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Nutrition:
The Pied Piper Of Life Extension




                                   Justin Rebo MD/MSc
What interventions have clinically
significant impacts on life and health span?
• Quitting smoking
• Reversing Extreme Obesity
• Basic exercise




• After these 3 things we are already well into
  the realm of diminishing returns
What interventions have clinically
significant impacts on life and health span?
• Quitting smoking
• Reversing Extreme Obesity
• Basic exercise




• After these 3 things we are already well into
  the realm of diminishing returns
• After 20 or so death rate doubles roughly
  every 10 years you’re alive
     • That means that if you double the death rate you only
       live ten years less on average.
Nutritional Approaches
• Different nutritional approaches can flourish
  because relative differences between them
  are small.
1987-2012 NIA CR Study

                                                                     Control diet was not ad-lib to avoid obesity.



                                                                                     30% CR on Rhesus Monkeys

                                                                                     Began 1987




                                                                                        No Lifespan
Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL,
Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R.
                                                                                      Increase On CR
Impact of caloric restriction on health and survival in rhesus monkeys from the
NIA study. Nature. 2012 Aug 29.
1987-2012 NIA CR Study

                                                                     Control diet was not ad-lib to avoid obesity.



                                                                                     30% CR on Rhesus Monkeys

                                                                                     Began 1987




                                                                                        No Lifespan
Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL,
Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R.
                                                                                      Increase On CR
Impact of caloric restriction on health and survival in rhesus monkeys from the
NIA study. Nature. 2012 Aug 29.
What can you do right now?
Increased mortality in the low–normal BMI (18.5-22.5) range persisted after eliminating
people who died in the first 10 years of follow-up and after limiting the analysis to non-
smokers to minimize the risk of reverse causality or residual confounding.
appendix
•   Study Selection Randomized clinical trials evaluating the effect of omega-3 on all-cause mortality, cardiac
    death, sudden death, myocardial infarction, and stroke. Including about 70,000 patients total.
•   Conclusion Overall, omega-3 PUFA supplementation was not associated with a lower risk of all-cause
    mortality, cardiac death, sudden death, myocardial infarction, or stroke based on relative and absolute
    measures of association.
Justin Rebo at Health Extension Salon #2
Justin Rebo at Health Extension Salon #2

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Justin Rebo at Health Extension Salon #2

  • 1. Nutrition: The Pied Piper Of Life Extension Justin Rebo MD/MSc
  • 2. What interventions have clinically significant impacts on life and health span? • Quitting smoking • Reversing Extreme Obesity • Basic exercise • After these 3 things we are already well into the realm of diminishing returns
  • 3. What interventions have clinically significant impacts on life and health span? • Quitting smoking • Reversing Extreme Obesity • Basic exercise • After these 3 things we are already well into the realm of diminishing returns
  • 4. • After 20 or so death rate doubles roughly every 10 years you’re alive • That means that if you double the death rate you only live ten years less on average.
  • 5. Nutritional Approaches • Different nutritional approaches can flourish because relative differences between them are small.
  • 6. 1987-2012 NIA CR Study Control diet was not ad-lib to avoid obesity. 30% CR on Rhesus Monkeys Began 1987 No Lifespan Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R. Increase On CR Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature. 2012 Aug 29.
  • 7. 1987-2012 NIA CR Study Control diet was not ad-lib to avoid obesity. 30% CR on Rhesus Monkeys Began 1987 No Lifespan Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R. Increase On CR Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature. 2012 Aug 29.
  • 8. What can you do right now?
  • 9. Increased mortality in the low–normal BMI (18.5-22.5) range persisted after eliminating people who died in the first 10 years of follow-up and after limiting the analysis to non- smokers to minimize the risk of reverse causality or residual confounding.
  • 11. Study Selection Randomized clinical trials evaluating the effect of omega-3 on all-cause mortality, cardiac death, sudden death, myocardial infarction, and stroke. Including about 70,000 patients total. • Conclusion Overall, omega-3 PUFA supplementation was not associated with a lower risk of all-cause mortality, cardiac death, sudden death, myocardial infarction, or stroke based on relative and absolute measures of association.

Editor's Notes

  1. Understandably once someone decides they want to live as healthy as long as possible they begin to look into what they can do right now to achieve that. And there are a few basic things you can do that in some circumstances that can substantially increase both your quality and quantity of life.So what are they?
  2. Well they are the most obvious things. If you smoke, stop now. Smoking can subtract 10 or more years of life expectancy. Don’t be obese; extreme obesity can be as bad as smoking. And do some basic exercise.There is no controversy on these basic things, and I encourage everyone to do them.Unfortunately after these basics we rapidly go into the realm of diminishing returns. There are a million and one diet and exercise routines with large cult followings each claiming to be the healthiest, and all of them enjoying bashing standard nutritional guidelines and each other.
  3. Well they are the most obvious things. If you smoke, stop now. Smoking can subtract 10 or more years of life expectancy. Don’t be obese; extreme obesity can be as bad as smoking. And do some basic exercise.There is no controversy on these basic things, and I encourage everyone to do them.Unfortunately after these basics we rapidly go into the realm of diminishing returns. There are a million and one diet and exercise routines with large cult followings each claiming to be the healthiest, and all of them enjoying bashing standard nutritional guidelines and each other.
  4. Ultimately there is so much ambiguity because the relative effects on lifespan is so small. So this allows an environment to exist where seemingly wildly disparate nutritional approaches are allowed to exist, simply because the data is too weak to disprove any of them. This should now be obvious, because even seemingly large effects to the death rate are not going to alter life expectancy very much.