This document presents a case report of a 35-year-old male patient who presented with status epilepticus and was diagnosed with tuberculous meningitis and Leri's disease. Leri's disease, also known as melorheostosis, is a rare bone disorder characterized by subperiosteal bone growth resembling hardened wax dripping down the side of a candle. The patient had a 20-year history of right leg pain and deformities. Imaging showed irregular bone growths along the right tibia and bones of the right hand. The patient was treated for tuberculous meningitis and with bisphosphonates for pain from the Leri's disease.
Evidence Based Practice in Medical Imaging- Ankylosing SpondylitisNoor Farahuda
This presentation is about evidence-based practice in medical imaging for a particular disease, which is the Ankylosing Spondylitis. It is actually focusing on the imaging modalities that have been used for diagnose the disease and the appearances of the disease on the image of the modalities.
Skeletal muscles disorder is disease and damage the brain or nerves that stimulate muscles and disorders of muscle fibers.
Types of that are :
1- Muscular Atrophy.
2- Muscular Dystrophy.
3- Inflammation of muscle (Myositis).
4- Disorders of Neuromuscular Transmission.
Evidence Based Practice in Medical Imaging- Ankylosing SpondylitisNoor Farahuda
This presentation is about evidence-based practice in medical imaging for a particular disease, which is the Ankylosing Spondylitis. It is actually focusing on the imaging modalities that have been used for diagnose the disease and the appearances of the disease on the image of the modalities.
Skeletal muscles disorder is disease and damage the brain or nerves that stimulate muscles and disorders of muscle fibers.
Types of that are :
1- Muscular Atrophy.
2- Muscular Dystrophy.
3- Inflammation of muscle (Myositis).
4- Disorders of Neuromuscular Transmission.
Avascular Necrosis of Humeral Head after Thalidomide Use: A Report of Two Cas...CrimsonPublishersOPROJ
Avascular Necrosis of Humeral Head after Thalidomide Use: A Report of Two Cases by Ahmad Rezaeian* in Crimson Publishers: Orthopedic Research and Reviews Journal
R3 stem cell treatment will help you recover from injuries and diseases without going into surgeries. When we talk about stem cell therapy, R3 is a pioneer of the stem cell industry. At present, Dr. Greene's R3 stem cell is the global leader in regenerative cell therapies.
Primary hydatidosis of the tibia is a rare disease. In an endemic area, it should be considered in the differential diagnosis of a
hypolucent osteolytic lesion on x-ray. If not properly managed, anaphylactic shock may occur intraoperatively, as well as increased recurrence of the disease. This is a case report of a primary tibial hydatid cyst, treated fi rst with curettage and phenolizaton, and then after recurrence, with total knee arthroplasty. We will review the literature of the diagnosis and the treatment of a tibial hydatid cyst.
Background: The spectrum of pathological bone lesions ranges from inflammatory to neoplastic conditions. Bone tumours are comparatively uncommon among wide array of lesions. The roentgenogram helps in defining exact location of lesion but becomes difficult to differentiate them. They often pose diagnostic problem as they constitute a small portion of diagnostic experience among pathologist.
Objective: To study histopathological spectrum of bone lesions & correlate them with age, gender and site of occurrence.
Results: All bone biopsies from January 2011 to December 2015 received at department of pathology, S.Nijalingappa Medical College, India. Total 121 cases of bone biopsies were analysed. They were decalcified & processed routinely. Out of 121 bone biopsies, 35 (28.9%) cases are non- neoplastic, 77 (63.6%) are neoplastic and 9 (7.4%) were inadequate for evaluation. The incidence of benign lesions are more than malignant with 51(66.2%) and 26(33.7%) cases respectively. Chronic osteomyelitis is the most common non-neoplastic lesion. Giant cell tumor and osteosarcoma are common benign and malignant lesions respectively. Femur is the common bone involved and metaphysis, the commonest site. The maximum numbers of cases are in the age group between 11-30 years with male preponderance.
