Heart rate
Regulation of heart rate
Vasomotor center – cardiac center
Motor (efferent) nerve fibers to heart
Factors affecting vasomotor center
Applied
This document summarizes the cardiac cycle and its phases. It begins with an introduction to the heart as a dual pump and defines the cardiac cycle. It then describes the normal duration of the cardiac cycle and its various phases, including atrial systole, atrial diastole, ventricular systole, and ventricular diastole. It discusses the pressure and volume changes that occur in the atria, ventricles, aorta and pulmonary artery during each phase of the cardiac cycle. It also summarizes the heart sounds and murmurs that can occur.
The cardiac cycle describes the sequence of events in one heartbeat. It begins with atrial systole which pushes additional blood into the ventricles. This is followed by ventricular systole where the ventricles contract to pump blood out. Isovolumic contraction occurs as ventricular pressure rises, closing the AV valves before ejection. Ejection then proceeds rapidly initially and more slowly later. Isovolumic relaxation happens as ventricular pressure falls, opening the AV valves before rapid ventricular filling from the atria. The cycle then repeats with atrial systole.
Regulation of arterial blood pressure (The Guyton and Hall Physiology)Maryam Fida
BLOOD PRESSURE
The pressure exerted by the blood on vessel wall is known as blood pressure.
SYSTOLIC BLOOD PRESSURE
The maximum pressure exerted in the arteries during systole of heart.
Normal systolic pressure: 120 mm Hg.
DIASTOLIC BLOOD PRESSURE
The minimum pressure exerted in the arteries during diastole of heart.
Normal diastolic pressure: 80 mm Hg.
PULSE PRESSURE
The difference between the systolic pressure and diastolic pressure.
Normal pulse pressure: 40 mm Hg (120 – 80 = 40).
MEAN ARTERIAL BLOOD PRESSURE
The average pressure existing in the arteries.
Mean Arterial Blood Pressure = Diastolic Pressure + 1/3 Pulse Pressure
Pulse Pressure = (Systolic – Diastolic)
Mean Arterial Blood Pressure =Diastolic Pressure+1/3(Systolic – Diastolic)
Cardiac cycle refers to a complete heartbeat from its generation to the beginning of the next beat.
Cardiac events that occur from –
beginning of one heart beat to the beginning of the next are called the cardiac cycle.
This document summarizes the cardiac cycle and its seven phases: 1) atrial systole, 2) isovolumetric ventricular contraction, 3) rapid ventricular ejection, 4) reduced ventricular ejection, 5) isovolumetric ventricular relaxation, 6) rapid ventricular filling, and 7) reduced ventricular filling. It describes the relationship between pressures, volumes, and heart sounds in the left atrium and ventricle, aorta, and jugular vein throughout each phase of the cycle. It also discusses how arrhythmias like tachycardia and atrial fibrillation can impact the cardiac cycle by reducing stroke volume and cardiac output.
1. The heart rate is regulated by the nervous system, specifically the vasomotor center located in the medulla oblongata.
2. The vasomotor center contains vasoconstrictor and vasodilator areas that regulate heart rate by sending sympathetic or parasympathetic signals via the spinal cord. The vasoconstrictor area increases heart rate while the vasodilator area decreases it.
3. Factors like emotions, exercise and respiration can trigger the vasomotor center to adjust heart rate through sympathetic or parasympathetic outflow as part of reflex responses mediated by baroreceptors and chemoreceptors.
The cardiac cycle describes the repeating sequence of events in the heart during one heartbeat. It begins with atrial systole which fills the ventricles with blood. This is followed by ventricular systole where the ventricles contract and eject blood out of the heart. The cardiac cycle is regulated by the heart's conduction system which coordinates the contractions of the atria and ventricles. It ensures the atria contract before the ventricles so blood is pumped efficiently through the heart and circulatory system with each heartbeat.
There are four main mechanisms that regulate blood pressure: nervous, renal, hormonal, and local. The nervous mechanism acts the fastest via the vasomotor system to control heart rate and vasoconstriction/vasodilation in response to baroreceptors and chemoreceptors. The renal mechanism regulates blood pressure long-term by controlling extracellular fluid volume and through the renin-angiotensin system. Hormonal and local factors also contribute to blood pressure regulation.
This document summarizes the cardiac cycle and its phases. It begins with an introduction to the heart as a dual pump and defines the cardiac cycle. It then describes the normal duration of the cardiac cycle and its various phases, including atrial systole, atrial diastole, ventricular systole, and ventricular diastole. It discusses the pressure and volume changes that occur in the atria, ventricles, aorta and pulmonary artery during each phase of the cardiac cycle. It also summarizes the heart sounds and murmurs that can occur.
The cardiac cycle describes the sequence of events in one heartbeat. It begins with atrial systole which pushes additional blood into the ventricles. This is followed by ventricular systole where the ventricles contract to pump blood out. Isovolumic contraction occurs as ventricular pressure rises, closing the AV valves before ejection. Ejection then proceeds rapidly initially and more slowly later. Isovolumic relaxation happens as ventricular pressure falls, opening the AV valves before rapid ventricular filling from the atria. The cycle then repeats with atrial systole.
Regulation of arterial blood pressure (The Guyton and Hall Physiology)Maryam Fida
BLOOD PRESSURE
The pressure exerted by the blood on vessel wall is known as blood pressure.
SYSTOLIC BLOOD PRESSURE
The maximum pressure exerted in the arteries during systole of heart.
Normal systolic pressure: 120 mm Hg.
DIASTOLIC BLOOD PRESSURE
The minimum pressure exerted in the arteries during diastole of heart.
Normal diastolic pressure: 80 mm Hg.
PULSE PRESSURE
The difference between the systolic pressure and diastolic pressure.
Normal pulse pressure: 40 mm Hg (120 – 80 = 40).
MEAN ARTERIAL BLOOD PRESSURE
The average pressure existing in the arteries.
Mean Arterial Blood Pressure = Diastolic Pressure + 1/3 Pulse Pressure
Pulse Pressure = (Systolic – Diastolic)
Mean Arterial Blood Pressure =Diastolic Pressure+1/3(Systolic – Diastolic)
Cardiac cycle refers to a complete heartbeat from its generation to the beginning of the next beat.
Cardiac events that occur from –
beginning of one heart beat to the beginning of the next are called the cardiac cycle.
This document summarizes the cardiac cycle and its seven phases: 1) atrial systole, 2) isovolumetric ventricular contraction, 3) rapid ventricular ejection, 4) reduced ventricular ejection, 5) isovolumetric ventricular relaxation, 6) rapid ventricular filling, and 7) reduced ventricular filling. It describes the relationship between pressures, volumes, and heart sounds in the left atrium and ventricle, aorta, and jugular vein throughout each phase of the cycle. It also discusses how arrhythmias like tachycardia and atrial fibrillation can impact the cardiac cycle by reducing stroke volume and cardiac output.
1. The heart rate is regulated by the nervous system, specifically the vasomotor center located in the medulla oblongata.
2. The vasomotor center contains vasoconstrictor and vasodilator areas that regulate heart rate by sending sympathetic or parasympathetic signals via the spinal cord. The vasoconstrictor area increases heart rate while the vasodilator area decreases it.
3. Factors like emotions, exercise and respiration can trigger the vasomotor center to adjust heart rate through sympathetic or parasympathetic outflow as part of reflex responses mediated by baroreceptors and chemoreceptors.
