This document provides an overview of imaging techniques used to evaluate the large bowel and various pathologies that can affect it. It discusses anatomy, investigations like barium enema and CT colonography. Conditions covered include large bowel obstruction, colorectal tumors like polyps and adenomas, and polyposis syndromes. Imaging findings for various lesions are presented along with descriptions of features seen on barium enema, CT, and colonoscopy.
Ultrasound detection of colonic polyps Dr. Muhammad Bin Zulfiqar
In this presentation we will discuss the role of USG in the diagnosis of Colonic polyps with charecterization.
Hepatobiliary system radiology revision notesTONY SCARIA
hepatobiliary system
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Ultrasound detection of colonic polyps Dr. Muhammad Bin Zulfiqar
In this presentation we will discuss the role of USG in the diagnosis of Colonic polyps with charecterization.
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hepatobiliary system
hepatic segments
image based questions
last minute revision
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hepatic investigations
based image based questions f
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
6. • The colon is necessary for optimal absorption of nutrients,
water and electrolytes and transit and storage of residue .
• Colonic innervation is extremely complex .
• Input from the Autonomic nervous system , extra intestinal
autonomic ganglia and the enteric nervous system
• Certain sites are prone to physiological narrowing – Ileocaecal
valve .
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7. RADIOLOGICAL INVESTIGATIONS
• PLAIN FILMS : (ERECT/SUPINE)
1. Intraluminal Colonic gas is normal
2. Close temporal proximity to either sigmoidoscopy or
colonoscopy may cause excessive colonic gas – should not be
mistaken for a pathology .
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8. • BARIUM ENEMA
1. Gold standard technique for imaging fine
mucosal detail .
2. Scrupulous colon cleansing is mandatory for
high quality studies .
3. Barium suspensions are contra indicated if
there is a risk of colonic perforation .
4. A series of films are taken to image the entire
colon in double contrast .
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9. • EVACUATION PROCTOGRAPHY (DEFECOGRAPHY)
1. Images rectal configuration during evacuation of a barium
paste
2. The subject is seated upright on a specifically designed radio
opaque commode.
3. Used to investigate difficult rectal evacuation .
4. May be modified by the addition of bladder , vaginal and
small bowel contrast – the entire pelvic floor .
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10. • COLONIC TRANSIT STUDIES
1. Used to investigate severely constipated patients
2. Measurement of whole gut transit time using radio opaque
markers ,
3. Ingested and followed by an abdominal film after an appropriate
interval .
• RECTAL ULTRASOUND
1. Uses a 360⁰ rotating endoprobe
2. Obtains high resolution axial images of the rectal wall
3. Primarily used to stage tumours .
• ANAL ENDOSONOGRAPHY
1. Modified rectal endoprobe to image the anal sphincters in
patients who are anally incontinent .
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11. LARGE BOWEL OBSTRUCTION
• Acute abdominal emergency with high morbidity and
mortality rates if left untreated.
• Abdominal radiography is usually the initial imaging
study performed .
• Computed tomography is the imaging method of
choice as it can establish the diagnosis and cause of
large-bowel obstruction.
• A contrast agent enema may be used to confirm or
exclude large-bowel obstruction.
• The marked distension of colon proximal to the level of
obstruction leads to
1. Mucosal edema
2. Bowel ischemia
3. If not treated, bowel infarction and perforation.
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12. • Patients with LBO are usually elderly .
• signs and symptoms are often insidious in
contrast to the abrupt onset of symptoms
seen in most SBOs
• Abdominal pain, constipation or obstipation
and abdominal distension .
• The major sites of obstruction include the
cecum, hepatic and splenic flexures and
recto-sigmoid colon.
• Occurs more frequently within the left colon
.
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15. 6/8/2017IMAGINGOFLARGEBOWEL
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64-YEAR-OLD MAN WITH LBO CAUSED BY A COLOCOLONIC INTUSSUSCEPTION.
a) CT scout image shows air-filled dilated colon terminating abruptly in the
left upper quadrant .
(b) Coronal reformatted CT image of the abdomen and pelvis shows a
transverse colonic intussusception.
