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IMAGING OF THE
LARGE BOWEL
Dr.Archana Koshy
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OVERVIEW
1. Anatomy
2. Investigations
3. Large bowel obstruction .
4. Colorectal tumours
5. Diverticular disease
6. Colitis
7. Miscellaneous conditions
8. Rectum and presacral space
9. Anus
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• The colon is necessary for optimal absorption of nutrients,
water and electrolytes and transit and storage of residue .
• Colonic innervation is extremely complex .
• Input from the Autonomic nervous system , extra intestinal
autonomic ganglia and the enteric nervous system
• Certain sites are prone to physiological narrowing – Ileocaecal
valve .
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RADIOLOGICAL INVESTIGATIONS
• PLAIN FILMS : (ERECT/SUPINE)
1. Intraluminal Colonic gas is normal
2. Close temporal proximity to either sigmoidoscopy or
colonoscopy may cause excessive colonic gas – should not be
mistaken for a pathology .
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• BARIUM ENEMA
1. Gold standard technique for imaging fine
mucosal detail .
2. Scrupulous colon cleansing is mandatory for
high quality studies .
3. Barium suspensions are contra indicated if
there is a risk of colonic perforation .
4. A series of films are taken to image the entire
colon in double contrast .
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• EVACUATION PROCTOGRAPHY (DEFECOGRAPHY)
1. Images rectal configuration during evacuation of a barium
paste
2. The subject is seated upright on a specifically designed radio
opaque commode.
3. Used to investigate difficult rectal evacuation .
4. May be modified by the addition of bladder , vaginal and
small bowel contrast – the entire pelvic floor .
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• COLONIC TRANSIT STUDIES
1. Used to investigate severely constipated patients
2. Measurement of whole gut transit time using radio opaque
markers ,
3. Ingested and followed by an abdominal film after an appropriate
interval .
• RECTAL ULTRASOUND
1. Uses a 360⁰ rotating endoprobe
2. Obtains high resolution axial images of the rectal wall
3. Primarily used to stage tumours .
• ANAL ENDOSONOGRAPHY
1. Modified rectal endoprobe to image the anal sphincters in
patients who are anally incontinent .
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LARGE BOWEL OBSTRUCTION
• Acute abdominal emergency with high morbidity and
mortality rates if left untreated.
• Abdominal radiography is usually the initial imaging
study performed .
• Computed tomography is the imaging method of
choice as it can establish the diagnosis and cause of
large-bowel obstruction.
• A contrast agent enema may be used to confirm or
exclude large-bowel obstruction.
• The marked distension of colon proximal to the level of
obstruction leads to
1. Mucosal edema
2. Bowel ischemia
3. If not treated, bowel infarction and perforation.
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• Patients with LBO are usually elderly .
• signs and symptoms are often insidious in
contrast to the abrupt onset of symptoms
seen in most SBOs
• Abdominal pain, constipation or obstipation
and abdominal distension .
• The major sites of obstruction include the
cecum, hepatic and splenic flexures and
recto-sigmoid colon.
• Occurs more frequently within the left colon
.
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X-ray abdomen, supine view shows a
HUGELY DILATED LOOP arising from the
pelvis with the “COFFEE-BEAN” SIGN in
a case of SIGMOID VOLVULUS
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64-YEAR-OLD MAN WITH LBO CAUSED BY A COLOCOLONIC INTUSSUSCEPTION.
a) CT scout image shows air-filled dilated colon terminating abruptly in the
left upper quadrant .
(b) Coronal reformatted CT image of the abdomen and pelvis shows a
transverse colonic intussusception.
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Transverse CT image of the pelvis in an 85-year-old woman with
LBO caused by distal fecal impaction. I
CT CONTRAST displayed using Lung window shows a dilated colon
and large mass of impacted stool in the rectum (arrow)..
COLORECTAL TUMOURS
• POLYPS
1. Macroscopic circumscribed tumour or mucosal elevation that
projects above a surrounding flat epithelial surface.
2. Polyps smaller than 5 mm diameter are most often inflammatory or
metaplastic lesions that have no malignant potential.
3. Medium (6–9 mm) and large (10 mm and more) polypoid lesions are
frequently neoplastic polyps, most often adenomas.
4. Other non-neoplastic polyps that occur in the colon are
hamartomatous polyps- found in the Peutz–Jeghers syndrome
5. Juvenile polyps may be single or multiple, and may be found in
children and adults.
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• Adenomatous polyps are common with the prevalence of 5–
10% in asymptomatic individuals older than 40 years of age.
• A term “ADVANCED ADENOMA” has been introduced to
emphasise the significance of polyps >10 mm diameter,
whereas small polyps (<10 mm) are frequently considered
inconsequential.
• Adenomatous polyps are SHARPLY CIRCUMSCRIBED, SESSILE
OR PEDUNCULATED LESIONS that tend to arise more
frequently in the rectosigmoid region, with a similar
distribution of carcinomas
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Radiologicalsignsofa polypondoublecontrastenema
(1) MENISCUS SIGN- A meniscus of barium forms around the base of
the polyp. When viewed en face, there is a ring shadow with a
sharp inner ring due to the soft tissue-barium interface and a
fuzzy outer ring due to fading of the barium peripherally.
(2) When it lies within a pool of barium, it appears as a negative filling
defect.
(3) When viewed obliquely, there is a thin meniscus of barium over its
surface creating “the bowler hat sign".
(4) If the polyp is pedunculated, a stalk is visible with a parallel tram
track of barium.
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Small polyp where the meniscal rim of barium between the
polyp base and adjacent mucosa causes the 'bowler-hat' sign.
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WHEN SEEN EN FACE, STALKED POLYPS PRODUCE A 'TARGET'
SIGN.
• CT COLONOGRAPHY
1. Facilitates a rapid complete interrogation of the colon and
rectum.
2. The attenuation characteristics of any suspicious lesion
helps differentiate faecal residue from polyp, as variable
attenuation due to some gas content is a distinguishing
feature of residue, but a polyp has uniform attenuation
similar to the bowel wall
3. Faecal residue tends to fall onto the dependent colon
surface, whereas polyps maintain their position despite
patient movement.
4. A definitive diagnosis of a lipoma is based on its fat density
.
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CT COLONOGRAPHY OF A LARGE SIGMOID POLYP WITH
HOMOGENEOUS ATTENUATION
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1. 2D CT colonography of a polypoid lesion in the caecum .
2. On standard abdominal windowing the attenuation of this polyp is the
same as for fat, confirming a lipoma
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Magnified view of the sigmoid colon demonstrates THE MID-
SIGMOID SESSILE POLYP EN FACE .
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SESSILE PEDUNCULATED
ADENOMAS :
1. Benign neoplasms of colorectal epithelium .
2. Dysplastic and potentially pre malignant with increased incidence
with age .
3. Villosity and dysplasia –Most important predictors of malignancy.
4. May be (a) Tubular
(b) Tubulovillous
(c) Villous
4. Villous adenomas have characteristic morphology , being broad
and relatively large ,with a frond like surface .
5. Most adenomas are asymptomatic but large polyps may bleed or
causes electrolyte disturbance secondary to mucus secretion .
6. Malignancy is defined by Invasive adenocarcinoma – Cells penetrate
the muscularis mucosa to reach the submucosa .
7. MALIGNANT POLYP – When a focus of invasive carcinoma is found
within an excised adenoma .
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POLYPOSIS SYNDROMES
• Seemingly innocuous polyps that carry no risk of malignancy when
single can convey increased risk when multiple.
PEUTZ JEGHERS SYNDROME :
1. Autosomal dominant condition characterised by
mucocutaneous pigmentation and intenstinal
hamartomatous polyps .
2. Patients may suffer from repeated episodes of
intussusception .
3. The hamartomas have no intrinsic malignant potential, but
the overlying mucosa may become dysplastic- increased risk
of upper GI cancer.
4. Increased risk of extra-intestinal cancers, particularly of the
ovary, thyroid, testis, pancreas and breast.
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PEUTZ JEGHERS SYNDROME - A LARGE PEDUNCULATED POLYP AND
A SMALLER SESSILE POLYP PROXIMALLY .
• JUVENILE POLYPOSIS
1. Very rare and presents in infancy.
2. The polyps are hamartomatous with cystic epithelial tubules in an
excess of lamina propria – the ‘Swiss cheese’ effect.
