Cells of the immune system can be categorized as cells of the innate immune system or cells of the adaptive immune system. Cells of the innate immune system include phagocytes such as macrophages, neutrophils, dendritic cells, and basophils and mast cells. Cells of the adaptive immune system include lymphocytes such as B cells and T cells. B cells are involved in antibody production while T cells include cytotoxic T cells and helper T cells that activate other immune cells. Natural killer cells are also lymphocytes that help identify and destroy tumor or virus infected cells.
Introduction
History
Types of immunity
Tissues of immunity
Cells of immunity
Basic aspects of immunology
Major histocompatibility complex
Cytokines
Disorders of immune system
Immune responses in periodontal pathogenesis
Periodontal vaccine
Host modulation
Conclusion
References
This presentation gives you the detailed description of various cells & organs of immune systems that participates (particularly, in combination), make communication between themselves to regulate the whole immune system very precisely.
Introduction
History
Types of immunity
Tissues of immunity
Cells of immunity
Basic aspects of immunology
Major histocompatibility complex
Cytokines
Disorders of immune system
Immune responses in periodontal pathogenesis
Periodontal vaccine
Host modulation
Conclusion
References
This presentation gives you the detailed description of various cells & organs of immune systems that participates (particularly, in combination), make communication between themselves to regulate the whole immune system very precisely.
Antigen processing and presentation by Dr K.Geetha, Associate Professor, Department of Biotechnology, Kamaraj College of Engineering & Technology, Near Virudhunagar, Madurai Dist.
By DR. MANPREET KAUR BEHL.
Description of classificaton of immune system, immune cells, HLA, MHC complexes, antigen presentation, t-cell responses and b-cell responses, antibody, isotype switching, hypersenstivity reactions etc.
introduction of adaptive immunity. classification of adaptive immunity, factor affecting it and mechanism of adaptive immunity comparison between adaptive immunity and innate immunity. characteristic of adaptive immunity . cell mediated immune responses immunoglobulins
types of immunoglobulins. functions of immunoglobulins, hypersensitivity reactions
cytokines play a key role in controlling the immune system. It facilitate other cells and organs to work, with this presentation you will be able to learn about what are cytokines, their types, & their biological roles along with diseases related to cytokines and cytokines based therapies.
Antigen processing and presentation by Dr K.Geetha, Associate Professor, Department of Biotechnology, Kamaraj College of Engineering & Technology, Near Virudhunagar, Madurai Dist.
By DR. MANPREET KAUR BEHL.
Description of classificaton of immune system, immune cells, HLA, MHC complexes, antigen presentation, t-cell responses and b-cell responses, antibody, isotype switching, hypersenstivity reactions etc.
introduction of adaptive immunity. classification of adaptive immunity, factor affecting it and mechanism of adaptive immunity comparison between adaptive immunity and innate immunity. characteristic of adaptive immunity . cell mediated immune responses immunoglobulins
types of immunoglobulins. functions of immunoglobulins, hypersensitivity reactions
cytokines play a key role in controlling the immune system. It facilitate other cells and organs to work, with this presentation you will be able to learn about what are cytokines, their types, & their biological roles along with diseases related to cytokines and cytokines based therapies.
Types of immune cells
∆Lymphoid cells
-lymphocytes
constitute 20%–40% of the body’s white blood cells and 99% of the cells in the lymph
continually circulate in the blood and lymph and are capable of migrating into the tissue spaces and lymphoid organs
lymphocytes enlarge into 15 µm-diameter blast cells, called lymphoblasts; these cells have a higher cytoplasm : nucleus ratio and more organellar complexity than small lymphocytes.
Lymphoblasts proliferate and eventually differentiate into-
effector cells or into
memory cells.
* B-lymphocytes
*T-lymphocytes
* Natural killer cells
∆mononuclear phagocytes
The mononuclear phagocytic system consists of monocytes circulating in the blood and macrophages in the tissues.
-macrophages
-monocytes
∆granulocytes cells
Granulocytes are at the front lines of attack during an immune response and are considered part of the innate immune system.
Granulocytes are white blood cells (leukocytes) that are classified as neutrophils, basophils, mast cells, or eosinophils on the basis of differences in cellular morphology and the staining of their characteristic cytoplasmic granules
The cytoplasm of all granulocytes is replete with granules that are released in response to contact with pathogens.