16. 6/8/2017IMAGINGOFLARGEBOWEL
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Transverse CT image of the pelvis in an 85-year-old woman with
LBO caused by distal fecal impaction. I
CT CONTRAST displayed using Lung window shows a dilated colon
and large mass of impacted stool in the rectum (arrow)..
17. COLORECTAL TUMOURS
• POLYPS
1. Macroscopic circumscribed tumour or mucosal elevation that
projects above a surrounding flat epithelial surface.
2. Polyps smaller than 5 mm diameter are most often inflammatory or
metaplastic lesions that have no malignant potential.
3. Medium (6–9 mm) and large (10 mm and more) polypoid lesions are
frequently neoplastic polyps, most often adenomas.
4. Other non-neoplastic polyps that occur in the colon are
hamartomatous polyps- found in the Peutz–Jeghers syndrome
5. Juvenile polyps may be single or multiple, and may be found in
children and adults.
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18. • Adenomatous polyps are common with the prevalence of 5–
10% in asymptomatic individuals older than 40 years of age.
• A term “ADVANCED ADENOMA” has been introduced to
emphasise the significance of polyps >10 mm diameter,
whereas small polyps (<10 mm) are frequently considered
inconsequential.
• Adenomatous polyps are SHARPLY CIRCUMSCRIBED, SESSILE
OR PEDUNCULATED LESIONS that tend to arise more
frequently in the rectosigmoid region, with a similar
distribution of carcinomas
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19. Radiologicalsignsofa polypondoublecontrastenema
(1) MENISCUS SIGN- A meniscus of barium forms around the base of
the polyp. When viewed en face, there is a ring shadow with a
sharp inner ring due to the soft tissue-barium interface and a
fuzzy outer ring due to fading of the barium peripherally.
(2) When it lies within a pool of barium, it appears as a negative filling
defect.
(3) When viewed obliquely, there is a thin meniscus of barium over its
surface creating “the bowler hat sign".
(4) If the polyp is pedunculated, a stalk is visible with a parallel tram
track of barium.
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22. • CT COLONOGRAPHY
1. Facilitates a rapid complete interrogation of the colon and
rectum.
2. The attenuation characteristics of any suspicious lesion
helps differentiate faecal residue from polyp, as variable
attenuation due to some gas content is a distinguishing
feature of residue, but a polyp has uniform attenuation
similar to the bowel wall
3. Faecal residue tends to fall onto the dependent colon
surface, whereas polyps maintain their position despite
patient movement.
4. A definitive diagnosis of a lipoma is based on its fat density
.
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24. 6/8/2017IMAGINGOFLARGEBOWEL
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1. 2D CT colonography of a polypoid lesion in the caecum .
2. On standard abdominal windowing the attenuation of this polyp is the
same as for fat, confirming a lipoma
27. ADENOMAS :
1. Benign neoplasms of colorectal epithelium .
2. Dysplastic and potentially pre malignant with increased incidence
with age .
3. Villosity and dysplasia –Most important predictors of malignancy.
4. May be (a) Tubular
(b) Tubulovillous
(c) Villous
4. Villous adenomas have characteristic morphology , being broad
and relatively large ,with a frond like surface .
5. Most adenomas are asymptomatic but large polyps may bleed or
causes electrolyte disturbance secondary to mucus secretion .
6. Malignancy is defined by Invasive adenocarcinoma – Cells penetrate
the muscularis mucosa to reach the submucosa .
7. MALIGNANT POLYP – When a focus of invasive carcinoma is found
within an excised adenoma .
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30. POLYPOSIS SYNDROMES
• Seemingly innocuous polyps that carry no risk of malignancy when
single can convey increased risk when multiple.
PEUTZ JEGHERS SYNDROME :
1. Autosomal dominant condition characterised by
mucocutaneous pigmentation and intenstinal
hamartomatous polyps .
2. Patients may suffer from repeated episodes of
intussusception .
3. The hamartomas have no intrinsic malignant potential, but
the overlying mucosa may become dysplastic- increased risk
of upper GI cancer.
