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Calorie Restriction does not extend
   lifespan in primates (or mice)
1935

                                                                          30-40% lifespan
                                                                          increase in rodents
                                                                          on CR




McCay, C. M.; Crowell, Mary F. Prolonging the Life Span. The Scientific
Monthly, 1934, Volume 39, Issue 5, pp. 405-414
?
2009 Study on 41 Strains of Mice

       40% CR vs Ad-Lib

      “the longest lifespan achieved under DR did not
      exceed the longest achieved under AL feeding”



                     increased               deceased
      male           5%                      27%
      female         21%                     26%




Liao CY, Rikke BA, Johnson TE, Diaz V, Nelson JF. Genetic variation in the
murine lifespan response to dietary restriction: from life extension to life
shortening. Aging Cell. 2010 Feb;9(1):92-5.
1989-2009 Study at University of Wisconsin

                                                                                 30% CR vs Ad Lib

                                                                                 Difference in “overall” mortality
                                                                                 is not statistically
                                                                                 significant, but trends in the
                                                                                 direction of a CR benefit.




Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM,
Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. Caloric restriction
delays disease onset and mortality in rhesus monkeys. Science. 2009 Jul
10;325(5937):201-4.
1989-2009 Study at University of Wisconsin

                                                                                 30% CR vs Ad Lib

                                                                                 Difference in “overall” mortality
                                                                                 is not statistically
                                                                                 significant, but trends in the
                                                                                 direction of a CR benefit.


                                                                                 Control
                                                                                 monkeys
Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM,         were
Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. Caloric restriction
delays disease onset and mortality in rhesus monkeys. Science. 2009 Jul          obese.
10;325(5937):201-4.
1987-2012 NIA CR Study
                                                                     Control diet was not ad-lib to avoid obesity.


                                                                                     30% CR on Rhesus Monkeys

                                                                                     Began 1987




                                                                                        No Lifespan
Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL,
Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R.
Impact of caloric restriction on health and survival in rhesus monkeys from the
                                                                                      Increase On CR
NIA study. Nature. 2012 Aug 29.
Summary

             Obese < CR

            Normal = CR

CR response varies by genotype (risky)

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Mark Hamalainen at Health Extension Salon #1

  • 1. Calorie Restriction does not extend lifespan in primates (or mice)
  • 2. 1935 30-40% lifespan increase in rodents on CR McCay, C. M.; Crowell, Mary F. Prolonging the Life Span. The Scientific Monthly, 1934, Volume 39, Issue 5, pp. 405-414
  • 3. ?
  • 4. 2009 Study on 41 Strains of Mice 40% CR vs Ad-Lib “the longest lifespan achieved under DR did not exceed the longest achieved under AL feeding” increased deceased male 5% 27% female 21% 26% Liao CY, Rikke BA, Johnson TE, Diaz V, Nelson JF. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell. 2010 Feb;9(1):92-5.
  • 5. 1989-2009 Study at University of Wisconsin 30% CR vs Ad Lib Difference in “overall” mortality is not statistically significant, but trends in the direction of a CR benefit. Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 2009 Jul 10;325(5937):201-4.
  • 6. 1989-2009 Study at University of Wisconsin 30% CR vs Ad Lib Difference in “overall” mortality is not statistically significant, but trends in the direction of a CR benefit. Control monkeys Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, were Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 2009 Jul obese. 10;325(5937):201-4.
  • 7.
  • 8. 1987-2012 NIA CR Study Control diet was not ad-lib to avoid obesity. 30% CR on Rhesus Monkeys Began 1987 No Lifespan Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R. Impact of caloric restriction on health and survival in rhesus monkeys from the Increase On CR NIA study. Nature. 2012 Aug 29.
  • 9. Summary Obese < CR Normal = CR CR response varies by genotype (risky)

Editor's Notes

  1. 1935
  2. Fig. 1 Strain variation in mean lifespan of ILSXISS recombinant inbred (RI) mice under ad libitum (AL) and dietary restriction (DR) diets. Lifespan were typically obtained from 10 AL and 10 DR mice from each strain (five males and five females per treatment group); sample sizes in a few strains were either greater or less than 10 (details in supporting Table S1). The mean lifespan in the upper two panels are shown for each strain [AL (h) and DR ( )], ranked in ascending order according to the AL means (A: males, 41 strains; B: females, 39 strains). The lower two panels illustrate the deviation (positive and negative) of the mean DR lifespan from the mean AL for the same strains, ranked from the strain with the greatest increase in lifespan under DR to the strain with the greatest decrease (C: males; D: females). Error bars represent SEM. *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001 by t-test (no experiment-wise Bonferroni correction).