This document provides guidelines for managing tuberculosis (TB) in an outpatient clinic in Ethiopia. It describes TB as a chronic bacterial infection, most commonly caused by Mycobacterium tuberculosis. It recommends smear microscopy and chest x-rays for diagnosis. Treatment categories are based on smear status and history: Category I includes new smear-positive cases and seriously ill patients treated with 2 months of 4 drugs followed by 6 months of 2 drugs. Category II includes relapse cases treated with longer regimens. Category III includes smear-negative cases treated for 8 weeks then 6 months. Outpatient clinics can treat Category I patients with weekly follow-up to monitor sputum clearance within 2 months and check for side effects.