4. Increased risk of extra-intestinal cancers, particularly of the
ovary, thyroid, testis, pancreas and breast.
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32. • JUVENILE POLYPOSIS
1. Very rare and presents in infancy.
2. The polyps are hamartomatous with cystic epithelial tubules in an
excess of lamina propria – the ‘Swiss cheese’ effect.
3. Typically smooth and pedunculated.
4. 50–200 polyps in the colon, with further lesions in the small bowel
and stomach.
5. Epithelial dysplasia is common in young adults, either in the
juvenile polyps or in coexisting adenomas.
6. Significant risk of colorectal cancer in this condition.
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33. • HEREDITARY NON-POLYPOSIS COLORECTAL CANCER
1. caused by a fault in the DNA mismatch repair gene and probably
accounts for 5 per cent of all colorectal cancer.
2. The criteria for this condition include
(A) three or more relatives with CRC
(B) one of these is a first-degree relative
(C) cases over two or more generations
(D) CRC diagnosed before the age of 50 years.
3. Cancers occur at an earlier age in HNPCC.
4. 70 per cent are in the proximal colon and multiple tumours are
common.
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35. • FAMILIAL ADENOMATOUS POLYPOSIS
1. Mutation of the APC tumour suppression gene on chromosome
5q21 and accounts for about 1 per cent of CRC.
2. Classically micro-adenomas develop in the early teens, becoming
macro-adenomas in the late teens.
3. More than 100 adenomas have to be present for the diagnosis, and
typically several hundred polyps are present throughout the large
bowel.
4. Rectal bleeding, diarrhoea and mucus discharge.
5. Two-thirds of symptomatic patients already have an overt cancer .
6. All affected patients eventually develop large-bowel carcinoma, so
that restorative proctocolectomy is now recommended once the
condition has been diagnosed.
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36. 6/8/2017IMAGINGOFLARGEBOWEL
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1. Double Contrast Barium
enema view of the
descending colon
2. Multiple small polyps
about 5 mm in size
creating ring shadow
menisci around their
bases, or as a filling
defect in the barium pool
38. COLORECTAL CANCER
1. Believed to arise from pre existing adenomatous polyps
2. Colorectal cancer incidence increases with age but mortality
rates have fallen over the years, probably due to poylpectomy
3. Risk of developing colorectal cancer is closely related to family
history .
4. Change in bowel habit , rectal bleeding and abdominal pain .
5. The majority of colorectal cancers are believed to arise from
sporadic adenomas ( adenoma-carcinoma sequence )
6. Adenomas are defined by dysplasia and cancer occurs when
the invasive adenocarcinoma crosses the muscularis mucosa to
reach the submucosa .
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39. 1. Surgical excision is relatively straightforward in the
colon unless the tumour is infiltrating locally.
2. The Dukes' and TNM systems both describe the
extent of tumour growth and nodal involvement.
3. Involvement of the mesorectal fascia is particularly
important when planning total mesorectal excision,
as fascial compromise necessitates pre-operative
radiotherapy to prevent local recurrence.
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44. •CT COLONOGRAPHY
1. Shows the extent of wall thickening (normal
distended colonic wall <4 mm) and extramural
infiltration.
2. With standard abdominal CT, the enhancement
within a tumour is usually homogeneous, but
may be heterogeneous with large
adenocarcinomas or mucinous tumours.
3. Extramural spread is suggested by the presence
of irregular projections from the serosal surface
into the surrounding fat, with clouding of the
pericolic fat and thickening of contiguous fascial
reflections.
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45. 1. Loss of normal fat planes is suggestive of local invasion.
2. Enhancement differentiates nodes from vessels. Nodal
enlargement may be due to reactive hyperplasia or
metastatic involvement.
3. The presence of retroperitoneal nodes or pelvic nodes
>1.0 cm in diameter, or clusters of more than three intra-
abdominal nodes, suggests metastatic involvement.
4. Ascites, peritoneal deposits and omental caking indicate
diffuse intra-peritoneal spread.
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48. 6/8/2017IMAGINGOFLARGEBOWEL
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64-year-old woman with locally advanced colon cancer presenting as palpable mass
in right upper quadrant.
