This document discusses endotracheal intubation. It begins by describing airway anatomy and then covers indications, contraindications, and preparation for rapid sequence intubation. The seven Ps of rapid sequence intubation are outlined. Preparation, equipment, patient positioning, laryngoscopy technique, tube placement confirmation, and post-intubation management are described in detail. Complications are briefly mentioned. Alternative intubation techniques like delayed sequence intubation and awake oral intubation are also summarized.
Pre-oxygenation is: safe, simple, cheap, effective, well-tolerated. This article provides a compelling argument in favour of pre-oxygenation prior to all general anaesthesia.
Anaesthesia to patiens with liver disease or a liver transplantscanFOAM
A presentation by Anna Januszkiewicz at the 2017 meeting of the Scandinavian Society of Anaestesiology and Intensive Care Medicine.
All available content from SSAI2017: https://scanfoam.org/ssai2017/
Delivered in collaboration between scanFOAM, SSAI & SFAI.
Differences between Paediatric and Adult airway gourav_singh
These slides contain a brief discussion about what all common differences between pediatric and adult airway can be found if you are in an ENT OPD or during Anesthesia.
Just a brief discussion.
A basic overview on the management of intra-operative bronchospasm: the risk factors, triggers, diagnosis, prevention and management. Includes a case scenario – discussion.
effective management of airway Management is the bread and butter of an analystologist, American society of anaesthesiology frequent guidelines and management algorithms
Pre-oxygenation is: safe, simple, cheap, effective, well-tolerated. This article provides a compelling argument in favour of pre-oxygenation prior to all general anaesthesia.
Anaesthesia to patiens with liver disease or a liver transplantscanFOAM
A presentation by Anna Januszkiewicz at the 2017 meeting of the Scandinavian Society of Anaestesiology and Intensive Care Medicine.
All available content from SSAI2017: https://scanfoam.org/ssai2017/
Delivered in collaboration between scanFOAM, SSAI & SFAI.
Differences between Paediatric and Adult airway gourav_singh
These slides contain a brief discussion about what all common differences between pediatric and adult airway can be found if you are in an ENT OPD or during Anesthesia.
Just a brief discussion.
A basic overview on the management of intra-operative bronchospasm: the risk factors, triggers, diagnosis, prevention and management. Includes a case scenario – discussion.
effective management of airway Management is the bread and butter of an analystologist, American society of anaesthesiology frequent guidelines and management algorithms
Endotracheal (ET) intubation involves the oral or nasal insertion of a flexible tube through the larynx into the trachea for the purposes of controlling the airway & mechanically ventilating the patient and is Performed by doctors, anesthetist, respiratory therapist or nurse practitioner in the procedure . it is emergency procedure.
Rapid sequence intubation (RSI) is a technique that is used when rapid control of the airway is needed as a precaution for patients that may have a 'full stomach' or other risks of pulmonary aspiration. A short description about RSI procedure according to IQARUS guideline.
Dr. Ummay Sumaiya
ICU DOCTOR
| IQARUS | Medical Treatment Facility / IQARUS - Cox’s Bazar - Bangladesh |
Mail: Ummay.Sumaiya@iqarus.com
ENDOTRACHEAL TUBE INTUBATION II Parts II Details II Clinical DiscussionSwatilekha Das
What is endotracheal intubation?
Endotracheal intubation is a procedure by which a tube is inserted through the mouth down into the trachea (the large airway from the mouth to the lungs). Before surgery, this is often done under deep sedation. In emergency situations, the patient is often unconscious at the time of this procedure.
For detailed information plz watch the slides till end.......
And plz like, share and comment and follow......