These granules contain a variety of proteins with distinct functions:
Some damage pathogens directly;
some regulate trafficking and activity of other white blood cells, including lymphocytes
-neutrophills
-basophils
-eosinophils
-dendritic cells
-mast cells
This slide is all about the hematopoeitic stem cells its two types myeloid and lymphoid. The different types of myleoid and lymphoid cells are explained in details. All details about different White Blood Cells and their function. B cell, T cell and Natural Killer cell and their function.
Immunology is the study of the immune system and how it protects us from infection and disease123. It is a branch of biology and medicine2. Are you looking for something specific about immunology?
Leukocytes constitute the cellular components of the innate and adaptive immune system and are critical for host defense. These cells mediate acute and chronic inflammation, modulate immune responses, and protect the host against numerous pathogens.
Disorders affecting leukocytes can be divided broadly into malignant disorders (tumors of leukocytes or their progenitors) and non-malignant disorders.
The malignant disorders are uncommon but clinically important entities
Non- malignant leukocyte disorders can involve any any of the leukocytes (neutrophils, eosinophils, basophils, monocytes, B cells, T cells, and natural killer cells)
but the disorders of greatest clinical relevance affect neutrophils; these will be our major focus.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
7. Macrophages
Activated by variety of stimuli in the course of an
immune response.
Activated macrophages are more effective then
resting ones in eliminating potential pathogen.
Activated macrophages secreted various cytotoxic
proteins that help to eliminate broad range of targets
including
o virus infected cells
o Tumor cells
o Intracellular bacteria
Also act as antigen presenting cells
9. Granulocytes
Neutrophils
Polymorphonuclear (PMN) leukocyte.
Has multilobed nucleus and granulated cytoplasm.
Stains with both acidic and basic dyes.
Constitute 50% to 70% of the circulating
leukocytes.
After release in to the blood, circulates 7 –10 hours
before migrating in to the tissues.
Life span is few days. (3 days)
11. Neutrophils
First cells to arrive at the site of inflammation.
In response to many types of infections the bone
marrow releases increased number of circulating
neutrophils called leukocytosis.
Act as phagocytic cells.
GRANULOCYTES
12. Neutrophils GRANULOCYTES
Lytic enzymes and bactericidal substances in
neutrophils are contained within primary and
secondary granules.
Larger denser primary granules are a type of
lysosome containing
peroxidase, lysozyme, various hydrolytic enzymes
Smaller secondary granules contains,
collagenases, lactoferrin, lysozyme
Both primary and secondary granules fuse with
phagosomes.
14. Eosinophils
Stain with acid dye eosin red.
Has bilobed nucleus and granulated cytoplasm.
Constitute 1% to 3% of WBC population.
Like neutrophils, motile phagocytic cells that can
migrate from blood into tissues.
Phagocytic role of eosinophils are less significant
than that of neutrophils.
Play a role in the defense against parasitic organisms
by secreting contents of eosinophilic granules, which
damage the parasite membrane.
GRANULOCYTES
16. Basophils
Basophil has a lobed nucleus and heavily granulated
cytoplasm.
Stains with basic dye methylene blue.
Non phagosytic granulocyte.
Constitute <1% of circulating WBC.
Function by releasing pharmacological active
substances from cytoplasmic granules.
Play a major role in certain allergic responses.
GRANULOCYTES
18. Mast Cells
By hematopoiesis, released into the blood as
undifferentiated cells.
Do not differentiate until they leave the blood and
enter the tissues, including
skin, connecting tissue of various organs,
mucosal epithelial tissues of respiratory, genitourinary
& digestive tracts
Like circulating basophils, mast cells have large
numbers of cytoplasmic granules that contains
histamines and other pharmacological active substances.
Play an important role in the development of allergies.
21. Dendritic Cells
Activation of T cells and
initiate adaptive immunity
Found mainly in lymphoid
tissue
Function as antigen
presenting cells (APC)
Most potent stimulator of
T-cell response
23. Dendritic Cells
DC covered with long membranous extensions
that resemble the dendrites of nerve cells.
Display class I & class II MHC.