A- Transverse ultrasound image shows colonic wall thickening .
B- Contrast-enhanced CT image confirms transverse colon mass with greater
nodularity along anterior mural surface and abdominal wall invasion.
51. SECONDARY CANCER
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1. Dissemination -direct invasion, along mesenteric planes, lymphatic
permeation, intraperitoneal seeding or by haematogenous spread.
2. Gastric cancer may invade the colon via the gastrocolic ligament, and
pancreatic cancer via the transverse mesocolon.
3. Ascitic flow causes tumour implantation mainly in the pelvis, loops of
small bowel in the right iliac fossa, superior border of the colon and
right paracolic gutter.
4. Peritoneal spread also involves the omentum, and omental cakes of
tumour typically involve the root of the omentum at its attachment to
the transverse colon. This is another cause of extrinsic masses
involving the transverse colon.
5. The metastases may be multiple, polypoid with a smooth surface due
to their submucosal location, and are often umbilicated as a result of
differential growth between the centre and the periphery.
55. DIVERTICULITIS
• Diverticulosis – acquired pulsion
diverticula due to the increased
colonic segmental pressure .
-Mucosal herniations through
vasular entry sites into pericolic fat
.
• Diverticulitis – Super imposed
inflammation
• Diverticular disease –
Encompasses both concepts .
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56. 1. The sigmoid colon is typically affected .
2. Muscular thickening due to elastosis ---Luminal narrowing
3. Causes progressive elastosis ----Longitudinal foreshortening
and accentuation of sigmoid corrugations .
4. Due to micro/macroperforation pericolic fibrosis and
inflammation also contribute .
5. Muscles covering the diverticula tend to atrophy as they
enlarge so that mucous membrane , connective tissue and
peritoneal tissue cover the mature diverticula .
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57. 1. The diverticula appear as flask or rounded like out pouchings
.
2. The produce ring shadows .
3. Projection beyond the bowel wall and the presence of a fluid
level within it- differentiates it from a polyp
4. Muscular change results in a serrated like appearance
5. Pronounced and persistent spasm, which reflects abnormal
motility .
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61. COMPLICATIONS
1. Diverticulitis results in pericolic abcess and localised
peritonitis .
2. Obstruction may complicate an episode of diverticulitis
and spasm may be severe enough to obiliterate the lumen.
3. Extension of the inflammation to a neighbouring viscera
may lead to FISTULATION
4. Symptoms – Pneumaturia and recurrent UTI .
5. Diverticular disease – cause of torrential and life
threatening haemorrhage in the elderly
6. Accounts for majority of Lower GI bleeds in this age group .
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62. 6/8/2017IMAGINGOFLARGEBOWEL
62FOCAL WALL THICKENING IS SEEN IN THE LEFT POSTERIOR PART OF THE
BLADDER ADJACENT TO THE INFLAMED SIGMOID (ARROW). A MODERATE
AMOUNT OF AIR IS ALSO PRESENT IN THE BLADDER, A FINDING
COMPATIBLE WITH A COLOVESICAL FISTULA.
64. COLITIS
• Describes colonic inflammation broadly divided into :
1. IDIOPATHIC
• ULCERATIVE COLITIS
• CROHN’S DISEASE
2. ISCHEMIC
3. INFECTIOUS
• HALLMARK –Mucosal inflammation and ulceration
• Contrast enemas remain the corner stone for the diagnosis .
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65. ULCERATIVE COLITIS
1. Characterised by relapsing and remitting proctitis
2. Rectum is always affected .
3. Affects young adults (15-25 ) years .
4. Attacks are characterised by bloody diarrhea
5. EXTRA INTESTINAL MANIFESTATIONS –
-Arthralgia
-Erythema Nodosum
-Pyoderma Gangrenosum
-Sclerosing Cholangitis
6. Proctoscopy and sigmoidoscopy with biopsy are essential .
7 . The changes progress through mucosal granularity and spontaneous
haemorrhage to frank, continuous ulceration .
