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Immunology for
 Life Extension
When Joe first
 asked me to do
this presentation
I immediately
 wanted to do
    this...
But I only have 4
minutes and 45
   seconds...
...to tell you
something interesting
 about life extension.
So I’ll start with
 a bold claim:
Knowing what to do, is
 more important than
the technology to do it
        with.
Case in point:
The Germ Theory:
Microorganisms are the
cause of many diseases.
Before the Germ Theory:

       People believed that
meat spontaneously produced flies,
   and mud produced snakes.
It was shown in 1668 that
meat did not produce flies
     in sealed flasks.
The discovery of microbes in 1674
 seemed to add renewed evidence to
the idea of Spontaneous Generation.
This sparked a back and
 forth about the “life force”
in boiled and unboiled soup.
Meanwhile, in Vienna, Semmelweis
 showed that surgeons washing their
hands could reduce mortality by over
                80%.
Semmelweis's observations
conflicted with established opinions
   of the time, and his ideas were
rejected by the medical community.
Some doctors were offended at the suggestion
    that they should wash their hands and
Semmelweis could offer no acceptable scientific
          explanation for his findings.
Semmelweis was committed to an asylum, where
   he died, ironically, of septicemia at age 47.
By then the debate about
 Spontaneous Generation became
so heated, that in 1860 a prize was
 created for resolving the conflict.
Pasteur claimed the prize, two
  years later, by exposing boiled
soup to air using a swan-neck flask
The resulting acceptance of the Germ
Theory triggered a medical revolution.

It had only taken two hundred years.
Up till the 1980s it was
believed that stomach ulcers
     are caused by stress
Never mind that by the 1950s John
Lykoudis had already cured himself and
30.000 others using antibiotics. He was
  fined and rejected from publication.
The true cause of stomach ulcers - H. Pylori -
was isolated by Marshall in 1983. Their paper
  was rejected from a Gastroenterological
 Conference (in the bottom 10% of papers).
It wasn’t until 1984, when he intentionally
    self-infected himself with H.Pylori, got a
stomach ulcer, and subsequently cured himself
       using antibiotics, that the medical
          establishment paid attention.
Stomach Cancer is the fourth most
  common form of cancer. More than
 800.000 people die from it every year.
The majority of stomach cancer is caused
              by H.Pylori.
How do pathogens
 survive in your
     body?
Microbes secrete things like
arginase and acetylcholinesterase
 to suppress the immune system.
Especially the action of arginase,
   which suppresses nitric oxide
production, might be one of the most
               potent
Arginase uses up supplies of
  L-Arginine required to
    produce nitric oxide
which in turn alters the balance of
     T-Helper cell subtypes
Many diseases that were thought to be
     caused by immune-system
 hyperactivity, are actually treatable
 with nitric oxide/immune boosters.
Chloroquine which is used as anti-
malarial and anti-rheumatic has been
 shown to have arginase-inhibiting
             properties
Arginase activity has also
been linked to colon cancer
Melanoma growth was shown to be
significantly inhibited by Viagra (a
    potent nitric oxide booster)
The anti-cancer properties of COX-2
 NSAIDs can be explained through
  their arginase blocking action
And there’s indication that the life
extending properties of aspirin and
naproxen also stem from their nitric
       oxide activity as well
Experimental NO-Aspirin has
 been shown to be 10-6000-fold
more potent for inhibiting cancer
But cancer isn’t
the only target
Arginase also is
  involved in
Eye Disease
and Infections
And that’s just
  Arginase
Many worms have specialized glands
 for producing acetylcholinesterase
  (the very thing most Alzheimer’s
            drugs inhibit)
I could go on...
But let’s stop
here for a second
Current and past
evidence suggests
 we still haven’t...
... fully come to terms
  with the pathogenic
   theory of disease.
We obviously don’t enjoy
 thinking about things
   living inside of us
Because of that we’ve
   talked ourselves into
believing, that our diseases
  are caused by too little
     exposure to germs
That’s called the hygiene
       hypothesis
There’s virtually no
 data to back it up
Counterexamples:

We’re just learning that...
Rosacea is caused by mites
(but we don’t treat for it yet)
Irritable Bowel Syndrome is caused by Amoeba
and Protozoa (which are different from bacteria)
         (but we don’t treat for it yet)
And Toxoplasmosis has been correlated with 6x
increased car accident rates (and 22% of the US
                 might have it)
           (but we don’t treat for it)
But of course it’s more
 complex than that...
Everything inside of you increases the
  likelihood of colonization by some
microbes, and decreases the likelihood
       of colonization by others
And they all modulate your
immune system to survive
There are more and less
preferable equilibria between
       all your guests
The smartest way to measure the quality of your
 particular equilibrium probably is indirectly.
By measuring its effects on your immune system.
Think of your Immune
  Cells as Nanobots
If you know what’s off, even
 simple interventions might
significantly extend your life
This extends beyond
cancer and infections
even to heart disease
As I’ve said:
Knowing what to do might be
   more important than
       technology!
Thank you!

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Paul Bohm at Health Extension Salon #2

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