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Paleo   Longevity
Paleo

 •   indigenous

 •   pre-agriculture
Paleo characteristics

    •   grain-free

    •   low carb

    •   fat & protein
        (ad libitum)

    •   food quality

    •   n6:n3
Why should you care?


     •   lean body comp

     •   low inflammation

     •   reduced exposure to insulin / sugar / glycation
Why should you care?

        •        fastest growing
                 diet/lifestyle movement

        •        self-experiments

        •        controlled studies


Lindeberg, S, Jönsson, T, Granfeldt, Y, Borgstrand, E, Soffman, J, Sjöström, K, and Ahrén, B. A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in
individuals with ischaemic heart disease.Diabetologia, 2007
Paleo + Life Extension
CR
Good news
   •   calories

   •   survival-oriented genetic expression

   •   repair mechanisms
Avoid Excess Protein


         •   parts, not fuel

         •   burned as sugar, byproducts

         •   raises: insulin, IGF-1, mTOR pathway

         •   try 1g/kg lean body mass
Protein Fasting
                       Autophagy


                  =>
Fat (eat it)
    •   butter

    •   coconut milk

    •   avocado

    •   macadamia nuts

    •   healthy animals
Fat (adapt)
   •   primary fuel

   •   fat stores

   •   doesn’t raise:
       insulin, IGF-1, mTOR

   •   autophagy

   •   reduces exposure to:
       sugar, glycation, excess protein
Most macronutrient studies are flawed


        •   merits of protein vs carbs only

        •   use only unhealthy fats

        •   “high-fat” when really high-carb

        •   animals that don’t eat fat
Most macronutrient studies are flawed

 •   do not allow for fat-adaptation

 •   Rhesus Monkey CR
     NIA vs Wisconsin
Most macronutrient studies are flawed


 •   survey data?!




              (Cronometer)
Whiton Protocol:

        Synthesizing Paleo + Life Extension



              joshwhiton.com

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Josh Whiton at Health Extension Salon #1

  • 1. Paleo Longevity
  • 2. Paleo • indigenous • pre-agriculture
  • 3. Paleo characteristics • grain-free • low carb • fat & protein (ad libitum) • food quality • n6:n3
  • 4. Why should you care? • lean body comp • low inflammation • reduced exposure to insulin / sugar / glycation
  • 5. Why should you care? • fastest growing diet/lifestyle movement • self-experiments • controlled studies Lindeberg, S, Jönsson, T, Granfeldt, Y, Borgstrand, E, Soffman, J, Sjöström, K, and Ahrén, B. A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease.Diabetologia, 2007
  • 6. Paleo + Life Extension
  • 7. CR Good news • calories • survival-oriented genetic expression • repair mechanisms
  • 8. Avoid Excess Protein • parts, not fuel • burned as sugar, byproducts • raises: insulin, IGF-1, mTOR pathway • try 1g/kg lean body mass
  • 9. Protein Fasting Autophagy =>
  • 10. Fat (eat it) • butter • coconut milk • avocado • macadamia nuts • healthy animals
  • 11. Fat (adapt) • primary fuel • fat stores • doesn’t raise: insulin, IGF-1, mTOR • autophagy • reduces exposure to: sugar, glycation, excess protein
  • 12. Most macronutrient studies are flawed • merits of protein vs carbs only • use only unhealthy fats • “high-fat” when really high-carb • animals that don’t eat fat
  • 13. Most macronutrient studies are flawed • do not allow for fat-adaptation • Rhesus Monkey CR NIA vs Wisconsin
  • 14. Most macronutrient studies are flawed • survey data?! (Cronometer)
  • 15. Whiton Protocol: Synthesizing Paleo + Life Extension joshwhiton.com

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