The document presents an overview of aging, defining it as the deterioration of physiological functions over time, and explores various theories associated with aging such as genetic, wear-and-tear, and oxidative damage theories. It also discusses the causes of aging, including cellular senescence and mitochondrial dysfunction, as well as the maximum human lifespan, noted to be around 121 years. Finally, it highlights the significance of cellular and extracellular changes in the aging process.

1. AGING
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Presentation by,
Somnath
kalidas kamble
MSc Part 1
Roll no - 06

2. CONTENTS
1. Short introduction
2. Definition
3. Theorieses of aging
4. causes of aging
5. life span
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3. STAGES OF HUMAN LIFE CYCLE
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AGING

4. WHAT IS AGING ?
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• Aging can be defined as the time related
deterioration of the physiological
functions necessary for survival .
Or
• Can be define as increase in impairment in
Physiological functions with age , Increased
in suspectebility to diseases and decrease in
ability of fertility

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6. THEORIES ASSOCIATED
WITH AGING
1. Genetic theory
2. Nongenetic theories
3. wear-and-tear theory
4. Cross-linking theory
5. Oxidative damage theory
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7. CHANGES ASSOCIATED WITH
AGING
• aging is the impact of time on the human
body, and it occurs on multiple levels:
1. Cellular changes
2. Extracellular changes
1) cellular changes –
a) Telomere shortening:
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8. • Enzymes changes
• Accumalation of aging pigments
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9. EXTRACELLULAR
CHANGES
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• The changes Occuring in the Intracellular
Spaces and lumen of blood Vascular system
are the example of extracellular changes
• Dementia
• Alzheimer's
• Progeria
• Parkinson’s
disease

10. CAUSES OF AGING
1. Cellular senescence and aging
2. Telomere shortening: linked to life expectancy and aging
3. Mitochondrial dysfunction and aging
4. Oxidative stress
5. Stem cell exhaustion:
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11. LIFE SPAN
• The maximum life span is a characteristic of the species.
• It is the maximum number of years a member of that species has
been known to survive.
• The maximum human life span is estimated to be 121 years
• he life spans of tortoises and lake trout are both unknown, but are
estimated to be more than 150 years.
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12. THANK YOU
• Reference
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• Developmental biology by T.subramonium
• Developmental biology 6th edition