Gordon Lithgow at Health Extension Salon #7
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Dr. Lithgow, from the Buck Institute, presents evidence from his lab that multiple age-related diseases share a common root in cellular aging processes, and furthermore that interventions designed to affect the aging process could prevent or delay such diseases.
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This document discusses the biology of healthy aging and longevity. It covers several topics:
1) Molecular mechanisms of aging including genome integrity, telomeres, epigenetics, protein stability, and pathways like mTOR, IIS, AMPK, and sirtuins that modify aging.
2) Biological models like yeast, worms, flies and mice that are used to study aging mechanisms.
3) Calorie restriction which increases longevity across species by reversing signs of aging.
4) Maintaining genome, telomere and epigenome integrity is important for healthy aging and preventing diseases.
5) Environmental factors and nutrition influence aging through epigenetic changes.
Introduction to gerontology
It includes: ageing mechanisms, theories of ageing, epidemiology, demography and international gerontology
Telomeres: The Real Biologic Clock
Learning and understanding the correlation between telomere shortening and disease is the most important principal to stop the aging process. Dr Sears is one of the worlds most respected and renown Anti-Aging physicians in the world. Please visit our website at www.alsearsmd.com or www.searwellnesscenter.com for tons of great free information.
Theories of Aging - Part 1 in medicine and health sciences
This document provides an overview of theories of aging. It discusses both biological/physiological and psychological perspectives on aging. From a biological standpoint, it describes programmed aging theories like the telomere theory, which proposes that cells can only divide a finite number of times due to shortening telomeres. It also discusses error theories of aging, like the free radical theory, which suggests aging results from cellular damage over time. The document aims to explain the aging process and major theories about what causes aging.
ageing ppt.pdf
This document provides an overview of the biology of aging, covering general concepts, theories of aging, aging at the cellular and molecular level, and interventions in the aging process. It discusses topics such as the universality and rates of senescence across species, primary aging processes, theories including evolutionary, genetic/developmental, and oxidative damage theories. It covers cellular aging concepts such as replicative senescence, telomere shortening, and the role of telomerase. It also discusses pro-longevity factors seen in long-lived human populations and exceptions to characteristics typically associated with aging.
New Standard of Care
The document discusses establishing a new standard of care for nutrition intervention based on whole food concentrates rather than isolated vitamins and minerals. It outlines the limitations of current recommendations and the growing evidence from clinical studies showing whole food concentrates are more effective at the cellular level in supporting health, healing and reducing oxidative stress. Whole food concentrates have been shown to help conditions like cancer, heart disease, immune function and more in peer-reviewed research. The evidence suggests whole food concentrates should replace multivitamins as the recommended daily standard of care once healthcare professionals are properly educated on the data.
The aging kidneys
This document discusses aging and the aging kidney. It begins by outlining the epidemiology and theories of aging, including how aging is a cumulative process influenced by both genetic and environmental factors. It then examines age-related changes in the kidney, including morphological changes like glomerulosclerosis, interstitial fibrosis, and vascular sclerosis. These changes are thought to be caused by factors like telomere shortening, oxidative stress, inflammation, and accumulation of advanced glycation end products over time. Managing these age-related changes and underlying disease processes is an important part of caring for the growing elderly population.
Aging- the biology of senescence
Aging is a natural phenomenon. it is the law of nature
this slide is about the various factors which independently or in combinations contribute to aging in humans
Anti-aging supplements? Myths, reality and speculation
This document discusses aging and life extension. It outlines various theories for why we age, including the disposable soma theory which is considered highly credible. It describes some mechanisms of aging like telomeres, free radicals, glycation, and the thymus. Supplementing with folic acid is shown to reduce cancer rates and Alzheimer's risk in studies. Animal models are discussed as relevant to humans despite differences in lifespan. Combining micronutrients like coenzymes and minerals is suggested to have additive benefits for lifespan based on studies in insects and rodents.
Health awareness
The document discusses the importance of health and avoiding illness. It notes that life is short and precious, so we must take care of our health. It then lists many diseases and health conditions that supplements may help prevent or treat by combating free radicals and supporting the immune system. The document emphasizes that free radicals damage our bodies as we age and that we all need antioxidants from supplements to stay healthy.
1
This document discusses pathology and methods in general and clinical pathology. It provides definitions of disease and death as basic notions in pathology. It also classifies pathogenic factors and discusses mechanisms of cellular injury, including depletion of ATP, damage to mitochondria, influx of calcium, accumulation of reactive oxygen species, and defects in membrane permeability. Autopsy and biopsy methods used in pathology are described.
