
39. Gas embolism cont‟d…..
• Events occurring with 2 mL/kg of air include,
tachycardia, cardiac arrhythmias, hypotension,
increased central venous pressure, alteration in
heart tones (i.e., millwheel murmur), cyanosis,
and electrocardiographic changes of right-sided
heart strain.
• Pulmonary edema can also be an early sign of
gas embolism.
40. How to diaganose gas embolism?
• Capnography is more valuable in providing
early diagnosis of gas embolism. EtCO2
decreases in the case of embolism.
• Δa-EtCO2 increases.
• Pulse oximetry is also helpful in recognizing
hypoxemia.
• Aspiration of gas or foamy blood from a central
venous line establishes the diagnosis.
41. How to treat gas embolism?
• Immediately stop insufflation and release the
pneumoperitoneum.
• ventilate with 100% oxygen.
• patient is placed in steep head-down and left
lateral decubitus (Durant) position.
42. How Durant position
helps?
• Head-down position keeps a left-ventricular air
bubble away from the coronary artery ostia (which
are near the aortic valve) so that air bubbles do not
enter and occlude the cornonary arteries.
• Left lateral decubitus positioning helps to trap air in
the non-dependent segment of the right ventricle,
preventing it entering the pulmonary artery & also
prevents the air from passing through a patent
foramen ovale.
43. Treatment of gas embolism cont‟d…
• A central venous or pulmonary artery catheter may
be introduced for aspiration of the gas.
• External cardiac massage may be helpful in
fragmenting CO2 emboli into small bubbles.
• Cardiopulmonary bypass of blood has been used
successfully to treat massive CO2 embolism.
• Hyperbaric oxygen treatment should be strongly
considered if cerebral gas embolism is suspected.
44. Respiratory Complications:
5) Aspiration of Gastric Contents
• Patients undergoing laparoscopy is at more risk.
• However, the increased IAP results in changes of
the lower esophageal sphincter that allow
maintenance of the pressure gradient across the
gastroesophageal junction and that may therefore
reduce the risk of regurgitation.
• Head-down position helps to prevent any
regurgitated fluid from entering the airway.
45. What are the effects of
pneumoperitoneum on CNS
physiology?
• elevated IAP causes an increase in intra-
cerebral pressure (ICP) by limiting cerebral
venous drainage.
• the increase in ICP may lead to cerebral oedema
• clinical studies have suggested that cerebral
perfusion pressure is maintained by the
increase in mean arterial pressure that occurs
with elevated IAP.
46. Effect of pneumoperitoneum on
CNS physiology cont‟d….
• Temporary neurological dysfunction that patients
often experience on emergence from prolonged
laparoscopic procedures, particularly those
requiring extended periods of steep Trendelenburg
positioning is due to cerebral oedema.
47. What are the effects of
pneumoperitoneum on Renal
physiology?
• An IAP of 20 mm Hg will reduce GFR by 25%.
• Mechanism for this is postulated to be an impaired renal
perfusion secondary to the combined effect of reduced
renal afferent flow due to impaired cardiac output and
reduced efferent flow due to raised renal venous
pressure.
• Diminished RBF is a potent trigger for RAAS.
48. Effect of pneumoperitoneum on
splanchnic physiology
• Initially with an IAP <10 mmHg venous return from
splanchnic vessels increase leading to a transient
increase in Cardiac output.
• Persistent IAPs over 20 mm Hg will cause a reduction
in mesenteric and gastrointestinal mucosal blood flow
by up to 40% with progressive tissue acidosis.
49. What are the problems with
positioning during laparoscopy?
• Extreme positions place the patient at risk of
movement on the table.
• patient should be securely positioned with
vulnerable pressure points and eyes being
protected throughout the procedure.
• No significant changes in shunt fraction or dead
space ventilation occurs even in a 10 0 - 20 0
head up or head down position.
50. Problems due to positioning
cont‟d….
• In trendelenburg position functional residual
capacity and ventilation-perfusion (V/Q) mismatch
are worsened.
• with cephalic movement of the lungs, the tracheal
tube may migrate endobronchially.
• Prolonged steep Trendelenburg position increases
the risk of cerebral oedema and upper airway
oedema which may present with stridor after
operation..
51. Problems due to positioning
cont‟d….
• Nerve compression due to overextension of the arm
must be avoided.
• Shoulder braces should be used with great caution
and must not impinge the brachial plexus.
52. Problems due to positioning
cont‟d….
• ‘well leg compartment syndrome’.