3. Typically smooth and pedunculated.
4. 50–200 polyps in the colon, with further lesions in the small bowel
and stomach.
5. Epithelial dysplasia is common in young adults, either in the
juvenile polyps or in coexisting adenomas.
6. Significant risk of colorectal cancer in this condition.
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• HEREDITARY NON-POLYPOSIS COLORECTAL CANCER
1. caused by a fault in the DNA mismatch repair gene and probably
accounts for 5 per cent of all colorectal cancer.
2. The criteria for this condition include
(A) three or more relatives with CRC
(B) one of these is a first-degree relative
(C) cases over two or more generations
(D) CRC diagnosed before the age of 50 years.
3. Cancers occur at an earlier age in HNPCC.
4. 70 per cent are in the proximal colon and multiple tumours are
common.
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SMALL RING SIGN EN FACE DUE TO A 3 MM POLYP IN THE DESCENDING COLON OF A
32-YEAR-OLD WOMAN WITH HNPCC
• FAMILIAL ADENOMATOUS POLYPOSIS
1. Mutation of the APC tumour suppression gene on chromosome
5q21 and accounts for about 1 per cent of CRC.
2. Classically micro-adenomas develop in the early teens, becoming
macro-adenomas in the late teens.
3. More than 100 adenomas have to be present for the diagnosis, and
typically several hundred polyps are present throughout the large
bowel.
4. Rectal bleeding, diarrhoea and mucus discharge.
5. Two-thirds of symptomatic patients already have an overt cancer .
6. All affected patients eventually develop large-bowel carcinoma, so
that restorative proctocolectomy is now recommended once the
condition has been diagnosed.
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1. Double Contrast Barium
enema view of the
descending colon
2. Multiple small polyps
about 5 mm in size
creating ring shadow
menisci around their
bases, or as a filling
defect in the barium pool
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• Innumerable colonic adenomas.
COLORECTAL CANCER
1. Believed to arise from pre existing adenomatous polyps
2. Colorectal cancer incidence increases with age but mortality
rates have fallen over the years, probably due to poylpectomy
3. Risk of developing colorectal cancer is closely related to family
history .
4. Change in bowel habit , rectal bleeding and abdominal pain .
5. The majority of colorectal cancers are believed to arise from
sporadic adenomas ( adenoma-carcinoma sequence )
6. Adenomas are defined by dysplasia and cancer occurs when
the invasive adenocarcinoma crosses the muscularis mucosa to
reach the submucosa .
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1. Surgical excision is relatively straightforward in the
colon unless the tumour is infiltrating locally.
2. The Dukes' and TNM systems both describe the
extent of tumour growth and nodal involvement.
3. Involvement of the mesorectal fascia is particularly
important when planning total mesorectal excision,
as fascial compromise necessitates pre-operative
radiotherapy to prevent local recurrence.
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A POLYPOID CARCINOMA WITH AN IRREGULAR INDRAWN BASE
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A plaque-like carcinoma at the hepatic flexure that has a smooth surface and is
recognized in this view only by its raised edge creating a defect in the barium pool
•CT COLONOGRAPHY
1. Shows the extent of wall thickening (normal
distended colonic wall <4 mm) and extramural
infiltration.
2. With standard abdominal CT, the enhancement
within a tumour is usually homogeneous, but
may be heterogeneous with large
adenocarcinomas or mucinous tumours.
3. Extramural spread is suggested by the presence
of irregular projections from the serosal surface
into the surrounding fat, with clouding of the
pericolic fat and thickening of contiguous fascial
reflections.
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1. Loss of normal fat planes is suggestive of local invasion.
2. Enhancement differentiates nodes from vessels. Nodal
enlargement may be due to reactive hyperplasia or
metastatic involvement.
3. The presence of retroperitoneal nodes or pelvic nodes
>1.0 cm in diameter, or clusters of more than three intra-
abdominal nodes, suggests metastatic involvement.
4. Ascites, peritoneal deposits and omental caking indicate
diffuse intra-peritoneal spread.
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• Frank carcinomaappearsas anannular , irregular ,ulceratedlesion–APPLE
COREAPPEARANCE
Abrupt , shoulderedmargins
Normalmucosalfolds cannotbetracedthroughthestrictureindicating
mucosaldestruction
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Annular carcinoma revealing the irregular lumen and thickened bowel wall
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64-year-old woman with locally advanced colon cancer presenting as palpable mass
in right upper quadrant.
A- Transverse ultrasound image shows colonic wall thickening .
B- Contrast-enhanced CT image confirms transverse colon mass with greater
nodularity along anterior mural surface and abdominal wall invasion.
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SECONDARY CANCER
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1. Dissemination -direct invasion, along mesenteric planes, lymphatic
permeation, intraperitoneal seeding or by haematogenous spread.
2. Gastric cancer may invade the colon via the gastrocolic ligament, and
pancreatic cancer via the transverse mesocolon.
3. Ascitic flow causes tumour implantation mainly in the pelvis, loops of
small bowel in the right iliac fossa, superior border of the colon and
right paracolic gutter.
4. Peritoneal spread also involves the omentum, and omental cakes of
tumour typically involve the root of the omentum at its attachment to
the transverse colon. This is another cause of extrinsic masses
involving the transverse colon.
5. The metastases may be multiple, polypoid with a smooth surface due
to their submucosal location, and are often umbilicated as a result of
differential growth between the centre and the periphery.
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MULTIPLE BIZARRE STRICTURES AND MUCOSAL PLEATING IN A WOMAN
WITH EXTENSIVE PERITONEAL CARCINOMATOSIS FROM AN OVARIAN PRIMARY
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53ENLARGED LYMPH NODES IN A 43-YEAR-OLD MAN WITH METASTATIC COLON
CANCER.
MULTIPLE HEPATIC METASTASES AS WELL AS ENLARGED PORTACAVAL AND
AORTOCAVAL NODES .
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54PULMONARY METASTASES IN A 47-YEAR-OLD MAN WITH COLON
CANCER.
SPIRAL CT SCAN SHOWS NUMEROUS METASTASES IN THE LUNGS.
DIVERTICULITIS
• Diverticulosis – acquired pulsion
diverticula due to the increased
colonic segmental pressure .
-Mucosal herniations through
vasular entry sites into pericolic fat
.
• Diverticulitis – Super imposed
inflammation
• Diverticular disease –
Encompasses both concepts .
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1. The sigmoid colon is typically affected .
2. Muscular thickening due to elastosis ---Luminal narrowing
3. Causes progressive elastosis ----Longitudinal foreshortening
and accentuation of sigmoid corrugations .
4. Due to micro/macroperforation pericolic fibrosis and
inflammation also contribute .
5. Muscles covering the diverticula tend to atrophy as they
enlarge so that mucous membrane , connective tissue and
peritoneal tissue cover the mature diverticula .
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1. The diverticula appear as flask or rounded like out pouchings
.
2. The produce ring shadows .
3. Projection beyond the bowel wall and the presence of a fluid
level within it- differentiates it from a polyp
4. Muscular change results in a serrated like appearance
5. Pronounced and persistent spasm, which reflects abnormal
motility .
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BARIUM ENEMA- SEVERE SIGMOID DIVERTICULAR DISEASE
WITH A COMPLICATING FISTULA TO THE VAGINA
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FOCAL, MASSLIKE THICKENING OF THE SIGMOID COLON (STRAIGHT ARROWS)
WITH ADJACENT STRANDING OF THE PERICOLIC FAT MINIMAL ADJACENT
MESENTERIC FLUID (CURVED ARROW) FAVORED DIVERTICULITIS.
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WALL THICKENING IN THE SIGMOID COLON (ARROWS) WITH ADJACENT
INFLAMMATORY CHANGES IN THE PERICOLIC FAT.
COMPLICATIONS
1. Diverticulitis results in pericolic abcess and localised
peritonitis .
2. Obstruction may complicate an episode of diverticulitis
and spasm may be severe enough to obiliterate the lumen.
3. Extension of the inflammation to a neighbouring viscera
may lead to FISTULATION
4. Symptoms – Pneumaturia and recurrent UTI .
5. Diverticular disease – cause of torrential and life
threatening haemorrhage in the elderly
6. Accounts for majority of Lower GI bleeds in this age group .
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62FOCAL WALL THICKENING IS SEEN IN THE LEFT POSTERIOR PART OF THE
BLADDER ADJACENT TO THE INFLAMED SIGMOID (ARROW). A MODERATE
AMOUNT OF AIR IS ALSO PRESENT IN THE BLADDER, A FINDING
COMPATIBLE WITH A COLOVESICAL FISTULA.
