Bag-mask ventilation (BVM) is the most important airway skill and first response to inadequate oxygenation. Mastering BVM technique requires practice and involves maintaining a face seal while ventilating with one hand. Factors like obesity, lack of dentures, facial hair or injuries can make BVM difficult. The key is optimizing head position, using oral/nasal airways, and a two-person technique before considering other advanced airway interventions for difficult ventilation.