The cardiac cycle describes the repeating sequence of events in the heart during one heartbeat. It begins with atrial systole which fills the ventricles with blood. This is followed by ventricular systole where the ventricles contract and eject blood out of the heart. The cardiac cycle is regulated by the heart's conduction system which coordinates the contractions of the atria and ventricles. It ensures the atria contract before the ventricles so blood is pumped efficiently through the heart and circulatory system with each heartbeat.
There are four main mechanisms that regulate blood pressure: nervous, renal, hormonal, and local. The nervous mechanism acts the fastest via the vasomotor system to control heart rate and vasoconstriction/vasodilation in response to baroreceptors and chemoreceptors. The renal mechanism regulates blood pressure long-term by controlling extracellular fluid volume and through the renin-angiotensin system. Hormonal and local factors also contribute to blood pressure regulation.
HEART RATE
REGULATION OF HEART RATE
VASOMOTOR CENTER – CARDIAC CENTER
MOTOR (EFFERENT) NERVE FIBERS TO HEART
FACTORS AFFECTING VASOMOTOR CENTER
for all medical & health care students
The cardiac cycle refers to the repeating sequence of events that occur with each heartbeat, from the beginning of one heartbeat to the beginning of the next. The cardiac cycle involves both atrial and ventricular contraction (systole) followed by relaxation (diastole). There are three main stages: 1) atrial systole, where the atria contract; 2) ventricular systole, where the ventricles contract; and 3) complete cardiac diastole, where both the atria and ventricles relax. The cycle allows for blood to flow through the heart and into the arteries with each heartbeat.
DETERMINANTS AND FACTORS AFFECTING CARDIAC OUTPUTakash chauhan
This document discusses the determinants and factors affecting cardiac output. It defines cardiac output as the volume of blood pumped by the heart each minute, which is determined by stroke volume and heart rate. Ejection fraction is explained as the fraction of blood ejected from the ventricles with each heartbeat. Cardiac output can vary due to physiological factors like age, sex, exercise, and pathological factors like fever or shock. Cardiac output is maintained by four main factors - venous return, force of contraction, heart rate, and peripheral resistance. Venous return depends on respiratory pumping, muscle pumping, gravity, and venous pressure.
Cardiac cycle (The Guyton and Hall physiology)Maryam Fida
Sequence of events from the beginning of one systole to the beginning of next consecutive systole.
One heart beat consists of one systole and one diastole.
Each cardiac cycle is initiated by the cardiac impulse which originates from the SA node.
During each cardiac cycle, certain events occur in the heart and these include pressure changes, volume changes, production of heart sounds, closure and opening of heart valves and electrical changes in the heart.
Cardiac muscle (The Guyton and Hall Physiology)Maryam Fida
In the heart there is Atrial muscle and Ventricular muscle which are separated from each other by the fibrous AV Rings containing Valves.
ATRIAL MUSCLE: thin walled. There are two sheets, superficial and deep sheet. Superficial sheet is common over both atria. Deep sheet is separate for each atrium. Muscle fibers in the deep sheet are at right angle to the muscle fibers in the superficial sheet.
FUNCTIONS OF THE ATRIUM:
1. Receive venous blood from large veins. So atria act as reservoir.
2. Conduct the blood into the ventricles.
3. Atrial contraction is responsible for last 25 % of ventricular filling.
4. In the right atrium there is SA Node(Pace maker) and AV node.
5. In the wall of the atria, there are low pressure stretch receptors and these are involved in various reflexes like brain bridge reflex and left atrial reflex.
6. Atria also produce a hormone i.e. Atrial Natriuretic Hormone. Whenever NaCl increases in ECF, it causes release of ANH which causes natriuresis.
VENTRICULAR MUSCLE:
Much thicker than atrial muscle. Thickness of right ventricle wall is 3-4 mm and thickness of left ventricle is 8 – 12 mm.
1.Involuntary
2.Has cross striations
3.Each cardiac muscle fiber consists of a number of cardiac cells, united at ends in series. Where as in skeletal muscle each muscle fiber is individual cell.
4.Cardiac muscle cells are branching and interdigitate.
5.Single central nucleus in each cell.
6. Atrial muscle and ventricular muscle act as separate functional syncytium and impulses from atria are conducted to ventricles through the AV Node and AV Bundle.
7. Sarcoplasmic system is present. In skeletal muscle triad is at the junction of A and I bands. In cardiac muscle T Tubules are much large and thus in cardiac muscle if we take a section it may form a diad or a triad. And these diads and triads are present at the level of Z Disks.
8.Between adjacent cardiac cells there are side to side and end to end connections and these are the intercellular junctions. These junctions are Gap Junctions. Or intercalated discs
9.When one part of myocardium is excited the whole muscle is excited.
10.Whole myocardium obeys all or none law as a whole.
11.No spike potential but action potential with plateau.
12.Has got long refractory period.
Absolute refractory period in ventricular muscle is 250 – 300 milli sec.
In atrial muscle Absolute refractory period is 150 milli sec
Because of long refractory period cardiac muscle cannot be tetanized.
This Presentation is all about the Cardiac cycle.
The cardiac cycle is the performance of the human heart from the ending of one heartbeat to the beginning of the next. It consists of two periods: one during which the heart muscle relaxes and refills with blood, called diastole, following a period of robust contraction and pumping of blood, dubbed systole.
This document discusses cardiovascular physiology, beginning with an overview of the cardiac cycle and events in the cycle. It then covers determinants of myocardial performance including preload, afterload, contractility, and heart rate. Pressure-volume loops are introduced as a way to assess ventricular function. Physiological and pathological hypertrophy are compared. Key aspects covered include the Wiggers diagram, Frank-Starling mechanism, Anrep effect, Bowditch phenomenon, and formulas for calculating cardiac values.
Origin and spread of cardiac impulse, pacemaker, conducting system of heart, ...Rajesh Goit
The document discusses the cardiac impulse and conduction system of the heart. It notes that the heartbeat originates from the sinus node, which acts as the natural pacemaker at a rate of 70-80 beats per minute. The impulse then spreads through the atrioventricular node and Purkinje fibers to contract the atria and ventricles in sequence. The conduction rates vary in different cardiac tissues. The sinus node controls the heartbeat under normal conditions, but abnormal pacemakers can develop elsewhere in rare cases. The conduction system ensures coordinated contraction of the heart chambers to effectively pump blood.
The cardiac cycle describes the sequence of events in the heart between two subsequent contractions. It consists of atrial systole, ventricular systole, atrial diastole, and ventricular diastole. During atrial systole, the atria contract and pump blood into the ventricles. Ventricular systole follows, where the ventricles contract and eject blood from the heart. The electrocardiogram (ECG) records the electrical activity of the heart throughout the cardiac cycle, represented by the P, Q, R, S, and T waves.
The document discusses the cardiac cycle and its various phases. It describes that the cardiac cycle consists of systole and diastole. Systole is the contraction phase where the ventricles pump blood out, while diastole is the relaxation phase where the ventricles fill with blood. The cycle is further divided into atrial and ventricular events. Each phase of the cardiac cycle is defined along with its duration and significance in the overall heart function.
The document summarizes key aspects of heart physiology:
- The heart pumps blood through two circuits and uses valves to ensure one-way blood flow.
- Cardiac muscle cells contract as a unit due to intercalated disks and gap junctions.