Conclusion: Though bone lesions are less common, if viewed in perspective of clinico-radiology and histopathology, correct diagnosis can be reached.
Key-words- Bone lesions, Chronic osteomyelitis, Osteosarcoma, Giant cell tumor, Histopathology
Annals of Hematology & Oncology is a peer-reviewed, open access journal published by Austin Publishers. It provides easy access to high quality Manuscripts covering various aspects in the field of medicine that includes early to late symptoms, diagnosis, staging, treatment, prognosis, and follow-up of two interrelated medical specialties namely hematology and oncology. This journal also focuses upon the study of blood, the blood-forming organs, and blood diseases, cancer etiology, diagnosis, staging, treatment, drugs, epidemiology, and awareness.
Austin Publishing Group is a successful host of more than hundred peer reviewed, open access journals in various fields of science and technology with intent to bridge the gap between academia and research access.
Annals of Hematology & Oncology accepts original research articles, review articles, case reports, mini reviews, rapid communication, opinions and editorials on all the related aspects of hematology and oncology.
Hydatid cyst, caused by echinococcus granulosa, can produce tissue cyst everywhere in body. Skeletal cystic lesion is rare specially in long bones like femur and because of its unusual presentation, its diagnosis may easily be missed, unless be kept in mind. Hydatid disease is a parasitic infestation of the humans that can practically affect any part of the body. It commonly affects liver, lung and muscles. Bone hydatid is less common occurring in only 0.5–2% of cases and humans act as an intermediate host. In the patient evaluated by us, the plain x-ray showed multiple osteolytic lesions along the lower one third of the femur and the upper end of tibia.
— Superior orbital fissure syndrome (SOFS) is a rare disease. So when a case of this came at Aravind Eye Institute, a detailed case report was prepared to publish. A 56 years old male patient, a known case of prostatic malignancy with skeletal metastasis presented with ptosis, exotropia, diminished pupillary reflex and limitations in extraocular movements of left eye. MRI brain revealed diffuse skull base and leptomeningeal metastasis. Whole body CT scan showed metastasis in ribs, scapula and in pelvic bones. He was diagnosed to have superior orbital fissure syndrome due to metastatic prostatic malignancy and was offered steroids and radiotherapy.
Avascular Necrosis of Humeral Head after Thalidomide Use: A Report of Two Cas...CrimsonPublishersOPROJ
Avascular Necrosis of Humeral Head after Thalidomide Use: A Report of Two Cases by Ahmad Rezaeian* in Crimson Publishers: Orthopedic Research and Reviews Journal
R3 stem cell treatment will help you recover from injuries and diseases without going into surgeries. When we talk about stem cell therapy, R3 is a pioneer of the stem cell industry. At present, Dr. Greene's R3 stem cell is the global leader in regenerative cell therapies.
Primary hydatidosis of the tibia is a rare disease. In an endemic area, it should be considered in the differential diagnosis of a
hypolucent osteolytic lesion on x-ray. If not properly managed, anaphylactic shock may occur intraoperatively, as well as increased recurrence of the disease. This is a case report of a primary tibial hydatid cyst, treated fi rst with curettage and phenolizaton, and then after recurrence, with total knee arthroplasty. We will review the literature of the diagnosis and the treatment of a tibial hydatid cyst.
Background: The spectrum of pathological bone lesions ranges from inflammatory to neoplastic conditions. Bone tumours are comparatively uncommon among wide array of lesions. The roentgenogram helps in defining exact location of lesion but becomes difficult to differentiate them. They often pose diagnostic problem as they constitute a small portion of diagnostic experience among pathologist.
Objective: To study histopathological spectrum of bone lesions & correlate them with age, gender and site of occurrence.