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CT WAS USED TO PLACE A PERCUTANEOUS DRAIN INTO THIS
LARGE PARACOLIC COLLECTION SECONDARY TO DIVERTICULAR
DISEASE.
COLITIS
• Describes colonic inflammation broadly divided into :
1. IDIOPATHIC
• ULCERATIVE COLITIS
• CROHN’S DISEASE
2. ISCHEMIC
3. INFECTIOUS
• HALLMARK –Mucosal inflammation and ulceration
• Contrast enemas remain the corner stone for the diagnosis .
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ULCERATIVE COLITIS
1. Characterised by relapsing and remitting proctitis
2. Rectum is always affected .
3. Affects young adults (15-25 ) years .
4. Attacks are characterised by bloody diarrhea
5. EXTRA INTESTINAL MANIFESTATIONS –
-Arthralgia
-Erythema Nodosum
-Pyoderma Gangrenosum
-Sclerosing Cholangitis
6. Proctoscopy and sigmoidoscopy with biopsy are essential .
7 . The changes progress through mucosal granularity and spontaneous
haemorrhage to frank, continuous ulceration .
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PLAIN FILMS
• In total colitis , the reliable features on air enema-
1. -Irregularity of the mucosal edge
2. -Increased thickness of the colon wall .
• In the absence of enough spontaneous intraluminal air to assess the
colonic wall, AIR ENEMA may be done .
• Plain films are used to detect ACUTE TOXIC
MEGACOLON/DILATATION ( when transverse colonic diameter >5.5
cm )
• The transverse colon is the most dilated on plain films , due to the
patients supine position .
• The mucosal line is irregular producing MUCOSAL ISLANDS.
• The colon has a consistency akin to blotting paper, so patients are at
risk of perforation and untimely death .
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TOXIC MEGACOLON – LUMINAL DILATATION , ABNORMAL
HAUSTRATION WITH MURAL THICKENING .
• Proctosigmoidoscopy is 10-15% more sensitive
overall for primary diagnosis of early , distal
ulcerative colitis .
• Contrast enema – Can accurately demonstrate
colonic morphology
-Exact location and extent of any stricture can be
identified .
• Any Barium examination is acutely contraindicated
If there is evidence of toxic dilatation .
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RADIOLOGICAL FEATURES
1. Earliest change
- Blurring of the mucosal line and a fine granularity when mucosa is
seen en face
- Abnormal barium adherence to altered colonic mucous
- Flecks of barium adhering to superficial erosion .
2. As the disease progresses, the granularity becomes coarser and
eventually frank ulceration develops – Projections of barium
outside the mucosal line .
3. Ulceration is continuous and tends to be superficial
4. Mucosal changes are accompanied by haustral blunting , luminal
narrowing and colonic shortening .
5. A tubular , short , featureless colon is typical of long standing colitis
.
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. CT scan of a patient with long-standing ulcerative colitis
- A SUBMUCOSAL HALO OF FAT WITHIN THE RECTUM
(ARROW)
- PERIRECTAL FIBROFATTY PROLIFERATION (*).
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Transverse CT image in a 32-yearold woman with ulcerative colitis and bloody
diarrhea demonstrates the double halo, or target, sign with inner (mucosa,
arrow) and outer (muscularis propria, arrowhead) rings of high attenuation
separated by a ring of low attenuation, which represents submucosa with
edema.
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72TRANSVERSE CT IMAGE IN A 35-YEAROLD PATIENT WITH ULCERATIVE COLITIS
AND TOXIC MEGACOLON SHOWS MARKEDLY DISTENDED TRANSVERSE COLON
WITH SHAGGY MUCOSA (ARROWS).
CROHN’S DISEASE
• Chronic relapsing immune mediated inflammatory
disease, with transmural and segmental involvement of
the small bowel.
• Mouth to anus often with multiple skip discontinuous
areas.
• The most common site is the small bowel (80%), the
terminal ileum being most commonly affected site in
the small bowel.
• Approximately ¼ th will have disease limited to the
large bowel and DD from U. Colitis becomes relevant .
• Abdominal pain, diarrhoea, weight loss- frequent
• Anemia, acute obstruction,
First radiological changes are
granularity and aphthous
ulceration .
APHTHOUS ULCERS – Small
and discrete , surrounded by
slightly elevated edematous
mucosa .
-Barium collects in the central
depression with the surrounding
elevation appearing as a
radiolucent halo
-occur on a background of
normal mucosa .
-NEVER SEEN IN ULCERATIVE
COLITIS .
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• As the disease
progresses,ulcers
become longitudinal
and deeper –
TRANSMURAL
ulceration .
• Deep longitudinal ulcers
combined with mucosal
edema – COBBLESTONE
APPEARANCE .
• Discontinuous , both
longitudinally and
circumferentially
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CONTRACTION AT THE SITE OF ULCER FORMATION –
PSEUDODIVERTICULA
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US IMAGE OF THE TERMINAL ILEUM-THICKENED (ARROW) WITH THICK,
ECHOGENIC SUBMUCOSA RELATED TO LYMPHEDEMA
ISCHEMIC COLITIS
1. The colon is particularly
vulnerable to mesenteric
ischemia .
2. Oedema , haemorrhage and
ulceration .
3. Spontaneous healing followed
by fibrosis – results in
subsequent colonic stricturing ,
4. Plain films – Splenic flexure
irregularity with mural
thickening ,
5. Characteristic edematous
THUMB PRINTING .
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SPLENIC FLEXURE “THUMB
PRINTING “
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DIFFUSE ISCHEMIC COLITIS.
• Diffuse, low-attenuation thickening of the colonic wall (arrows).
• This is an example of the halo sign.
SEGMENTAL ISCHEMIC COLITIS .
Focal thickening of two colonic loops in the left abdomen (arrows).
INFECTIOUS COLITIS
1. Bacterial colitis is common and imaging usually reveals non
specific pancolitis .
2. Eg’s : Campylobacter , Salmonella , Shigella , Yersinia
3. TUBERCULOSIS – morphology is similar to crohn’s disease.
-A conical , contracted caecum is characteristic ; Longitudinal and
aphthoid ulcers may occur .
4. NEUTROPENIC COLITIS (TYPHILITIS)- Occurs in
immunocompromised patients , secondary to chemotherapy and
presents with right sided inflammation .
5 . GRAFT VERSUS HOST DISEASE – Non specific colitis
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MODERATE THICKENING OF THE COLON (ARROWS) AND INFLAMMATORY CHANGES
IN THE MESENTERIC FAT. E COLI WAS CULTURED FROM STOOL
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52-year-old woman with infectious colitis.
• Gray-scale ultrasound image shows concentric wall thickening and blurring of
normal mural stratification in colon.
• Power Doppler image reveals marked hyperemia in affected segment.
PSEUDOMEMBRANOUS
COLITIS
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Marked colonic wall thickening and mucosal
plaques
• Presents with
diffuse watery diarrhea and
abdominal
cramps.
• The rectosigmoid colon is
almost invariably involved,
with 3–8-mm in diameter,
creamy, white, elevated
plaques or nodules.
• The disease can progress to
toxic megacolon with transmural
injury..
• Severe cases show a markedly thickened colonic
wall with a “thumbprinting,” low attenuation from
mucosal and submucosal edema,irregular mucosal
contour with polypoid protrusions, pericolonic
stranding, and ascites
• The colonic diameter is often enlarged.
• After administration of intravenous contrast
material, the target sign may be seen with
enhanced mucosa and serosa.
• The average wall thickness is 14.7 mm.
6/8/2017IMAGINGOFLARGEBOWEL
84
Marked wall thickening throughout the colon (thickness, 15 mm)
and pericolic inflammation.
• The thickening in the transverse colon is asymmetric
6/8/2017IMAGINGOFLARGEBOWEL
85
6/8/2017IMAGINGOFLARGEBOWEL
86
. IN THE SIGMOID COLON, A SHAGGY THICKENED BOWEL WALL WITH
ALTERNATING AREAS OF NECROSIS AND PLAQUES.