- The heart's conduction system uses specialized pacemaker cells and Purkinje fibers to coordinate contractions.
- An electrocardiogram tracks the heart's electrical activity during a cardiac cycle of atrial and ventricular filling/contraction.
Cardiac output (The Guyton and Hall Physiology)Maryam Fida
Cardiac output is the volume of blood pumped by each ventricle per minute. It is calculated as stroke volume multiplied by heart rate. Normal cardiac output is 5 liters per minute. Cardiac output is regulated by factors that influence stroke volume and heart rate. Stroke volume depends on end diastolic volume and end systolic volume. Heart rate is controlled by the autonomic nervous system, including the parasympathetic and sympathetic nerves, as well as the vasomotor center in the medulla. Parasympathetic stimulation decreases heart rate while sympathetic stimulation increases it.
The cardiac cycle describes the sequence of events in the heart from the beginning of one heartbeat to the next. It consists of both electrical and mechanical events in the atria and ventricles over a total duration of 0.8 seconds for each cycle. The cycle includes atrial systole, atrial diastole, ventricular systole (consisting of isovolumic contraction and ejection phases), and ventricular diastole (consisting of relaxation, rapid filling, reduced filling, and last rapid filling phases). Precise timing and coordination of the opening and closing of the atrioventricular and semilunar valves are crucial for efficient pumping of blood throughout the cardiac cycle.
1. Blood pressure is regulated through short, intermediate, and long-term control mechanisms. Short-term control is achieved through baroreceptor and chemoreceptor reflexes that sense changes in blood pressure and cardiac output.
2. Intermediate control is provided by the renin-angiotensin system, which causes vasoconstriction. Long-term control involves the renin-angiotensin-aldosterone system and hormones like vasopressin and atrial natriuretic peptide that regulate blood volume and vascular tone.
3. Local control of blood pressure is achieved through the actions of vasodilators like nitric oxide and vasoconstrictors like endothelin and angiotensin
SEMINAR ON BLOOD PRESSURE REGULATION, Determinants of Arterial BP
Functions Of Blood Pressure
Physiological Variations In Bp
Blood Pressure Regulation
Applied Physiology
The document summarizes several aspects of regional circulations, including the coronary, cutaneous, cerebral, skeletal muscle, splanchnic, and renal circulations. Specific details provided on the coronary circulation include its high blood flow even at rest, regulation of flow through metabolic and neural mechanisms, and implications for conditions like myocardial infarction and heart failure. Key aspects of the cutaneous circulation discussed are its role in temperature regulation through sympathetic nervous system control of arterioles and anastomoses, and local vasodilation or constriction in response to heating and cooling.
The document discusses the regulation of blood flow to tissues and organs. It describes acute control which occurs rapidly through vasoconstriction or vasodilation and long term control which involves changes to blood vessel structure over days or weeks. Key mechanisms of acute control include autoregulation to maintain constant blood flow despite pressure changes, active hyperemia to increase flow during increased activity, and reactive hyperemia providing a temporary surge in flow after ischemia. Long term control involves angiogenesis and developing collateral blood vessels. Regulation also occurs through vasoactive hormones, ions, and other chemicals that cause vasoconstriction or vasodilation.
The conduction system of the heart generates and conducts electrical impulses to coordinate the rhythmic contraction of the heart muscles. It consists of the sinoatrial node, internodal pathways, atrioventricular node, bundle of His, and Purkinje fibers. The sinoatrial node acts as the natural pacemaker by initiating electrical impulses. These impulses then travel through the internodal pathways to the atrioventricular node, where they are delayed to allow the atria to contract before the ventricles. The impulse then travels down the bundle of His which splits into right and left bundle branches to coordinate simultaneous contraction of the ventricles.
The cardiac cycle begins with the spontaneous generation of an action potential in the sinus node which triggers contractions that move through the heart. It consists of systole, where the heart contracts to pump blood, and diastole, where the heart relaxes and refills with blood. Each cycle takes approximately 0.8 seconds and involves coordinated opening and closing of valves between the atria and ventricles and between the ventricles and arteries. Pressure and volume curves change dynamically throughout the cycle as the heart contracts and relaxes, pumping blood through the body.
This document discusses normal and abnormal heart rates and the regulation of heart rate. It defines normal heart rate as between 60-80 beats per minute. Tachycardia is over 100 bpm and bradycardia is under 60 bpm. It describes physiological and pathological conditions that can cause tachycardia or bradycardia. The regulation of heart rate involves the vasomotor center in the medulla which receives input from higher brain centers, respiratory centers, and baroreceptors. This center controls the sympathetic and parasympathetic nervous system output to the heart to maintain normal heart rate.
Cardiac reflexes maintain homeostasis through feedback loops between the heart and central nervous system. Key reflexes include the baroreceptor reflex which regulates blood pressure via stretch receptors in the carotid sinus and aorta, the chemoreceptor reflex which responds to changes in blood oxygen and pH via the carotid and aortic bodies, and the Bezold-Jarisch reflex which induces hypotension, bradycardia, and coronary dilation in response to ventricular stimuli. Other reflexes like the Valsalva maneuver and Cushing reflex maintain cardiac function during changes in intrathoracic and intracranial pressure respectively.
HEART RATE
REGULATION OF HEART RATE
VASOMOTOR CENTER – CARDIAC CENTER
MOTOR (EFFERENT) NERVE FIBERS TO HEART
FACTORS AFFECTING VASOMOTOR CENTER
for all medical & health care students
The cardiac cycle refers to the repeating sequence of events that occur with each heartbeat, from the beginning of one heartbeat to the beginning of the next. The cardiac cycle involves both atrial and ventricular contraction (systole) followed by relaxation (diastole). There are three main stages: 1) atrial systole, where the atria contract; 2) ventricular systole, where the ventricles contract; and 3) complete cardiac diastole, where both the atria and ventricles relax. The cycle allows for blood to flow through the heart and into the arteries with each heartbeat.
DETERMINANTS AND FACTORS AFFECTING CARDIAC OUTPUTakash chauhan
This document discusses the determinants and factors affecting cardiac output. It defines cardiac output as the volume of blood pumped by the heart each minute, which is determined by stroke volume and heart rate. Ejection fraction is explained as the fraction of blood ejected from the ventricles with each heartbeat. Cardiac output can vary due to physiological factors like age, sex, exercise, and pathological factors like fever or shock. Cardiac output is maintained by four main factors - venous return, force of contraction, heart rate, and peripheral resistance. Venous return depends on respiratory pumping, muscle pumping, gravity, and venous pressure.
Cardiac cycle (The Guyton and Hall physiology)Maryam Fida
Sequence of events from the beginning of one systole to the beginning of next consecutive systole.
One heart beat consists of one systole and one diastole.
Each cardiac cycle is initiated by the cardiac impulse which originates from the SA node.
During each cardiac cycle, certain events occur in the heart and these include pressure changes, volume changes, production of heart sounds, closure and opening of heart valves and electrical changes in the heart.
Cardiac muscle (The Guyton and Hall Physiology)Maryam Fida
In the heart there is Atrial muscle and Ventricular muscle which are separated from each other by the fibrous AV Rings containing Valves.
ATRIAL MUSCLE: thin walled. There are two sheets, superficial and deep sheet. Superficial sheet is common over both atria. Deep sheet is separate for each atrium. Muscle fibers in the deep sheet are at right angle to the muscle fibers in the superficial sheet.
