Primary immunodeficiency disorders are hereditary conditions present at birth that impair the immune system's ability to fight infections and diseases. There are over 150 known types that can affect B cells, T cells, or other immune components. Some common primary immunodeficiencies include severe combined immunodeficiency (SCID), where both cellular and humoral immunity is absent due to a lack of T cells; Bruton's agammaglobulinemia, an X-linked disorder affecting B cell function; and DiGeorge's syndrome, where T cell development is impaired. Secondary immunodeficiencies are acquired later in life from external factors like malnutrition, disease, or medical treatments.