THE RECTUM
• The rectum is the last segment of the
gastrointestinal tract and is bounded by the
sigmoid colon the anus.
• The proximal portion located within the
peritoneal cavity and the distal portion being
extraperitoneal.
• The inferior aspect of the rectum, or the
anorectal junction, is defined anatomically by
the dentate line, which spans 5–10 mm of the
anal canal and marks the transitional zone.
6/8/2017IMAGINGOFLARGEBOWEL
87
6/8/2017IMAGINGOFLARGEBOWEL
88
6/8/2017IMAGINGOFLARGEBOWEL
89
RECTAL CANCER
1. 40 % of colorectal cancers occur in the rectum
2. Immobility permits accurate radiotherapy and
accessibility allows transanal local excision.
3. Rectal staging is particularly useful .
4. MRI and TRUS remain a higher modality for
investigation in comparison to CT- Able to
visualise the muscularis propria .
6/8/2017IMAGINGOFLARGEBOWEL
90
6/8/2017IMAGINGOFLARGEBOWEL
91
6/8/2017IMAGINGOFLARGEBOWEL
92
6/8/2017IMAGINGOFLARGEBOWEL
93
• An irregular mass in the rectum with an associated enlarged perirectal lymph
node .
• Axial 2D image obtained at the level of the mid abdomen reveals
lymphadenopathy (arrows) along the course of the IMV (arrowhead).
6/8/2017IMAGINGOFLARGEBOWEL
94

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  • 1. IMAGING OF THE LARGE BOWEL Dr.Archana Koshy 6/8/2017IMAGINGOFLARGEBOWEL 1
  • 2. OVERVIEW 1. Anatomy 2. Investigations 3. Large bowel obstruction . 4. Colorectal tumours 5. Diverticular disease 6. Colitis 7. Miscellaneous conditions 8. Rectum and presacral space 9. Anus 6/8/2017IMAGINGOFLARGEBOWEL 2
  • 6. • The colon is necessary for optimal absorption of nutrients, water and electrolytes and transit and storage of residue . • Colonic innervation is extremely complex . • Input from the Autonomic nervous system , extra intestinal autonomic ganglia and the enteric nervous system • Certain sites are prone to physiological narrowing – Ileocaecal valve . 6/8/2017IMAGINGOFLARGEBOWEL 6
  • 7. RADIOLOGICAL INVESTIGATIONS • PLAIN FILMS : (ERECT/SUPINE) 1. Intraluminal Colonic gas is normal 2. Close temporal proximity to either sigmoidoscopy or colonoscopy may cause excessive colonic gas – should not be mistaken for a pathology . 6/8/2017IMAGINGOFLARGEBOWEL 7
  • 8. • BARIUM ENEMA 1. Gold standard technique for imaging fine mucosal detail . 2. Scrupulous colon cleansing is mandatory for high quality studies . 3. Barium suspensions are contra indicated if there is a risk of colonic perforation . 4. A series of films are taken to image the entire colon in double contrast . 6/8/2017IMAGINGOFLARGEBOWEL 8
  • 9. • EVACUATION PROCTOGRAPHY (DEFECOGRAPHY) 1. Images rectal configuration during evacuation of a barium paste 2. The subject is seated upright on a specifically designed radio opaque commode. 3. Used to investigate difficult rectal evacuation . 4. May be modified by the addition of bladder , vaginal and small bowel contrast – the entire pelvic floor . 6/8/2017IMAGINGOFLARGEBOWEL 9
  • 10. • COLONIC TRANSIT STUDIES 1. Used to investigate severely constipated patients 2. Measurement of whole gut transit time using radio opaque markers , 3. Ingested and followed by an abdominal film after an appropriate interval . • RECTAL ULTRASOUND 1. Uses a 360⁰ rotating endoprobe 2. Obtains high resolution axial images of the rectal wall 3. Primarily used to stage tumours . • ANAL ENDOSONOGRAPHY 1. Modified rectal endoprobe to image the anal sphincters in patients who are anally incontinent . 6/8/2017IMAGINGOFLARGEBOWEL 10
  • 11. LARGE BOWEL OBSTRUCTION • Acute abdominal emergency with high morbidity and mortality rates if left untreated. • Abdominal radiography is usually the initial imaging study performed . • Computed tomography is the imaging method of choice as it can establish the diagnosis and cause of large-bowel obstruction. • A contrast agent enema may be used to confirm or exclude large-bowel obstruction. • The marked distension of colon proximal to the level of obstruction leads to 1. Mucosal edema 2. Bowel ischemia 3. If not treated, bowel infarction and perforation. 6/8/2017IMAGINGOFLARGEBOWEL 11
  • 12. • Patients with LBO are usually elderly . • signs and symptoms are often insidious in contrast to the abrupt onset of symptoms seen in most SBOs • Abdominal pain, constipation or obstipation and abdominal distension . • The major sites of obstruction include the cecum, hepatic and splenic flexures and recto-sigmoid colon. • Occurs more frequently within the left colon . 6/8/2017IMAGINGOFLARGEBOWEL 12
  • 14. 6/8/2017IMAGINGOFLARGEBOWEL 14 X-ray abdomen, supine view shows a HUGELY DILATED LOOP arising from the pelvis with the “COFFEE-BEAN” SIGN in a case of SIGMOID VOLVULUS
  • 15. 6/8/2017IMAGINGOFLARGEBOWEL 15 64-YEAR-OLD MAN WITH LBO CAUSED BY A COLOCOLONIC INTUSSUSCEPTION. a) CT scout image shows air-filled dilated colon terminating abruptly in the left upper quadrant . (b) Coronal reformatted CT image of the abdomen and pelvis shows a transverse colonic intussusception.
  • 16. 6/8/2017IMAGINGOFLARGEBOWEL 16 Transverse CT image of the pelvis in an 85-year-old woman with LBO caused by distal fecal impaction. I CT CONTRAST displayed using Lung window shows a dilated colon and large mass of impacted stool in the rectum (arrow)..
  • 17. COLORECTAL TUMOURS • POLYPS 1. Macroscopic circumscribed tumour or mucosal elevation that projects above a surrounding flat epithelial surface. 2. Polyps smaller than 5 mm diameter are most often inflammatory or metaplastic lesions that have no malignant potential. 3. Medium (6–9 mm) and large (10 mm and more) polypoid lesions are frequently neoplastic polyps, most often adenomas. 4. Other non-neoplastic polyps that occur in the colon are hamartomatous polyps- found in the Peutz–Jeghers syndrome 5. Juvenile polyps may be single or multiple, and may be found in children and adults. 6/8/2017IMAGINGOFLARGEBOWEL 17
  • 18. • Adenomatous polyps are common with the prevalence of 5– 10% in asymptomatic individuals older than 40 years of age. • A term “ADVANCED ADENOMA” has been introduced to emphasise the significance of polyps >10 mm diameter, whereas small polyps (<10 mm) are frequently considered inconsequential. • Adenomatous polyps are SHARPLY CIRCUMSCRIBED, SESSILE OR PEDUNCULATED LESIONS that tend to arise more frequently in the rectosigmoid region, with a similar distribution of carcinomas 6/8/2017IMAGINGOFLARGEBOWEL 18
  • 19. Radiologicalsignsofa polypondoublecontrastenema (1) MENISCUS SIGN- A meniscus of barium forms around the base of the polyp. When viewed en face, there is a ring shadow with a sharp inner ring due to the soft tissue-barium interface and a fuzzy outer ring due to fading of the barium peripherally. (2) When it lies within a pool of barium, it appears as a negative filling defect. (3) When viewed obliquely, there is a thin meniscus of barium over its surface creating “the bowler hat sign". (4) If the polyp is pedunculated, a stalk is visible with a parallel tram track of barium. 6/8/2017IMAGINGOFLARGEBOWEL 19
  • 20. 6/8/2017IMAGINGOFLARGEBOWEL 20 Small polyp where the meniscal rim of barium between the polyp base and adjacent mucosa causes the 'bowler-hat' sign.
  • 21. 6/8/2017IMAGINGOFLARGEBOWEL 21 WHEN SEEN EN FACE, STALKED POLYPS PRODUCE A 'TARGET' SIGN.