B and T lymphocytes are the mediators of
immunity, but their function is under the control
of dendritic cells.
Dendritic cells in the periphery capture and
process antigens.
24. Dendritic Cells
Express lymphocyte co-stimulatory molecules,
(B7, CD40)
Migrate to lymphoid organs and secrete
cytokines to initiate immune responses.
They not only activate lymphocytes, they also
tolerize T cells to antigens that are innate to the
body (self-antigens), thereby minimizing
autoimmune reactions.
25. Cells of the immune system:
APC
• Cells that link the innate and adaptive arms
– Antigen presenting cells (APCs)
• Heterogenous population with role in innate immunity
and activation of Th cells
• Rich in MHC class II molecules
– Examples
• Dendritic cells
• Macrophages
• B cells
• Others (Mast cells)
27. Cells of the Adaptive Immune System:
• Lymphocytes (Lymphoid Cells)
– B cells
• Plasma cells (Ab producing)
• Memory cells
– T cells
• Cytotoxic (CTL)
• Helper (Th)
– Th1
– Th2
– Null cells (NK cells)
28. Lymphoid Cells
Contributes 20-40% of body’s WBCs,
Naïve or unprimed cells are small, motile, non-
phagocytic cells.
Can not be distinguished morphologically.
Resting cells are in G0 phase of cell cycle.
Small lymphocytes are 6 um in diameter.
Cytoplasm barely covers the rim around
nucleus.
29. Lymphoid Cells
Have,
o densely packed chromatin
o few mitochondria
o poorly developed endoplasmic reticulum
o Golgi apparatus
Life span of effector cell is few days to few
weeks.
30. B-Lymphocytes
Derived its name from its site of maturation in the
Bursa of fabricius in birds and Bone marrow in humans
•Plasma cells (Ab producing)
•Memory cells
31. B-CELL RRECEPTORS
Membrane bond Ig molecules
i.e.,1.5 x 105
molecules/cell
CD 45 (Marker B220)
MHC II (Antigen Presenting
receptor)
CD35(Complement receptor)
CD21(Complement receptor)
CD32(Fc RII)ɤ
32. T-CELL RRECEPTORS
TCR
Thy 1 (1st
receptor remains
throughout life span of the cell)
CD4 (T- helper cell)
CD8 (T- cytotoxic cell)
Ratio of Th : Tc = 2:1
34. Specificity of adaptive immune
response
• Resides with Ag
Receptor on T and B
cells
• TCR and BCR – both
specific for only ONE
antigenic determinant
• TCR is monovalent
• BCR is divalent
T cell
TCR Ag
B cell
BCR
Ag
Ag
35.
36. Cytotoxic T cells (Tc) and Class I MHC proteins
The cell-cell interaction between
the infected cell and the Tc
cell is mediated by the
MHC/antigen complex and TCR
The Tc cell produces cytotoxic proteins
perforins—produce holes or pores in the
target cell and granzymes enter the
virus infected cell causing apoptosis or
programmed cell death
The cytotoxic proteins only affect those
cells to which the Tc cell has specifically
interacted
37. T helper cells and (TH) Class II MHC proteins
Specialized TH cell involved in
the inflammatory response
Cell-cell interaction mediated
by the TCR and the class II
MHC-antigen complex activates
The TH cell which produces
cytokines
TNF-alpha (tumor necrosis factor)
IFN-gamma (interferon)
GM-CSF (granulocyte-monocyte
colony stimulating factor)
These cytokines further stimulate
macrophages to increase phagocytic
activity and to in turn produce cytokines
that promote inflammation
38. NATURAL-KILLER CELLS
Fails to express membrane molecules that
distinguished B and T cells.
Fails to express antigen binding receptors.
Constitute 5% - 10% of lymphocytes in human
peripheral blood.
NK cells have ability to recognize tumor or
virus infected cells.
NK cells express membrane receptor CD16 for
a specific region of antibody molecule (ADCC).
40. Human red blood cells
(red), activated platelets
(purple) and white blood
cells - monocyte (green)
and T lymphocyte
(orange).
Colorized-SEM
(scanning electron
micrograph)
Magnification:-1200x--
(Based on an image
size of 1 inch in the
narrow dimension)
Cells of the Immune System