FUNCTIONS OF THE ATRIUM:
1. Receive venous blood from large veins. So atria act as reservoir.
2. Conduct the blood into the ventricles.
3. Atrial contraction is responsible for last 25 % of ventricular filling.
4. In the right atrium there is SA Node(Pace maker) and AV node.
5. In the wall of the atria, there are low pressure stretch receptors and these are involved in various reflexes like brain bridge reflex and left atrial reflex.
6. Atria also produce a hormone i.e. Atrial Natriuretic Hormone. Whenever NaCl increases in ECF, it causes release of ANH which causes natriuresis.
VENTRICULAR MUSCLE:
Much thicker than atrial muscle. Thickness of right ventricle wall is 3-4 mm and thickness of left ventricle is 8 – 12 mm.
1.Involuntary
2.Has cross striations
3.Each cardiac muscle fiber consists of a number of cardiac cells, united at ends in series. Where as in skeletal muscle each muscle fiber is individual cell.
4.Cardiac muscle cells are branching and interdigitate.
5.Single central nucleus in each cell.
6. Atrial muscle and ventricular muscle act as separate functional syncytium and impulses from atria are conducted to ventricles through the AV Node and AV Bundle.
7. Sarcoplasmic system is present. In skeletal muscle triad is at the junction of A and I bands. In cardiac muscle T Tubules are much large and thus in cardiac muscle if we take a section it may form a diad or a triad. And these diads and triads are present at the level of Z Disks.
8.Between adjacent cardiac cells there are side to side and end to end connections and these are the intercellular junctions. These junctions are Gap Junctions. Or intercalated discs
9.When one part of myocardium is excited the whole muscle is excited.
10.Whole myocardium obeys all or none law as a whole.
11.No spike potential but action potential with plateau.
12.Has got long refractory period.
Absolute refractory period in ventricular muscle is 250 – 300 milli sec.
In atrial muscle Absolute refractory period is 150 milli sec
Because of long refractory period cardiac muscle cannot be tetanized.
This Presentation is all about the Cardiac cycle.
The cardiac cycle is the performance of the human heart from the ending of one heartbeat to the beginning of the next. It consists of two periods: one during which the heart muscle relaxes and refills with blood, called diastole, following a period of robust contraction and pumping of blood, dubbed systole.
This document discusses cardiovascular physiology, beginning with an overview of the cardiac cycle and events in the cycle. It then covers determinants of myocardial performance including preload, afterload, contractility, and heart rate. Pressure-volume loops are introduced as a way to assess ventricular function. Physiological and pathological hypertrophy are compared. Key aspects covered include the Wiggers diagram, Frank-Starling mechanism, Anrep effect, Bowditch phenomenon, and formulas for calculating cardiac values.
Origin and spread of cardiac impulse, pacemaker, conducting system of heart, ...Rajesh Goit
The document discusses the cardiac impulse and conduction system of the heart. It notes that the heartbeat originates from the sinus node, which acts as the natural pacemaker at a rate of 70-80 beats per minute. The impulse then spreads through the atrioventricular node and Purkinje fibers to contract the atria and ventricles in sequence. The conduction rates vary in different cardiac tissues. The sinus node controls the heartbeat under normal conditions, but abnormal pacemakers can develop elsewhere in rare cases. The conduction system ensures coordinated contraction of the heart chambers to effectively pump blood.
The cardiac cycle describes the sequence of events in the heart between two subsequent contractions. It consists of atrial systole, ventricular systole, atrial diastole, and ventricular diastole. During atrial systole, the atria contract and pump blood into the ventricles. Ventricular systole follows, where the ventricles contract and eject blood from the heart. The electrocardiogram (ECG) records the electrical activity of the heart throughout the cardiac cycle, represented by the P, Q, R, S, and T waves.
The document discusses the cardiac cycle and its various phases. It describes that the cardiac cycle consists of systole and diastole. Systole is the contraction phase where the ventricles pump blood out, while diastole is the relaxation phase where the ventricles fill with blood. The cycle is further divided into atrial and ventricular events. Each phase of the cardiac cycle is defined along with its duration and significance in the overall heart function.
The document summarizes key aspects of heart physiology:
- The heart pumps blood through two circuits and uses valves to ensure one-way blood flow.
- Cardiac muscle cells contract as a unit due to intercalated disks and gap junctions.
- The heart's conduction system uses specialized pacemaker cells and Purkinje fibers to coordinate contractions.
- An electrocardiogram tracks the heart's electrical activity during a cardiac cycle of atrial and ventricular filling/contraction.
Cardiac output (The Guyton and Hall Physiology)Maryam Fida
Cardiac output is the volume of blood pumped by each ventricle per minute. It is calculated as stroke volume multiplied by heart rate. Normal cardiac output is 5 liters per minute. Cardiac output is regulated by factors that influence stroke volume and heart rate. Stroke volume depends on end diastolic volume and end systolic volume. Heart rate is controlled by the autonomic nervous system, including the parasympathetic and sympathetic nerves, as well as the vasomotor center in the medulla. Parasympathetic stimulation decreases heart rate while sympathetic stimulation increases it.
The cardiac cycle describes the sequence of events in the heart from the beginning of one heartbeat to the next. It consists of both electrical and mechanical events in the atria and ventricles over a total duration of 0.8 seconds for each cycle. The cycle includes atrial systole, atrial diastole, ventricular systole (consisting of isovolumic contraction and ejection phases), and ventricular diastole (consisting of relaxation, rapid filling, reduced filling, and last rapid filling phases). Precise timing and coordination of the opening and closing of the atrioventricular and semilunar valves are crucial for efficient pumping of blood throughout the cardiac cycle.
1. Blood pressure is regulated through short, intermediate, and long-term control mechanisms. Short-term control is achieved through baroreceptor and chemoreceptor reflexes that sense changes in blood pressure and cardiac output.
2. Intermediate control is provided by the renin-angiotensin system, which causes vasoconstriction. Long-term control involves the renin-angiotensin-aldosterone system and hormones like vasopressin and atrial natriuretic peptide that regulate blood volume and vascular tone.
3. Local control of blood pressure is achieved through the actions of vasodilators like nitric oxide and vasoconstrictors like endothelin and angiotensin
SEMINAR ON BLOOD PRESSURE REGULATION, Determinants of Arterial BP
Functions Of Blood Pressure
Physiological Variations In Bp
Blood Pressure Regulation
Applied Physiology
The document summarizes several aspects of regional circulations, including the coronary, cutaneous, cerebral, skeletal muscle, splanchnic, and renal circulations. Specific details provided on the coronary circulation include its high blood flow even at rest, regulation of flow through metabolic and neural mechanisms, and implications for conditions like myocardial infarction and heart failure. Key aspects of the cutaneous circulation discussed are its role in temperature regulation through sympathetic nervous system control of arterioles and anastomoses, and local vasodilation or constriction in response to heating and cooling.
The document discusses the regulation of blood flow to tissues and organs. It describes acute control which occurs rapidly through vasoconstriction or vasodilation and long term control which involves changes to blood vessel structure over days or weeks. Key mechanisms of acute control include autoregulation to maintain constant blood flow despite pressure changes, active hyperemia to increase flow during increased activity, and reactive hyperemia providing a temporary surge in flow after ischemia. Long term control involves angiogenesis and developing collateral blood vessels. Regulation also occurs through vasoactive hormones, ions, and other chemicals that cause vasoconstriction or vasodilation.