Results: All bone biopsies from January 2011 to December 2015 received at department of pathology, S.Nijalingappa Medical College, India. Total 121 cases of bone biopsies were analysed. They were decalcified & processed routinely. Out of 121 bone biopsies, 35 (28.9%) cases are non- neoplastic, 77 (63.6%) are neoplastic and 9 (7.4%) were inadequate for evaluation. The incidence of benign lesions are more than malignant with 51(66.2%) and 26(33.7%) cases respectively. Chronic osteomyelitis is the most common non-neoplastic lesion. Giant cell tumor and osteosarcoma are common benign and malignant lesions respectively. Femur is the common bone involved and metaphysis, the commonest site. The maximum numbers of cases are in the age group between 11-30 years with male preponderance.
Conclusion: Though bone lesions are less common, if viewed in perspective of clinico-radiology and histopathology, correct diagnosis can be reached.
Key-words- Bone lesions, Chronic osteomyelitis, Osteosarcoma, Giant cell tumor, Histopathology
Annals of Hematology & Oncology is a peer-reviewed, open access journal published by Austin Publishers. It provides easy access to high quality Manuscripts covering various aspects in the field of medicine that includes early to late symptoms, diagnosis, staging, treatment, prognosis, and follow-up of two interrelated medical specialties namely hematology and oncology. This journal also focuses upon the study of blood, the blood-forming organs, and blood diseases, cancer etiology, diagnosis, staging, treatment, drugs, epidemiology, and awareness.
Austin Publishing Group is a successful host of more than hundred peer reviewed, open access journals in various fields of science and technology with intent to bridge the gap between academia and research access.
Annals of Hematology & Oncology accepts original research articles, review articles, case reports, mini reviews, rapid communication, opinions and editorials on all the related aspects of hematology and oncology.
Hydatid cyst, caused by echinococcus granulosa, can produce tissue cyst everywhere in body. Skeletal cystic lesion is rare specially in long bones like femur and because of its unusual presentation, its diagnosis may easily be missed, unless be kept in mind. Hydatid disease is a parasitic infestation of the humans that can practically affect any part of the body. It commonly affects liver, lung and muscles. Bone hydatid is less common occurring in only 0.5–2% of cases and humans act as an intermediate host. In the patient evaluated by us, the plain x-ray showed multiple osteolytic lesions along the lower one third of the femur and the upper end of tibia.
— Superior orbital fissure syndrome (SOFS) is a rare disease. So when a case of this came at Aravind Eye Institute, a detailed case report was prepared to publish. A 56 years old male patient, a known case of prostatic malignancy with skeletal metastasis presented with ptosis, exotropia, diminished pupillary reflex and limitations in extraocular movements of left eye. MRI brain revealed diffuse skull base and leptomeningeal metastasis. Whole body CT scan showed metastasis in ribs, scapula and in pelvic bones. He was diagnosed to have superior orbital fissure syndrome due to metastatic prostatic malignancy and was offered steroids and radiotherapy.
A Case of Multiple Cranial Nerves Palsy Post Electrocutionijtsrd
Multiple cranial neuropathies are uncommon but not rare. Localization also depends on the etiology. Electrocution can cause neuropraxia, axonal damage, and necrosis of soft tissue and bones. We are presenting a rare case of post electrocution injury secondary infection of the head leading to the right side all cranial nerves palsy. Our patient suffered an electrocution injury. Post electrocution injury, he developed right sided multiple cranial nerve palsy. CT head was suggestive of skull base osteomyelitis. MRI brain images showed the right cavernous sinus involvement, soft tissue enhancement at the eight sphenoid sinus, right mastoiditis, soft tissue enhancement in the right infra temporal fossa and sphenoid wings. Escherashia Coli and Candida were isolated from purulent ear discharge. This could be secondary infection. This is a very rare case where a patient developed all right sided Lower Motor Neuron type cranial nerve palsies due to infection following electrocution. However, other etiology cannot be ruled out. Dr. Rahul Soni | Dr. Abhinav Kumar | Dr. Kuldeep Kumar Ashta "A Case of Multiple Cranial Nerves Palsy Post Electrocution" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-6 , October 2021, URL: https://www.ijtsrd.com/papers/ijtsrd47638.pdf Paper URL : https://www.ijtsrd.com/medicine/other/47638/a-case-of-multiple-cranial-nerves-palsy-post-electrocution/dr-rahul-soni
Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome is a genetic disorder caused by
mutation in the Proteoglyacn PRG4 gene on chromosome 1. The syndrome is characterized by congenital or early onset camptodactyly and childhood-onset of non-inflammatory arthropathy, coxa vara deformity,or other dysplasia associated with progressive hip disease and non-inflammatory pericardial effusion. It has an autosomal recessive mode of inheritance and the causative gene is located on chromosome band 1q25-31.
