This document presents a seismic analysis of multistory building frames with different column and beam geometries. The analysis is conducted using Staad Pro software on a symmetrical 24.38x24.38m G+10 building located in seismic zone III with medium soil. Three different plan configurations are analyzed with column and beam sizes of 230mmx230mm, 300mmx300mm, and 380mmx380mm. The results show that maximum support reaction and axial forces occur in the plan with the smallest member sizes, while maximum reaction moment occurs in the plan with the largest member sizes. In conclusion, support reaction and axial forces decrease while reaction moment increases as member size increases.