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66. PLAIN FILMS
• In total colitis , the reliable features on air enema-
1. -Irregularity of the mucosal edge
2. -Increased thickness of the colon wall .
• In the absence of enough spontaneous intraluminal air to assess the
colonic wall, AIR ENEMA may be done .
• Plain films are used to detect ACUTE TOXIC
MEGACOLON/DILATATION ( when transverse colonic diameter >5.5
cm )
• The transverse colon is the most dilated on plain films , due to the
patients supine position .
• The mucosal line is irregular producing MUCOSAL ISLANDS.
• The colon has a consistency akin to blotting paper, so patients are at
risk of perforation and untimely death .
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68. • Proctosigmoidoscopy is 10-15% more sensitive
overall for primary diagnosis of early , distal
ulcerative colitis .
• Contrast enema – Can accurately demonstrate
colonic morphology
-Exact location and extent of any stricture can be
identified .
• Any Barium examination is acutely contraindicated
If there is evidence of toxic dilatation .
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69. RADIOLOGICAL FEATURES
1. Earliest change
- Blurring of the mucosal line and a fine granularity when mucosa is
seen en face
- Abnormal barium adherence to altered colonic mucous
- Flecks of barium adhering to superficial erosion .
2. As the disease progresses, the granularity becomes coarser and
eventually frank ulceration develops – Projections of barium
outside the mucosal line .
3. Ulceration is continuous and tends to be superficial
4. Mucosal changes are accompanied by haustral blunting , luminal
narrowing and colonic shortening .
5. A tubular , short , featureless colon is typical of long standing colitis
.
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. CT scan of a patient with long-standing ulcerative colitis
- A SUBMUCOSAL HALO OF FAT WITHIN THE RECTUM
(ARROW)
- PERIRECTAL FIBROFATTY PROLIFERATION (*).
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Transverse CT image in a 32-yearold woman with ulcerative colitis and bloody
diarrhea demonstrates the double halo, or target, sign with inner (mucosa,
arrow) and outer (muscularis propria, arrowhead) rings of high attenuation
separated by a ring of low attenuation, which represents submucosa with
edema.
73. CROHN’S DISEASE
• Chronic relapsing immune mediated inflammatory
disease, with transmural and segmental involvement of
the small bowel.
• Mouth to anus often with multiple skip discontinuous
areas.
• The most common site is the small bowel (80%), the
terminal ileum being most commonly affected site in
the small bowel.
• Approximately ¼ th will have disease limited to the
large bowel and DD from U. Colitis becomes relevant .
• Abdominal pain, diarrhoea, weight loss- frequent
• Anemia, acute obstruction,
74. First radiological changes are
granularity and aphthous
ulceration .
APHTHOUS ULCERS – Small
and discrete , surrounded by
slightly elevated edematous
mucosa .
-Barium collects in the central
depression with the surrounding
elevation appearing as a
radiolucent halo
-occur on a background of
normal mucosa .
-NEVER SEEN IN ULCERATIVE
COLITIS .
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75. • As the disease
progresses,ulcers
become longitudinal
and deeper –
TRANSMURAL
ulceration .
• Deep longitudinal ulcers
combined with mucosal
edema – COBBLESTONE
APPEARANCE .
• Discontinuous , both
longitudinally and
circumferentially
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78. ISCHEMIC COLITIS
1. The colon is particularly
vulnerable to mesenteric
ischemia .
2. Oedema , haemorrhage and
ulceration .
3. Spontaneous healing followed
by fibrosis – results in
subsequent colonic stricturing ,
4. Plain films – Splenic flexure
irregularity with mural
thickening ,
5. Characteristic edematous
THUMB PRINTING .
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SPLENIC FLEXURE “THUMB
PRINTING “
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DIFFUSE ISCHEMIC COLITIS.
• Diffuse, low-attenuation thickening of the colonic wall (arrows).
• This is an example of the halo sign.
SEGMENTAL ISCHEMIC COLITIS .
Focal thickening of two colonic loops in the left abdomen (arrows).
80. INFECTIOUS COLITIS
1. Bacterial colitis is common and imaging usually reveals non
specific pancolitis .
