Isoenzymes (or isozymes) are a group of enzymes that catalyze the same reaction but have different enzyme forms and catalytic efficiencies. Isozymes are usually distinguished by their electrophoretic mobilities.
Isoenzymes (or isozymes) are a group of enzymes that catalyze the same reaction but have different enzyme forms and catalytic efficiencies. Isozymes are usually distinguished by their electrophoretic mobilities.
This presentation gives an overview of Lipid Rafts, how it was discovered, its importance and the future research in this area,Feel free to comment and ask any questions
Basics only
Ultrastructure, Chemical composition and Functions of Golgi complex
• Golgi apparatus is a complex network of smooth membrane enclosed organelle which helps in collection, packaging, distribution and secretion of biomolecules.
• Golgi apparatus is referred as Golgi complex, Golgi bodies, Golgi some, dictyosomes, lipochondria, Dalton Complex, Baker’s bodies, Carbohydrate factory, ‘traffic police’ of cell.
Hemoglubin is are carrier protein for oxygen and CO2. it a pigmented and globular protein present within the red blood cell, its structure, synthesis, and how it function in the transportation of oxygen and CO2 are given in this presentation
Structure and function of plasma membrane 2ICHHA PURAK
The presentation consists of 72 slides,describes following heads
DEFINITION : STRUCTURE OF PLASMA MEMBRANE
COMPONENTS OF PLASMA MEMBRANE ( (BIOCHEMICAL PROPERTIES)
LIPID BILAYER
PROTEINS
CARBOHYDRATES
CHOLESTEROL
MODELS EXPLAINING STRUCTURE OF BIO MEMBRANE
FLUID MOSAIC MODEL
MOBILITY OF MEMBRANE
GLYCOCALYX : GLYCOPROTEINS AND GLYCOLIPIDS
TRANSPORT OF IONS AND MOLECULES ACROSS PLASMA MEMBRANE
FUNCTIONS OF PLASMA MEMBRANE
DIVERSITY OF CELL MEMBRANES
SITE OF ATPASE ION CARRIER CHANNELS AND PUMPS-RECEPTORS
This presentation gives an overview of Lipid Rafts, how it was discovered, its importance and the future research in this area,Feel free to comment and ask any questions
Basics only
Ultrastructure, Chemical composition and Functions of Golgi complex
• Golgi apparatus is a complex network of smooth membrane enclosed organelle which helps in collection, packaging, distribution and secretion of biomolecules.
• Golgi apparatus is referred as Golgi complex, Golgi bodies, Golgi some, dictyosomes, lipochondria, Dalton Complex, Baker’s bodies, Carbohydrate factory, ‘traffic police’ of cell.
Hemoglubin is are carrier protein for oxygen and CO2. it a pigmented and globular protein present within the red blood cell, its structure, synthesis, and how it function in the transportation of oxygen and CO2 are given in this presentation
Structure and function of plasma membrane 2ICHHA PURAK
The presentation consists of 72 slides,describes following heads
DEFINITION : STRUCTURE OF PLASMA MEMBRANE
COMPONENTS OF PLASMA MEMBRANE ( (BIOCHEMICAL PROPERTIES)
LIPID BILAYER
PROTEINS
CARBOHYDRATES
CHOLESTEROL
MODELS EXPLAINING STRUCTURE OF BIO MEMBRANE
FLUID MOSAIC MODEL
MOBILITY OF MEMBRANE
GLYCOCALYX : GLYCOPROTEINS AND GLYCOLIPIDS
TRANSPORT OF IONS AND MOLECULES ACROSS PLASMA MEMBRANE
FUNCTIONS OF PLASMA MEMBRANE
DIVERSITY OF CELL MEMBRANES
SITE OF ATPASE ION CARRIER CHANNELS AND PUMPS-RECEPTORS
the branch of science concerned with the chemical and physico-chemical processes and substances that occur within living organisms.
the processes and substances with which the science of biochemistry is concerned.