  • 22. • CT COLONOGRAPHY 1. Facilitates a rapid complete interrogation of the colon and rectum. 2. The attenuation characteristics of any suspicious lesion helps differentiate faecal residue from polyp, as variable attenuation due to some gas content is a distinguishing feature of residue, but a polyp has uniform attenuation similar to the bowel wall 3. Faecal residue tends to fall onto the dependent colon surface, whereas polyps maintain their position despite patient movement. 4. A definitive diagnosis of a lipoma is based on its fat density . 6/8/2017IMAGINGOFLARGEBOWEL 22
  • 23. 6/8/2017IMAGINGOFLARGEBOWEL 23 CT COLONOGRAPHY OF A LARGE SIGMOID POLYP WITH HOMOGENEOUS ATTENUATION
  • 24. 6/8/2017IMAGINGOFLARGEBOWEL 24 1. 2D CT colonography of a polypoid lesion in the caecum . 2. On standard abdominal windowing the attenuation of this polyp is the same as for fat, confirming a lipoma
  • 25. 6/8/2017IMAGINGOFLARGEBOWEL 25 Magnified view of the sigmoid colon demonstrates THE MID- SIGMOID SESSILE POLYP EN FACE .
  • 27. ADENOMAS : 1. Benign neoplasms of colorectal epithelium . 2. Dysplastic and potentially pre malignant with increased incidence with age . 3. Villosity and dysplasia –Most important predictors of malignancy. 4. May be (a) Tubular (b) Tubulovillous (c) Villous 4. Villous adenomas have characteristic morphology , being broad and relatively large ,with a frond like surface . 5. Most adenomas are asymptomatic but large polyps may bleed or causes electrolyte disturbance secondary to mucus secretion . 6. Malignancy is defined by Invasive adenocarcinoma – Cells penetrate the muscularis mucosa to reach the submucosa . 7. MALIGNANT POLYP – When a focus of invasive carcinoma is found within an excised adenoma . 6/8/2017IMAGINGOFLARGEBOWEL 27
  • 30. POLYPOSIS SYNDROMES • Seemingly innocuous polyps that carry no risk of malignancy when single can convey increased risk when multiple. PEUTZ JEGHERS SYNDROME : 1. Autosomal dominant condition characterised by mucocutaneous pigmentation and intenstinal hamartomatous polyps . 2. Patients may suffer from repeated episodes of intussusception . 3. The hamartomas have no intrinsic malignant potential, but the overlying mucosa may become dysplastic- increased risk of upper GI cancer. 4. Increased risk of extra-intestinal cancers, particularly of the ovary, thyroid, testis, pancreas and breast. 6/8/2017IMAGINGOFLARGEBOWEL 30
  • 31. 6/8/2017IMAGINGOFLARGEBOWEL 31 PEUTZ JEGHERS SYNDROME - A LARGE PEDUNCULATED POLYP AND A SMALLER SESSILE POLYP PROXIMALLY .
  • 32. • JUVENILE POLYPOSIS 1. Very rare and presents in infancy. 2. The polyps are hamartomatous with cystic epithelial tubules in an excess of lamina propria – the ‘Swiss cheese’ effect. 3. Typically smooth and pedunculated. 4. 50–200 polyps in the colon, with further lesions in the small bowel and stomach. 5. Epithelial dysplasia is common in young adults, either in the juvenile polyps or in coexisting adenomas. 6. Significant risk of colorectal cancer in this condition. 6/8/2017IMAGINGOFLARGEBOWEL 32
  • 33. • HEREDITARY NON-POLYPOSIS COLORECTAL CANCER 1. caused by a fault in the DNA mismatch repair gene and probably accounts for 5 per cent of all colorectal cancer. 2. The criteria for this condition include (A) three or more relatives with CRC (B) one of these is a first-degree relative (C) cases over two or more generations (D) CRC diagnosed before the age of 50 years. 3. Cancers occur at an earlier age in HNPCC. 4. 70 per cent are in the proximal colon and multiple tumours are common. 6/8/2017IMAGINGOFLARGEBOWEL 33
  • 34. 6/8/2017IMAGINGOFLARGEBOWEL 34 SMALL RING SIGN EN FACE DUE TO A 3 MM POLYP IN THE DESCENDING COLON OF A 32-YEAR-OLD WOMAN WITH HNPCC
  • 35. • FAMILIAL ADENOMATOUS POLYPOSIS 1. Mutation of the APC tumour suppression gene on chromosome 5q21 and accounts for about 1 per cent of CRC. 2. Classically micro-adenomas develop in the early teens, becoming macro-adenomas in the late teens. 3. More than 100 adenomas have to be present for the diagnosis, and typically several hundred polyps are present throughout the large bowel. 4. Rectal bleeding, diarrhoea and mucus discharge. 5. Two-thirds of symptomatic patients already have an overt cancer . 6. All affected patients eventually develop large-bowel carcinoma, so that restorative proctocolectomy is now recommended once the condition has been diagnosed. 6/8/2017IMAGINGOFLARGEBOWEL 35
  • 36. 6/8/2017IMAGINGOFLARGEBOWEL 36 1. Double Contrast Barium enema view of the descending colon 2. Multiple small polyps about 5 mm in size creating ring shadow menisci around their bases, or as a filling defect in the barium pool
  • 38. COLORECTAL CANCER 1. Believed to arise from pre existing adenomatous polyps 2. Colorectal cancer incidence increases with age but mortality rates have fallen over the years, probably due to poylpectomy 3. Risk of developing colorectal cancer is closely related to family history . 4. Change in bowel habit , rectal bleeding and abdominal pain . 5. The majority of colorectal cancers are believed to arise from sporadic adenomas ( adenoma-carcinoma sequence ) 6. Adenomas are defined by dysplasia and cancer occurs when the invasive adenocarcinoma crosses the muscularis mucosa to reach the submucosa . 6/8/2017IMAGINGOFLARGEBOWEL 38
  • 39. 1. Surgical excision is relatively straightforward in the colon unless the tumour is infiltrating locally. 2. The Dukes' and TNM systems both describe the extent of tumour growth and nodal involvement. 3. Involvement of the mesorectal fascia is particularly important when planning total mesorectal excision, as fascial compromise necessitates pre-operative radiotherapy to prevent local recurrence. 6/8/2017IMAGINGOFLARGEBOWEL 39
  • 42. 6/8/2017IMAGINGOFLARGEBOWEL 42 A POLYPOID CARCINOMA WITH AN IRREGULAR INDRAWN BASE
  • 43. 6/8/2017IMAGINGOFLARGEBOWEL 43 A plaque-like carcinoma at the hepatic flexure that has a smooth surface and is recognized in this view only by its raised edge creating a defect in the barium pool
  • 44. •CT COLONOGRAPHY 1. Shows the extent of wall thickening (normal distended colonic wall <4 mm) and extramural infiltration. 2. With standard abdominal CT, the enhancement within a tumour is usually homogeneous, but may be heterogeneous with large adenocarcinomas or mucinous tumours. 3. Extramural spread is suggested by the presence of irregular projections from the serosal surface into the surrounding fat, with clouding of the pericolic fat and thickening of contiguous fascial reflections. 6/8/2017IMAGINGOFLARGEBOWEL 44
  • 45. 1. Loss of normal fat planes is suggestive of local invasion. 2. Enhancement differentiates nodes from vessels. Nodal enlargement may be due to reactive hyperplasia or metastatic involvement. 3. The presence of retroperitoneal nodes or pelvic nodes >1.0 cm in diameter, or clusters of more than three intra- abdominal nodes, suggests metastatic involvement. 4. Ascites, peritoneal deposits and omental caking indicate diffuse intra-peritoneal spread. 6/8/2017IMAGINGOFLARGEBOWEL 45
  • 46. • Frank carcinomaappearsas anannular , irregular ,ulceratedlesion–APPLE COREAPPEARANCE Abrupt , shoulderedmargins Normalmucosalfolds cannotbetracedthroughthestrictureindicating mucosaldestruction 6/8/2017IMAGINGOFLARGEBOWEL 46
  • 47. 6/8/2017IMAGINGOFLARGEBOWEL 47 Annular carcinoma revealing the irregular lumen and thickened bowel wall
  • 48. 6/8/2017IMAGINGOFLARGEBOWEL 48 64-year-old woman with locally advanced colon cancer presenting as palpable mass in right upper quadrant. A- Transverse ultrasound image shows colonic wall thickening . B- Contrast-enhanced CT image confirms transverse colon mass with greater nodularity along anterior mural surface and abdominal wall invasion.