The conduction system of the heart generates and conducts electrical impulses to coordinate the rhythmic contraction of the heart muscles. It consists of the sinoatrial node, internodal pathways, atrioventricular node, bundle of His, and Purkinje fibers. The sinoatrial node acts as the natural pacemaker by initiating electrical impulses. These impulses then travel through the internodal pathways to the atrioventricular node, where they are delayed to allow the atria to contract before the ventricles. The impulse then travels down the bundle of His which splits into right and left bundle branches to coordinate simultaneous contraction of the ventricles.
The cardiac cycle begins with the spontaneous generation of an action potential in the sinus node which triggers contractions that move through the heart. It consists of systole, where the heart contracts to pump blood, and diastole, where the heart relaxes and refills with blood. Each cycle takes approximately 0.8 seconds and involves coordinated opening and closing of valves between the atria and ventricles and between the ventricles and arteries. Pressure and volume curves change dynamically throughout the cycle as the heart contracts and relaxes, pumping blood through the body.
This document discusses normal and abnormal heart rates and the regulation of heart rate. It defines normal heart rate as between 60-80 beats per minute. Tachycardia is over 100 bpm and bradycardia is under 60 bpm. It describes physiological and pathological conditions that can cause tachycardia or bradycardia. The regulation of heart rate involves the vasomotor center in the medulla which receives input from higher brain centers, respiratory centers, and baroreceptors. This center controls the sympathetic and parasympathetic nervous system output to the heart to maintain normal heart rate.
Cardiac reflexes maintain homeostasis through feedback loops between the heart and central nervous system. Key reflexes include the baroreceptor reflex which regulates blood pressure via stretch receptors in the carotid sinus and aorta, the chemoreceptor reflex which responds to changes in blood oxygen and pH via the carotid and aortic bodies, and the Bezold-Jarisch reflex which induces hypotension, bradycardia, and coronary dilation in response to ventricular stimuli. Other reflexes like the Valsalva maneuver and Cushing reflex maintain cardiac function during changes in intrathoracic and intracranial pressure respectively.
The document discusses the mechanisms that regulate blood pressure in the short term, including the nervous system and chemicals. It explains that the nervous system, including the baroreceptor reflex and chemoreceptors, controls blood pressure by changing peripheral resistance within seconds or minutes in response to changes in blood pressure. The document also outlines the roles of the vasomotor center, sympathetic and parasympathetic activity, and adrenal glands in short term blood pressure regulation.
The cardiovascular system consists of the heart and blood vessels that circulate blood throughout the body. The heart has four chambers and uses valves to ensure one-way blood flow. It is regulated by the autonomic nervous system. During each cardiac cycle, the atria contract followed by ventricular contraction that pumps blood out of the heart into the arteries. Relaxation of the ventricles allows blood to flow back into the heart. The conductive system generates electrical signals that coordinate the heart's pumping action.
CARDIAC AUTONOMIC SYSTEM CLINICAL SIGNIFICANCE.pptxaamirrashid39
This document discusses the anatomy and physiology of the cardiac autonomic nervous system. It covers the extrinsic and intrinsic innervation of the heart, including the sympathetic and parasympathetic fibers. Evaluation methods for the autonomic system are described, such as orthostatic tests, heart rate variability, and tilt-table testing. Conditions related to autonomic dysfunction like postural orthostatic tachycardia syndrome and neurally mediated syncope are explained. The role of the autonomic system in arrhythmias and other cardiac conditions is also summarized.
The cardiovascular system consists of the heart and blood vessels. The heart pumps blood through two circuits: systemic circulation which pumps oxygenated blood to the body, and pulmonary circulation which pumps deoxygenated blood to the lungs. The heart has four chambers, valves to ensure one-way blood flow, and a specialized conduction system to coordinate contractions. Nervous and chemical factors regulate heart rate and function to meet metabolic demands. Electrocardiograms record the heart's electrical activity and are used to diagnose cardiovascular disorders.
Nervous and hormonal regulation of heart beat.pptxVidushirastogi17
nervous and hormonal regulation of heartbeat
Heart rate refers to the number of times the heart beats per minute and is directly related to workload being placed on the heart
The normal heart rate of resting adult human- 60-100
Bradycardia- slow heart rate (below 60 bpm)
Tachycardia- fast heart rate (above 100 bpm)
Irregular pattern in heart beating is termed as Arrhythmia
The conduction system of the heart consists of specialized cardiac muscle fibers that generate and conduct electrical impulses through the heart to coordinate the cardiac cycle. The key components are the sinoatrial node, atrioventricular node, bundle of His, and Purkinje fibers. The sinoatrial node initiates the heartbeat and stimulates the atria to contract. The impulse then travels to the atrioventricular node and through the bundle of His to stimulate simultaneous contraction of the ventricles. The autonomic nervous system also regulates heart rate in response to physiological demands on the body.
The document defines arterial blood pressure and its components: systolic, diastolic, pulse, and mean arterial pressure. It discusses factors that regulate blood pressure, including the nervous system's vasomotor center and reflexes, the kidneys' regulation of fluid volume and renin-angiotensin system, and hormonal factors. It also covers hypertension and hypotension, defining each and describing primary vs. secondary causes, manifestations, and treatment approaches.
Heart rate is the number of heartbeats per unit of time, usually per minute.
The heart rate is based on the number of contractions of the ventricles (the lower chambers of the heart).
Functional Organization of Autonomic ActivityAkash Agnihotri
This slide including Functional Organization of Autonomic Activity
A little intro about ANS
Then Organization of the nervous system including
Afferent/Efferent: Transmission
Somatic and Autonomic Nervous system
Sympathetic and Parasympathetic nervous system
Enteric nervous system
Their functions, differences in between functions and organization with some tables and figures
Then, the Role of the CNS in the control of autonomic functions
with example
Then, presynaptic modulation and postsynaptic modulation
Also, Innervations by the ANS
And lastly Transmitters other than acetylcholine and noradrenaline
The document discusses the regulation of blood pressure through three main mechanisms:
1. The nervous mechanism regulates blood pressure in the short-term through the vasomotor center and vasomotor fibers that cause vasoconstriction and vasodilation in response to signals from baroreceptors and chemoreceptors.
2. The renal mechanism regulates blood pressure in the long-term by controlling extracellular fluid volume and through the renin-angiotensin system.
3. The hormonal mechanism involves hormones like ADH, aldosterone, atrial natriuretic peptide that can increase or decrease blood pressure.
The autonomic nervous system (ANS) consists of motor neurons that innervate smooth and cardiac muscle and glands to ensure optimal support for body activities through subconscious control. The ANS has two divisions - the sympathetic and parasympathetic divisions - that generally have opposite effects on target organs. The sympathetic division mobilizes the body during times of stress or activity while the parasympathetic division promotes rest and recovery functions. Precise control of the ANS is achieved through dynamic interactions between the two divisions.
The autonomic nervous system (ANS) consists of motor neurons that innervate smooth and cardiac muscle and glands to ensure optimal support for body activities through subconscious control. The ANS has two divisions - the sympathetic and parasympathetic divisions - which generally have opposite effects on target organs. The sympathetic division mobilizes the body during times of stress or activity while the parasympathetic division promotes rest and recovery functions. Precise control of the ANS is achieved through dynamic antagonism between the two divisions.
