This document compares the power efficiency and area of a 4-bit priority encoder designed using a fully automatic layout versus a semi-custom layout on 65nm technology. Simulation results show that the semi-custom design has improved power efficiency by 29.61μW and reduced area by 253.8μm2 compared to the fully automatic design. The semi-custom design manually draws the layout of the CMOS circuit, while the fully automatic design generates the layout from a Verilog file.