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
5. INDICATIONS
● Relief of airway obstruction
Epiglotittis, Facial burns, Smoke inhalation, Vocal cord edema
● Protection of the airway
Prevent aspiration, Absence of coordinated swallowing
● Support Ventilation
Respiratory arrest, Post anaesthesia recovery
6. CONTRAINDICATIONS
● Absolute
Total upper airway obstruction
Total loss of facial/ oropharyngeal landmarks
● Relative
Anticipated difficult airways
The crash airway
7. The Seven Ps of Rapid Sequence Intubation
1. Preparation
2. Preoxygenation
3. Pretreatment
4. Paralysis with induction
5. Positioning
6. Placement of tube
7. Postintubation management
8. 1. PREPARATION
• Oxygen source and tubing
• Ambu bag
• Mask with valve, various sizes and shapes
• Oropharyngeal And Nasopharyngeal airways
• Suction catheters,nasogastric suction
connections & Suction source
• Pulse oximetry
• Carbon dioxide detector
• Endotracheal tubes
• Laryngoscopes
• Syringes
• Magill forceps
• Stylets and gum elastic bougie
• Water-soluble lubricant or anesthetic jelly
• Rescue devices: VLS, LMA, ILMA, i-gel®
• Surgical cricothyroidotomy kit
• Medications for topical airway anesthesia,
sedation, and rapid-sequence intubation
9. Preintubation Checklists
PRE-ARRIVAL
1. Bag mask ventilation setup with oxygen running at >15 L/min
2. Suction connected and running
3. Laryngoscope functioning and ready
4. Ready an endotracheal tube
5. Back-up devices such as laryngeal mask airway available and ready
6. Cricothyrotomy set
7. End-tidal CO2 detector ready
10. PRE-INTUBATION
1. Assess the airway: open mouth, examine neck mobility, palpate anterior neck
2. Decide best approach: awake, sedated, or RSI
3. Communicate intubation medication orders to nurses,
including post-intubation medications
4. Optimally position patient
5. Preoxygenate patient (usually with face mask oxygen at 60 L/min)
6. Apply nasal cannula at 10–15 L/min in preparation for apneic oxygenation
7. Discuss airway plan with entire team
8. Ensure functioning pulse oximeter
9. Ensure patient intravenous catheter
10.Ensure assistants are ready (nurses, respiratory therapists)
11. ET TUBE
The endotracheal tubes size (“give me a 6.0 tube”) refers to its internal diameter in
millimeters (mm). The ETT will typically list both the inner diameter and outer diameter
on the tube (for example, a 6.0 endotracheal tube will list both the internal diameter, ID
6.0, and outer diameter, OD 8.8).
The narrower the tube, the greater resistance to gas flow.
After successfully intubating the patient the depth of the endotracheal tube ending at the
teeth or lips should be noted. This depth provides a baseline measurement to ensure the
tube has not traveled out of the trachea or deeper into the trachea
12. Ideally, the distal tip of the ETT is 4 cm (+/- 2 cm) above the carina on chest x-ray in adults
the patient typically needs to be intubated with at least 7.5-8.0 size ETT
The typical depth of the endotracheal tube is 23 cm for men and 21 cm for women, measured at the central incisors.
The average size of the tube for an adult male is 8.0, and an adult female is 7.0, though this is somewhat an
institution dependent practice.
Pediatric tubes are sized using the equation: size = ((age/4) +4) for uncuffed ETTs, with cuffed tubes being one-half
size smaller
Typically a pediatric ETT is taped at a depth of 3 x the tube size in a child (i.e., a 4.0 ETT commonly gets taped at
around 12cm depth).
14. ASSESSING FOR A DIFFICULT AIRWAY
The American Society of Anesthesiology Difficult Airway Guidelines state that “in
patients with no gross upper airway pathology or anatomic anomaly, there is
insufficient published evidence to evaluate the effect of a physical examination on
predicting the presence of a difficult airway“
The Mallampati classification predicts intubation difficulty based on the visibility of
intraoral structures. Classes III and IV predict difficult intubation.
A short thyromental distance (less than 6 cm or 3 fingerbreadths) when the head is
extended predicts difficult intubation.
20. Difficult Bag & mask ventilation
MOANS
Mask seal
Obstruction or obesity
Aged
No teeth
Stiffness (resistance to
ventilation)
Difficult SGA Placement
RODS
Restricted mouth opening
Obstruction or obesity
Distorted anatomy
Stiffness (resistance to ventilation)
21.
22. 2. PREOXYGENATION
preoxygenation increases safe apnea time from 1 to 8 minutes
Administer 100% oxygen for at least 3 minutes using a NRBM (60-70% O2)
Higher oxygen delivery is possible by increasing the oxygen regulator to its
maximum “flush” rate(90% to 97% O2)
23.
24. IF unable to achieve oxygen saturation >95% with spontaneous breathing,
consider the use of bag-valve-mask ventilation OR BiPAP
In obese patients, safe apnoea time can be improved by preoxygenating the
patient in head up position and continuing oxygenation through nasal cannula
25. 3. PRETREATMENT
Decrease adverse physiologic response to laryngoscopy and RSI
Fentanyl can decrease the reflex sympathetic response to airway
manipulation. Used in patients in whom a rise BP & HR could be detrimental
as in hypertensive emergency,
Reactive airway disease: Albuterol, 2.5 mg, by nebulizer. If time does not
permit albuterol nebulizer, give lidocaine 1.5 mg/kg IV.
