The document discusses COX-1 and COX-2 inhibitors. It notes that there are two forms of the cyclooxygenase enzyme, COX-1 and COX-2, which are involved in inflammation. COX-1 has beneficial effects and is present in most tissues, while COX-2 is primarily found at sites of inflammation. COX-1 inhibitors selectively inhibit COX-1, while COX-2 inhibitors selectively inhibit COX-2. Many classes of non-steroidal anti-inflammatory drugs act as COX inhibitors, including indoles, fenamates, oxicams, pyrazolones, and anilides. Selective COX-2 inhibitors like cele
the presentation is about antihistamine drugs used in treatment of alllergic conditions. it explains all medicinal chemistry aspects of antihistamines.
lead optimization of macrolide drug about
Contents
Introduction
MOA of Antibiotic
Macrolides- General Consideration
Mechanism of Action of Macrolide Antibiotics
Inhibition Of Protein Synthesis
Chemistry of Macrolides
Classification of Macrolide Antibiotics
Structure Activity Relationship
Lead Optimization
Structure of Macrolide Drug
Roxithromycin
Erythromycin
Macrolide Indications
the presentation is about antihistamine drugs used in treatment of alllergic conditions. it explains all medicinal chemistry aspects of antihistamines.
lead optimization of macrolide drug about
Contents
Introduction
MOA of Antibiotic
Macrolides- General Consideration
Mechanism of Action of Macrolide Antibiotics
Inhibition Of Protein Synthesis
Chemistry of Macrolides
Classification of Macrolide Antibiotics
Structure Activity Relationship
Lead Optimization
Structure of Macrolide Drug
Roxithromycin
Erythromycin
Macrolide Indications
Protein and peptide drug delivery systemSagar Savale
Protein and Peptide drug delivery system are the Novel drug Delivery System. Proteins and peptides are the most abundant components of biological cells. They exist functioning such as
enzymes, hormones, structural element and immunoglobulin. The distinction between peptides and proteins is having a peptide contains less than 20 amino acids, having a molecular weight less, while a protein possesses 50 or more amino acids and its molecular weight lies above this value. The most of pharmaceutical proteins and peptides are absorbed IM, IV and Subcutaneous route of Absorption, but the oral route is more convenient for absorption of protein as compared to other. Various problems associated with administration of protein and peptide drugs are needed to overcome by different pharmaceutical approaches. Several approaches available for
maximizing pharmacokinetic and pharmacodynamics properties are chemical modification,
formulation vehicles, mucoadhesive polymeric system, use of enzyme inhibitors, absorption
enhancers, penetration enhancers etc.
Industrial enzymes in the synthesis of drugs/ intermediatesPHARMA IQ EDUCATION
Importance of the following enzymes for the synthesis of drugs
1. introduction
2. penicillin acylase
3. lipase
4. oxidoreductase
5. transaminase
6. protease
Conclusion
References
Thanks
In this research, two drugs were bonded through amide and ester attachment, using lactic acid as
aspacer binder, produced di pro drug such as Procain and Ciprofloxacin. Since Procain has ailocail
anesthetic action and Ciprofloxacin as antibacterial drug was reacted with lactic acid produced ester
compound (1), then the carboxylic acid of lactic acid could reacted with free Procain oil produced amide
attachment, the controlled drug release in different pH values at 37C˚was studied to improve their
characteristic and to minimize the side effect of the drug could be used in broad spectrum activity as
atherapeutic material.This mutual prodrug was used with another biological active drug instead of single
action. The prepared prodrug was characterized by FTIR, 1HNMR ,and UV. spectroscopies ,physical
properties were determined and physical properties weremeasured.The biological assay were conducted
for prepared prodrug using the microorganism such as E.coli, staphylococcus aureus, pseudomonas
acuroginosoma, the prepared prodrug appear high biological activity,compared with standardGentamycin.
AMINOGLYCOSIDE-INTRODUCTION,HISTORY, MECHANISM OF ACTION, CHEMISTRY, RESISTANCE TO ANTIBIOTICS, CLASSIFICATION ,PHARMACOKINETIC, ADVERSE EFFECT, THERAPEUTIC USE
Protein and peptide drug delivery systemSagar Savale
Protein and Peptide drug delivery system are the Novel drug Delivery System. Proteins and peptides are the most abundant components of biological cells. They exist functioning such as
enzymes, hormones, structural element and immunoglobulin. The distinction between peptides and proteins is having a peptide contains less than 20 amino acids, having a molecular weight less, while a protein possesses 50 or more amino acids and its molecular weight lies above this value. The most of pharmaceutical proteins and peptides are absorbed IM, IV and Subcutaneous route of Absorption, but the oral route is more convenient for absorption of protein as compared to other. Various problems associated with administration of protein and peptide drugs are needed to overcome by different pharmaceutical approaches. Several approaches available for
maximizing pharmacokinetic and pharmacodynamics properties are chemical modification,
formulation vehicles, mucoadhesive polymeric system, use of enzyme inhibitors, absorption
enhancers, penetration enhancers etc.
Industrial enzymes in the synthesis of drugs/ intermediatesPHARMA IQ EDUCATION
Importance of the following enzymes for the synthesis of drugs
1. introduction
2. penicillin acylase
3. lipase
4. oxidoreductase
5. transaminase
6. protease
Conclusion
References
Thanks
In this research, two drugs were bonded through amide and ester attachment, using lactic acid as
aspacer binder, produced di pro drug such as Procain and Ciprofloxacin. Since Procain has ailocail
anesthetic action and Ciprofloxacin as antibacterial drug was reacted with lactic acid produced ester
compound (1), then the carboxylic acid of lactic acid could reacted with free Procain oil produced amide
attachment, the controlled drug release in different pH values at 37C˚was studied to improve their
characteristic and to minimize the side effect of the drug could be used in broad spectrum activity as
atherapeutic material.This mutual prodrug was used with another biological active drug instead of single
action. The prepared prodrug was characterized by FTIR, 1HNMR ,and UV. spectroscopies ,physical
properties were determined and physical properties weremeasured.The biological assay were conducted
for prepared prodrug using the microorganism such as E.coli, staphylococcus aureus, pseudomonas
acuroginosoma, the prepared prodrug appear high biological activity,compared with standardGentamycin.
AMINOGLYCOSIDE-INTRODUCTION,HISTORY, MECHANISM OF ACTION, CHEMISTRY, RESISTANCE TO ANTIBIOTICS, CLASSIFICATION ,PHARMACOKINETIC, ADVERSE EFFECT, THERAPEUTIC USE
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxEduSkills OECD
Andreas Schleicher presents at the OECD webinar ‘Digital devices in schools: detrimental distraction or secret to success?’ on 27 May 2024. The presentation was based on findings from PISA 2022 results and the webinar helped launch the PISA in Focus ‘Managing screen time: How to protect and equip students against distraction’ https://www.oecd-ilibrary.org/education/managing-screen-time_7c225af4-en and the OECD Education Policy Perspective ‘Students, digital devices and success’ can be found here - https://oe.cd/il/5yV
How to Create Map Views in the Odoo 17 ERPCeline George
The map views are useful for providing a geographical representation of data. They allow users to visualize and analyze the data in a more intuitive manner.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
How to Split Bills in the Odoo 17 POS ModuleCeline George
Bills have a main role in point of sale procedure. It will help to track sales, handling payments and giving receipts to customers. Bill splitting also has an important role in POS. For example, If some friends come together for dinner and if they want to divide the bill then it is possible by POS bill splitting. This slide will show how to split bills in odoo 17 POS.
