The document summarizes key aspects of the human genome and genome projects. It discusses that a genome contains an organism's complete DNA including all genes. It describes the physical structure of human DNA including nuclear DNA, mitochondrial DNA, and RNA. It provides details on the goals and completion of the Human Genome Project in 2003, two years ahead of schedule. The project aimed to identify all human genes and map the 3 billion base pairs of human DNA.
Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and a functional
A crisp and precise presentaion on Human genome project which will help you in your studies.
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Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and a functional
A crisp and precise presentaion on Human genome project which will help you in your studies.
For original ppt file, contact me at :
Instagram: _s_a_k_s_h_a_m_
Twitter: @_SakshamAgrawal
or mail me at saksham.agrawal512@gmail.com
Human Genome Project (HGP)
Main objectives Human Genome Project (HGP)
Goals for the HGP
Medical Implications
Applications of HGP
Timeline of HGP
Technical aspects in HGP
Mapping strategies
Sequencing strategies
. Shotgun sequencing method
Sanger sequencing method
Outcomes of HGP
The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and a functional standpoint.
HGP was conceived in 1984 & officially begun in earnest in October 1990.
HGP is a large multicentric, international collaborative venture, the main aim of which is to determine the nucleotide sequence of the entire human nuclear genome.
In 1997, United States established the National Human Genome Research Institute (NHGRI).
The HGP was an international research groups from six countries- USA, UK, France, Germany, Japan and China, & several laboratories and a large no. of scientists and technicians from various disciplines.
this is done by me and my team mates of Wayamba University Sri Lanka for our project.From now we decided to allow download this file.I would be greatful if you could send your comments..
And I'm willing to help you in similar works.I'm in final year of my degree(.BSc Biotechnology)..
pubudu_gokarella@yahoo.com
Human Genome Project (HGP)
Main objectives Human Genome Project (HGP)
Goals for the HGP
Medical Implications
Applications of HGP
Timeline of HGP
Technical aspects in HGP
Mapping strategies
Sequencing strategies
. Shotgun sequencing method
Sanger sequencing method
Outcomes of HGP
The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and a functional standpoint.
HGP was conceived in 1984 & officially begun in earnest in October 1990.
HGP is a large multicentric, international collaborative venture, the main aim of which is to determine the nucleotide sequence of the entire human nuclear genome.
In 1997, United States established the National Human Genome Research Institute (NHGRI).
The HGP was an international research groups from six countries- USA, UK, France, Germany, Japan and China, & several laboratories and a large no. of scientists and technicians from various disciplines.
this is done by me and my team mates of Wayamba University Sri Lanka for our project.From now we decided to allow download this file.I would be greatful if you could send your comments..
And I'm willing to help you in similar works.I'm in final year of my degree(.BSc Biotechnology)..
pubudu_gokarella@yahoo.com
What is bioinformatics?
About human genome
Human genome project
Aim of human genome project
History
Sequencing Strategy
Benefits of Human Genome Project research
Disadvantages of human genome project
Conclusion
References
Describe in your own words the benefits, but also the problems of ha.pdfarenamobiles123
Describe in your own words the benefits, but also the problems of having the human genome
deciphered. Write several paragraphs.
Solution
The history of the human race has been filled with curiosity and discovery about our abilities and
limitations. As an egotistical creature with a seemingly unstoppable desire for new
accomplishments, we attempt feats with emotion and tenacity. People worldwide raced to be the
first to discover the secrets and the ability of flight. Enormous amounts of monies were spent on
sending people into space and the race to land on the moon. With the rapid growth of scientific
knowledge and experimental methods, humans have begun to unravel and challenge another
mystery, the discovery of the entire genetic make-up of the human body.
This endeavor, the Human Genome Project (HGP), has created hopes and expectations about
better health care. It has also brought forth serious social issues. To understand the potential
positive and negative issues, we must first understand the history and technical aspects of the
HGP.
History of the Human Genome Project
The HGP has an ultimate goal of identifying and locating the positions of all genes in the human
body. A researcher named Renato Dulbecco first suggested the idea of such a project while the
U.S. Department of Energy (DOE) was also considering the same project because issues related
to radiation and chemical exposure were being raised. Military and civilian populations were
being exposed to radiation and possible carcinogenic chemicals through atomic testing, the use
of Agent Orange in Vietnam, and possible nuclear power facility accidents. Genetic knowledge
was needed to determine the resiliency of the human genome.