• compartment syndrome of the lower limbs presents
after operation with disproportionate lower limb
pain, rhabdomyolysis, and potentially myoglobin-
associated acute renal failure leading to
significantly increased morbidity and mortality.
53. Positioning cont‟d….
• Risks may be mitigated by moving the patient’s legs
at regular intervals during surgery, and using
heel/ankle supports instead of calf/knee supports
(Lloyd–Davies stirrups).
• A pulseoximeter can be placed on the great toe
throughout surgery to assess the adequacy of
pulsatile flow to distal areas of the lower limbs.
54. Positioning cont‟d….
• In the reverse Trendelenburg position, the extreme
‘head-up’ posture results in reduced venous return,
leading to hypotension and potentially myocardial
and cerebral ischaemia.
• Particularly vulnerable are the elderly,
hypovolaemic patients, and those with pre-existing
ischaemic heart disease or cerebrovascular
disease.
55. Conduct of anaesthesia
• The most common technique used for laparoscopic
surgeries is General anaesthesia.
• protects against gastric acid aspiration, allows
optimal control of CO2, and facilitates good
surgical access.
56. Pre-anaesthetic check up
• Pneumoperitoneum stresses cardiovascular and
respiratory system more.
• Lee cardiac risk index can be used for
quantification of cardiac risk.
• For patients with heart disease the postoperative
benefits of laparoscopy must be balanced against
the intraoperative risks.
57. Pre-anaesthetic check up
• In a patient with poor pulmonary reserve
preoperatively like individuals with COPD more
extensive preoperative evaluation including PFT is
advisable.
• Pulmonary function tests (PFT) identify patients
who are likely to experience hypercarbia and
acidosis.
61. Monitoring cont‟d…..
• Effects of pneumoperitoneum on the respiratory
system can be assessed using by information
available on work stations such as peak and
plateau airway pressures, delivered tidal volumes,
and observing dynamic flow-volume loops.
62. Monitoring cont‟d….
• Pressure-based indices of preload such as central
venous pressure may be misleading while
commercially available minimally invasive devices
such as the oesophageal Doppler monitor may
provide more accurate assessments of preload.
63. G.A. for laproscopic surgery
• bag and mask ventilation before intubation
should be minimized to avoid gastric
distension.
• insertion of a nasogastric tube may be required
to deflate the stomach-improve surgical view,
avoid gastric injury on trochar insertion.
64. Induction
• Propofol : 2-2.5 mg/kg.
• Thiopentone : 4-6 mg/kg.
Advantages of propofol:
1. significantly quicker recovery
2. an earlier return of psychomotor function compared
with thiopental or methohexital.
3. incidence of nausea and vomiting is markedly less
than other IV anaesthetics.
4. because of its pharmacokinetics, it is superior to
barbiturates for maintenance of anaesthesia
65. Induction
• Midazolam : 0.1- 0.2 mg/kg.
• Midazolam is safe and effective for induction even in
patients with severe aortic stenosis.
• Etomidate : 0.3-0.45 mg/kg.
• Good choice in cardiac patients as there is no change in
HR, MAP, PCWP, CVP, SV, CI, PVR & SVR.
66. Inhalational agents
• Maintaining deep level of anaesthesia with agents like
Halothane, Isoflurane & Sevoflurane blunt the
haemodynamic response to pneumoperitoneum.
• Nitrous oxide causing nausea & vomiting is
controversial. But it may distend the bowel, in patients
with intestinal obstruction.
• Once adequate depth of hypnosis is achieved, use of
vasoactive drugs such as esmolol or labetalol may be
more appropriate to treat hypertension.
67. Muscle relaxants
• Prevents high intra-abdominal and intra-thoracic
pressures due to pneumoperitoneum.
• Decreases PIP, thereby minimizing effects on
haemodynamics, risk of pneumothorax and
respiratory dead space.
• Muscle paralysis reduces the IAP needed for the
same degree of abdominal distention.
68. G.A. for laproscopic surgery cont‟d…
• Succinylcholine 1-2mg/kg iv.
• Non depolarizing muscle relaxants
Vecuronium 0.04-0.05mg/kg or Atracurium: 0.5mg/kg,
Rocuronium: 0.6-1mg/kg iv.
• Reversal :
• Inj. Neostigmine : 0.05 mg/kg IV
• Inj. Glycopyrolate : 0.01 mg/kg IV
70. Use of L.M.A
• remains controversial.
• There is increased risk of aspiration.