26.
27. INDUCTION AGENTS
Etomidate - short duration of action, protects from myocardial and cerebral
ischemia, causes minimal histamine release, and causes little hemodynamic
depression.
Propofol - rapid onset and shorter duration of action than etomidate. It has
anticonvulsant and antiemetic properties, and may lower ICP without triggering
histamine release.
Ketamine- analgesia and amnesia. Ketamine preserves the respiratory drive,
hence ideal for awake intubation. Ketamine increases bp and heart rate, which
may be useful in hypovolemic or hypotensive state
28.
29. Neuromuscular blockade eliminates protective airway reflexes.
Neuromuscular blockade can facilitate tracheal intubation, improve mechanical
ventilation, and help control ICP
Neuromuscular blockers include depolarizing (Ach-) and nondepolarizing
agents(Ach+)
4. PARALYSIS
30. Succinylcholine
A depolarizing agent
rapid onset after IV dosing and a
shorter duration of action than
nondepolarising agents
After brief fasciculation, complete
relaxation occurs at 60 seconds, with
maximal paralysis at 2 to 3 minutes.
Effective respirations resume in 8 to
12 minutes
31. Rocuronium is an intermediate-duration( nondepolarizing)that is an excellent
alternative to succinylcholine for RSI due to its shorter duration of action.
Vecuronium bromide is an intermediate- to long-acting( non depolarizing) .
Has no cardiac effects. Hypersensitivity reactions are rare, doses are only
minimally cumulative, and excretion is biliary.
Atracurium is a non-depolarizing neuromuscular blocking drug. is a
competitive antagonist atneuromuscular junction. It competes with
acetylcholine for binding sites.
32. Sugammadex is a reversal agent that reverses blockade from rocuronium or
vecuronium by encapsulating the molecules of the nondepolarizing agents
circulating in plasma. The dose is 2 to 4 milligrams/kg.
Neostigmine, a cholinesterase inhibitor, may be used to reverse
neuromuscular blockade, but it has undesirable cardiac and cholinergic side
effects.
33. It is usual to wait 45 seconds from when the succinylcholine is given and 60 seconds from when rocuronium is
given to allow sufficient paralysis to occur.
37. Protecting the airway against aspiration prior to intubation
Flex the lower neck and extend the atlanto occipital joint (sniffing
position) to align the oropharyngeal laryngeal axis for direct view of
larynx
Best when ear is horizontally alligned with sternal notch
47. PROCEDURE
1. Clear the oropharynx.
Remove dentures and any obscuring blood, secretions, or vomitus. Suction
airway clear.
2. Hold laryngoscope in left hand. Hold the laryngoscope at the base, where the
blade inserts to the handle.
3. Use right hand to: Open the mouth. Operate suction catheter.
Manipulate larynx to enhance visualization.
Insert the ETT.
48. 4. Insert blade into the right cor ner of the patient’s mouth. Carefully advance blade
into oropharynx. Lift and hyperextend the head. Use the vertical flange of the curved
Macintosh blade to push the tongue toward the left side of the oropharynx.
5. Visualize and lift the epiglottis. Lift the epiglottis directly with the straight blade
(Miller) or indirectly with the curved blade (Macintosh).
6. Visualize vocal cords (arytenoids).
Look for the arytenoid cartilages to avoid overly deep insertion of the blade, which is a
common error. BURP maneuver may improve visualization.
49. 7. Advance ETT. Visualize tube and cuff passing through vocal cords. Correct tube
placement is a minimum of 2 cm above the carina
8. Inflate balloon. Use 5–7 mL of air. Check cuff pressure to avoid tracheal injury
from pressure
9. Confirm ETT placement.
Listen for bilateral breath sounds and the absence of epigastric sounds.
Confirm placement with capnography or colori- metric carbon dioxide detector.
10. Secure ETT.
Use commercial tube holder, adhesive tape, or umbilical tape.
59. Awake Oral Intubation
sedative and topical anesthetic agents are administered to permit management
of a difficult airway without neuromuscular blockade.
ketamine, is often the best choice
Aliquots of ketamine at a dose of 0.5 mg/kg IV, titrated to the desired level of
sedation and procedural tolerance, is an effective method