2. Eg’s : Campylobacter , Salmonella , Shigella , Yersinia
3. TUBERCULOSIS – morphology is similar to crohn’s disease.
-A conical , contracted caecum is characteristic ; Longitudinal and
aphthoid ulcers may occur .
4. NEUTROPENIC COLITIS (TYPHILITIS)- Occurs in
immunocompromised patients , secondary to chemotherapy and
presents with right sided inflammation .
5 . GRAFT VERSUS HOST DISEASE – Non specific colitis
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52-year-old woman with infectious colitis.
• Gray-scale ultrasound image shows concentric wall thickening and blurring of
normal mural stratification in colon.
• Power Doppler image reveals marked hyperemia in affected segment.
83. PSEUDOMEMBRANOUS
COLITIS
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Marked colonic wall thickening and mucosal
plaques
• Presents with
diffuse watery diarrhea and
abdominal
cramps.
• The rectosigmoid colon is
almost invariably involved,
with 3–8-mm in diameter,
creamy, white, elevated
plaques or nodules.
• The disease can progress to
toxic megacolon with transmural
injury..
84. • Severe cases show a markedly thickened colonic
wall with a “thumbprinting,” low attenuation from
mucosal and submucosal edema,irregular mucosal
contour with polypoid protrusions, pericolonic
stranding, and ascites
• The colonic diameter is often enlarged.
• After administration of intravenous contrast
material, the target sign may be seen with
enhanced mucosa and serosa.
• The average wall thickness is 14.7 mm.
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85. Marked wall thickening throughout the colon (thickness, 15 mm)
and pericolic inflammation.
• The thickening in the transverse colon is asymmetric
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87. THE RECTUM
• The rectum is the last segment of the
gastrointestinal tract and is bounded by the
sigmoid colon the anus.
• The proximal portion located within the
peritoneal cavity and the distal portion being
extraperitoneal.
• The inferior aspect of the rectum, or the
anorectal junction, is defined anatomically by
the dentate line, which spans 5–10 mm of the
anal canal and marks the transitional zone.
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90. RECTAL CANCER
1. 40 % of colorectal cancers occur in the rectum
2. Immobility permits accurate radiotherapy and
accessibility allows transanal local excision.
3. Rectal staging is particularly useful .
4. MRI and TRUS remain a higher modality for
investigation in comparison to CT- Able to
visualise the muscularis propria .
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• An irregular mass in the rectum with an associated enlarged perirectal lymph
node .
• Axial 2D image obtained at the level of the mid abdomen reveals
lymphadenopathy (arrows) along the course of the IMV (arrowhead).
The colon is approximately 100-200 cm long ans is distinguished from small bowel by three longitudinal muscular bands – TAENIA COLI ( OMENTALIS,MESOCOLICA, LIBERA ) – FORMS THE HAUSTRAL SACCUALTIONS
Conventionally divided into CAECUM ( INCLUDING THE APPENDIX ) , ASCENDING COLON , HEPATIC FLEXURE , TRANSVERSE COLON , SPLENIC FLEXURE , DESCENDING COLON AND SIGNMOID COLON .
The Rectum is the distal portion of the colon
Begins where the sigmoid mesocolon ends and is defined by the third sacral segment .
No haustra , instead is thrown into two or three full thickness folds , The valves of Houston .
Supplied via branches of the Internal iliac arteries and directly from the anal canal distally .
The Anal sphincter is the most complex sphincter in the human body and is closely integrated with pelvic floor function .
Two sphincter muscles surround the anal canal –
Striated external sphincter
Smooth muscle internal sphincter
The colonic arterial supply is via ileocolic ranches of the SMA ( RIGHT AND MIDDLE COLIC ARTERIES ) AND THE INFERIOR MES A ( LEFT COLIC A )
SIGMOID ARTERIES ARE ALSO BRANCHES OF THE IMA
VENOUS DRAINAGE OF THE RIGHT AND LEFT COLON IS TO THE SMV AND IMV RESPECTIVELY
Spasm at these sites misleads to the diagnosis of a stricture .