• Difficulties are encountered when trying to maintain
effective gas transfer while delivering higher airway
pressures required during pneumoperitoneum.
71. Use of Proseal LMA
• Several randomized controlled trials assessing the
use of Proseal LMA (PS-LMA) vs COTT, with data
advocating the use of PS-LMA as effective and
efficient for pulmonary ventilation in laparoscopic
surgery has been published.
72. Pressure control Vs volume
control..
• The use of pressure controlled modalities affords
higher instantaneous flow peaks, minimizing peak
pressures, and have been shown to provide
improved alveolar recruitment and oxygenation in
laparoscopic surgery.
• Volume control modalities use constant flow to
deliver a pre-set tidal volume and ensure an
adequate minute volume at the expense of an
increased risk of barotrauma and high inflation
pressures.
73. About PEEP…
• Various studies support that a PEEP of 5 cm H2O
should be considered essential during laparoscopic
surgeries to decrease intraoperative atelectasis.
• Addition of titrated levels of PEEP can be used to
minimize alveolar de-recruitment.
• But must be used cautiously as increasing PEEP
may further compromise cardiac output.
74. Analgesia
• Up to 80% of patients will require opioid analgesia
at some stage perioperatively.
• Subdural, epidural, and more recently transversus
abdominis plane block, are increasingly utilized as
opiate-sparing techniques.
• Wound infiltration can be done with local
anaesthetic.
75. Antiemetics
• Laparoscopy is associated with high incidence
of postoperative nausea and vomiting.
• This may worsen pain, and extend the period of
hospital admission for patients.
76. Antiemetics cont‟d….
• General measures such as deflating the
stomach, avoiding known emetogenic drugs
and ensuring good quality postoperative
analgesia decreases PONV.
• Multi-modal regime such as ondansetron,
cyclizine, and dexamethasone seems effective.
77. Regional anaesthesia in
laproscopic surgery
• Epidural anaesthesia may be an alternative for
general anaesthesia.
• It provides excellent postoperative analgesia and
lower incidence of postoperative nausea and
vomiting.
• In hyperbaric spinal anaesthesia the level of block
can migrate in the cephalad direction, causing
hypotension and bradycardia.
78. Regional anaesthesia cont‟d…
• Success with regional anaesthesia requires a
relaxed and cooperative patient, a supportive staff
and a skilled surgeon.
• However, laparoscopic procedures conducted
under regional anaesthesia require expertise.
79. Local anaesthesia in laproscopic
surgeries
• Laproscopic hernia and some gynaecological
procedures like laparoscopic sterilization can be
performed under local anaesthesia.
• Some patients may not be able to relax the
abdominal muscles because of discomfort from
pneumoperitoneum and some would only tolerate a
lower IAP (4-6 mmHg).
• May require deeper sedation or conversion to
general anaesthesia.
80. Postoperative management
• Pain will usually be maximal during the first 2 h
post-procedure and a prolonged duration of
significant discomfort is rare.
• Postoperative shoulder-tip pain after laparoscopic
surgery is common.
• This may be reduced if the surgeon expels as much
gas from the peritoneal cavity as possible.
81. Postoperative management
• All patients should receive supplemental oxygen.
• This helps to mitigate the effects of
pneumoperitoneum on respiratory function.
• Alveolar recruitment techniques, using short-term
continuous positive airway pressure or high flow
oxygen delivery systems may be used.
82. Conclusion
• Pre-op evaluation of cardio-pulmonary status.
• Slow insufflation with IAP 12-14 mmHg.
• Positioning.
• Intra-operative monitoring.
• Aware of intra-operative complications.
• The proportion of surgical cases performed
laparoscopically will continue to increase and
anaesthetists must safely manage the specific
physiological alterations and challenges that
laparoscopy presents.
83. Bibliography
• Miller‟s anesthesia 7th edition.
• A practice of Anesthesia 7th edition Wylie.
• Anaesthesia in Laparoscopic Surgery- Jayashree
Sood & Anil Kumar Jain.
• Anaesthesia for laproscopic surgery- Paul Hayden.
Critical care and pain| Volume 1| Number 5 2011.
• Secrets of safe laparoscopic surgery: Anaesthetic
and surgical considerations- Arati & Ashutosh, J
Minim Access Surg. 2010 Oct-Dec; 6(4): 91–94.
• Anesthesia for laparoscopic surgery. Girish.P.Joshi.
Canadian Journal of Anesthesia. June 2002. Vol.49