  • 51. SECONDARY CANCER 6/8/2017IMAGINGOFLARGEBOWEL 51 1. Dissemination -direct invasion, along mesenteric planes, lymphatic permeation, intraperitoneal seeding or by haematogenous spread. 2. Gastric cancer may invade the colon via the gastrocolic ligament, and pancreatic cancer via the transverse mesocolon. 3. Ascitic flow causes tumour implantation mainly in the pelvis, loops of small bowel in the right iliac fossa, superior border of the colon and right paracolic gutter. 4. Peritoneal spread also involves the omentum, and omental cakes of tumour typically involve the root of the omentum at its attachment to the transverse colon. This is another cause of extrinsic masses involving the transverse colon. 5. The metastases may be multiple, polypoid with a smooth surface due to their submucosal location, and are often umbilicated as a result of differential growth between the centre and the periphery.
  • 52. 6/8/2017IMAGINGOFLARGEBOWEL 52 MULTIPLE BIZARRE STRICTURES AND MUCOSAL PLEATING IN A WOMAN WITH EXTENSIVE PERITONEAL CARCINOMATOSIS FROM AN OVARIAN PRIMARY
  • 53. 6/8/2017IMAGINGOFLARGEBOWEL 53ENLARGED LYMPH NODES IN A 43-YEAR-OLD MAN WITH METASTATIC COLON CANCER. MULTIPLE HEPATIC METASTASES AS WELL AS ENLARGED PORTACAVAL AND AORTOCAVAL NODES .
  • 54. 6/8/2017IMAGINGOFLARGEBOWEL 54PULMONARY METASTASES IN A 47-YEAR-OLD MAN WITH COLON CANCER. SPIRAL CT SCAN SHOWS NUMEROUS METASTASES IN THE LUNGS.
  • 55. DIVERTICULITIS • Diverticulosis – acquired pulsion diverticula due to the increased colonic segmental pressure . -Mucosal herniations through vasular entry sites into pericolic fat . • Diverticulitis – Super imposed inflammation • Diverticular disease – Encompasses both concepts . 6/8/2017IMAGINGOFLARGEBOWEL 55
  • 56. 1. The sigmoid colon is typically affected . 2. Muscular thickening due to elastosis ---Luminal narrowing 3. Causes progressive elastosis ----Longitudinal foreshortening and accentuation of sigmoid corrugations . 4. Due to micro/macroperforation pericolic fibrosis and inflammation also contribute . 5. Muscles covering the diverticula tend to atrophy as they enlarge so that mucous membrane , connective tissue and peritoneal tissue cover the mature diverticula . 6/8/2017IMAGINGOFLARGEBOWEL 56
  • 57. 1. The diverticula appear as flask or rounded like out pouchings . 2. The produce ring shadows . 3. Projection beyond the bowel wall and the presence of a fluid level within it- differentiates it from a polyp 4. Muscular change results in a serrated like appearance 5. Pronounced and persistent spasm, which reflects abnormal motility . 6/8/2017IMAGINGOFLARGEBOWEL 57
  • 58. 6/8/2017IMAGINGOFLARGEBOWEL 58 BARIUM ENEMA- SEVERE SIGMOID DIVERTICULAR DISEASE WITH A COMPLICATING FISTULA TO THE VAGINA
  • 59. 6/8/2017IMAGINGOFLARGEBOWEL 59 FOCAL, MASSLIKE THICKENING OF THE SIGMOID COLON (STRAIGHT ARROWS) WITH ADJACENT STRANDING OF THE PERICOLIC FAT MINIMAL ADJACENT MESENTERIC FLUID (CURVED ARROW) FAVORED DIVERTICULITIS.
  • 60. 6/8/2017IMAGINGOFLARGEBOWEL 60 WALL THICKENING IN THE SIGMOID COLON (ARROWS) WITH ADJACENT INFLAMMATORY CHANGES IN THE PERICOLIC FAT.
  • 61. COMPLICATIONS 1. Diverticulitis results in pericolic abcess and localised peritonitis . 2. Obstruction may complicate an episode of diverticulitis and spasm may be severe enough to obiliterate the lumen. 3. Extension of the inflammation to a neighbouring viscera may lead to FISTULATION 4. Symptoms – Pneumaturia and recurrent UTI . 5. Diverticular disease – cause of torrential and life threatening haemorrhage in the elderly 6. Accounts for majority of Lower GI bleeds in this age group . 6/8/2017IMAGINGOFLARGEBOWEL 61
  • 62. 6/8/2017IMAGINGOFLARGEBOWEL 62FOCAL WALL THICKENING IS SEEN IN THE LEFT POSTERIOR PART OF THE BLADDER ADJACENT TO THE INFLAMED SIGMOID (ARROW). A MODERATE AMOUNT OF AIR IS ALSO PRESENT IN THE BLADDER, A FINDING COMPATIBLE WITH A COLOVESICAL FISTULA.
  • 63. 6/8/2017IMAGINGOFLARGEBOWEL 63 CT WAS USED TO PLACE A PERCUTANEOUS DRAIN INTO THIS LARGE PARACOLIC COLLECTION SECONDARY TO DIVERTICULAR DISEASE.
  • 64. COLITIS • Describes colonic inflammation broadly divided into : 1. IDIOPATHIC • ULCERATIVE COLITIS • CROHN’S DISEASE 2. ISCHEMIC 3. INFECTIOUS • HALLMARK –Mucosal inflammation and ulceration • Contrast enemas remain the corner stone for the diagnosis . 6/8/2017IMAGINGOFLARGEBOWEL 64
  • 65. ULCERATIVE COLITIS 1. Characterised by relapsing and remitting proctitis 2. Rectum is always affected . 3. Affects young adults (15-25 ) years . 4. Attacks are characterised by bloody diarrhea 5. EXTRA INTESTINAL MANIFESTATIONS – -Arthralgia -Erythema Nodosum -Pyoderma Gangrenosum -Sclerosing Cholangitis 6. Proctoscopy and sigmoidoscopy with biopsy are essential . 7 . The changes progress through mucosal granularity and spontaneous haemorrhage to frank, continuous ulceration . 6/8/2017IMAGINGOFLARGEBOWEL 65
  • 66. PLAIN FILMS • In total colitis , the reliable features on air enema- 1. -Irregularity of the mucosal edge 2. -Increased thickness of the colon wall . • In the absence of enough spontaneous intraluminal air to assess the colonic wall, AIR ENEMA may be done . • Plain films are used to detect ACUTE TOXIC MEGACOLON/DILATATION ( when transverse colonic diameter >5.5 cm ) • The transverse colon is the most dilated on plain films , due to the patients supine position . • The mucosal line is irregular producing MUCOSAL ISLANDS. • The colon has a consistency akin to blotting paper, so patients are at risk of perforation and untimely death . 6/8/2017IMAGINGOFLARGEBOWEL 66
  • 67. 6/8/2017IMAGINGOFLARGEBOWEL 67 TOXIC MEGACOLON – LUMINAL DILATATION , ABNORMAL HAUSTRATION WITH MURAL THICKENING .
  • 68. • Proctosigmoidoscopy is 10-15% more sensitive overall for primary diagnosis of early , distal ulcerative colitis . • Contrast enema – Can accurately demonstrate colonic morphology -Exact location and extent of any stricture can be identified . • Any Barium examination is acutely contraindicated If there is evidence of toxic dilatation . 6/8/2017IMAGINGOFLARGEBOWEL 68
  • 69. RADIOLOGICAL FEATURES 1. Earliest change - Blurring of the mucosal line and a fine granularity when mucosa is seen en face - Abnormal barium adherence to altered colonic mucous - Flecks of barium adhering to superficial erosion . 2. As the disease progresses, the granularity becomes coarser and eventually frank ulceration develops – Projections of barium outside the mucosal line . 3. Ulceration is continuous and tends to be superficial 4. Mucosal changes are accompanied by haustral blunting , luminal narrowing and colonic shortening . 5. A tubular , short , featureless colon is typical of long standing colitis . 6/8/2017IMAGINGOFLARGEBOWEL 69
  • 70. 6/8/2017IMAGINGOFLARGEBOWEL 70 . CT scan of a patient with long-standing ulcerative colitis - A SUBMUCOSAL HALO OF FAT WITHIN THE RECTUM (ARROW) - PERIRECTAL FIBROFATTY PROLIFERATION (*).