Orthopedic Clinical Manifestations of Ectodermal Dysplasia. Case Presentationkomalicarol
Ectodermal dysplasias represent a heterogeneous group of alterations, characterized by the abnormal development of embryological derivatives of the ectoderm.We present a patient who, upon
examination of the osteomyoarticular system, presents intense
rotation of the lower limbs with the toes backwards, which the
patient performed without difficulty, in an unforced, voluntary and
painless way. Orthopedic clinical manifestations are infrequent in
skeletal dysplasias, lower limb disorders even rarer, which is why
we present these striking alterations, a fundamental objective of
the study
This is my first presentation friends, it was my project and I selected this topic and this was my presentation, I hope it will be informative for all of you.
I am in T.Y.B.pharmacy, MGV's College of Pharmacy, Nashik.
If there is any mistake or any problem in this presentation, please let me know......, thank you.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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1. www.ejpmr.com 474
Yadav et al. European Journal of Pharmaceutical and Medical Research
LERI’S DISEASE
Keshri Singh Yadav*1
, Subhash Chandra Yadav2
, Ankur Yadav3
, Nirdesh Chouhan3
and Asif Hussain4
1
Junior Resident, P.G. Department of Medicine, S.N. Medical College, Agra, India.
2
Assistant Professor, P.G. Department of Medicine, S.N. Medical College, Agra, India.
3
Junior Residents, P.G. Department of Medicine, S.N. Medical College, Agra, India.
4
Junior Resident Department of Orthopedics, S.N. Medical College, Agra, India.
Article Received on 12/01/2016 Article Revised on 04/02/2016 Article Accepted on 24/02/2016
INTRODUCTION
Melorheostosis is a relatively rare chronic sclerosing
bone disorder also known as Leri’s disease, candle bone
disease,or melting wax syndrome. The disease was first
described by Leri and Joanny[1]
in 1922. The disease
affects men and women equally. Most common
presentation is pain & most common bone part is
diaphysis of long bones of lower limb of one side with
rare involvement of axial skeleton. Radiological pictures
shows flowing hyperosteosis’ resembling hardened wax
which has dripped down the side of candle.
CASE REPORT
A 35 years male presented to us in status epilepticus in
emergency department. Patient has history of fever of
high grade, headache and projectile vomiting from five
days and became unconceous after seizure( GTCS type)
from two days. Patient have history of right leg pain (dull
aching) since 20 years of age & then develop mild
swelling & limitation of knee & elbow joint movements
which was gradually progressed so much that patient was
unable to walk from 7 to 8 months.There was no relevant
family history or trauma or any other musculoskeletal
disorder.
On examination blood pressure of the patient was 100/80
mmHg,pulse rate 94 per minute, regular ,pallor present
but icterus , cyanosis,and, clubbing were absent & paedal
oedema was present.
CNS- Patient was in postictal phase with GCS-
E4V4M3. Signs of meningeal irritation were present.
Deep tendon reflexes were diminished and planter reflex
were bilaterally equivocal, tone in right upper & lower
limb increased due to flexion deformity at both knee and
elbow joint and pupils were bilaterally semidialated and
normaly reacting to light. On respiratory system
examination, bilaterally vesicular breath sound present.