The document summarizes cardiac physiology, including:
1. The cardiac cycle involves repetitive contraction (systole) and relaxation (diastole) of the heart chambers. Blood moves through the circulatory system based on pressure differences.
2. Key factors that influence cardiac output are preload, contractility, and afterload. Cardiac output is calculated as stroke volume multiplied by heart rate.
3. The autonomic nervous system and electrolytes like sodium, potassium, and calcium play important roles in regulating heart rate and contractility. The conduction system allows for coordinated contraction of the heart chambers.
1 CARDIOVASCULAR SYSTEM - INTRO, PROPERTIES ,CARDIAC CYC.pdfFridahchungu
The cardiovascular system consists of the heart, blood vessels, and blood. The heart pumps blood through the blood vessels in two circuits - systemic and pulmonary circulation. The heart has four chambers: right and left atria receive blood while right and left ventricles pump blood out. The cardiovascular system transports oxygen, nutrients, hormones and other substances to tissues and removes carbon dioxide and other waste. Each heartbeat is known as the cardiac cycle and consists of systole, when the heart contracts, and diastole, when the heart relaxes and refills with blood.
The cardiovascular system includes the heart and blood vessels. The heart weighs 200-400 grams and pumps around 7,751 litres of blood daily. It is located behind the sternum and is surrounded by membranes. Blood enters and exits the heart through major vessels while valves regulate flow between chambers. The heart muscle generates electrical impulses and contractions to circulate blood throughout the body. Cardiac output is regulated intrinsically through preload and afterload as well as extrinsically through the nervous and endocrine systems.
The cardiovascular system consists of the heart and blood vessels. The heart has four chambers and pumps blood through two circuits. It is innervated by the autonomic nervous system. The cardiac cycle involves atrial and ventricular contraction and relaxation. Factors such as hormones, temperature, exercise and the autonomic nervous system regulate heart rate and cardiac output.
The document discusses the circulatory system and blood pressure regulation. It describes the different types of blood vessels - arteries, arterioles, capillaries and veins. Arteries carry blood away from the heart while veins carry blood back to the heart. Capillaries are where gas and nutrient exchange occurs. Blood pressure is regulated through short-term mechanisms like the baroreceptor reflex and long-term mechanisms like the renin-angiotensin system. Heart failure and shock can occur if the heart or blood vessels are unable to effectively circulate blood and maintain adequate blood pressure.
Cardiac innervation seminar by Dr Manish Ruhela, SMS Medical College,jaipurmanishdmcardio
The document discusses the innervation of the heart. It notes that the heart receives nerve supply from the cardiac plexus, formed by sympathetic and parasympathetic fibers. The sympathetic fibers originate from the spinal cord and travel through the sympathetic trunk. They have long postganglionic fibers. The parasympathetic fibers originate from the brainstem and travel through the vagus nerve. They have short postganglionic fibers and more localized effects. Baroreceptors in the carotid sinus and aortic arch detect blood pressure changes and trigger the baroreceptor reflex to maintain blood pressure homeostasis.
Similar to Heart rate by Pandian M, Tutor, Dept of Physiology, DYPMCKOP,MH (20)
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The thalamus is located in the center of the cerebral hemispheres. It receives sensory input from various areas and projects to different cortical regions. The thalamus and cortex work as a single functional unit, with the thalamus integrating inputs and the cortex performing higher-level processing.
Anatomically, the thalamus is divided into anterior, lateral, and medial groups of nuclei. The lateral group contains sensory relay nuclei that project to sensory cortices. Association nuclei in the medial and dorsal groups integrate sensory and limbic inputs and project to association cortices. Nonspecific nuclei in the intralaminar and midline regions are involved in arousal, emotions, and alertness.
Damage to the
Pulmonary surfactant is produced by type II alveolar cells and acts to reduce surface tension in the lungs. It is composed primarily of phospholipids including dipalmitoyl phosphatidylcholine and surfactant proteins. Surfactant functions to prevent alveolar collapse during exhalation by reducing surface tension and to maintain uniform alveolar size. Disruption of surfactant production can lead to respiratory distress syndrome in newborns and adults with lung injury.
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The document provides an overview of the anatomy and physiology of the heart. It describes the four chambers of the heart, including the two atria that receive blood and two thick-walled ventricles that pump blood. The left ventricle must work harder than the right ventricle due to higher systemic resistance. Valves including the tricuspid, mitral, pulmonary and aortic valves are described. Their roles in regulating blood flow and sounds produced from their closure are also summarized. The conducting system including the sinoatrial node, atrioventricular node and Purkinje fibers is briefly outlined. Finally, the document lists references for further reading on cardiac anatomy and physiology.
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Cardiac muscle has unique properties that allow the heart to function as a syncytium.
1) Cardiac cells are branched and joined by intercalated discs containing desmosomes and gap junctions, allowing action potentials to spread between cells.
2) The heart has specialized pacemaker cells in the sinoatrial node that generate action potentials spontaneously due to unstable membrane potentials and funny channels.
3) Cardiac action potentials have a plateau phase due to calcium influx through L-type calcium channels, allowing the heart to contract forcefully for over 200ms.
The document discusses renal tubular reabsorption and secretion. It covers:
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2. In the loop of Henle, the descending limb reabsorbs water by passive diffusion. The thick ascending limb actively reabsorbs sodium, chloride, and potassium.
3. The distal tubules and collecting ducts reabsorb approximately 7% of filtered NaCl and 8-17% of water. They secrete potassium and hydrogen ions. The medullary collecting duct is perme
The document summarizes the three main processes involved in urine formation: glomerular filtration, tubular reabsorption, and tubular secretion. It describes glomerular filtration in detail, including the characteristics of the filtration membrane that allow it to be highly selective. The normal glomerular filtration rate is 125 mL/minute, with the kidneys producing a total of about 180 L of filtrate per day. Glomerular filtration rate is regulated by several factors that influence the net filtration pressure across the glomerular membrane.
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1. The document discusses the physiology of micturition and bladder dysfunctions.
2. It describes the anatomy and innervation of the urinary bladder, as well as the mechanism of micturition and how micturition is controlled.
3. Various bladder dysfunctions that can occur due to lesions at different levels of the neuraxis are also discussed.
The countercurrent mechanism involves the loops of Henle and vasa recta working together to create and maintain an osmotic gradient in the renal medulla. The loops of Henle function as countercurrent multipliers, actively transporting ions from the thick ascending limb to increase the osmolarity of the interstitial fluid. The vasa recta parallel the loops of Henle and function as countercurrent exchangers, rapidly exchanging fluids between ascending and descending limbs to minimize washing out solutes and preserve the osmotic gradient as blood flows through the medulla. This countercurrent system allows urine to be concentrated as water is reabsorbed along the nephron according to the osmotic gradient in the
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The document discusses the neuromuscular junction and muscle contraction physiology. It defines the neuromuscular junction as the connection between motor neurons and muscle fibers that initiates muscle contraction. The structure and function of the neuromuscular junction is described, including the roles of acetylcholine, receptors, and acetylcholinesterase. The sliding filament model of muscle contraction is introduced. Different muscle fiber types, properties of muscle tissue, and the sarcomere as the contractile unit are defined.