Worldwide discussion about a HGP began in 1985. In 1986, the DOE announced its\' Human
Genome Initiative which emphasized the development of resources and technologies for genome
mapping, sequencing, computation, and infrastructure support that would lead to the entire
human genome map. United States involvement began in October 1990 and was coordinated by
the DOE and the National Institute of Health (NIH). With an estimated cost of 3 billion dollars,
sources of funding also include the National Science Foundation (NSF) and the Howard Hughes
Medical Institute (HHMI). Because of the involvement of the NIH, DOE, and NSF who receive
U.S. Congressional funding, the HGP is partly funded through federal tax dollars. Expected to
last 15 years, technological advancements have accelerated the expected date of completion to
the year 2003. This completion date would coincide with the 50th anniversary of Watson and
Crick\'s description of the structure of DNA molecule.
Human Genome Project Goals
The specific goals of the HGP are to::
Technical Aspects of the HGP
Mapping Strategies
To sequence the human genome, maps are needed. Physical maps are a series of overlapping
pieces of DNA isolated in bacteria. Physical maps are used to describe the DNA\'s chemical
characteristics..
In this paper, we briefly reviewed the numbers in life from a statistical genetic approach. The human genome comprises of 6 billion chemical bases of DNA. The DNA encodes 30,000 genes. It consists of two parts; the nuclear genome; which consists of 3,200,000,000 nucleotides of DNA, divided into 24 linear molecules, the shortest 50,000,000 nucleotides in length and the longest 260,000,000 nucleotides, each contained in a different chromosome and the mitochondrial genome; which contains approximately 16,600 base pairs encoding 37 genes. Most human cells have 46 chromosomes. However, the number of chromosomes in the nuclei of a person with Down syndrome is 47. The DNA of any two people on Earth is 99.6 percent identical, the 0.4 percent variation represents about 20 million base pairs. Almost all 98 percent of the human DNA is noncoding, while in bacteria, only 2% of the genetic material does not code for anything.
The project was a great success, delivering the first rough draft human genome sequence in 2000 and the final high-quality version in April, 2003, ahead of schedule and under budget. For years, many considered the Human Genome Project to be biology's equivalent to "Man on the moon". This slide tends to explain the benefits of such project to medical diagnosis, treatment and management in India.
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The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
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Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
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1. Human
Genome
Presented by
Peyman Ghoraishizadeh
Department of Obstetric
&Gynecology
University Of Putra Malaysia
2. What is a Genome and Gene?
A genome is an organism’s
complete set of DNA, including all
of its genes
Each genome contains all of the
information needed to build and
maintain that organism
A gene produce a protein
3. The Physical Structure of the Human
Genome
Nuclear DNA
The nucleus contains long strands of
DNA that encode genetic information
double helix
DNA contains base, sugar and phosphate
group
Two strand are connected to each other
by chemical pairing of each base
suitable molecule for carrying our genetic
information
4. Organelle DNA
Not all genetic information is found
in nuclear DNA
Each mitochondrion has its own set
of genes
Cells often have multiple
mitochondria
Responsible for energy conversion
The energy-conversion process that
takes place in the mitochondria
takes place aerobically
There are many diseases caused by
mutations in mitochondrial DNA
(mtDNA) like deafness
5. Ribonucleic Acids
ribonucleic acid (RNA) is a chain, or
polymer, of nucleotides with the same
5' to 3' direction of its strands
RNA has a 2' oxygen atom that is not
present in DNA
uracil takes the place of the thymine
nucleotide found in DNA
6. Structural Genes
Sequences that code for proteins
Regulatory Sequences
makes up a numerically insignificant fraction
of the genome but provides critical functions
certain sequences indicate the beginning and
end of genes, sites for initiating replication
and recombination
regulatory sequences are inherited
Junk DNA
sequences are components of an organism's
DNA that do not encode protein sequences
over 98% of the human genome is
noncoding DNA ,[1]
7. Other DNA Regions
Forty to forty-five percent of our
genome is made up of short sequences
that are repeated, sometimes hundreds of
times
There are numerous forms of "repetitive
DNA“
They have some functions such as
stabilizing the chromosome structure or
inactivating one of the two X
chromosomes in developing females, a
process called X-inactivation
The most highly repeated sequences
found so far in mammals are
called "satellite DNA"
These sequences are associated with
chromosome structure and are found at
the centromeres (or centers)
and telomeres (ends) of chromosomes
they do not play a role in the
coding of proteins, they do play a
significant role in chromosome
structure, duplication, and cell
division
8. Haplotype
is a combination of alleles (DNA sequences) at
adjacent locations (loci) on a chromosome
that are transmitted together
A haplotype may be one locus, several loci, or
an entire chromosome depending on the
number of recombination events that have
occurred between a given set of loci
A second meaning of the term haplotype is a
set of single-nucleotide polymorphisms
(SNPs) on a single chromosome of a
chromosome pair that are
associated statistically
It is thought that these associations, and the
identification of a few alleles of a haplotype
sequence, can unambiguously identify all other
polymorphic sites in its region. Such
information is very valuable for investigating
the genetics of common diseases, and has been
investigated for the human species by the
International HapMap Project .