Per abdomen- soft, non tender, no organomegaly present.
There was no sign of inflamation in upper & lower limb.
There was hard bony swelling over right hand & wrist
joint and great toe & tibia along with hyperpigmentation
of skin overlying deformed right hand and right lower
limb (fig-1&2) .
Figure 1 Right leg showing multiple bony swellings
Haematological examination Hb 12.3mg/dl,TLC
12000/cumm,N85L14E01.Ceribrospinal fluid protein
244mg/dl,glucose 23mg/dl,N05L95,RBC 03. blood sugar
114mg/ dl,serum creatinine 1.2 mg/dl, blood urea
45mg/dl,Na 141 meq/l,K 4.5 meq/l,ca 9.9 meq/l, AST
45.0 U/L, ALT 55 U/L ,urine 2-4 pus cells no albumin
and sugar.Body mass index of the patient was 15.2
SJIF Impact Factor 3.628
Case Report
ISSN 3294-3211
EJPMR
EUROPEAN JOURNAL OF PHARMACEUTICAL
AND MEDICAL RESEARCH
www.ejpmr.com
ejpmr, 2016,3(3), 474-476
*Author for Correspondence: Dr. Keshri Singh Yadav
Junior resident, P.G. Department of Medicine, S.N. Medical College, Agra, India.
ABSTRACT
Melorheostosis or leri’s disease is a rare bone disorder which is characterized by subperiosteal sclerosis of bones.
The most common bone part is diaphysis of long bones of lower limb of one side with rare involvement of axial
skeleton. Some times bones of the hands and feet may involved. Radiological pictures shows flowing hyperosteosis’
resembling hardened wax which has dripped down the side of the candle.although patient presented with seizure and
diagnosed as tubercular meningitis but we are reporting this case because of its rarety, in a young male.
KEY WORDS: Melorheostosis, Subperiosteal sclerosis, Candle dripping, flowing wax.
2. www.ejpmr.com 475
Yadav et al. European Journal of Pharmaceutical and Medical Research
kg/mm2
. HIV ELISA, Hbs Ag, anti HCV were non
reactive. On the basis of above investigation diagnosis of
tubercular meningitis was made and treatment started
accordingly along with antiepileptics.
Figure 2 Right hand showing multiple bony swelling
X-ray of right leg (Fig-3) showed dense irregular cortical
hyperostosis , which looks like candle wax, extending
along tibia of right leg resulting in deformity of bone. X-
ray of right hand showed irregular cortical thickening of
metacarpals and phalanges . X-ray picture of left upper
and lower limb appear normal.
Figure 3 X ray both legs showing subperiosteal bony
growths
The orthopedic and radiology experts were consulted and
diagnosis of Leri disease with tubercular meningitis was
made. Antitubercular treatment was given along with
bishphosphonate. Some operative treatment was adviced
by orthopedicians but patient refuses to take treatment.