BECAUSE BARIUM PERITONITIS IS POTENTIALLY FATAL .
TAILOR THE STUDY AS THE PATHOLOGY INVOLVED .
Image showing materials and things required for defecography - barium sulfate (black arrow), rectal insufflation syringe and tube (black curved arrow), commode on foot end of table (black arrowhead
NORMAL TRANSIT TIME .
The distended ahaustral sigmoid loop assumes an inverted “U” shape with its apex under either dome. The opposed inner walls of the loops appear as a single line giving the “coffee bean” appearance .
a) CT scout image
shows DILATED, AIR-FILLED COLON TERMINATING IN MARKEDLY DILATED SIGMOID COLON FOLDED UPON ITSELF WITH ITS APEX
(THE “COFFEE BEAN SIGN”) IN THE MIDLINE UPPER ABDOMEN (BLACK ARROW). THE SIGMOID ALSO CONFORMS TO AN “UPSIDE
DOWN U” CONFIGURATION. THERE IS NO GAS IN THE RECTUM (WHITE ARROW). (b) Midline coronal reformatted CT
image of the abdomen and pelvis shows DILATED, STOOL-FILLED COLON PROXIMAL TO THE VOLVULUS (BLACK ARROW) WITH
A DISTAL “WHIRL” OF THE MESENTERY AT THE POINT OF VOLVULUS (WHITE ARROW).
Depends on the angle at which it is viewed and its relationship to the barium pool.
Magnified view of the sigmoid colon demonstrates THE MID-SIGMOID SESSILE POLYP EN FACE (ARROWHEAD)
Sessile
Pedunculated
THE RISK OF MALIGNANCY IN A 1 CM POLYP IS APPROX 10 % IF VILLOUS
Most histological types of polyp can be associated with a corresponding
polyposis syndrome, all of which are relatively uncommon
All patients whose risk of malignancy is significant require careful surveillance and
consideration for prophylactic surgery.
Although metaplastic polyps are characterised by a lack of dysplasia, the polyps in hyperplastic polyposis may contain adenocarcinoma, raising the possibility of a separate syndrome, serrated adenomatous polyposis.
Whereas isolated juvenile polyps are thought to carry no malignant risk, patients with the rarer juvenile polyposis (thought to he autosomal dominant and defined as five or
more gastrointestinal polyps) are at risk of developing associated
adenocarcinoma and require both upper and lower gastrointestinal
surveillance. The role of prophylactic colectomy remains unclear.
Peutz jeghers syndrome showing a large pedunculated polyp and a smaller sessile polyp proximally .
CHECK FOR AN IMAGE ,
Adenomatous polyposis coli gene
PATIENTS WITH AN AUTOSOMAL DOMINANY CONDITIOPN SUCH AS FAP WILL inevitably develop colorectal cancer and they account for 1% of all the cases
BARIUM ENEMA DETECTS APPROX 85 % OF COLORECTAL CANCERS .
PATIENTS WITH AN AUTOSOMAL DOMINANY CONDITIOPN SUCH AS FAP WILL inevitably develop colorectal cancer and they account for 1% of all the cases
DUKE DESCRIBED THE STAGING COMBINED BOWEL WALL PENETRATION ( MUSCULARIS MUCOSA ) AND LYMPH NODE STATUS .
Colon cancer in a 74-year-old man. Contrast
material–enhanced spiral CT scan shows luminal
NARROWING AND MARKED WALL THICKENING INVOLVING THE RIGHT SIDE OF THE TRANSVERSE COLON (ARROW). THERE IS ADJACENT
STRANDING OF THE SEROSA AND MESENTERIC FAT, A FINDING COMPATIBLE WITH LOCAL TUMOR EXTENSION.
Tumor invasion in a 72-year-old woman
with sigmoid cancer. Contrast-enhanced CT scan shows
a MASS IN THE SIGMOID COLON (ARROW) WITH INFILTRATION OF THE SURROUNDING FAT AND EXTENSION INTO THE PRESACRAL SPACE.
