This document discusses halogenation reactions, which involve replacing a halogen atom with another substance or adding halogens to a substance. It describes three main types of halogenation reactions: addition to unsaturated bonds, substitution reactions where halogens replace hydrogen, and replacement reactions where halogens replace other groups. The document also discusses common halogenating agents used to catalyze these reactions like iron, antimony, and phosphorus compounds. Finally, it provides an overview of reaction kinetics and how rate equations are used to relate the rate of reaction to reactant concentrations and determine the order of reactions.

1. HALOGENATION
PRESENTING BY:
Mr. PURUSHOTHAM K.N
ASSI.PROFESSOR
DEPT.OF.PH.CHEMISTRY
SACCP, B.G.NAGARA.
2022-2023

2. Contents
1.Halogenation
2. Types of halogenation
3.Kinetics of halogenation

3. HALOGENATION
Halogenation refers to a type of chemical reaction that involves
the replacement of a halogen atom with another substance,
wherein it ends up as a part of that substance or a compound
during the halogenation reaction, there is usually an addition of
one or more halogens to the substance.
For example
the addition of bromine to ethene produces the substituted
alkane 1,2‐dibromoethane.

4. The preparation of organic compounds containing fluorine, chlorine,
bromine and iodine can be done by a variety of methods.
The conditions and procedures differ, not only for each member of the
halogen family but also with the type and structure of the compound
undergoing treatment.
The chlorine derivatives, because of the greater economy preparation,
are the most important compound

5. Halogenations may involve reactions of
Addition
Substitution i.e. of hydrogen,
Replacement, i.e. of groups for example, the hydroxyl or sulfonic acid group

6. Types of halogenations
Halogenations may involve reactions of
1. Addition to an unsaturated bond
2. Substitution for hydrogen or
3. By replacement of another group for example hydroxyl (–OH) or
sulfonic (–SO3H)

7. Addition to an unsaturated bond

8. Substitution reaction

9. By Electrophilic substitution

10. Halogenations By replacement of another group for example
hydroxyl (–OH)

11. Halogenating agents
• Each type of reaction may involve not only a specific halogenating
agent but also a suitable catalyst or activator.
• Many of the catalysts are halogen carriers.
• Fe, antimony, and P, are exist in two valencies as halogen compounds,
are used, as they are less stable at the higher valence and give up part
of their halogen during the process

12. I2 , Br2 , and Cl2 are capable of forming mixed halogens are also
frequently employed as catalysts in halogenation processes.
• Activated carbon, clays, and other compounds also serve to catalyze
halogenation processes.
• Where the halogen is energized to an activated state by means of light,
heat, nuclear energy, or free radicals,
• It may then proceed to react by addition as in reaction (lb) or by
substitution without the need of a catalyst

13. Kinetics and the Rate Equation
• The study of reaction rates is called kinetics.
• The rate of a reaction is as important as the position of equilibrium.
• (Just because a reaction has a favorable DG°, does not mean the reaction
will spontaneously go).
• The rate of a reaction is how fast the products appear and how slow the
reactants disappear.
• These can be obtained experimentally by monitoring the concentrations of
either the products or reactants with respect to time.
• Reaction rates depend on the concentrations of reactants
• since at higher concentrations, collisions between reactants (leading to a
reaction) are more likely.

14. • The rate equation (rate law) relates the concentrations of the reactants to
the rate of reaction.
• Consider: A + B → C + D
• Rate = Kr [A]a [B]b
• The rate is proportional to the concentrations of A and B raised to some
power (a and b)
• Where kr is a rate constant, and a and b have to be determined
experimentally.
• Values a and b are usually whole numbers, and are called the order of
the reaction.
• (a+b) is the overall order of a reaction. Kinetics and the Rate Equation

15. • Consider the following reaction:
• CH3 -Br + -OH → CH3 -OH + Br-
• Experiments show that doubling the concentration of bromomethane,
doubles the rate of reaction. Also doubling the [- OH] doubles the rate.
• Therefore the rate is proportional to both [CH3Br] and [-OH], and the rate
equation would read:
• Rate = kr [CH3Br] [-OH]
• The rate is said to be first order w.r.t. bromomethane, and first order w.r.t.
hydroxide ion.
• The reaction is second order overall.

16. • However, similar reactions can have different kinetic orders. (CH3
)3C-Br + -OH → (CH3 )3C-OH + Br-
• For this reaction, doubling the [t-butylbromide] doubles the rate, but
doubling [-OH] has no effect on the rate.
• Rate = kr [(CH3 )3C-Br]
• First order w.r.t. t-butylbromide, but zeroth order w.r.t. hydroxide ion.
The order has to be obtained experimentally.

17. REFERENCE
• Pharmaceutical Engineering- C.V.S. Subrahmanyam. 293-381.
• https://www.slideshare.net/JoonJyotiSahariah/crystalli-zation-ppt

18. thank you