Degeneration & regeneration of nerve fiber.ppt by Dr. PANDIAN M.Pandian M
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Hemoglobin is the protein in red blood cells that carries oxygen from the lungs to tissues and carbon dioxide from tissues back to the lungs. It is composed of globin and heme, with the heme portion containing iron that binds to oxygen. Hemoglobin allows for the efficient transport of oxygen and carbon dioxide throughout the body.
COMPOSITION
BLOOD CELLS
PLASMA
SERUM
FUNCTIONS
NUTRITIVE FUNCTION
RESPIRATORY FUNCTION
EXCRETORY FUNCTION
TRANSPORT OF HORMONES AND ENZYMES
REGULATION OF WATER BALANCE
REGULATION OF ACID-BASE BALANCE
REGULATION OF BODY TEMPERATURE
STORAGE FUNCTION
DEFENSIVE FUNCTION
Blood is a connective tissue composed of plasma and cellular elements. Plasma is 55% of blood and contains water, proteins, nutrients, gases, and electrolytes. Cellular elements include red blood cells, white blood cells, and platelets. Red blood cells transport oxygen and carbon dioxide. White blood cells help fight infection. Platelets help with blood clotting. Blood has many functions including nutrient transport, waste removal, temperature regulation, hormone transport, and immune defense. Anemia is a decrease in red blood cells or hemoglobin and can be caused by blood loss, increased cell destruction, or decreased cell production.
Determination of WBC count by Dr. Pandian M..pptxPandian M
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Dr. Pandian M describes the procedure for performing a platelet count. Platelets serve important hemostatic functions and their normal range is 1.5-4 lakhs/cumm. The procedure involves mixing blood with a diluting fluid in a Neubauer chamber, then counting platelets in grid squares under a microscope. For the sample, 40 platelets were counted in 1/50 mm3, indicating a platelet count of 2 lakhs/mm3 of blood, within the normal range. Abnormally high or low platelet counts can occur due to various bone marrow and other disorders.
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• Pitfalls and pivots needed to use AI effectively in public health
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- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
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These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
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2. Objectives
•Heart rate
•Regulation of heart rate
•Vasomotor center – cardiac center
•Motor (efferent) nerve fibers to heart
•Factors affecting vasomotor center
•Applied
3. NORMAL HEART RATE
• Normal heart rate is 70 to 72/minute.
• It ranges between 60 and 80 per minute
4. VASOMOTOR CENTER – CARDIAC CENTER
• Vasomotor center is the nervous center that regulates the
heart rate
• It is the same center in brain, which regulates the blood
pressure.
• It is also called the cardiac center.
• Vasomotor center is bilaterally situated in the reticular
formation of medulla oblongata and lower part of pons.
5. Areas of Vasomotor Center
Vasomotor center is formed by three areas:
1. Vasoconstrictor area or Accelerator center
2. Vasodilator area or Inhibitory center
3. Sensory area.
6. VASOCONSTRICTOR AREA –
CARDIOACCELERATOR CENTER
Situation:-
•In reticular formation of medulla in floor of IV ventricle
and it forms the lateral portion of vasomotor center.
•It is otherwise known as pressor area or cardioaccelerator
center.
7. Function
•Vasoconstrictor area increases the HR by sending
accelerator impulses to heart, through sympathetic
nerves.
•It also causes constriction of blood vessels.
•Stimulation of this center in animals increases the HR and
•its removal or destruction decreases the heart rate.
Control Vasoconstrictor area is under the control of
hypothalamus and cerebral cortex.
8. VASODILATOR AREA –
CARDIOINHIBITORY CENTER
Situation;-
•In the reticular formation of medulla oblongata in
the floor of IV ventricle.
•It forms the medial portion of vasomotor center.
•It is also called depressor area or
cardioinhibitory center
9. •Function
•Vasodilator area decreases the HR by sending
inhibitory impulses to heart through vagus nerve.
•It also causes dilatation of blood vessels.
•When this area is removed or destroyed, heart rate
increases.
10. Control
•Vasodilator area is under the control of cerebral
cortex and hypothalamus.
•It is also controlled by the impulses from
baroreceptors, chemoreceptors and other
sensory impulses via afferent nerves.
11. SENSORY AREA
Situation
• Sensory area is in the posterior part of vasomotor center,
• which lies in nucleus of tractus solitarius in medulla and pons.
Function
• Sensory area receives sensory impulse via glossopharyngeal
nerve and vagus nerve from periphery, particularly, from the
baroreceptors.
• In turn, this area controls the vasoconstrictor and vasodilator
areas.
12. MOTOR (EFFERENT) NERVE FIBERS TO HEART
• Heart receives efferent nerves from both the divisions
of autonomic nervous system.
• Parasympathetic fibers arise from the medulla
oblongata and pass through vagus nerve.
• Sympathetic fibers arise from upper thoracic (T1 to
T4) segments of spinal cord
14. Origin
• Parasympathetic nerve fibers supplying heart arise
from the dorsal nucleus of vagus.
• medulla oblongata and is in close contact with
vasodilator area.
15. Distribution
• Preganglionic parasympathetic nerve fibers from dorsal
nucleus of vagus reach the heart
• by passing through the main trunk of vagus and
cardiac branch of vagus.
• After reaching the heart, preganglionic fibers terminate
on postganglionic neurons.
• Postganglionic fibers from these neurons innervate
heart muscle.
16. • Most of the fibers from right vagus terminate in
sinoatrial (SA) node.
• Remaining fibers supply the atrial muscles and
atrioventricular (AV) node.
• Most of the fibers from left vagus supply AV node and
some fibers supply the atrial muscle and SA node.
• Ventricles do not receive the vagus nerve supply.
18. Function
•Vagus nerve is cardioinhibitory in function and
carries
•inhibitory impulses from vasodilator area to the
heart.
19. SYMPATHETIC NERVE FIBERS
Sympathetic nerve fibers supplying the heart have
cardioacceleratory function.
Origin
• Preganglionic fibers of the sympathetic nerves to heart arise
from lateral gray horns of the first 4 thoracic (T1 to T4)
segments of the spinal cord.
• These segments of the spinal cord receive fibers from
vasoconstrictor area of vasomotor center.
20. Course and Distribution
• Preganglionic fibers reach the superior, middle and
• inferior cervical sympathetic ganglia situated in the
sympathetic chain.
• Inferior cervical sympathetic ganglion fuses with first
thoracic sympathetic ganglion, forming stellate
ganglion.
• From these ganglia, the postganglionic fibers arise.
21. Function
•Sympathetic nerves are cardioaccelerators in
function
•and carry cardioaccelerator impulses from
vasoconstrictor area to the heart.
22. SENSORY (AFFERENT) NERVE
FIBERS FROM HEART
• Afferent (sensory) nerve fibers from the heart pass
through inferior cervical sympathetic nerve.
• These nerve fibers carry sensations of stretch and pain
from the heart to brain via spinal cord.
24. The autonomic nervous system has two divisions:
• Sympathetic and parasympathetic:-
• Sympathetic impulses from the accelerator center along sympathetic
nerves increase heart rate and
• force of contraction during exercise and stressful situations (the
neurotransmitter is norepinephrine).
• Parasympathetic impulses from the inhibitory center along the vagus
nerves decrease the heart rate (the neurotransmitter is acetylcholine).
• At rest these impulses slow down the depolarization of the SA node to
what we consider a normal resting rate,
• they also slow the rate after exercise is over.
