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Immune Deficiency
- 1. Immune Deficiency By Mr.Vinay Prajapati TutorIndex nursing college
- 2. Immune Deficiency • Immune Deficiency A Condition When Immunity Power Any One Host In Deficient And Low • Immune Deficiency Is Many Type Of Low Just Like • Heredity • Any Disorder
- 3. Auto Immune Disorder • If Some Condition To Immune System Not Work In Which Condition Immune System Work In wrong Way Self System Antibodies Produce And Self Immune System Harm • There Are Two Type Of Immune Deficiency • Primary Immune Deficiency • Secondary Immune Deficiency
- 4. Primary immune deficiency • At Birth Host Do Not Presents Immune Cell Due To Heredity Factor • Phagocytic Dysfunction • T-cell And B-cell Deficiency
- 5. Secondary Immune Deficiency • Secondary Immune Deficiency A Condition In Good Immune Part But Due To Some Disorder To Working Less Example – Infection , Malnutrition, Chronic Stress, Burn Diabetes Mellitus, Immune Toxic, Drug Self Administration ,Drugs Alcohol
- 6. Primary immune deficiency Phagocytic Dysfunction • Phagocytic Cell Is Doing In A Body Phagocytic Process • Example, Becteriosidal,and Becteriostetic • Phagocytic Divided In A Two Part • Professional Phagocytic Cell • Non-p Professional L Phagocytic Cell
- 7. Primary immune deficiency Professional Phagocytic Cell • WBC cell primary function micro-organism ,substance in golf receptor to bind and golf • Non-P Professional l Phagocytic cell - Primary work not golf cell and micro- organism west products remove
- 8. Phagocytic Deficiency Its Refers It’s A Class Of Medical Condition Where Phagocyte Have Diminished Ability To Fight Infection - Etiology - Genetic Factor,
- 9. Clinical Manifestation • Cuteness Abscess • Chronic Eczema • Bronchitis • Pneumonia • Chronic Otites Media • Gingivitis • Stomatitis • Cellulites
- 10. Diagnostic Evolution • History Taking • Physical Examination • Laboratory Analysis By (NBT) Nitro Blue Tetrozolism Reeducates Test
- 11. Medical Management • Bacteria And Fungal Infection Control • Granulocyte Transfusion (WBC) • Cell Therapy • Hematopoietic Stem Cell • Genes therapy
- 12. B-cell deficiency • B-lymphocyte Don't Produce In The Body Due To B- lymphocyte Level In Decrease In The Body That’s Why Decrease Level Of Lymphocyte No Immunity Produce Against Forge Bodies • Immunity Process Two Types • Cell-mediated Immunity -Cell-mediated Immune Responses Involve The Destruction Of Infected Cells By Cytotoxic T Cells, Or The Destruction Of Intracellular Pathogens By Macrophages
- 13. B-cell deficiency • B-lymphocyte Don't Produce In The Body Due To B- lymphocyte Level In Decrease In The Body That’s Why Decrease Level Of Lymphocyte No Immunity Produce Against Forge Bodies • Immunity Process Two Types • Cell-mediated Immunity -Cell-mediated Immune Responses Involve The Destruction Of Infected Cells By Cytotoxic T Cells, Or The Destruction Of Intracellular Pathogens By Macrophages
- 14. B-cell deficiency • Humoral Immunity - The Humoral Immune Response Is Mediated By Antibody Molecules That Are Secreted By Plasma Cells. Antigen That Binds To The B-cell Antigen Receptor Signals B Cells And Is, At The Same Time, Internalized And Processed Into Peptides That Activate Armed Helper
- 15. Cell-mediated and Humoral Immunity
- 16. Classification • X-linked Agama Globulinemia • Hypogammaglobulinemia
- 17. Clinical Manifestation • Autoimmune Thrombocytopenia Purpose • Autoimmune Hemolytic Anemia • Arthritis • Hypothyroidism • Fever • Weight loss • Anemia • Thrombocytopenia
- 18. Clinical Manifestation • Spleenomegaly • Lymphadenopathy
- 19. Diagnosis Evolution • History Taking • Physical Examination • Serum Immunoglobulin Analysis • Antibodies Tutees' • Hemoglobin • Hemetocrite Levels
- 20. Medical Management • Intervenes Immunoglobulin • Antibodies Replacement Therapy • Symptomatic Treatment
- 21. T-cell lymphocytes • T-lymphocyte Give Immunity To Prevent Foregone Substance Micro – Organism, T- Cell Helper Cell , T-cell Kill Specific Antigen • Most primary t cell immune deficiency are genetic in origin partial t cell immune deficiencies constitute a hetrogenues cluster of disorder characterized by an incomplete reduction in t cell number or activity • Bone Marrow Screed T -Cell Preachercer ( Immature T-cell ) In Blood Steam , Through Blood Steam T- Cell Reach In The Thymus Gland There T- Cell Preachers (Mature) And Convert In Two Type • 1) CD4 • 2) CD8
- 22. T-cell Lymphocytes Deficiency Classification • T-cell Lymphocytes Deficiency Classification in a two type • 1) Thymic Hypoplasia • 2) Chronic Mucocutaneaus Candidacies East
- 23. Thymic Hypoplasia • It Is A Lack Of Thymic Influence On The Immune System. The Thymus Is Usually Rudimentary And T-cells Are Deficient Or Absent. They Are Similarly Depleted In The Thymus-dependent Areas Of The Lymph Nodes And Spleen. • Infants With This Defect Are Extremely Vulnerable To Viral, Fungal, And Protozoal Infections. The B-cell System And Serum Immunoglobulin's Are Entirely Un-affected.
- 25. Chronic Mucocutaneous Candidiasis • Chronic Mucocutaneous Candidiasis (CMCC) Is A Heterogeneous Group Of Syndromes With The Common Features Of Chronic Noninvasive Candida Infections Of The Skin, Nails, And Mucous Membranes That Are Usually Resistant To Topic Treatment And Absence Of Invasive Fungal Infections. The Classic Forms Have Associated Autoimmune Manifestations (Most Commonly Endocrinopathies), And Patients May Have Other Microbial Infections. Milder Forms Have Oral Candidiasis With Or Without Associated Staphylococcal Skin Infections. CMCC Is Caused By Genetic Defects In The Immune System
- 27. Clinical Manifestation • Hypoparathyroidism • Hypocalcaemia • Congenital heart failure • Cleft lip and palate • Dimorphic facial feature • Renal abnormality • Susceptible to yeast fungal • Protozoon viral infection • Susceptible to child diseases like chickenpox ,measles , rubella • tetany • Addison diseases
- 28. Diagnosis Evolution • History Taking • Physical Examination • Immunoglobulin Analysis • Blood Analysis
- 29. Medical Management • Oral Calcium Supplement With Vitamin –D • Symptomatic Treatment • Thymus Graft