  • 71. 6/8/2017IMAGINGOFLARGEBOWEL 71 Transverse CT image in a 32-yearold woman with ulcerative colitis and bloody diarrhea demonstrates the double halo, or target, sign with inner (mucosa, arrow) and outer (muscularis propria, arrowhead) rings of high attenuation separated by a ring of low attenuation, which represents submucosa with edema.
  • 72. 6/8/2017IMAGINGOFLARGEBOWEL 72TRANSVERSE CT IMAGE IN A 35-YEAROLD PATIENT WITH ULCERATIVE COLITIS AND TOXIC MEGACOLON SHOWS MARKEDLY DISTENDED TRANSVERSE COLON WITH SHAGGY MUCOSA (ARROWS).
  • 73. CROHN’S DISEASE • Chronic relapsing immune mediated inflammatory disease, with transmural and segmental involvement of the small bowel. • Mouth to anus often with multiple skip discontinuous areas. • The most common site is the small bowel (80%), the terminal ileum being most commonly affected site in the small bowel. • Approximately ¼ th will have disease limited to the large bowel and DD from U. Colitis becomes relevant . • Abdominal pain, diarrhoea, weight loss- frequent • Anemia, acute obstruction,
  • 74. First radiological changes are granularity and aphthous ulceration . APHTHOUS ULCERS – Small and discrete , surrounded by slightly elevated edematous mucosa . -Barium collects in the central depression with the surrounding elevation appearing as a radiolucent halo -occur on a background of normal mucosa . -NEVER SEEN IN ULCERATIVE COLITIS . 6/8/2017IMAGINGOFLARGEBOWEL 74
  • 75. • As the disease progresses,ulcers become longitudinal and deeper – TRANSMURAL ulceration . • Deep longitudinal ulcers combined with mucosal edema – COBBLESTONE APPEARANCE . • Discontinuous , both longitudinally and circumferentially 6/8/2017IMAGINGOFLARGEBOWEL 75
  • 76. 6/8/2017IMAGINGOFLARGEBOWEL 76 CONTRACTION AT THE SITE OF ULCER FORMATION – PSEUDODIVERTICULA
  • 77. 6/8/2017IMAGINGOFLARGEBOWEL 77 US IMAGE OF THE TERMINAL ILEUM-THICKENED (ARROW) WITH THICK, ECHOGENIC SUBMUCOSA RELATED TO LYMPHEDEMA
  • 78. ISCHEMIC COLITIS 1. The colon is particularly vulnerable to mesenteric ischemia . 2. Oedema , haemorrhage and ulceration . 3. Spontaneous healing followed by fibrosis – results in subsequent colonic stricturing , 4. Plain films – Splenic flexure irregularity with mural thickening , 5. Characteristic edematous THUMB PRINTING . 6/8/2017IMAGINGOFLARGEBOWEL 78 SPLENIC FLEXURE “THUMB PRINTING “
  • 79. 6/8/2017IMAGINGOFLARGEBOWEL 79 DIFFUSE ISCHEMIC COLITIS. • Diffuse, low-attenuation thickening of the colonic wall (arrows). • This is an example of the halo sign. SEGMENTAL ISCHEMIC COLITIS . Focal thickening of two colonic loops in the left abdomen (arrows).
  • 80. INFECTIOUS COLITIS 1. Bacterial colitis is common and imaging usually reveals non specific pancolitis . 2. Eg’s : Campylobacter , Salmonella , Shigella , Yersinia 3. TUBERCULOSIS – morphology is similar to crohn’s disease. -A conical , contracted caecum is characteristic ; Longitudinal and aphthoid ulcers may occur . 4. NEUTROPENIC COLITIS (TYPHILITIS)- Occurs in immunocompromised patients , secondary to chemotherapy and presents with right sided inflammation . 5 . GRAFT VERSUS HOST DISEASE – Non specific colitis 6/8/2017IMAGINGOFLARGEBOWEL 80
  • 81. 6/8/2017IMAGINGOFLARGEBOWEL 81 MODERATE THICKENING OF THE COLON (ARROWS) AND INFLAMMATORY CHANGES IN THE MESENTERIC FAT. E COLI WAS CULTURED FROM STOOL
  • 82. 6/8/2017IMAGINGOFLARGEBOWEL 82 52-year-old woman with infectious colitis. • Gray-scale ultrasound image shows concentric wall thickening and blurring of normal mural stratification in colon. • Power Doppler image reveals marked hyperemia in affected segment.
  • 83. PSEUDOMEMBRANOUS COLITIS 6/8/2017IMAGINGOFLARGEBOWEL 83 Marked colonic wall thickening and mucosal plaques • Presents with diffuse watery diarrhea and abdominal cramps. • The rectosigmoid colon is almost invariably involved, with 3–8-mm in diameter, creamy, white, elevated plaques or nodules. • The disease can progress to toxic megacolon with transmural injury..
  • 84. • Severe cases show a markedly thickened colonic wall with a “thumbprinting,” low attenuation from mucosal and submucosal edema,irregular mucosal contour with polypoid protrusions, pericolonic stranding, and ascites • The colonic diameter is often enlarged. • After administration of intravenous contrast material, the target sign may be seen with enhanced mucosa and serosa. • The average wall thickness is 14.7 mm. 6/8/2017IMAGINGOFLARGEBOWEL 84
  • 85. Marked wall thickening throughout the colon (thickness, 15 mm) and pericolic inflammation. • The thickening in the transverse colon is asymmetric 6/8/2017IMAGINGOFLARGEBOWEL 85
  • 86. 6/8/2017IMAGINGOFLARGEBOWEL 86 . IN THE SIGMOID COLON, A SHAGGY THICKENED BOWEL WALL WITH ALTERNATING AREAS OF NECROSIS AND PLAQUES.
  • 87. THE RECTUM • The rectum is the last segment of the gastrointestinal tract and is bounded by the sigmoid colon the anus. • The proximal portion located within the peritoneal cavity and the distal portion being extraperitoneal. • The inferior aspect of the rectum, or the anorectal junction, is defined anatomically by the dentate line, which spans 5–10 mm of the anal canal and marks the transitional zone. 6/8/2017IMAGINGOFLARGEBOWEL 87
  • 90. RECTAL CANCER 1. 40 % of colorectal cancers occur in the rectum 2. Immobility permits accurate radiotherapy and accessibility allows transanal local excision. 3. Rectal staging is particularly useful . 4. MRI and TRUS remain a higher modality for investigation in comparison to CT- Able to visualise the muscularis propria . 6/8/2017IMAGINGOFLARGEBOWEL 90
  • 93. 6/8/2017IMAGINGOFLARGEBOWEL 93 • An irregular mass in the rectum with an associated enlarged perirectal lymph node . • Axial 2D image obtained at the level of the mid abdomen reveals lymphadenopathy (arrows) along the course of the IMV (arrowhead).

Editor's Notes

  1. The colon is approximately 100-200 cm long ans is distinguished from small bowel by three longitudinal muscular bands – TAENIA COLI ( OMENTALIS,MESOCOLICA, LIBERA ) – FORMS THE HAUSTRAL SACCUALTIONS Conventionally divided into CAECUM ( INCLUDING THE APPENDIX ) , ASCENDING COLON , HEPATIC FLEXURE , TRANSVERSE COLON , SPLENIC FLEXURE , DESCENDING COLON AND SIGNMOID COLON . The Rectum is the distal portion of the colon Begins where the sigmoid mesocolon ends and is defined by the third sacral segment . No haustra , instead is thrown into two or three full thickness folds , The valves of Houston . Supplied via branches of the Internal iliac arteries and directly from the anal canal distally . The Anal sphincter is the most complex sphincter in the human body and is closely integrated with pelvic floor function . Two sphincter muscles surround the anal canal – Striated external sphincter Smooth muscle internal sphincter
  2. The colonic arterial supply is via ileocolic ranches of the SMA ( RIGHT AND MIDDLE COLIC ARTERIES ) AND THE INFERIOR MES A ( LEFT COLIC A ) SIGMOID ARTERIES ARE ALSO BRANCHES OF THE IMA VENOUS DRAINAGE OF THE RIGHT AND LEFT COLON IS TO THE SMV AND IMV RESPECTIVELY