Biochemistry is the study of the chemical substances and vital processes occurring in living organisms. Biochemists focus heavily on the role, function, and structure of biomolecules. The study of the chemistry behind biological processes and the synthesis of biologically active molecules are examples of biochemistry.
cell organelles, nucleus, mitochondria, plasma memebrane,ribosomes, golgi bodies, lysosomes, chloroplast
(helpfull for B.Sc. students as well as competitions tests
What is biochemistry?
Biochemistry explores chemical processes related to living organisms. It is a laboratory-based science combining biology and chemistry.
Biochemists study the structure, composition, and chemical reactions of substances in living systems and, in turn, their functions and ways to control them. Biochemistry emerged as a separate discipline when scientists combined biology with organic, inorganic, and physical chemistry. They began to study areas such as:
How living things get energy from food
The chemical basis of heredity
What fundamental changes occur in disease
Biochemistry includes the sciences of molecular biology, immunochemistry, and neurochemistry, as well as bioinorganic, bioorganic, and biophysical chemistry.
What do biochemists do?
Biochemists interact with scientists from a wide variety of other disciplines, usually on problems that are a very small piece of a very large and complex system.
Biochemists in industry are interested in specific applications that will lead to marketable products
Biochemists in academia or government labs conduct more basic and less applied research
Where is biochemistry used?
Biochemistry has obvious applications in medicine, dentistry, and veterinary medicine. Other applications include:
Food Science
Biochemists determine the chemical composition of foods, research ways to develop abundant and inexpensive sources of nutritious foods, develop methods to extract nutrients from waste products, and/or invent ways to prolong the shelf life of food products.
Agriculture
Biochemists study the interaction of herbicides/insecticides with plants and pests. They examine the structure–activity relationships of compounds, determine their ability to inhibit growth, and evaluate the toxicological effects on surrounding life.
Pharmacology, Physiology, Microbiology, Toxicology, and Clinical Chemistry
Biochemists investigate the mechanisms of drug actions; engage in viral research; conduct research pertaining to organ function; or use chemical concepts, procedures, and techniques to study the diagnosis and therapy of disease and the assessment of health.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
2. INTERNALENVIONMENT
It is the condition that prevails within the
body of an organism, particularly with respect
to the composition of the tissue fluid.
First proposed by the French physiologist
‘CLAUDE BENARD’ (1813 – 78).
He states that maintenance of a constant
internal environment was necessary for the
survival of an organism in a varying external
environment.
3. ROBERTHOOKE (1665)
Using an early
microscopic
viewed cork
and saw many
repeating box
like structure s
and called
them ‘cell’
4. A CELL
A cell is chemical
system that able to
maintain its
structure and
reproduce cells are
the fundamental
units of life . All
livings are
composed of cells
5. STRUCTURE OF A CELL
• NUCLEUS –
a)It stores the cell hereditary material or DNA.
b)It coordinate the cell activities which include growth
intermediary metabolism, protein synthesis and
reproduction ( cell division).
• CELL MEMBRANE
a) It consist of a lipid bilayer with embedded protein.
b) It protect the cell from its surrounding
c) It controls the movement of substance in and out of
cell and organelles
6. • CYTOPLASM- substance that fills the cell.
a) It is jelly like substance
b) made up of 80% water and is clear and
colorless
c) It also consist of carbohydrates ,
inorganic salts , lipids and enzymes.
• RIBOSOME – It is a protein synthetic
machinery.
a) It has two subunits – large and small.
b) Made of protein and ribosomal RNA .
7. • MITOCHONDRIA –
a) It is organelle within eukaryotic cells
b) produce adenosine triphosphate
(ATP), the main energy molecules used
by the cell.
c) Therefore it is also called ‘the
powerhouse of the cell’.
• ENDOPLASMIC RETICULUM –
a) A web -like series of membrane within the
cytoplasm in the form of flattened sheets ,
sacs , tubes .
b) It creates many membrane enclosed
spaces – spreads throughout the
cytoplasm.
8. • CENTRIOLES –
a) They are part of specialized region of the
cell the called centrosome.
b) They are involved in the production of
micro tubes which have many function
including moving chromosomes during
cell division.
• GOLGI APPARATUS
a) Responsible for transporting , modifying
and packaging protein and lipids into
vessels for delivery to target destination.
