Host-Parasite relationship is the extreme case of animal association, in which both partners influence each others life by affecting each others metabolism and behaviour using different adaptive mechanisms in order to ensure their survival.
Organism living in or on another living organism, obtaining its nutrition from that host organism and causing some degree of measurable damage to the host.
Plays a role in ecology and evolution.
Organism living in or on another living organism, obtaining its nutrition from that host organism and causing some degree of measurable damage to the host.
Plays a role in ecology and evolution.
A bacteriophage (informally, phage) is a virus that infects and replicates within a bacterium. The term is derived from "bacteria" and the Greek (phagein), "to devour". Bacteriophages are composed of proteins that encapsulate a DNA or RNA genome, and may have relatively simple or elaborate structures. Their genomes may encode as few as four genes, and as many as hundreds of genes. Phages replicate within the bacterium following the injection of their genome into its cytoplasm. Bacteriophages are among the most common and diverse entities in the biosphere.
Phages are widely distributed in locations populated by bacterial hosts, such as soil or the intestines of animals. One of the densest natural sources for phages and other viruses is sea water, where up to 9×108 virions per milliliter have been found in microbial mats at the surface,] and up to 70% of marine bacteria may be infected by phages. They have been used for over 90 years as an alternative to antibiotics in the former Soviet Union and Central Europe, as well as in France. They are seen as a possible therapy against multi-drug-resistant strains of many bacteria (see phage therapy). Nevertheless, phages of Inoviridae have been shown to complicate biofilms involved in pneumonia and cystic fibrosis, shelter the bacteria from drugs meant to eradicate disease and promote persistent infection
Microbial interactions are ubiquitous, diverse, critically important in the function of any biological community.
The most common cooperative interactions seen in microbial systems are mutually beneficial. The interactions between the two populations are classified according to whether both populations and one of them benefit from the associations, or one or both populations are negatively affected.
A bacteriophage (informally, phage) is a virus that infects and replicates within a bacterium. The term is derived from "bacteria" and the Greek (phagein), "to devour". Bacteriophages are composed of proteins that encapsulate a DNA or RNA genome, and may have relatively simple or elaborate structures. Their genomes may encode as few as four genes, and as many as hundreds of genes. Phages replicate within the bacterium following the injection of their genome into its cytoplasm. Bacteriophages are among the most common and diverse entities in the biosphere.
Phages are widely distributed in locations populated by bacterial hosts, such as soil or the intestines of animals. One of the densest natural sources for phages and other viruses is sea water, where up to 9×108 virions per milliliter have been found in microbial mats at the surface,] and up to 70% of marine bacteria may be infected by phages. They have been used for over 90 years as an alternative to antibiotics in the former Soviet Union and Central Europe, as well as in France. They are seen as a possible therapy against multi-drug-resistant strains of many bacteria (see phage therapy). Nevertheless, phages of Inoviridae have been shown to complicate biofilms involved in pneumonia and cystic fibrosis, shelter the bacteria from drugs meant to eradicate disease and promote persistent infection
Microbial interactions are ubiquitous, diverse, critically important in the function of any biological community.
The most common cooperative interactions seen in microbial systems are mutually beneficial. The interactions between the two populations are classified according to whether both populations and one of them benefit from the associations, or one or both populations are negatively affected.
MLS 313 Basic Medical_Parasitology Part A.pptShuaibubukhari
At the end of the module the students should be able to:
Define all parasitological terms.
Classify parasites of medical importance into their various groups.
For each parasite describe:
-The life cycle of common parasites, Geographical distribution, mode of transmission.
-Effects of parasites on human body: Local or general, clinical symptoms of infection
- Means of diagnosis, prevention, control and treatment
Learn about the science of microbiology, and important terms to consider. Microbiology is important to know about for our health and safety. Use our Microbiology 101 guide to become a bacteria expert, with terminology and more!
Incineration is the method of choice for treating large volumes of infectious waste, animal carcasses, and contaminated bedding materials. Because incinerators usually are located some distance from the laboratory, additional precautions for handling and packaging of infectious waste are necessary.
Types of Biomedical Waste Disposal
Autoclaving. The process of autoclaving involves steam sterilization. ...
Incineration. The major benefits of incineration are that it is quick, easy, and simple. ...
Chemicals. When it comes to liquid waste, a common biomedical waste disposal method can be chemical disinfection. ...
Microwaving.
Prokaryotes are always unicellular, while eukaryotes are often multi-celled organisms. Additionally, eukaryotic cells are more than 100 to 10,000 times larger than prokaryotic cells and are much more complex. The DNA in eukaryotes is stored within the nucleus, while DNA is stored in the cytoplasm of prokaryotes
Difference between prokaryotic and eukaryotic cell.pptxAmjad Afridi
Eukaryotic cells have several other membrane-bound organelles not found in prokaryotic cells.
These include the mitochondria (convert food energy into adenosine triphosphate, or ATP, to power biochemical reactions); rough and smooth endoplasmic reticulum ,golgi complex and in the case of plant cells, chloroplasts
All of these organelles are located in the eukaryotic cell's cytoplasm.
Mycology is the branch of biology concerned with the study of fungi.
The word 'myco' is derived from the Greek word mýkēs meaning “mushroom, fungus”.
Heinrich Anton de Bary is the father of Mycology.
Fungi are eukaryotic organisms that include such as yeasts, moulds and mushrooms. These organisms are classified under kingdom fungi.
Fungi are diverse and widespread.
Fungi metabolism consists on a series of reactions (biochemical reactions) constantly occurring inside the cells to keep it alive and active and in the results biosynthesis of a huge number of compounds.