WELOCITY GENETICS DNA TESTING PROGRAM 14 FEB 2023.pptx
Predictive Healthcare with DNA Testing for Gene Based Wellness Solutions; Find out the Root cause and predict future heath risks. Get gene based diet plan
Brucellosis dr. satti new
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Immunotec Presentation Updated 24 11 09
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Theories of Aging - Part 1 in medicine and health sciences
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Joe describes the strategic mission of the Health Extension community with charts and graphs. Since aging is not a medical indication according to the FDA, therapies cannot be approved to treat it, so companies are not started to translate research into practice, and thus work in this area is generally, massively underfunded. How do we change this?
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Rob Meagley and Andrew Bleloch at Health Extension Salon #5
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Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
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Gastritis and Gastric Health
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Combination Therapies
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Gordon Lithgow at Health Extension Salon #7
- 1. The Buck Institute for Research on Aging Interdisciplinary Research Center on Geroscience
- 3. Kathleen Casey-Kirschling 1st Jan, 1946, 00.01AM
- 4. The Choice
- 5. Mechanisms of aging and disease are tightly linked Aging can be slowed
- 6. cardiovascular disease Parkinson’s Disease Huntington’s Disease Alzheimer’s Disease diabetes sarcopenia osteoperosis osteoarthritis macular degeneration adult cancer
- 7. tuberculosis small pox polio syphilis German measles mumps chicken pox pertussis diphtheria tenatus flu
- 9. cardiovascular disease Parkinson’s Disease Huntington’s Disease Alzheimer’s Disease diabetes sarcopenia osteoperosis osteoarthritis macular degeneration adult cancer
- 10. Aging cardiovascular disease Parkinson’s Disease Huntington’s Disease Alzheimer’s Disease diabetes sarcopenia osteoporosis osteoarthritis macular degeneration adult cancer
- 11. What is aging?
- 12. Longevity Variation • Roundworm – 15 days • Fruit Fly – 50 days • Mouse – 2-3 years • Naked mole rate – 30+ years • Human - 82 years • Bowhead whales – 180 years • Quahog clam - 220 years
- 14. Famous people born at the same time as currently living clams Mary Queen of Scots (1542-1587)
- 15. Why is aging a risk factor for disease?
- 16. How are we getting to the answer?
- 18. age-1
- 19. Age (days) 0 5 10 15 20 25 30 35 FractionAlive 0.0 0.2 0.4 0.6 0.8 1.0 0 5 10 15 20 25 30 35 40 45 50 55 60 age-1Wild type (N2) Copyright – Gordon J. Lithgow
- 20. • Surprisingly easy to modulate aging and increase “healthspan” • Surprisingly large effects on lifespan • Surprisingly similar genes in very different species • A wide variety of biochemical and physiological processes (100s of genes) • Complex
- 21. Aging as a loss of homeostasis
- 28. Heat shock Nutritional fluctuations Osmolarity Heavy metals/oxidants Oxidative stress Endocrine pathways Insulin-like, steroid hormones Intracellular damage and repair signaling Metabolic control Aging outcomes Infection/inflammation Homeostatic factors are targets for interventions in aging
- 29. Can drugs be found that slow aging or postpone age-related disease?
- 30. Rapamycin
- 31. Some promising drug candidates
- 33. Jens Tyedmers, Axel Mogk and Bernd Bukau Nature Reviews, Molecular Cell Biology volume 11, 2010 Protein homeostasis
- 34. Human diseases caused by a failure in protein homeostasis
- 35. Does maintaining protein quality determine normal aging?
- 36. Dyes that bind amyloid thioflavin T
- 38. Suppression of worm Alzheimer’s +ThtControl Chris Link, U Colorado
- 39. Alavez et al. Nature 2011
- 43. 800,000 and 21 www.nature.com (2008)
- 44. Parallel screening (NPL-640 from TimTec (Newark, DE) RPS-O Aβ DAF-16 localization SASPPGC1α NFkappaB Metal resistance checkpoint Mammalian cellsC. elegans
- 45. Lithium Ashland, Oregon's Lithia Park
- 46. Lithium suppresses the accumulation of insoluble proteins during aging YoungControl Day11Control YoungLithium Day11Lithium
- 47. 0 5 10 15 20 25 0.00 0.25 0.50 0.75 1.00 0mM 5mM 10mM 20mM 50mM 100mM Days FractionSurviving Lithium McColl et al. J. Biol. Chem. 2008
- 48. A ray of sunshine from a petri dish Vitamin D
- 49. Now what?
- 52. The Nobel Prize in Physiology or Medicine 2002 "for their discoveries concerning 'genetic regulation of organ development and programmed cell death' Sydney Brenner Robert Horovitz John Suslston
Editor's Notes
- We know aging is the largest risk factor and the that aging mechanisms are connected to early origins of the disease…..
- Concept of biological stress V physical stress, hormones and continum.
- Concept of biological stress V physical stress, hormones and continum.