10. CELL COLONIES
• First step towards cell specialization.
• Clumping towards of otherwise
independent cells must had survival
value among cell species.
• Interdependence in multicellular
organisms.
11. TISSUE SPECIALIZATION
• It is a group of cells that are specialized
in a similar way to perform a common
function.
• Its main function are contraction,
receptors tissue for irritability , nerve
tissue for conduction, glandular tissue for
secretion etc.
• Other types of specialized : bone, cartilage
, connective tissue and vascular tissue.
12. ORGAN SPECIALIZATION
• A organ is a collection of differently specialized
tissue, organized for the performance of a
common general function.
• Each tissue has a different role in the overall
function of a organ.
• For example- the stomach is a digestive organ. It
is made up of connective tissue to hold it
together , vascular tissue to nourish it, glandular
tissue to provide digestive secretion , muscular
tissue to mix the food and move it into other
parts of digestive system.
13. SYSTEM SPECIALIZATION
• It is a highest level of integration in the
body.
• It consist of several organs , each of which
has a limited role in the overall performance
of the system.
• Example – The nervous system has nerves to
carry excitation to and from the receptors
and effectors, brain centers to make
connection between incoming and outgoing
excitation and so forth.
14. INTEGRATION OF THE COMPLEX
ORGANISM : HOMEOSTASIS
• The physical and chemical condition that
surrounds a specialized cell in the human
body must be more constant because the
cell has lost its ability to cope with
environmental changes.
• it can carried out in three major ways:
i. The organisation of tissue and organs
into system along with coordination for a
single function.
15. ii. Some coordination is supplied by endocrine
glands , whose secretion are carried all over
the body in the blood stream to affect
widely scattered tissue in a constant
fashion.
iii. The nervous system is completely devoted
to coordinating the many diverse functions
of the other organs and system of the body.
• Every change in the external and internal
environment or both tends to alter internal
conditions from those needed by the
specialized cells for adequate functioning
and survival that is ‘functional integrity’ .
16. METABOLISM OF A CELL
CELL METABOLISM
a. The activities of the
individual cell that
are involved in
transforming food
and oxygen into
cellular structure
and eliminating
waste from the cell
are called cell
metabolism
INTERMEDIARY
METABOLISM
i. The chemical reactions
involve simple chemical
‘food’ compounds-
blood glucose , amino
acids , fatty acid,
minerals and oxygen
that have been broken
down from more
complex compounds in
this process
17. CELL AS A CHEMICAL FACTORY
• ANABOLISM –
metabolic reaction
that require
energy input to
proceed are
collectively known
as anabolism.
• CATABOLISM–
The necessary
energy is supplied
other chemical
reaction that
release energy
collectively known
as catabolism.
18. CONTROL OF METABOLISM
•The necessary energy , structure
and food for the cell . The rate at
which chemical reaction can
proceed often depends on
enzymes
19. •CATALYSTS are chemical that
speed up the rate at which chemical
reaction go on without being used up
in the reactions.
20. CONTROL OF METABOLISM BY THE
CIRCULATORY SYSTEM
• Circulating system consist of:
i. The heart which maintains the flow of blood
by its pumping action.
ii. The pulmonary circulation system of blood
vessels which carries oxygen between the
heart and the lungs.
iii. The systematic circulation system which
carries blood from the heart to all the other
tissue of the body and back again to the heart
.
21. It plays a role in maintenance of other
body system by transporting hormones
and nutrients taking away waste
products and providing all living body
cells with a fresh supply of oxygen and
removing carbon dioxide.
Homeostasis is disturbed if the
cardiovascular are or lymphatic systems
are not functioning correctly.
22. Homeostasis and the internal
environment
Oxygen and carbon dioxide content of the
blood are controlled by the co2 level.
The acidity of the blood is also critical .
Blood glucose level is maintained between
60 and 130mg/100ml of blood.
The endocrine glands as well as the nervous
system, organize the body response to
response to change.
The chemical composition of the blood is
also regulated the by such mechanism.
23. The body temperature must be kept
within narrow limits .
Change in blood temperature must
be kept within narrow limits.
Regulatory behavior is a part of the
homeostatic process