  3. Spasm at these sites misleads to the diagnosis of a stricture .
  4. BECAUSE BARIUM PERITONITIS IS POTENTIALLY FATAL . TAILOR THE STUDY AS THE PATHOLOGY INVOLVED .
  5. Image showing materials and things required for defecography - barium sulfate (black arrow), rectal insufflation syringe and tube (black curved arrow), commode on foot end of table (black arrowhead
  6. NORMAL TRANSIT TIME .
  7. The distended ahaustral sigmoid loop assumes an inverted “U” shape with its apex under either dome. The opposed inner walls of the loops appear as a single line giving the “coffee bean” appearance . a) CT scout image shows DILATED, AIR-FILLED COLON TERMINATING IN MARKEDLY DILATED SIGMOID COLON FOLDED UPON ITSELF WITH ITS APEX (THE “COFFEE BEAN SIGN”) IN THE MIDLINE UPPER ABDOMEN (BLACK ARROW). THE SIGMOID ALSO CONFORMS TO AN “UPSIDE DOWN U” CONFIGURATION. THERE IS NO GAS IN THE RECTUM (WHITE ARROW). (b) Midline coronal reformatted CT image of the abdomen and pelvis shows DILATED, STOOL-FILLED COLON PROXIMAL TO THE VOLVULUS (BLACK ARROW) WITH A DISTAL “WHIRL” OF THE MESENTERY AT THE POINT OF VOLVULUS (WHITE ARROW).
  8. Depends on the angle at which it is viewed and its relationship to the barium pool.
  9. Magnified view of the sigmoid colon demonstrates THE MID-SIGMOID SESSILE POLYP EN FACE (ARROWHEAD)
  10. Sessile Pedunculated
  11. THE RISK OF MALIGNANCY IN A 1 CM POLYP IS APPROX 10 % IF VILLOUS
  12. Most histological types of polyp can be associated with a corresponding polyposis syndrome, all of which are relatively uncommon All patients whose risk of malignancy is significant require careful surveillance and consideration for prophylactic surgery. Although metaplastic polyps are characterised by a lack of dysplasia, the polyps in hyperplastic polyposis may contain adenocarcinoma, raising the possibility of a separate syndrome, serrated adenomatous polyposis. Whereas isolated juvenile polyps are thought to carry no malignant risk, patients with the rarer juvenile polyposis (thought to he autosomal dominant and defined as five or more gastrointestinal polyps) are at risk of developing associated adenocarcinoma and require both upper and lower gastrointestinal surveillance. The role of prophylactic colectomy remains unclear.
  13. Peutz jeghers syndrome showing a large pedunculated polyp and a smaller sessile polyp proximally .
  14. CHECK FOR AN IMAGE ,
  15. Adenomatous polyposis coli gene
  16. PATIENTS WITH AN AUTOSOMAL DOMINANY CONDITIOPN SUCH AS FAP WILL inevitably develop colorectal cancer and they account for 1% of all the cases BARIUM ENEMA DETECTS APPROX 85 % OF COLORECTAL CANCERS . PATIENTS WITH AN AUTOSOMAL DOMINANY CONDITIOPN SUCH AS FAP WILL inevitably develop colorectal cancer and they account for 1% of all the cases
  17. DUKE DESCRIBED THE STAGING COMBINED BOWEL WALL PENETRATION ( MUSCULARIS MUCOSA ) AND LYMPH NODE STATUS .
  18. Colon cancer in a 74-year-old man. Contrast material–enhanced spiral CT scan shows luminal NARROWING AND MARKED WALL THICKENING INVOLVING THE RIGHT SIDE OF THE TRANSVERSE COLON (ARROW). THERE IS ADJACENT STRANDING OF THE SEROSA AND MESENTERIC FAT, A FINDING COMPATIBLE WITH LOCAL TUMOR EXTENSION.
  19. Tumor invasion in a 72-year-old woman with sigmoid cancer. Contrast-enhanced CT scan shows a MASS IN THE SIGMOID COLON (ARROW) WITH INFILTRATION OF THE SURROUNDING FAT AND EXTENSION INTO THE PRESACRAL SPACE.
  20. MULTIPLE BIZARRE STRICTURES AND MUCOSAL PLEATING in a woman with EXTENSIVE PERITONEAL CARCINOMATOSIS from an ovarian primary
  21. Enlarged lymph nodes in a 43-year-old man with metastatic colon cancer. CONTRAST-ENHANCED SPIRAL CT SCAN SHOWS MULTIPLE HEPATIC METASTASES AS WELL AS ENLARGED PORTACAVAL AND AORTOCAVAL NODES (ARROWS
  22. Pulmonary metastases in a 47-year-old man with colon cancer. SPIRAL CT SCAN SHOWS NUMEROUS METASTASES IN THE LUNGS.
  23. MOST PATIENTS ARE ASYMPOTOIMATIC BUT LEFT SIDED ABDOMINAL PAIN BOUTS OF DIVERTICULITIS WORSENING OF LEFT ILIAC FOSSA PAIN CONSTIPATION /DIARRHEA LEFT SIDED APPENDICITIS
  24. Diverticulitis in a 42-year-old man with pain and heme-positive stools. AT ENDOSCOPY, DIVERTICULITIS WAS DIAGNOSED.
  25. wall thickening in the SIGMOID COLON (ARROWS) WITH ADJACENT INFLAMMATORY CHANGES IN THE PERICOLIC FAT.
  26. BECAUSE OF THE RISK OF PERFORTION , BARIUM ENEMA IS CONTRAINDICATED ACUTEL.Y . AND IF NECESSARY, WATER SOLUBLE CONTRAST CAN BE USED . ULTTASOUND – FIRST IMAGING MODALITY CAN REVEAL MURAL THICKENING AND PERICOLIC INFLAMMATION SEEN AS ALTERED FATTY ECHOGENICITY , INCOMPRESSIBILITY AND ABCESS . Commonest fistualtion is COLOVESICAL between the sigmoid colon and the bladder . Fistulas may also occur to the vagina or skin .
  27. Colovesical fistula. CT scan obtained with oral and intravenous contrast material shows moderate wall thickening in the sigmoid colon (S) with adjacent inflammatory changes and stranding of the pericolic fat. FOCAL WALL THICKENING IS SEEN IN THE LEFT POSTERIOR PART OF THE BLADDER ADJACENT TO THE INFLAMED SIGMOID (ARROW). A MODERATE AMOUNT OF AIR IS ALSO PRESENT IN THE BLADDER, A FINDING COMPATIBLE WITH A COLOVESICAL FISTULA. SMALL COLLECTIONS OF RETAINED BARIUM ARE IDENTIFIED CT also allows detection of other complications within diverticula.
  28. PROXIMAL SPREAD OCCURS IN A CONTINUOUS FASHION IN APPROX TWO THIRDS OF PATIENTS, HALF OF WHOM HAVE TOTAL COLITIS AT THE TIME OF PRESENTATION .
  29. Air enema CAN ASSESS THE COLON MORE RAPIDLY AND WITH LESS DISCOMFORT AND LESS RISK .
  30. TOXIC MEGACOLON – LUMINAL DILATATION , ABNORMAL HAUSTRATION WITH MURAL THICKENING .
  31. ULCERATION ALWAYS OCCURS AGAINST A BACKGROUND OF DIFFUSELY ABNORMAL MUCOSA .
  32. EXTENSIVE COBBLESTONE DUE TO LINEAR ULCERATION AND MUCOSAL EDEMA .
  33. Infectious colitis from Escherichia coli in a 52-year-old man with abdominal pain and severe bloody diarrhea.
  34. TRANSVERSE CT IMAGE IN A 56-YEAROLD MAN WITH PSEUDOMEMBRANOUS COLITIS WHO WAS UNDERGOING ANTIBIOTIC TREATMENT FOR ENDOCARDITIS.
  35. TRANSITIONAL ZONE : between the columnar epithelium of the gastrointestinal tract and the squamous epithelium of the anoderm and perianal skin
  36. The rectum is accessible and relatively immobile
  37. Rectal cancer in a 65-year-old man with rectal bleeding. Spiral CT scan obtained with rectal contrast material shows an ECCENTRIC RECTAL CANCER (BLACK ARROW) AS WELL AS ADJACENT NODES (WHITE ARROWS).
  38. images show irregular wall thickening (arrows) of the rectum. Note the extension of the mass into the perirectal fat on the right side (arrowheads in c).