9. What was Human Genome Project
The Human Genome Project was
an international research effort to
determine the sequence of the
human genome and identify the
genes that it contains.
The Project was coordinated by
the National Institutes of Health
and the U.S. Department of
Energy. Additional contributors
included universities across the
United States and international
partners in the United Kingdom,
France, Germany, Japan, and
China
10. The Human Genome Project
formally began in 1990 and was
completed in 2003,2 years ahead of
its original schedule
The work of the Human Genome
Project has allowed researchers to
begin to understand the blueprint for
building a person
researchers learn more about the
functions of genes and proteins
this knowledge will have a major
impact in the fields of medicine,
biotechnology, and the life sciences
11. What were the goals of the Human
Genome Project
Project goals were to
Identify all the approximately 20,000-25,000 genes in human DNA,
Determine the sequences of the 3 billion chemical base pairs that make up human
DNA,
Store this information in databases,
Improve tools for data analysis,
Transfer related technologies to the private sector, and
Address the ethical, legal, and social issues (ELSI) that may arise from the project.
The Project also
aimed to sequence the genomes of several other organisms that are
important to medical research, such as the mouse and the fruit fly.
12. What is DNA sequencing
Sequencing means determining
the exact order of the base pairs
in a segment of DNA
method used by the HGP to
produce the finished version of
the human genetic code is map-
based, or BAC-based, sequencing
More recently scientists
estimated that there are less than
30,000 human genes. However,
we still have to make guesses at
the actual number of genes,
because not all of the human
genome sequence is annotated
13. Omic Projects
International HapMap
Project
that aims to develop
a haplotype map (HapMap) of
the human genome, which will
describe the common patterns of
human genetic variation
HapMap is a key resource for
researchers to find genetic variants
affecting health, disease and
responses to drugs and
environmental factors
14. Encode DNA
Encyclopedia of DNA Elements (ENCODE )
The goal is to find all functional elements in the human genome
On 5 September 2012, initial results of the project were released
These publications combine to show that approximately 20%
of noncoding DNA in the human genome is functional while an
additional 60% is transcribed with no known function.
These results demonstrate that gene regulation is far more complex
than previously believed.
15. Human Genome Project
YESTERDAY
Just a half-century ago, very little was known about the genetic factors that contribute
to human disease
The Human Genome project spurred a revolution in biotechnology innovation around
the world
In April 2003, researchers successfully completed the Human Genome Project
TODAY
The Human Genome Project has already fueled the discovery of more than 1,800
disease genes
As a result of the Human Genome Project, today’s researchers can find a gene
suspected of causing an inherited disease in a matter of days, rather than the years it
took before the genome sequence was in hand
16. TOMORROW
An ambitious new initiative, The Cancer Genome Atlas aims to identify
all the genetic abnormalities seen in 50 major types of cancer.
Based on a deeper understanding of disease at the genomic level, we will
see a whole new generation of targeted interventions, many of which
will be drugs that are much more effective and cause fewer side
effects than those available today.