High-frequency oscillatory ventilation (HFOV) is a life-support technique used in severe respiratory failure, delivering rapid, small breaths to improve lung recruitment while reducing barotrauma. It is indicated for conditions like ventilator-associated lung injury, acute respiratory distress syndrome, and refractory hypoxemia, but is contraindicated in obstructive airway diseases and significant intracranial issues. Key settings include bias flow, mean airway pressure, amplitude, frequency, and inspiratory time, with potential complications such as hypotension and pneumothorax.