Role of ultrasound in right iliac fossa painMadhu Sudana
This presentation briefly outlines the role of ultrasound in differential diagnosis of right iliac fossa pain.
Reference :- White, E. and Rudralingam, V. ‘Seeing past the appendix: the role of ultrasound in right iliac fossa pain’.
i made this ppt for presentation in class............i have added some already prepared ppts...
i think it wil be useful to some residents out there who dont find time in busy work schedules....all the best
Role of ultrasound in right iliac fossa painMadhu Sudana
This presentation briefly outlines the role of ultrasound in differential diagnosis of right iliac fossa pain.
Reference :- White, E. and Rudralingam, V. ‘Seeing past the appendix: the role of ultrasound in right iliac fossa pain’.
i made this ppt for presentation in class............i have added some already prepared ppts...
i think it wil be useful to some residents out there who dont find time in busy work schedules....all the best
various congenital gastrointestinal diseases manifesting in childhood or even in adults, their radiographic findings on various imaging modalities such as radiograph, barium, ultrasound etc.
Small intestine/Intestinal obstruction/crohns disease/ileostomy/viscous organ...RajeevPandit10
all about small intestine, anatomy, physiology, intestinal obstruction, crohns disease/ileostomy/viscous organ perforation, meckels diverticulum, mysenteric ischemia, short bowel syndrome, celiac disease
A brief anatomical, embryological, patho-physiological and surgical description of the Vermiform Appendix.
Surface Anatomy of Appendix, Appendicectomy, surgical approach, complications, Appendicular lump and abscess, Neoplasia, Carcinoid syndrome, Pseudomyxoma Peritonei, The Alvarado Score
Learn Barium Meal & Follow Through for the beginners from a Radiology Resident.For some image description please go through the text book "David Sutton" because i have described these image during my presentation Verbally..There are many animations used inside this presentation so to see all the pictures which are placed layer by layer with the help of animations you simple need to download this presentation first.... Thanx.
Learn Chest X-Ray With Its Normal Positioning & Radio-AnatomyDr.Santosh Atreya
Learn Chest X-Ray With Its Normal Positioning & Radio-Anatomy..For some image description please go through the text book "David Sutton" because i have described these image during my presentation Verbally..There are many animations used inside this presentation so to see all the pictures which are placed layer by layer with the help of animations you simple need to download this presentation first.... Thanx.
This is a powerpoint(case presentation) for radiology and imaging resident.There are many animations used inside this presentation so to see all the pictures which are placed layer by layer with the help of animations you simple need to download this presentation first.... Thanx.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Intussusception in Adults-Submucosal Lipoma at Transverse colon-A rare cause
1. Lipoma at the Transverse Colon:
A rare Cause for Intussusception
in Adults
Dr. Santosh Atreya
MD Residency Department of Radiology &
Imaging
Phase-B
BSMMU
2. Topics To Be Discussed Today
• Introduction of Colonic Lipoma
• Introduction of intussusception
• Etiology
• Epidemiology
• Clinical presentation
• Radiological features
• Management
3. COLONIC LIPOMA
• Colonic Lipoma
• Rare non-epithelial neoplasms
• First described by bauer in 1757
• Incidence : 0.2 % to 4.4 %.
• More common in elderly women
• Mainly in the cecum and ascending
colon.
• Most common sub mucosal
tumour in colon
• Most of them are small in size,
solitary and asymptomatic.
• 30 % of them reach 2 cm
4. • Adult intussusception is thought to be rare,
accounting for an estimated 5% of all
intussusceptions and only 1% of small bowel
obstructions.
5. Intussusception
• Agha,AJR 1986;146.
-25 adult intussusceptions
-a causative factor was identified in 23
patients(92%)
-other 2 cases were considered indeterminate
6. • Ekran,Int J Colorectal Dis 2005;20
-13 adult Intussusceptions
-a pathologic cause for the Intussusception was
identified in 92.3%
-only one case was considered to be idiopathic
7. INTUSSUSCEPTION
• Describes in which one segment of the
intestine telescopes or invaginates into the
lumen of an adjacent segment of intestine.
•It is common in children & an
important cause of an acute
abdomen .
•Rare in adult population
where it is usually caused by a
focal lesion acting as a lead
point.
10. Epidemiology
• The vast majority of intussusceptions occur in
children (95%), usually after the first three
months of life most frequently seen in
children under 2 years of age.