MULTIPLE BIZARRE STRICTURES AND MUCOSAL PLEATING in a woman
with EXTENSIVE PERITONEAL CARCINOMATOSIS from an ovarian primary
Enlarged lymph nodes in a 43-year-old
man with metastatic colon cancer. CONTRAST-ENHANCED SPIRAL CT SCAN SHOWS MULTIPLE HEPATIC METASTASES AS WELL AS ENLARGED PORTACAVAL AND AORTOCAVAL NODES (ARROWS
Pulmonary metastases in a 47-year-old
man with colon cancer. SPIRAL CT SCAN SHOWS NUMEROUS METASTASES IN THE LUNGS.
MOST PATIENTS ARE ASYMPOTOIMATIC BUT LEFT SIDED ABDOMINAL PAIN
BOUTS OF DIVERTICULITIS
WORSENING OF LEFT ILIAC FOSSA PAIN
CONSTIPATION /DIARRHEA
LEFT SIDED APPENDICITIS
Diverticulitis in a 42-year-old man with
pain and heme-positive stools. AT ENDOSCOPY, DIVERTICULITIS WAS DIAGNOSED.
wall thickening
in the SIGMOID COLON (ARROWS) WITH ADJACENT INFLAMMATORY CHANGES IN THE PERICOLIC FAT.
BECAUSE OF THE RISK OF PERFORTION , BARIUM ENEMA IS CONTRAINDICATED ACUTEL.Y . AND IF NECESSARY, WATER SOLUBLE CONTRAST CAN BE USED .
ULTTASOUND – FIRST IMAGING MODALITY
CAN REVEAL MURAL THICKENING AND PERICOLIC INFLAMMATION SEEN AS ALTERED FATTY ECHOGENICITY , INCOMPRESSIBILITY AND ABCESS .
Commonest fistualtion is COLOVESICAL between the sigmoid colon and the bladder .
Fistulas may also occur to the vagina or skin .
Colovesical fistula. CT scan obtained with
oral and intravenous contrast material shows moderate
wall thickening in the sigmoid colon (S) with adjacent
inflammatory changes and stranding of the pericolic
fat. FOCAL WALL THICKENING IS SEEN IN THE LEFT POSTERIOR
PART OF THE BLADDER ADJACENT TO THE INFLAMED SIGMOID
(ARROW). A MODERATE AMOUNT OF AIR IS ALSO PRESENT IN
THE BLADDER, A FINDING COMPATIBLE WITH A COLOVESICAL FISTULA.
SMALL COLLECTIONS OF RETAINED BARIUM ARE IDENTIFIED
CT also allows detection of other complications within diverticula.
PROXIMAL SPREAD OCCURS IN A CONTINUOUS FASHION IN APPROX TWO THIRDS OF PATIENTS, HALF OF WHOM HAVE TOTAL COLITIS AT THE TIME OF PRESENTATION .
Air enema CAN ASSESS THE COLON MORE RAPIDLY AND WITH LESS DISCOMFORT AND LESS RISK .
ULCERATION ALWAYS OCCURS AGAINST A BACKGROUND OF DIFFUSELY ABNORMAL MUCOSA .
EXTENSIVE COBBLESTONE DUE TO LINEAR ULCERATION AND MUCOSAL EDEMA .
Infectious colitis from Escherichia coli in a 52-year-old man with abdominal pain and severe bloody diarrhea.
TRANSVERSE CT IMAGE IN A 56-YEAROLD MAN WITH PSEUDOMEMBRANOUS COLITIS WHO WAS UNDERGOING ANTIBIOTIC TREATMENT FOR ENDOCARDITIS.
TRANSITIONAL ZONE : between the columnar epithelium of the gastrointestinal tract and the squamous epithelium of the anoderm and perianal skin
The rectum is accessible and relatively immobile
Rectal cancer in a 65-year-old man with
rectal bleeding. Spiral CT scan obtained with rectal
contrast material shows an ECCENTRIC RECTAL CANCER (BLACK ARROW) AS WELL AS ADJACENT NODES (WHITE ARROWS).
images show irregular wall thickening (arrows) of the rectum. Note the extension of the
mass into the perirectal fat on the right side (arrowheads in c).