These compounds area usually divided into primary and secondary metabolites.
Primary metabolism is common to several species and usually produces compounds with the function of assuring fungi growth and development.
Primary metabolites are involved in the growth, development, and reproduction of organisms.
The primary metabolites consist of vitamins, amino acids, nucleosides and organic acids
Staphylococcus aureus is a bacterium that causes staphylococcal food poisoning, a form of gastroenteritis with rapid onset of symptoms. S. aureus is commonly found in the environment (soil, water and air) and is also found in the nose and on the skin of humans.
Communicable diseases are illnesses that spread from one person to another or from an animal to a person, or from a surface or a food. Diseases can be transmitted during air travel through: direct contact with a sick person. respiratory droplet spread from a sick person sneezing or coughing.
Bacteria have their own enzymes for
1. Cell wall formation
2. Protein synthesis
3. DNA replication
4. RNA synthesis
5. Synthesis of essential metabolites
Infections spread from animals to human are called zoonotic infections.
The term zoonos is’ Derived from the Greek
ZOON (animals) and NOSES (diseases)
Pathogens shared with wild or domestic animals cause more than 60% of infectious diseases in man.
Ozone (O3) is a molecule made up of three atoms of oxygen (O), and very reactive gas.
Bluish gas that harmful to breathe.
Is mostly found in the stratosphere, where it protects us from the Sun’s harmful ultraviolet (UV) radiation.
Although it represents only a tiny fraction of the atmosphere, ozone is essential for life on Earth.
Ozone in the stratosphere— a layer of the atmosphere between 15 and 50 kilometers (10 and 31 miles) above us—acts as a shield to protect Earth’s surface from the sun’s harmful ultraviolet radiation.
H: Infects only Human beings
I: Immunodeficiency Virus weakness the Immune system and increases the risk of infections
V: Virus that attacks the body and finally kills the body’s immune system
Tuberculosis is a communicable chronic granulomatous disease caused by Mycobacterium tuberculosis , where the center of the granuloma is Caseous necrosis
It usually involves the lungs but may affect any organ or tissue in the body
Airborne spread of droplet nuclei
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
2. Whether or not you will catch a disease depends on:
(1) YOU: your health, nutrition, immune status.
(2) The pathogen's VIRULENCE
(A) How TOXIC the organism is?
(B) How INVASIVE the organism is
3. SYMBIOSIS: The term host and parasite relationship is also know
as Symbiosis mean the coexistence of two organisms in which one
extracts the nutrition from other.
PARASITIOLOGY: Is a branch of microbiology, refer to the
scientific study of parasitism.
DISEASE: Any abnormal form or condition of the body is called
“Disease”.
INFECTIOUS DISEASE: A disease condition caused by the
presence or growth or increased numbers of infectious
microorganisms or parasites.
PATHOGEN: Is defined as any microorganism that has the
capacity to cause disease.
VIRULENCE: The degree of pathogenicity in of microorganism:
4. MUTUALISM: Is a symbiosis in which both members benefit from
the relationship
COMMENSALISM: Is a relationship in which one member
benefits, and the other one neither benefits
nor is harmed.
OPPORTUNISTS: These are organisms that normally don't cause
disease but will if given an opportunity.
NORMAL FLORA: Harmless microbes. Do not cause disease but
give benefit to its host.
5. A HOST is any organism that allows another organism/bacteria etc.
to live in or on it.
The organism on which parasite lives is known as the host.
Host is larger in size.
Host is always harmed ( Infection/disease/death).
HOST
6. The PARASITE is the organism loving on or in the host
Smaller in size and get its food and shelter from its host
May be Microscopic ( Bacteria, fungus, Viruses) or Macroscopic i.e.
(Helminths, protozoa, algae etc.)
Some parasitic diseases are easily treated and some are not.
In biology/ecology, parasitism is a non-mutual symbiotic relationship
between species.
Where one species, the parasite, the benefits at the expense of the
other, the host.
21. HOW TO DETERMINE IF AN ORGANISM IS THE ETIOLOGIC
AGENT OF DISEASE
REVIEW KOCH'S POSTULATES:
1. The agent must be observed in every case of the disease.
2. The agent must be isolated from a diseased host and grown in pure
culture.
3. When purified agent is inoculated into a healthy but susceptible
host, it must cause the same disease.
4. The agent must be reisolated from the newly infected, diseased
host, and be identical to the previously identified causative agent.
Pathogenesis refers to the sequence of events during the course of an infection within the host, and the mechanisms giving rise to these events. It includes entry of the virus into the body, multiplication and spread, the development of tissue damage, and the production of an immune response.
Steps: To cause disease, a pathogen must successfully achieve four steps or stages of pathogenesis: exposure (contact), adhesion (colonization), invasion, and infection.5
Diseases burden increase
The term infectious diseases applies when an interaction with a microbe causes damage to the host cell and the associated damage or altered physiology results in clinical signs and symptoms of disease.
Diseases burden increase
The term infectious diseases applies when an interaction with a microbe causes damage to the host cell and the associated damage or altered physiology results in clinical signs and symptoms of disease.
Diseases burden increase
The term infectious diseases applies when an interaction with a microbe causes damage to the host cell and the associated damage or altered physiology results in clinical signs and symptoms of disease.
Diseases burden increase
The term infectious diseases applies when an interaction with a microbe causes damage to the host cell and the associated damage or altered physiology results in clinical signs and symptoms of disease.
Diseases burden increase
The term infectious diseases applies when an interaction with a microbe causes damage to the host cell and the associated damage or altered physiology results in clinical signs and symptoms of disease.