11. • In adults,Secondary to malignant neoplasms
in about half of the cases
• Most neoplasms-related cases are due to
Adenocarcinoma
GIST
Metastatic melanomas
Lipoma-Rare
12. Adult Intussusception
• Pathogenesis:
• The tumour may act as a
foreign body
provoke abnormal
peristaltic movement
leads to telescoping of
one bowel segment into
the dilated distal part.
The trapped section of bowel may have cut off
blood supply
Resulting ischaemia - Mucosa sensitive to
ischaemia-Responds sloughing off into the gut
13. LOCATION
• In adults no pattern of distribution is present
as such as in the vast majority of cases a lead
point lesion is present, and thus the location
will depend on the location of that lesion. In
children there is a strong predilection for the
ileocolic region:
14. In Children
Commences in the ileum as the result of the lymphoid tissue
& tends to be associated with mesenteric adenitis. The
enlarged lymphatic patches are forced into ileum by
peristaltic movement & acting as a tumour, one part of the
ileum is pulled into the other & finally pulled into the colon.
15. Location in children
• ileocolic: most common (75-
95%), presumably due to the
abundance of lymphoid tissue
related to the terminal ileum
and the anatomy of the
ileocaecal region
• ileoileocolic: second most
common
• ileoileal and
colocolic: uncommon
• gastric intussusception: rare, but
documented
18. Types
•Enteroenteric involving only the small bowel
•Colocolic involving only the large bowel
•Ileocolic involving the terminal ileum and
ascending colon
20. • In early stages may be
unremarkable. However in
advanced stages it may show
signs of bowel obstruction.
• Meniscussign:
• Crescent of gaswithin colonic
lumenthat outlines the apexof
intussusceptum-More frequently
identified in right
hypochondrium.
• Little air in smallintestine.
Plain Radiograph
Supine film.
There are multiple gas-filled
loops of slightly dilated small bowel. In addition,
there is a soft-tissue mass
in the right iliac fossa (arrow). A 5-month-old child
with mesenteric adenitis
27. • However this
investigation is performer
dependant and at times
may be missed by an
inexperienced sonologist
• Should always be done
by a radiologist
28. FLUOROSCOPY
• A contrast enema: Gold
standard, demonstrating the
intussusception as an
occluding mass prolapsing into
the lumen, giving the "coiled
spring” appearance (barium in
the lumen of the
intussusceptum and in the
intraluminal space).
• Contraindication Perforation,
29. • In children both diagnostic (the gold standard
in the diagnosis of intussusception) and
therapeutic.
30. CT
• CT has become the
modality of choice for
assessment of acute
abdomen in adults.
• The appearance on CT is
characteristic and depends
on the imaging plane
• Best known is the so-called
bowel-within-bowel
configuration when
imaged at right angles to
the lumen, and a soft
tissue sausage when
imaged longitudinally. 23 years old women with 2 weeks history of
intermittent abdominal pain, minimal
diarrhoea, no nausea or vomiting.
31. MRI
• Recent developments in MRI with ultrafast multiplanar
techniques now allow for rapid evaluation of the
bowel, particularly in cases of small bowel obstruction.
• Multiplanar HASTE (half-fourier single shot turbo spin
echo) imaging to be particularly useful in the evaluation
of intussusception. This sequence is relatively motion-
insensitive and has the ability to obtain heavily T2-
weighted data within a single breath-hold.
It can
• demonstrate intussusception clearly, as there is high
contrast resolution between the high signal of
intraluminal fluid and the intermediate to low
32. • signal of the bowel
wall.
• MRI’s multiplanar
ability allows precise
localization of the
segment of bowel
involved . An
underlying lead
point may also be
identified.
Axial multiplanar HASTE (half-fourier spin turbo echo, ) imaging
showing intussusception in the bowel adjacent to the right kidney. (b)
and (c)
Coronal HASTE images showing the target (arrow) and
sausage shapes of the intussusception. A lead point was
not identified.The diagnosis of myofibroblastic tumour was made at
surgery.
33. Treatment and prognosis
laparotomy is usually
required, especially as in most
cases a lead point requiring
treatment is present.
In children, intussusception reduction
can be achieved without recourse to
surgery in most cases. Using a water-
soluble medium or air introduced via
a rectal catheter.
34. Take Home Messages
• Common in children. Rare in adults (Lipoma causing
intussusception is more rare : 0.2 % to 4.4 %. )
• In adults almost half of the cases associated with lead
point.
• In children both diagnosis & treatment falls under
Radiology whereas in adults surgery is indicated for
treatment.
• Unlike children in adults any site may be involved,
depending upon the site of lead point.
• Various important radiological signs-Should be
remembered.