25. Our next question might be: What information is received by the
medulla to initiate changes?
1. Because the heart pumps blood, it is essential to maintain
normal blood pressure.
2. Blood contains oxygen, which all tissues must receive
continuously.
3. Therefore, changes in blood pressure and oxygen level of
the blood are stimuli for changes in heart rate
27. • Pressoreceptors and chemoreceptors are located in the carotid arteries and
aortic arch.
• Pressoreceptors in the carotid sinuses and aortic sinus detect changes in
blood pressure.
• Chemoreceptors in the carotid bodies and aortic body detect changes in
the oxygen content of the blood.
• The sensory nerves for the carotid receptors are the glossopharyngeal (9th
cranial) nerves;
• the sensory nerves for the aortic arch receptors are the vagus (10th cranial)
nerves.
• If we now put all of these facts together in a specific example, you will see
that the regulation of heart rate is a reflex, and the nerve impulses follow a
reflex arc.
28.
29. Reflex Arc
• A reflex arc is the pathway that nerve impulses travel when a
reflex is elicited, and there are five essential parts:
1. Receptors—detect a change (the stimulus) and generate
impulses.
2. Sensory neurons—transmit impulses from receptors to the
CNS.
3. Central nervous system—contains one or more synapses
(interneurons may be part of the pathway).
4. Motor neurons—transmit impulses from the CNS to the
effector.
5. Effector—performs its characteristic action.
31. • A person who stands up suddenly from a lying position may feel light-
headed or dizzy for a few moments,
• because blood pressure to the brain has decreased abruptly.
• The drop in blood pressure is detected by pressoreceptors in the carotid
sinuses—notice that they are “on the way” to the brain, a very strategic
location.
• The drop in blood pressure causes fewer impulses to be generated by the
pressoreceptors.
• These impulses travel along the hering’s nerve branch of
glossopharyngeal nerves to the medulla, and the decrease in the frequency
of impulses stimulates the accelerator center.
Reflex arc like action on Heart
32.
33. • The accelerator center generates impulses that are carried by
sympathetic nerves to the SA node, AV node, and ventricular
myocardium.
• As heart rate and force increase, blood pressure to the brain is
raised to normal, and the sensation of light-headedness passes.
• When blood pressure to the brain is restored to normal, the heart
receives more parasympathetic impulses from the inhibitory
center along the vagus nerves to the SA node and AV node.
• These parasympathetic impulses slow the heart rate to a normal
resting pace.
34. • The heart will also be the effector in a reflex stimulated by a decrease in the
oxygen content of the blood.
• The aortic receptors ({chemoreceptor}carotid bodies and aortic body ) are
strategically located so as to detect such an important change as soon as
blood leaves the heart.
• The reflex arc in this situation would be
(1) aortic chemoreceptors,
(2) vagus nerves (sensory),
(3) accelerator center in the medulla,
(4) sympathetic nerves, and
(5) the heart muscle, which will increase its rate and force of
contraction to circulate more oxygen to correct the hypoxemia.
35. • the hormone epinephrine is secreted by the adrenal medulla in
stressful situations.
• One of the many functions of epinephrine is to increase heart
rate and force of contraction.
• This will help supply more blood to tissues in need of more
oxygen.
36. The Cardiovascular Stress Response
• Get the heart to beat faster: ↑ SNS tone, ↓ PNS tone
• Norepinephrine (NE) and epinephrine (Epi) ↑ slow inflow of Na+ and
Ca++ increase rate of re-excitation in SA node.
• This ↑ Ca++ also increases contractility.
• SNS terminals also excite AV node and whole myocardium: enhances
contractility everywhere.
37. PNS
• Vagus nerve (via ACh) ↓ HR by ↓ slow inflow of Na+ and
Ca++ and by ↑ the subsequent outflow of potassium (K+).
• Acts at SA and AV nodes.
• May treat SNS-driven heart attack by gagging or massage of
carotid arteries activate vagal reflexes PNS counteracts
SNS.
38. Heart rate
Autonomic regulation (medullary
CV center): Receives input from
higher brain centers and variety of
sensory receptors
• Proprioceptors
• Chemoreceptors
• Baroreceptors
• Sympathetic output ↑HR and
contractility
• Parasympathetic impulses
↓ HR
• Little effect on contractility
(does not innervate
ventricular myocardium)
39.
40.
41. Atrial stretch receptors
• Atrial stretch receptors present in the walls of atria are
also called low-pressure receptors.
• Types of atrial stretch receptors. Atrial stretch receptor
have been studied in detail by Prof. A. S. Paintal (an
Indian scientist) in 1953.
• These can be divided into following types:
43. • Several factors contribute to regulation of heart rate:
• Chemical regulation
• Cardiac activity depressed by
• Hypoxia
• Acidosis
• Alkalosis
• Hormones
• Catecholamine's and thyroid hormones increase HR and contractility
• Cations
• Alterations in balance of K+, Na+ and Ca2+ alter HR and contractility
Heart rate
44. • Several other factors contribute to regulation of heart rate:
• Age
• Gender
• Female HR higher
• Physical fitness
• Resting bradycardia
• Body temperature
• Increase causes SA node to discharge more rapidly
Heart rate
45. TACHYCARDIA
The term “tachycardia” means fast heart rate, Usually defined
in an adult person as faster than 100 beats/min.
Physiological Conditions when Tachycardia Occurs
1. Childhood
2. Exercise
3. Pregnancy
4. Emotional conditions such as anxiety.
46.
47. Pathological Conditions when Tachycardia Occurs
1. Fever
2. Anemia
3. Hypoxia
4. Hyperthyroidism
5. Hypersecretion of catecholamine's
6. Cardiomyopathy
7. Diseases of heart valves
48. BRADYCARDIA
• The term “bradycardia” means a slow heart rate,
• Usually defined as fewer than 60 beats/min.
Physiological Conditions
when Bradycardia Occurs
1. Sleep
2. Athletes.
Pathological Conditions when
Bradycardia Occurs
1. Hypothermia
2. Hypothyroidism
3. Heart attack
4. Congenital heart disease
5. Degenerative process of aging
6. Obstructive jaundice
7. Increased intracranial pressure.
49.
50.
51. Drugs which Induce Bradycardia
1. Beta blockers
2. Channel blockers
3. Digitalis and other antiarrhythmic drugs.
52. Vasopressin
• Enhances water retention
• Causes vasoconstriction
• Secretion increased by aortic baroreceptors and
atrial sensors
http://www.cvphysiology.com/Blood%20Pressure/BP016.htm
53.
54. Summary of long term BP control
• Cardiac output and BP depend on renal control
of extra-cellular fluid volume via:
• Pressure natriuresis, (increased renal filtration)
• Changes in:
• Vasopressin
• Aldosterone
• Atrial natiuretic peptide
All under the control of altered cardiovascular
receptor signaling
55. SUMMARY
• As you can see, the nervous system regulates the
functioning of the heart based on what the heart is
supposed to do.
• The pumping of the heart maintains normal blood
pressure and proper oxygenation of tissues,
• The nervous system ensures that the heart will be able
to meet these demands in different situations.
56. References
•Text book of Medical Physiology
• Guyton & Hall
•Human Physiology
• Vander
•Text book of Medical Physiology
• Indukurana, Sembu, LPR
•Principles of Anatomy and Physiology
• Totora
•Net source