DISCUSSION
Melorheostosis is a rare chronic bone disorder which was
first described in 1922 by Leri and Joanny[1]
. Male and
female are equally affected, and no hereditary features
have been discovered. The onset of this rare diseases is
insidious, and the first symptom is usually dull aching
pain due to subperiosteal bone formation. Skin become
rough, hard and in 17% of cases that may include
hyperpigmentation. Melorheostosis mainly affects, the
long bones of the upper and lower limb, and also short
bones of hand and foot, but rarely the axial skeleton.[2,3]
Melorheostosis may present in a monostotic, polyostotic,
or monomelic form. The monomelic form is most
common.[4]
The most accepted hypothesis was given by Murray and
McCredie1979.[5]
was that, embryonic infection of nerve
root causes neural scarring and segmental bone sclerosis
responsible for melorheostosis. One possible etiology of
melorheostosis is a loss of function mutation in the
LEMD3 gene (12q12–12q14.3), a protein involved in
bone morphogenic protein and tumor growth factor-β
signaling.[6]
It is associated with vascular malformations, soft tissue
masses adjacent to the affected bone and scleroderma of
the overlying skin.[7]
Routine laboratory findings usually
are normal. Histological findings are usually nonspecific
and often show dense bone formation, a mixture of
mature and immature bone elements.[7]
Osteoclastic
activity is not a prominent feature; however, osteoblastic
activity along the margins of osteons is common.[8]
Treatment is mainly symptomatic. Most patient receives
nonoperative treatment. Operative treatment consists of
tendon lengthening, excision of hyperostotic bone,
osteotomies ,sympathectomy and amputation[3]
.Bisphosphonate are commonly use.[3]
Potential causes of
the bone pain in melorheostosis include increased
osteoclastic bone resorption and activation of pain
receptors, raised intraosseous pressure and increased
vascularity secondary to hyperosteosis and soft tissue
involvement around joints. Thus, bisphosphonate
treatment via a number of mechanisms would be
expected to reduce inflammatory bone pain and
symptoms in melorheostosis. Bisphosphonates inhibit
osteoclast mediated bone resorption by direct and
indirect actions on osteoblasts and macrophages and
bone vascularity. They have been shown to decrease
bone pain, slow progression of bone lesion.[9]
The
prognosis of a patient with melorheostosis is variable and
depends on the anatomical location, extension into the
soft tissues, and soft tissue changes. Melorheostosis does
not shorten life span, however, morbidity may be
considerable. The disease exhibits a slow, chronic
course, with periods of exacerbation and arrest.
Recurrence usually is expected after operative
excision.[10]
REFERENCES
1. Leri A, Joanny J. Une affection non décrite des os
hyperostose “en coulée” sur toute la longeur d'un
member ou “melorhéostose.” Bull Mem Soc Med
Hosp Paris. 1922; 46: 1141–1145.
2. Greenspan A, Azouz EM. Bone dysplasia series:
melorheostosis: review and update. Can Assoc
Radiol J. 1999; 50: 324–330.
3. Freyschmidt J.: Melorheostosis: a review of 23
cases. Eur Radiol 2001; 11: 474–9
4. Zeiller SC, Vaccaro AR, Wimberley DW, Albert TJ,
Harrop JS, Hilibrand AS. Severe myelopathy
resulting from melorheostosis of the cervicothoracic
spine: a case report. J Bone Joint Surg Am. 2005;
87: 2759–2762.
3. www.ejpmr.com 476
Yadav et al. European Journal of Pharmaceutical and Medical Research
5. Murray RO, McCredie J. Melorheostosis and the
sclerotomes: a radiological correlation. Skeletal
Radiol. 1979; 4: 57–71.
6. Hellemans J, Preobrazhenska O, Willaert A, Debeer
P, Verdonk PC, Costa T, et al. Loss-of-function
mutations in LEMD3 result in osteopoikilosis,
Buschke- Ollendorff syndrome and melorheostosis.
Nat Genet. 2004; 36: 1213–1218.
7. Ethunandan M, Khosla N, Tilley E, Webb A.
Melorheostosis involving the craniofacial skeleton. J
Craniofac Surg. 2004; 15: 1062–1065.
8. Campbell CJ, Papademetriou T, Bonfiglio M.
Melorheostosis: a report of the clinical,
roentgenographic, and pathological findings in
fourteen cases. J Bone Joint SurgAm. 1968; 50:
1281–1304.
9. Wood J, Bonjean K, Ruetz S, et al. Novel
antiangiogenic effects of the bisphosphonate
compound zoledronic acid. J Pharm Experimental
Therapeutics 2002; 302: 1055–61.
10. Goldman AB, Schneider R, Huvos AS, Lane J. Case
report 778. Melorheostosis presenting as two soft-
tissue masses with osseous changes limited to the
axial skeleton. Skeletal Radiol. 1993; 22(3): 206-
210.